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Nature Immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 449 - 456
Intestinal phagocytes transport oral antigens and promote immune tolerance, but their role in innate immune responses remains unclear. Here we found that... 
FLAGELLIN | PATTERN-RECOGNITION | NOD-LIKE RECEPTORS | ACTIVATES CASPASE-1 | MACROPHAGES | INTERLEUKIN-1-BETA | INFLAMMASOME RECEPTORS | INFECTION | NLRP3 INFLAMMASOME | SECRETION | IMMUNOLOGY | Inflammasomes - metabolism | Humans | Receptors, Interleukin-1 - genetics | Salmonella Infections - genetics | Salmonella Infections - immunology | Clonal Anergy | Caspase 1 - metabolism | Monocytes - metabolism | Monocytes - immunology | Intestines - immunology | Host-Pathogen Interactions - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Apoptosis Regulatory Proteins - genetics | Pseudomonas - immunology | Toll-Like Receptors - metabolism | Neutrophil Infiltration - immunology | Neutrophils - pathology | Apoptosis Regulatory Proteins - immunology | Flagellin - immunology | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Neutrophils - immunology | Salmonella - genetics | Signal Transduction - genetics | Phagocytes - immunology | Neutrophil Infiltration - genetics | Mice, Knockout | Pseudomonas Infections - immunology | Salmonella - immunology | Animals | Intestines - microbiology | Phagocytes - microbiology | Inflammasomes - immunology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - biosynthesis | Calcium-Binding Proteins - genetics
Journal Article
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 8, pp. 3829 - 3839
We have examined the molecular pathways involved in the adjuvant action of cholera toxin (CT) and two novel nontoxic molecules, multiple-mutated CT (mmCT) and... 
CELLS | TRANSCRIPTIONAL ACTIVITY | ACTIVATION | IMMUNOGENICITY | HEAT-LABILE ENTEROTOXIN | IMMUNE-RESPONSES | ESCHERICHIA-COLI | ETEC VACCINE | IMMUNOLOGY | NF-KAPPA-B | MUCOSAL ADJUVANT | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | Adjuvants, Immunologic - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Interleukin-1beta - immunology | Male | Caspase 1 - immunology | Enzyme Activation - drug effects | Enzyme Activation - immunology | Signal Transduction - immunology | Signal Transduction - drug effects | Calcium-Binding Proteins - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Cyclic AMP - immunology | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - immunology | Th17 Cells - immunology | Adult | Female | Th17 Cells - cytology | Cholera Toxin - pharmacology | Carrier Proteins - immunology | Calcium-Binding Proteins/immunology | Signal Transducing/immunology | Apoptosis Regulatory Proteins/immunology | Cyclic AMP/ immunology | Enzyme Activation/drug effects/immunology | Adjuvants | Immunologi inom det medicinska området | Interleukin-1beta/ immunology | Adaptor Proteins | Th17 Cells/cytology/ immunology | Signal Transduction/ drug effects/immunology | Caspase 1/immunology | Carrier Proteins/immunology | Cholera Toxin/ pharmacology | Cyclic AMP-Dependent Protein Kinases/ immunology | CARD Signaling Adaptor Proteins/immunology | Immunologic/ pharmacology | Immunology in the medical area | Inflammasomes/ immunology
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 174 - 184
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear.... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-18 LEVELS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOVASCULAR-DISEASE | RECEPTOR | ESSENTIAL-HYPERTENSION | PROTEINS | T-CELLS | AGE | CELL BIOLOGY | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2014, Volume 192, Issue 3, pp. 919 - 928
The Lyn tyrosine kinase regulates inhibitory signaling in B and myeloid cells: loss of Lyn results in a lupus-like autoimmune disease with hyperactive B cells... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | PROTEIN | DENDRITIC CELLS | DISEASE | GERMINAL CENTER | DEFICIENT MICE | IMMUNOLOGY | MATURATION | AUTOANTIBODY PRODUCTION | T-CELLS | T-Lymphocyte Subsets - immunology | Antibody Specificity | Antibodies, Antinuclear - biosynthesis | Myeloproliferative Disorders - enzymology | Immune Complex Diseases - immunology | Spleen - immunology | Kidney - pathology | Antibodies, Antinuclear - immunology | Cell Count | Germinal Center - immunology | Kidney - immunology | Homeostasis | Myeloproliferative Disorders - immunology | Immunoglobulin M - immunology | Myeloproliferative Disorders - genetics | src-Family Kinases - deficiency | Lupus Nephritis - etiology | Immunoglobulin G - biosynthesis | Autoimmunity - immunology | Immunoglobulin G - immunology | Myeloid Differentiation Factor 88 - immunology | Calcium Signaling - immunology | Spleen - pathology | Immunoglobulin Class Switching | Disease Models, Animal | B-Lymphocytes - enzymology | Lymphocyte Activation | Mice, Inbred C57BL | Mice, Transgenic | Lupus Nephritis - immunology | Germinal Center - pathology | Organ Specificity | src-Family Kinases - immunology | Immune Complex Diseases - pathology | Antibodies, Antinuclear - genetics | Lupus Nephritis - enzymology | Animals | B-Lymphocytes - immunology | Myeloid Differentiation Factor 88 - deficiency | Lymphopoiesis - immunology | Mice | src-Family Kinases - genetics | Immunoglobulin M - biosynthesis | Plasma Cells - immunology
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 79 - 87
Influenza virus infection is recognized by the innate immune system through Toll like receptor (TLR) 7 and retinoic acid inducible gene I. These two... 
