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1. Full Text Geneva Cocktail for Cytochrome P450 and P‐Glycoprotein Activity Assessment Using Dried Blood Spots
by Bosilkovska, M and Samer, C F and Déglon, J and Rebsamen, M and Staub, C and Dayer, P and Walder, B and Desmeules, J A and Daali, Y
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2014, Volume 96, Issue 3, pp. 349 - 359
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and... 
P4502B6 ACTIVITY | VORICONAZOLE | LC-MS/MS | SINGLE-POINT | ORAL MIDAZOLAM | VOLUNTEERS | IN-VIVO | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | KAROLINSKA COCKTAIL | BUPROPION HYDROXYLATION | Predictive Value of Tests | Pharmaceutical Preparations - blood | Caffeine - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Dried Blood Spot Testing | Humans | Omeprazole - blood | Bupropion - blood | Midazolam - administration & dosage | Substrate Specificity | Male | Chromatography, High Pressure Liquid | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Coffee | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Feasibility Studies | Enzyme Inhibitors - administration & dosage | Young Adult | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Capsules | Spectrometry, Mass, Electrospray Ionization | Flurbiprofen - administration & dosage | Adult | Dextromethorphan - pharmacokinetics | Terfenadine - blood | ATP-Binding Cassette, Sub-Family B, Member 1 - blood | Pharmaceutical Preparations - administration & dosage | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 Enzyme System - blood | Administration, Oral | Isoenzymes | Caffeine - blood | Omeprazole - administration & dosage | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Carbonated Beverages | Midazolam - pharmacokinetics | Bupropion - administration & dosage | Dextromethorphan - blood | Flurbiprofen - blood | Phenotype | Pilot Projects | Midazolam - blood | Dextromethorphan - administration & dosage | Usage | Glycoproteins | Liquid chromatography | Research | Pharmacokinetics | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
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2. Full Text Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: A clinical trial
by Kempf, Kerstin and Herder, Christian and Erlund, Iris and Kolb, Hubert and Martin, Stephan and Carstensen, Maren and Koenig, Wolfgang and Sundvall, Jouko and Bidel, Siamak and Kuha, Suvi and Tuomilehto, Jaakko
American Journal of Clinical Nutrition, ISSN 0002-9165, 04/2010, Volume 91, Issue 4, pp. 950 - 957
Background: Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included... 
WOMEN | NUTRITION & DIETETICS | PLASMA | ADIPONECTIN | INSULIN-RESISTANCE | ANTIOXIDANT | ELEVATED LEVELS | MARKERS | HUMANS | INCREASES | HEALTHY | Single-Blind Method | Dinoprost - blood | Chlorogenic Acid - blood | Cholesterol - blood | Humans | Middle Aged | Male | Coffee - chemistry | Inflammation - drug therapy | Lipids - blood | Plant Preparations - pharmacology | Plant Preparations - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Dinoprost - analogs & derivatives | Interleukin-18 - blood | Anti-Inflammatory Agents - pharmacology | Caffeine - blood | Risk Factors | Biomarkers - blood | Apolipoproteins - blood | Adiponectin - blood | Diabetes Mellitus, Type 2 - blood | Caffeic Acids - blood | Caffeic Acids - metabolism | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Prevention | Oxidative stress | Nutritional aspects | Inflammation | Research | Coffee | Health aspects
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3. Full Text Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening
by Wang, Ying I and Abaci, Hasan Erbil and Shuler, Michael L
Biotechnology and Bioengineering, ISSN 0006-3592, 01/2017, Volume 114, Issue 1, pp. 184 - 194
ABSTRACT Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB) remains a formidable challenge for central nervous system drug... 
organ on a chip | TEER | blood–brain barrier | human iPS cells | permeability | blood-brain barrier | BBB | DOXORUBICIN | MAINTAINS | IN-VITRO MODELS | FLOW | TRANSPORT | CELLS RESIST ELONGATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENDOTHELIAL-CELLS | SHEAR-STRESS | EXPRESSION | Microfluidic Analytical Techniques - methods | Cell Line | Drug Evaluation, Preclinical - methods | Induced Pluripotent Stem Cells - physiology | Humans | Microfluidic Analytical Techniques - instrumentation | Electric Impedance | Permeability | Equipment Design | Tissue Array Analysis - methods | Blood-Brain Barrier - metabolism | Models, Biological | Induced Pluripotent Stem Cells - metabolism | Dextran | Anthracyclines | Analysis | Therapeutics | Stem cells | Microfluidics | Electric properties | Caffeine | Endothelium | Homeopathy | Materia medica and therapeutics | Bioengineering | Pharmacology | Blood-brain barrier | Drugs | Screening | Brain | Barriers | Mathematical models | In vivo methods and tests | blood brain barrier
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4. Full Text Sources of inaccuracy in the measurement of adult patients’ resting blood pressure in clinical settings: a systematic review
by Kallioinen, Noa and Hill, Andrew and Horswill, Mark S and Ward, Helen E and Watson, Marcus O
Journal of Hypertension, ISSN 0263-6352, 12/2016, Volume 35, Issue 3, pp. 421 - 441
BACKGROUND:To interpret blood pressure (BP) data appropriately, healthcare providers need to be knowledgeable of the factors that can potentially impact the... 
