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The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1968 - 1977
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that... 
NOTCH | ESTROGEN | ADJUVANT TAMOXIFEN | RECEPTOR | CELL BIOLOGY | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | p-Aminoazobenzene - analogs & derivatives | Receptors, Notch - genetics | Receptors, Notch - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | p-Aminoazobenzene - pharmacology | Neoplastic Stem Cells - pathology | Estradiol - pharmacology | Jagged-1 Protein | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Isoenzymes - genetics | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Benzazepines - pharmacology | Retinal Dehydrogenase - genetics | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Survival Analysis | Cell Line, Tumor | Retinal Dehydrogenase - antagonists & inhibitors | Mice | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Gene Expression Regulation, Neoplastic | Cell Cycle Proteins - antagonists & inhibitors | Estrogen Receptor Antagonists - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Isoenzymes - metabolism | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Antineoplastic Agents, Hormonal - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Homeodomain Proteins - antagonists & inhibitors | Tamoxifen - pharmacology | Breast Neoplasms - mortality | Cell Proliferation - drug effects | Isoenzymes - antagonists & inhibitors | Receptor, Notch4 | Drug Resistance, Neoplasm - drug effects | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2011, Volume 187, Issue 12, pp. 6539 - 6549
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 171 - 185
We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed... 
COLON-CANCER | METASTASIS | ONCOLOGY | NOTCH | NICHE | SELF-RENEWAL | RECEPTOR | GROWTH-FACTOR | TUMOR ANGIOGENESIS | DIFFERENTIATION | ANGIOCRINE FACTORS | CELL BIOLOGY | ADAM17 Protein | RNA, Small Interfering - genetics | Immunoprecipitation | Receptors, Notch - metabolism | Colorectal Neoplasms - genetics | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Drug Resistance, Neoplasm | Immunoblotting | Peptide Fragments - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Jagged-1 Protein | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | ADAM Proteins - antagonists & inhibitors | Liver Neoplasms - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Cell Communication | Xenograft Model Antitumor Assays | ADAM Proteins - metabolism | Phenotype | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Liver Neoplasms - metabolism | Mice | ADAM Proteins - genetics | Colorectal Neoplasms - pathology | Endothelial Cells - pathology | Calcium-Binding Proteins - genetics | Genetic aspects | Colorectal cancer | Stem cells | Endothelium | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2012, Volume 189, Issue 11, pp. 5113 - 5117
Although the NLRP3 inflammasome plays a pivotal role in host defense, its uncontrolled activation is associated with inflammatory disorders, suggesting that... 
ACTIVATION | PATTERN-RECOGNITION | MACROPHAGES | THIOREDOXIN | IMMUNOLOGY | RECEPTORS | EXPRESSION | Interferon-beta - immunology | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Calcium-Binding Proteins - antagonists & inhibitors | Mitochondria - immunology | Adenosine Triphosphate - pharmacology | Signal Transduction - immunology | Inflammasomes - drug effects | Calcium-Binding Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Female | Nuclear Proteins - genetics | Macrophages, Peritoneal - drug effects | Carrier Proteins - immunology | DNA-Binding Proteins | Apoptosis Regulatory Proteins - immunology | S-Nitroso-N-Acetylpenicillamine - metabolism | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Macrophages, Peritoneal - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Nuclear Proteins - immunology | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Animals | Interferon-beta - pharmacology | Signal Transduction - drug effects | Inflammasomes - immunology | Nuclear Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Macrophages, Peritoneal - metabolism | Nitric Oxide - metabolism | S-Nitroso-N-Acetylpenicillamine - pharmacology | Calcium-Binding Proteins - genetics | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties | Proteins | Cell division | Biochemistry | Cell cycle | Index Medicus | s
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 03/2014, Volume 25, Issue 6, pp. 936 - 947
Emerging findings suggest that two lineages of mitochondrial Ca2+ uptake participate during active and resting states: 1) the major eukaryotic membrane... 
