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Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 19071 - 19076
.... Here, we show that deficiency of matrix Gla protein (MGP), a BMP inhibitor, causes induction of Notch ligands, dysregulation of endothelial differentiation, and the development of cerebral AVMs in MGP null (Mgp-/-) mice... 
Cardiovascular system | Ephrins | Kidneys | Transfection | Lungs | Small interfering RNA | Arteriovenous malformations | Immunoblotting | Ligands | Endothelial cells | DEFECTS | shunt | telangiectasia | angiogenesis | MULTIDISCIPLINARY SCIENCES | NOTCH | hereditary hemorrhagic | MICE LACKING | LETHALITY | LIGANDS | brain circulation | ENDOTHELIAL-CELLS | DIFFERENTIATION | animal model | RECEPTORS | EXPRESSION | Bone Morphogenetic Proteins - antagonists & inhibitors | RNA, Small Interfering - genetics | Extracellular Matrix Proteins - deficiency | Receptors, Notch - metabolism | X-Ray Microtomography | Intercellular Signaling Peptides and Proteins - metabolism | Serrate-Jagged Proteins | Gene Deletion | Jagged-2 Protein | Intracranial Arteriovenous Malformations - etiology | Membrane Proteins - metabolism | Receptors, Eph Family - metabolism | Cell Differentiation - physiology | Real-Time Polymerase Chain Reaction | Endothelial Cells - physiology | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Extracellular Matrix Proteins - genetics | Calcium-Binding Proteins - deficiency | Ephrin-B2 - metabolism | Intracranial Arteriovenous Malformations - prevention & control | Mice, Knockout | Animals | Analysis of Variance | Guanylate Kinases - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Calcium-Binding Proteins - genetics | Physiological aspects | Bone morphogenetic proteins | Nervous system | Degeneration | Research | Health aspects | Neurophysiology | Biological Sciences | hereditary hemorrhagic telangiectasia
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 490, Issue 7418, pp. 107 - 111
... (NLR family, apoptosis inhibitory protein 5)/NLRC4 (NLR family, CARD-domain-containing 4) inflammasome(2-4... 
CYTOSOLIC PHOSPHOLIPASE A | FLAGELLIN | III SECRETION APPARATUS | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | INFECTION | PYROPTOSIS | CASPASE-1 ACTIVATION | IMMUNE RECOGNITION | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 43, Issue 4, pp. 751 - 763
The crosstalk between inflammation and tumorigenesis is now clearly established. However, how inflammation is elicited in the metastatic environment and the... 
colorectal cancer | cell death | innate immunity | metastasis | interleukin-18 | inflammasome | NLRP3 | Fas | natural killer (NK) cells | caspase-1 | immunosurveillance | Cell death | Natural killer (NK) cells | Colorectal cancer | Immunosurveillance | Innate immunity | Inflammasome | Metastasis | Interleukin-18 | Caspase-1 | APOPTOSIS | ACTIVATION | INTERLEUKIN-18 | CASPASE-1 | IMMUNOTHERAPY | IMMUNOSUPPRESSION | KUPFFER CELLS | RECEPTOR | CYTOKINE | DEATH | IMMUNOLOGY | Immunologic Surveillance | Interleukin-18 - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Neoplasm Proteins - physiology | Radiation Tolerance | Tumor Microenvironment | DNA-Binding Proteins - deficiency | Apoptosis Regulatory Proteins - deficiency | Killer Cells, Natural - immunology | Liver Neoplasms - secondary | Inflammasomes - deficiency | Carrier Proteins - physiology | Interleukin-1beta - physiology | Adenocarcinoma - immunology | Mice, Inbred C57BL | Gastrointestinal Microbiome | Calcium-Binding Proteins - deficiency | Liver Neoplasms - immunology | Radiation Chimera | Immunity, Innate | Adenocarcinoma - secondary | Mice, Knockout | Fas Ligand Protein - physiology | Inflammasomes - physiology | Animals | Colorectal Neoplasms - immunology | Caspase 1 - deficiency | Cell Line, Tumor | Mice | Neoplasm Proteins - deficiency | Colorectal Neoplasms - pathology | Cytotoxicity, Immunologic | Lymphocytes, Tumor-Infiltrating - immunology | Killer cells | Microbiota (Symbiotic organisms) | Growth | Cytokines | Liver | Inflammation | Gene expression | Inflammatory bowel disease | Scholarships & fellowships | Rodents | Tumorigenesis | Immune system | Tumors | Apoptosis
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2003, Volume 40, Issue 3, pp. 501 - 514
Targeted deletion of focal adhesion kinase ( fak) in the developing dorsal forebrain resulted in local disruptions of the cortical basement membrane located... 