MEDICINE, RESEARCH & EXPERIMENTAL | STRANDED-RNA | DYING CELLS | HUMAN MACROPHAGES | INTERLEUKIN-1-BETA | INFECTION | IMMUNOLOGY | A-VIRUS | CASPASE-1 ACTIVATION | CRYOPYRIN/NALP3 | T-CELLS | NALP3 INFLAMMASOME | CD8-Positive T-Lymphocytes - cytology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Immunity, Innate - genetics | Cell Movement - genetics | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Lung - virology | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Lung - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Macrophages, Alveolar - immunology | Macrophages, Alveolar - virology | Antibody Formation - immunology | Immunity, Cellular - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Mice, Knockout | Carrier Proteins - genetics | Immunity, Cellular - immunology | Immunity, Innate - immunology | Immunoglobulin Isotypes - blood | Animals | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Survival Analysis | Nasal Lavage Fluid - immunology | Immunoglobulin Isotypes - immunology | Mice | Macrophages, Alveolar - metabolism | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Calcium-Binding Proteins - genetics | Multiprotein Complexes - immunology | Brief Definitive Reports
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7414, pp. 160 - 164
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175153
IL-1 beta is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.... 
VITAMIN-D | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | PSORIASIN S100A7 | INFLAMMATORY CASPASES | KERATINOCYTES | 1,25-DIHYDROXYVITAMIN D-3 | MOLECULAR-CLONING | EXPRESSION | T-CELLS | Caspases - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | S100 Proteins - immunology | Psoriasis - genetics | S100 Proteins - genetics | Th17 Cells - drug effects | Transfection | Inflammasomes - drug effects | Psoriasis - pathology | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-1beta - secretion | Psoriasis - immunology | S100 Calcium Binding Protein A7 | Apoptosis Regulatory Proteins - immunology | DNA - immunology | Signal Transduction | Caspases - genetics | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-1beta - immunology | Vitamin D - pharmacology | Keratinocytes - cytology | Keratinocytes - immunology | DNA - genetics | Interleukin-17 - antagonists & inhibitors | Keratinocytes - drug effects | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Interferon-gamma - pharmacology | Interleukins | Physiological aspects | Development and progression | Skin diseases | Genetic aspects | Inflammation | Research | Cell culture | Transcription | Interleukin | Helper cells | Lymphocytes T | Inflammatory diseases | Vitamin D | Lymphocytes | Interleukin 1 | Lesions | Deoxyribonucleic acid--DNA | Psoriasis | Cytokines | Dermatology | Keratinocytes | Caspase | Epidermis | Hazards | Gene expression | Caspase-5 | Hospitals | Biopsy | Interferon | Autoimmune diseases | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
PLoS Pathogens, ISSN 1553-7366, 06/2013, Volume 9, Issue 6, p. e1003400
Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a... 
LEGIONELLA-PNEUMOPHILA | FLAGELLIN | PROTEIN | DISTINCT PATHWAYS | RECOGNITION | INFLAMMASOME ACTIVATION | INTERLEUKIN-1-BETA | INNATE | LEGIONNAIRES DISEASE | MICROBIOLOGY | DIFFERENTIAL REQUIREMENT | VIROLOGY | PARASITOLOGY | Interleukin-1alpha - immunology | Caspases - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Cytosol - immunology | Enzyme Activation - immunology | Legionnaires' Disease - immunology | Calcium-Binding Proteins - immunology | Legionnaires' Disease - microbiology | Legionella pneumophila - pathogenicity | Bacterial Secretion Systems - immunology | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Cell Line | Legionella pneumophila - immunology | Apoptosis Regulatory Proteins - immunology | Macrophages - pathology | Caspases - genetics | Interleukin-1beta - immunology | Inflammasomes - genetics | Mice, Knockout | Immunity, Innate - immunology | Animals | Inflammasomes - immunology | Legionnaires' Disease - pathology | Cytosol - microbiology | Mice | Host-parasite relationships | Physiological aspects | Research | Interleukins | Cytosol | Health aspects | Bacterial infections | Microbiology | Cytokines | Infections | Experiments | Bacteriology | Recruitment | Scholarships & fellowships | E coli | Bone marrow | Bacteria | Interferon | Gram-negative bacteria | Adapter proteins | Apoptosis
Journal Article