Hypertension | Measurement | Vital signs | Clinical deterioration | Blood pressure determination | Blood Pressure | Cold Temperature | Reproducibility of Results | Humans | Blood Pressure Determination - instrumentation | Alcohol Drinking - physiopathology | Blood Pressure Determination - standards | Tobacco Use - physiopathology | Hypertension - physiopathology | Blood Pressure Determination - methods | Eating - physiology | Nicotine - pharmacology | Rest - physiology | White Coat Hypertension - physiopathology | Caffeine - pharmacology | Arm | Urinary Bladder - physiology | vital signs | Reviews | clinical deterioration | hypertension | measurement | blood pressure determination
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5. Full Text Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure: A prospective study among United States Adults
by Chen, Liwei and Caballero, Benjamin and Mitchell, Diane C and Loria, Catherine and Lin, Pao-Hwa and Champagne, Catherine M and Elmer, Patricia J and Ard, Jamy D and Batch, Bryan C and Anderson, Cheryl A.M and Appel, Lawrence J
Circulation, ISSN 0009-7322, 06/2010, Volume 121, Issue 22, pp. 2398 - 2406
Background-Increased consumption of sugar-sweetened beverages (SSBs) has been associated with an elevated risk of obesity, metabolic syndrome, and type II... 
Hypertension | Blood pressure | Diet | Follow-up studies | LIFE-STYLE MODIFICATION | blood pressure | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | CLINICAL-TRIAL | RATS | CAFFEINE | WOMEN | follow-up studies | OBESITY | FRUCTOSE | PERIPHERAL VASCULAR DISEASE | diet | hypertension | URIC-ACID | Beverages - adverse effects | United States - epidemiology | Prospective Studies | Humans | Middle Aged | Sweetening Agents - adverse effects | Male | Hypertension - chemically induced | Hypertension - prevention & control | Adult | Dietary Sucrose - administration & dosage | Dietary Sucrose - adverse effects | Female | Aged | Blood Pressure - drug effects | Blood Pressure - physiology | Hypertension - epidemiology | Sweetening Agents - administration & dosage | Type 2 diabetes | Obesity | Nutritional aspects | Regulation | Research | Metabolic syndrome X | Beverages | Risk factors
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6. Full Text Precise, accurate and user-independent blood collection system for dried blood spot sample preparation
by Neto, Ricardo and Gooley, Andrew and Breadmore, Michael C and Hilder, Emily F and Lapierre, Florian
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 5/2018, Volume 410, Issue 14, pp. 3315 - 3323
An accurate and precise 3 μL blood collection and dispensing system is presented for the preparation of dried blood spot (DBS) samples. Using end-to-end glass... 
Biochemistry, general | Glass capillary | Chemistry | Analytical Chemistry | Food Science | Monitoring/Environmental Analysis | Microsampling | Dried blood spot | Characterization and Evaluation of Materials | Laboratory Medicine | Blood | LC-MS/MS | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | DEVICE | QUANTITATIVE BIOANALYSIS | HEMATOCRIT | Reproducibility of Results | Sample Size | Dried Blood Spot Testing - instrumentation | Caffeine - blood | Humans | Hematocrit | Equipment Design | Blood Specimen Collection - instrumentation | Accuracy | Sample preparation | Methodology | Capillarity | Mathematical analysis | Dispensing | Collection | Conjugation | Capillaries | Coefficient of variation | Caffeine
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7. Full Text Simultaneous determination of uric acid, xanthine, hypoxanthine and caffeine in human blood serum and urine samples using electrochemically reduced graphene oxide modified electrode
by Raj, M. Amal and John, S. Abraham
Analytica Chimica Acta, ISSN 0003-2670, 04/2013, Volume 771, pp. 14 - 20
► Glassy carbon electrode was modified with graphene by self assembly method. ► Modified electrode was characterized by Raman spectroscopy. ► Graphene modified... 