NEURONAL MIGRATION | MATRIX METALLOPROTEINASES | TYROSINE PHOSPHORYLATION | ALPHA-6 INTEGRINS | ECTOPIC EXPRESSION | CENTRAL-NERVOUS-SYSTEM | BETA-DYSTROGLYCAN | FOCAL ADHESION KINASE | NEUROSCIENCES | MENINGEAL CELLS | BASEMENT-MEMBRANE | Immunohistochemistry | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Protein-Tyrosine Kinases - metabolism | Homeodomain Proteins - metabolism | Astrocytes - pathology | Cerebral Cortex - pathology | Glial Fibrillary Acidic Protein - metabolism | Muscular Dystrophies - genetics | Protein-Tyrosine Kinases - deficiency | Focal Adhesion Kinase 1 | Calbindins | Neurons - metabolism | Serine Endopeptidases | Disease Models, Animal | Fibroblasts - metabolism | Muscular Dystrophies - metabolism | Muscular Dystrophies - congenital | Silver Staining | Nerve Tissue Proteins | Basement Membrane - metabolism | Blotting, Western | Precipitin Tests | Mice, Knockout | Infection | Staining and Labeling | Mice | Mutation | Dura Mater | Astrocytes - metabolism | Neurons - pathology | Microtubule-Associated Proteins - metabolism | Otx Transcription Factors | Phosphopyruvate Hydratase - metabolism | Basement Membrane - pathology | Dystroglycans | Cerebral Cortex - metabolism | Cerebral Cortex - ultrastructure | Phosphotyrosine - metabolism | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Lamins - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Cell Adhesion Molecules, Neuronal - metabolism | Cerebral Cortex - abnormalities | Extracellular Matrix Proteins - metabolism | Fibroblasts - virology | Cells, Cultured | Focal Adhesion Protein-Tyrosine Kinases | Microscopy, Electron | Muscular Dystrophies - pathology | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Carrier Proteins - metabolism | Calbindin 2 | Bacterial Proteins - metabolism | Heterozygote | Proteins | Neurons | Rodents | Protein expression | Kinases | Embryos | Muscular dystrophy | Deoxyribonucleic acid--DNA | Cell adhesion & migration
Journal Article
Journal Article
Cancer cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 626 - 641
Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch receptor signaling promotes luminal cell fate specification in the mammary... 
TO-MESENCHYMAL TRANSITION | ONCOLOGY | SIGNALING PATHWAY | CLAUDIN-LOW | HEPATOCYTE GROWTH-FACTOR | NOTCH | STEM-CELL | TUMOR-SUPPRESSOR | LUMINAL-B | MAMMARY TUMORIGENESIS | TRANSCRIPTIONAL TARGET | CELL BIOLOGY | Immunohistochemistry | Proto-Oncogene Proteins c-met - metabolism | Receptor, IGF Type 1 - metabolism | Cell Proliferation | Mammary Glands, Animal - transplantation | Oligonucleotide Array Sequence Analysis | Receptors, Notch - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Databases, Genetic | Glycosyltransferases - deficiency | Caveolins - metabolism | Caveolins - genetics | Mammary Neoplasms, Experimental - genetics | Mammary Glands, Animal - growth & development | Intercellular Signaling Peptides and Proteins - metabolism | Breast Neoplasms - enzymology | Claudins - metabolism | Cell Transformation, Neoplastic - genetics | Gene Expression Regulation, Developmental | Serrate-Jagged Proteins | Mammary Neoplasms, Experimental - pathology | Neoplastic Stem Cells - pathology | Female | Membrane Proteins - metabolism | Glycosyltransferases - genetics | Mammary Glands, Animal - enzymology | Mammary Neoplasms, Experimental - enzymology | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Signal Transduction | Mammary Glands, Animal - pathology | Cells, Cultured | Gene Expression Profiling - methods | Cell Transformation, Neoplastic - metabolism | Neoplastic Stem Cells - transplantation | Mice, Knockout | Proto-Oncogene Proteins c-met - genetics | Glycosyltransferases - metabolism | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice | Cell Transformation, Neoplastic - pathology | Neoplastic Stem Cells - enzymology | Molecular genetics | Children's hospitals | Oncology, Experimental | Genes | Stem cells | Breast cancer | Genetic aspects | Research | Tumors | Cancer | Càncer de mama | Proteïnes de membrana | Cellular signal transduction | Gene expression | Expressió gènica | Transducció de senyal cel·lular | Membrane proteins
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 32, pp. E440 - E449
Astrocytes regulate synaptic connectivity in the CNS through secreted signals. Here we identified two astrocyte-secreted proteins, hevin and SPARC, as regulators of excitatory synaptogenesis in vitro and in vivo... 
