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Developmental Cell, ISSN 1534-5807, 2002, Volume 3, Issue 6, pp. 889 - 901
Signaling by RANKL is essential for terminal differentiation of monocytes/mcrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play... 
LYMPH-NODE ORGANOGENESIS | CELLS | CYCLOSPORINE-A | OSTEOPROTEGERIN-LIGAND | KEY REGULATOR | C-FOS | RECEPTOR ACTIVATOR | GENE-EXPRESSION | DEVELOPMENTAL BIOLOGY | OSTEOPETROSIS | NF-KAPPA-B | CELL BIOLOGY | Transcription, Genetic - drug effects | Genetic Testing | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | RANK Ligand | Osteoclasts - cytology | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Calcineurin - genetics | Cell Culture Techniques | Active Transport, Cell Nucleus - genetics | Signal Transduction - genetics | Nuclear Proteins | Signal Transduction - drug effects | Calcium Signaling - drug effects | Active Transport, Cell Nucleus - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-fos - genetics | Mice | Transcription, Genetic - genetics | Calcium Signaling - genetics | Receptor Activator of Nuclear Factor-kappa B | Transcription Factors - deficiency | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - deficiency | Cell Differentiation - genetics | Carrier Proteins - pharmacology | Hematopoietic Stem Cells - drug effects | Gene Expression Regulation - genetics | Membrane Glycoproteins - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Hematopoietic Stem Cells - metabolism | NFATC Transcription Factors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Osteoclasts - metabolism | Membrane Glycoproteins - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Carrier Proteins - genetics | TNF Receptor-Associated Factor 6 | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Calcineurin - metabolism | Osteoclasts - drug effects | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 11/2014, Volume 33, Issue 45, pp. 5238 - 5250
Metastatic breast tumors undergo epithelial-to-mesenchymal transition (EMT), which renders them resistant to therapies targeted to the primary cancers. The... 
APOPTOSIS | ACTIVATION | RESPIRATORY STRESS | mitochondrial DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial retrograde signaling | breast cancer | MTDNA DEPLETION | CELL BIOLOGY | DNA DEPLETION | GENOME INSTABILITY | ONCOLOGY | ESRP1 | COPY NUMBER | IN-VIVO | GENETICS & HEREDITY | RESISTANCE | epithelial-mesenchymal transition | cancer stem cells | MUTATIONS | Epithelial Cells - metabolism | Humans | Lung Neoplasms - metabolism | Immunoblotting | Transplantation, Heterologous | Mitochondrial Proteins - genetics | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Calcineurin - genetics | DNA, Mitochondrial - genetics | Lung Neoplasms - secondary | MCF-7 Cells | Mitochondria - genetics | Neoplastic Stem Cells - metabolism | RNA Interference | Mitochondrial Proteins - metabolism | Neoplastic Stem Cells - pathology | Female | Lung Neoplasms - genetics | Cell Line | Gene Expression | DNA, Mitochondrial - metabolism | Gene Dosage | Mitochondria - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Oxygen Consumption - genetics | Calcineurin - metabolism | RNA | Stem cells | Physiological aspects | Breast cancer | Genetic aspects | Mitochondrial DNA | Health aspects | Signal transduction | Metastasis | Tumors | Index Medicus | epithelial | mesenchymal transition
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2007, Volume 104, Issue 8, pp. 2815 - 2820
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 46, pp. 40401 - 40412
Two genes on chromosome 21, namely dual specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1), have been... 