TRANSPORTER FAMILY SLC25 | CONFOCAL MICROSCOPY | ESSENTIAL COMPONENT | LIVER-MITOCHONDRIA | MG/P-I CARRIER | CALCIUM UNIPORTER | ENDOPLASMIC-RETICULUM | NEURONAL MITOCHONDRIA | VENTRICULAR MYOCYTES | PERMEABILITY TRANSITION | CELL BIOLOGY | Amino Acid Transport Systems, Acidic - antagonists & inhibitors | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Calcium Channels - metabolism | Oxidative Stress | Calcium - metabolism | Humans | Amino Acid Transport Systems, Acidic - metabolism | Calcium-Binding Proteins - antagonists & inhibitors | Mitochondrial Proteins - genetics | Membrane Potential, Mitochondrial - drug effects | Mitochondrial Membrane Transport Proteins - genetics | Cation Transport Proteins - metabolism | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Antiporters - genetics | Cell Death | Cation Transport Proteins - genetics | Ion Transport - drug effects | Clone Cells | Calcium Channels - genetics | Calcium Signaling | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Mitochondrial Membrane Transport Proteins - metabolism | Histamine - pharmacology | Mitochondrial Proteins - antagonists & inhibitors | Gene Expression Regulation | Antiporters - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Oxygen Consumption - drug effects | Amino Acid Transport Systems, Acidic - genetics | HeLa Cells | Antiporters - antagonists & inhibitors | Calcium-Binding Proteins - genetics | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, pp. 10791 - 10791
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches... 
AIRWAY EPITHELIAL-CELLS | ASPERGILLUS-FUMIGATUS | III SECRETION APPARATUS | CHRONIC GRANULOMATOUS-DISEASE | ENVIRONMENT INTERACTIONS | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | HOST-DEFENSE | NLRP3 INFLAMMASOME | LUNG INFECTION | IMMUNE RECOGNITION | Immunohistochemistry | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Child, Preschool | Male | Cystic Fibrosis - immunology | Young Adult | Calcium-Binding Proteins - immunology | Autophagy - genetics | Interleukin 1 Receptor Antagonist Protein - pharmacology | Child | Cytokines - genetics | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Respiratory Mucosa - cytology | Cystic Fibrosis - microbiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cystic Fibrosis - genetics | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aspergillus fumigatus | Calcium-Binding Proteins - genetics | Infant | Interleukin 1 Receptor Antagonist Protein - genetics | CARD Signaling Adaptor Proteins - genetics | Autophagy - immunology | Apoptosis Regulatory Proteins - genetics | Adult | Female | Pseudomonas aeruginosa | Lung - metabolism | Macrophages - immunology | Cytokines - immunology | In Situ Nick-End Labeling | CARD Signaling Adaptor Proteins - immunology | Cell Line | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Inflammation | Inflammasomes - genetics | Pseudomonas Infections - immunology | Carrier Proteins - genetics | Animals | Epithelial Cells - immunology | Inflammasomes - immunology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide | Aspergillosis - immunology | Index Medicus
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 04/2017, Volume 206, pp. 24 - 35
Ghrelin and nesfatin-1 are two peptidyl hormones primarily involved in food intake regulation. We previously reported that the amount of dietary carbohydrates,... 
NUCB2/nesfatin-1 | Macronutrients | Food intake | Ghrelin | Tryptophan | Glucose | Metabolism | Fatty acids | MARINE TELEOST | PHYSIOLOGY | RAINBOW-TROUT | MESSENGER-RNA EXPRESSION | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENERGY-BALANCE | PLASMA GHRELIN | ZOOLOGY | ACYL DELTA-6 DESATURASE | GLUCAGON-LIKE PEPTIDE-1 | TELEOST FISH | TROUT ONCORHYNCHUS-MYKISS | Tissue Culture Techniques - veterinary | Intestinal Mucosa - metabolism | Calcium-Binding Proteins - agonists | Calcium-Binding Proteins - antagonists & inhibitors | Cytoplasm - metabolism | Intestines - metabolism | RNA, Messenger - metabolism | Tryptophan - metabolism | DNA-Binding Proteins - metabolism | Intestinal Mucosa - cytology | Protein Precursors - antagonists & inhibitors | Fatty Acids, Nonesterified - metabolism | Fish Proteins - genetics | Goldfish - physiology | DNA-Binding Proteins - agonists | Hepatopancreas - metabolism | Fish Proteins - antagonists & inhibitors | Immunohistochemistry - veterinary | Calcium-Binding Proteins - metabolism | Protein Precursors - agonists | Nerve Tissue Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Protein Precursors - genetics | Hepatopancreas - cytology | Nerve Tissue Proteins - agonists | Gene Expression Regulation | Ghrelin - genetics | Fish Proteins - metabolism | DNA-Binding Proteins - genetics | Organ Specificity | Nerve Tissue Proteins - genetics | Ghrelin - agonists | Protein Precursors - metabolism | Protein Transport | Ghrelin - antagonists & inhibitors | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Fish Proteins - agonists | Animals | Glucose - metabolism | Kinetics | Calcium-Binding Proteins - genetics | Intestines - cytology | Immunohistochemistry | Monounsaturated fatty acids | Linolenic acids | Physiological aspects | Omega-3 fatty acids | Dextrose | Index Medicus
Journal Article