Extracellular matrix | Synaptic cleft 1 | Matricellular protein | Osteonectin | SPARC-Like | osteonectin | SC1 | synaptic cleft 1 | RAT | EXTRACELLULAR-MATRIX GLYCOPROTEIN | INTEGRIN | MULTIDISCIPLINARY SCIENCES | RECEPTOR | matricellular protein | CELL-SURVIVAL | SUPERIOR COLLICULUS | SPARC-Like 1 | EXPRESSION | extracellular matrix | SUPERFICIAL LAYERS | BRAIN | Central Nervous System - ultrastructure | Central Nervous System - metabolism | Extracellular Matrix Proteins - deficiency | Humans | Superior Colliculi - ultrastructure | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - cytology | Osteonectin - deficiency | Synapses - metabolism | HEK293 Cells | Neurogenesis - drug effects | Extracellular Matrix Proteins - metabolism | Astrocytes - cytology | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Astrocytes - drug effects | Retinal Ganglion Cells - ultrastructure | Synapses - drug effects | Extracellular Matrix Proteins - chemistry | Superior Colliculi - metabolism | Extracellular Matrix Proteins - antagonists & inhibitors | Superior Colliculi - drug effects | Osteonectin - metabolism | Rats | Calcium-Binding Proteins - deficiency | Synapses - ultrastructure | Osteonectin - chemistry | Rats, Sprague-Dawley | Astrocytes - ultrastructure | Animals | Central Nervous System - cytology | Superior Colliculi - cytology | Mice | Retinal Ganglion Cells - drug effects | Astrocytes - secretion | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Current opinion in genetics & development, ISSN 0959-437X, 2002, Volume 12, Issue 3, pp. 349 - 361
... 14.6 cardiomyopathic hamster) that share common genetic protein abnormalities similar to those of the human disease... 
mouse model | dystrophin-glycoprotein complex | muscular dystrophy | SKELETAL-MUSCLE | SMOOTH-MUSCLE | STEM-CELL FUNCTION | NITRIC-OXIDE SYNTHASE | GENETICS & HEREDITY | MUSCLE DEGENERATION | BETA-SARCOGLYCAN | EXTRACELLULAR-MATRIX | DEFICIENT MICE | SARCOGLYCAN-SARCOSPAN COMPLEX | ALPHA-SARCOGLYCAN | CELL BIOLOGY | Integrins - deficiency | Membrane Glycoproteins - metabolism | Cytoskeletal Proteins - genetics | Humans | Integrins - genetics | Caveolins - metabolism | Muscular Dystrophies - genetics | Neoplasm Proteins - metabolism | Caveolins - genetics | Dystroglycans | Integrins - metabolism | Cytoskeletal Proteins - deficiency | Caveolin 3 | Membrane Proteins - deficiency | Mice, Inbred mdx | Muscle Proteins - metabolism | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Neuropeptides - genetics | Neoplasm Proteins - genetics | Disease Models, Animal | Glycoproteins - genetics | Calcium-Binding Proteins | Membrane Proteins - genetics | Mice, Transgenic | Neuropeptides - metabolism | Membrane Glycoproteins - genetics | Dystrophin-Associated Proteins | Muscle Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Dystrophin - genetics | Mice | Neoplasm Proteins - deficiency | Membrane Glycoproteins - deficiency | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article