Raman spectra | Electrochemical reduction | Human blood plasma | Purine derivatives | Graphene oxide | CHEMISTRY, ANALYTICAL | FILM-MODIFIED ELECTRODE | VOLTAMMETRIC DETERMINATION | SENSITIVE DETERMINATION | GLASSY-CARBON ELECTRODE | SENSOR | THEOPHYLLINE | PASTE ELECTRODE | REDUCTION | NANOTUBES | Humans | Oxides - chemistry | Hypoxanthine - chemistry | Xanthine - urine | Electrodes | Uric Acid - chemistry | Uric Acid - urine | Time Factors | Purines - blood | Spectrum Analysis, Raman | Uric Acid - blood | Catalysis | Graphite - chemistry | Caffeine - urine | Blood Chemical Analysis - methods | Oxidation-Reduction | Urinalysis - instrumentation | Xanthine - blood | Caffeine - blood | Xanthine - chemistry | Blood Chemical Analysis - instrumentation | Urinalysis - methods | Purines - urine | Hypoxanthine - blood | Purines - chemistry | Caffeine - chemistry | Electrochemistry | Hypoxanthine - urine | Purines | Biological products | Raman spectroscopy | Graphene | Index Medicus
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8. Full Text Caffeine Reduces Myocardial Blood Flow During Exercise
by Higgins, John P., MD, MBA, MPhil and Babu, Kavita M., MD
American Journal of Medicine, The, ISSN 0002-9343, 2013, Volume 126, Issue 8, pp. 730.e1 - 730.e8
Abstract Caffeine consumption has been receiving increased interest from both the medical and lay press, especially given the increased amounts now available... 
Internal Medicine | Myocardial blood flow | Endothelial function | Athletes | Cardiovascular effects | Caffeine | COFFEE | CARDIAC-ARRHYTHMIAS | ENERGY DRINKS | NORMAL VOLUNTEERS | ADENOSINE | MEDICINE, GENERAL & INTERNAL | NITRIC-OXIDE | VASODILATION | RECEPTORS | CORONARY-ARTERY-DISEASE | Coronary Vessels - drug effects | Phosphodiesterase Inhibitors - adverse effects | Humans | Caffeine - adverse effects | Caffeine - pharmacology | Heart - drug effects | Phosphodiesterase Inhibitors - pharmacology | Exercise - physiology | Hemodynamics - drug effects
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9. Full Text A review of calibrated blood oxygenation level‐dependent (BOLD) methods for the measurement of task‐induced changes in brain oxygen metabolism
by Blockley, Nicholas P and Griffeth, Valerie E. M and Simon, Aaron B and Buxton, Richard B
NMR in Biomedicine, ISSN 0952-3480, 08/2013, Volume 26, Issue 8, pp. 987 - 1003
The dynamics of the blood oxygenation level‐dependent (BOLD) response are dependent on changes in cerebral blood flow, cerebral blood volume and the cerebral... 
oxygen metabolism | calibrated BOLD | review | respiratory challenge | Respiratory challenge | Review | Oxygen metabolism | Calibrated BOLD | SIGNAL CHANGES | BASE-LINE | CEREBROVASCULAR REACTIVITY | CAFFEINE-INDUCED CHANGES | TIDAL CARBON-DIOXIDE | OXIDATIVE-METABOLISM | HUMAN VISUAL-CORTEX | CEREBRAL PERFUSION | BIOPHYSICS | SPECTROSCOPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | QUANTITATIVE BOLD | EXTRACTION FRACTION | Neuroimaging - methods | Motor Activity - physiology | Reproducibility of Results | Oxyhemoglobins - metabolism | Humans | Hematocrit | Oxygen Consumption | Hemoglobins - metabolism | Magnetic Resonance Imaging - methods | Brain Mapping - methods | Calibration | Forecasting | Oxygen - metabolism | Brain - metabolism | Models, Biological | Hyperoxia - metabolism | Multimodal Imaging - methods | Blood Volume | Research Design | Aging - metabolism | Hypercapnia - metabolism | Measurement | Physiological aspects | Brain | Analysis | Blood flow
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10. Full Text Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content role of habitual versus nonhabitual drinking
by Corti, Roberto and Binggeli, Christian and Sudano, Isabella and Spieker, Lukas and Hänseler, Edgar and Ruschitzka, Frank and Chaplin, William F and Lüscher, Thomas F and Noll, Georg
Circulation, ISSN 0009-7322, 12/2002, Volume 106, Issue 23, pp. 2935 - 2940
Background-Coffee is the most abundantly consumed stimulant worldwide. However, its cardiovascular safety remains controversial. Possible health hazards have... 
Hypertension | Coffee | Caffeine | Nervous system, sympathetic | SYSTEM | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | HUMANS | RISK | nervous system, sympathetic | CORONARY HEART-DISEASE | WOMEN | caffeine | coffee | MEN | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | CONSUMPTION | Peroneal Nerve - physiology | Caffeine - administration & dosage | Injections, Intravenous | Administration, Oral | Sympathetic Nervous System - drug effects | Humans | Electrocardiography - drug effects | Feeding Behavior | Reference Values | Hemodynamics - physiology | Coffee - chemistry | Peroneal Nerve - drug effects | Sympathetic Nervous System - physiology | Time Factors | Muscles - innervation | Caffeine - pharmacology | Adult | Blood Pressure - drug effects | Blood Pressure - physiology | Hemodynamics - drug effects
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