TAU-PROTEIN | FUNCTIONAL-LINK | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-SYNDROME | CALCINEURIN PHOSPHATASE-ACTIVITY | SYNDROME CRITICAL REGION | HUMAN HOMOLOG | STRIATED-MUSCLES | T-CELLS | Chromosomes, Human, Pair 21 - metabolism | Protein Binding - genetics | Down Syndrome - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Intracellular Signaling Peptides and Proteins - metabolism | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | Calcineurin - genetics | tau Proteins - genetics | HEK293 Cells | Muscle Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | NFATC Transcription Factors - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Signal Transduction - genetics | Chromosomes, Human, Pair 21 - genetics | Glycogen Synthase Kinase 3 - metabolism | Muscle Proteins - genetics | Animals | Glycogen Synthase Kinase 3 - genetics | Down Syndrome - genetics | Mice | Transcription, Genetic - genetics | Calcineurin - metabolism | NFATC Transcription Factors - genetics | Index Medicus | NFAT Transcription Factor | Down Syndrome | Molecular Bases of Disease | RCAN1 | Phosphorylation | Dual Specificity Kinase | Calcineurin | Dyrk1A | Glycogen Synthase Kinase 3 | Neurological Diseases
Journal Article
Cell, ISSN 0092-8674, 2002, Volume 110, Issue 4, pp. 479 - 488
The heart responds to stress signals by hypertrophic growth, which is accompanied by activation of the MEF2 transcription factor and reprogramming of cardiac... 
ACTIVATION | MYOGENESIS | P300 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | CALCINEURIN | MEF2 TRANSCRIPTION FACTOR | DEPENDENT PROTEIN-KINASE | ASSOCIATION | BINDING | MITR | CELL BIOLOGY | Phosphotransferases - metabolism | Phosphorylation | Heart - embryology | Repressor Proteins | Male | DNA-Binding Proteins - metabolism | Calcineurin - genetics | Aging - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 1 | Phosphotransferases - genetics | MEF2 Transcription Factors | Gene Expression Regulation, Developmental - physiology | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Histone Deacetylases - genetics | Stress, Physiological - genetics | Enzyme Inhibitors - pharmacology | Histone Deacetylases - deficiency | Cardiomegaly - physiopathology | Histone Deacetylase 2 | Histone Deacetylases - metabolism | Myocardium - pathology | Stress, Physiological - physiopathology | Signal Transduction - genetics | Cardiomegaly - enzymology | Myogenic Regulatory Factors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Stress, Physiological - enzymology | Hypertension - pathology | Hypertension - physiopathology | Aging - pathology | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Myocardium - enzymology | Animals | Carrier Proteins - metabolism | Hypertension - complications | Mice | Transcriptional Activation - physiology | Cardiomegaly - genetics | Calcineurin - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Aging - metabolism | Physiological aspects | Enzymes | Cellular signal transduction | Regulation | Heart enlargement | Heart muscle | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2006, Volume 441, Issue 7093, pp. 595 - 600
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e86206 - e86206
Journal Article
PLoS Genetics, ISSN 1553-7390, 09/2017, Volume 13, Issue 9, pp. e1006982 - e1006982
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 11, pp. 9049 - 9062
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43543 - 43556
Endorepellin, the angiostatic C-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits angiogenesis by simultaneously binding to the alpha 2... 
CANCER GROWTH | COLON CARCINOMA-CELLS | DOMAIN-III | ANGIOSTATIC ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERLECAN PROTEIN CORE | VEGF RECEPTOR-2 | HEPARAN-SULFATE PROTEOGLYCAN | BASEMENT-MEMBRANE PROTEOGLYCANS | TUMOR-GROWTH | ALPHA-2-BETA-1 INTEGRIN | Protein Kinase C - genetics | MAP Kinase Signaling System - physiology | Human Umbilical Vein Endothelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Active Transport, Cell Nucleus - physiology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Proto-Oncogene Proteins c-akt - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Cell Nucleus - metabolism | MAP Kinase Kinase 4 - metabolism | TOR Serine-Threonine Kinases - genetics | Heparan Sulfate Proteoglycans - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Kinase C - metabolism | Swine | Human Umbilical Vein Endothelial Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Peptide Fragments - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | NFATC Transcription Factors - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Neovascularization, Physiologic - physiology | Transcription, Genetic - physiology | Animals | Cell Nucleus - genetics | Heparan Sulfate Proteoglycans - metabolism | MAP Kinase Kinase 4 - genetics | NFATC Transcription Factors - genetics | Index Medicus | Proteoglycan | Angiogenesis | Vascular Endothelial Growth Factor (VEGF) | AP1 | VEGF Receptor 2 | Vascular Biology | Calcineurin | Perlecan | Glycobiology and Extracellular Matrices | Endothelial Cell | NFAT1
Journal Article