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Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4908 - 4927
...+/calmodulin-dependent protein kinase II (CaMKII), another prominent component of the PSD. Here, we show that recombinant synGAP (r-synGAP... 
NMDA RECEPTOR | DOMAIN | STIMULATION | INHIBITION | CALPAIN | CLONING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | HIPPOCAMPAL-NEURONS | PLASTICITY | Oncogene Proteins - genetics | ras Proteins - genetics | Phosphorylation | ras GTPase-Activating Proteins - chemistry | rap1 GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | ras Proteins - metabolism | Neurons - cytology | GTPase-Activating Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - genetics | ras GTPase-Activating Proteins - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | ras Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | rap1 GTP-Binding Proteins - metabolism | ras GTPase-Activating Proteins - metabolism | Oncogene Proteins - chemistry | Cells, Cultured | Oncogene Proteins - metabolism | Rats | Synapses - enzymology | GTPase-Activating Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Neurons - enzymology | GTPase-Activating Proteins - genetics | rap1 GTP-Binding Proteins - genetics | rap GTP-Binding Proteins | Ras Protein | Ras-related Protein 1 (Rap1) | Postsynaptic Density | Ca2 | Synaptic Plasticity | Small GTPase | Neurobiology | Mass Spectrometry (MS) | Cyclin-dependent Kinase 5 (CDK5) | Protein Kinase | Calmodulin-dependent Protein Kinase II (CaMKII) | Synaptic GTPase-activating Protein (synGAP)
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 43385
.... Hippocampal kinases (CaMK, CaMKIV, CREB and ERK1/2) phosphorylation in the target subregion was assayed and the effects of kinase inhibitors (KN93 or U0126... 
BILATERAL VESTIBULAR DEAFFERENTATION | DORSAL HIPPOCAMPUS | PLACE CELLS | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN | SPATIAL MEMORY | THETA-RHYTHM | KNOCKOUT MICE | SYNAPTIC PLASTICITY | PROTEIN-KINASE-II | ALPHA-CAMKII | Otolithic Membrane - metabolism | Nitriles - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - genetics | CREB-Binding Protein - genetics | Otolithic Membrane - pathology | CA1 Region, Hippocampal - pathology | CREB-Binding Protein - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Motion Sickness - physiopathology | CA1 Region, Hippocampal - metabolism | Otolithic Membrane - physiopathology | Phosphorylation - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Motion Sickness - genetics | Butadienes - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Motion Sickness - metabolism | Signal Transduction | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Motion Sickness - pathology | Gene Expression Regulation | Rats | Sulfonamides - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | Rats, Sprague-Dawley | Rotation | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | CA1 Region, Hippocampal - physiopathology | Benzylamines - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Ca2+/calmodulin-dependent protein kinase IV | Otoliths | Extracellular signal-regulated kinase | Retention | Cyclic AMP response element-binding protein | Habituation | Signal transduction | Etiology | Motion sickness | Ca2+/calmodulin-dependent protein kinase | Vestibular system | Hippocampus | Ca2+/calmodulin-dependent protein kinase II
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 47, pp. 32926 - 32936
Journal Article
PLoS ONE, ISSN 1932-6203, 2016, Volume 11, Issue 11, p. e0166763
...) plays a critical role in the viral life cycle. For medical and virological interests, we exploited the HEK293T kidney cells to test 3 candidate protein kinases on NS5A S235 phosphorylation... 
I-ALPHA | INFECTION | INHIBITORS | RNA REPLICATION | AFFINITY | MULTIDISCIPLINARY SCIENCES | Phosphorylation - physiology | Proto-Oncogene Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Serine - genetics | Viral Nonstructural Proteins - genetics | Casein Kinase Ialpha - genetics | Proto-Oncogene Proteins - genetics | Serine - metabolism | Gene Knockdown Techniques | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Cell Cycle Proteins - genetics | Cell Line, Tumor | Hepacivirus - physiology | Viral Nonstructural Proteins - metabolism | Casein Kinase Ialpha - metabolism | Virus Replication - physiology | Protein-Serine-Threonine Kinases - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Casein | RNA | Analysis | Serine | Liver | Hepatitis C virus | Protein kinases | Calmodulin | Drugs | Phosphorylation | Toxicity | Casein kinase I | Cytotoxicity | Viruses | Genomes | Infections | Biochemistry | Kinases | Proteins | Hepatitis | Calcium-binding protein | Life cycle engineering | Polo-like kinase | RNA polymerase | Gene expression | Ribonucleic acid--RNA | Virology | Medicine | Polymerase chain reaction | Hepatocytes | MicroRNAs | Isoforms | Interferon | Mutation | Hepatitis C | Molecular biology | Ca2+/calmodulin-dependent protein kinase II | Life cycles | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e64946
Genome-wide association (GWA) studies have described a large number of new candidate genes that contribute to of Type 2 Diabetes (T2D... 
INSULIN | INHIBITION | NUCLEAR | CDK5 | METABOLISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | PANCREATIC BETA-CELLS | CREB COACTIVATOR TORC2 | ENDOPLASMIC-RETICULUM STRESS | RNA, Small Interfering - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 1 - genetics | Phosphorylation | Ribosomal Protein S6 Kinases - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Phosphoenolpyruvate Carboxykinase (GTP) - metabolism | Homeostasis | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Hepatocytes - metabolism | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | Gene Knockdown Techniques | Cyclin-Dependent Kinase 5 - genetics | Glycogen - metabolism | RNA Interference | Pyruvic Acid - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Genome-Wide Association Study | Signal Transduction | Glucagon - physiology | Cyclin-Dependent Kinase 5 - metabolism | Hep G2 Cells | Protein Transport | Transcription Factors - metabolism | tRNA Methyltransferases | Glucose - metabolism | Polymorphism, Single Nucleotide | Protein Processing, Post-Translational | Primary Cell Culture | Genome, Human | Type 2 diabetes | Glycogen | Genes | Genomics | Genomes | Glucose | Insulin | Cells | Dextrose | Protein kinase A | Cell culture | Regulations | Neurosciences | Glucagon | Liver | Pyruvic acid | Kinases | Nuclei | Cyclin-dependent kinase 5 | Proteins | Signal transduction | Rodents | Cell cycle | Pancreas | Localization | Gluconeogenesis | Fasting | RNA-mediated interference | Diabetes mellitus | Ribosomal protein S6 | Metabolism | Gene expression | Medical screening | Musculoskeletal system | Signaling | Storage | Cellular biology | Hepatocytes | Glycolysis | Diabetes | Mutation | Molecular biology | Pharmaceuticals
Journal Article
Human mutation, ISSN 1059-7794, 2018, Volume 39, Issue 12, pp. 2008 - 2024
Journal Article
Cell metabolism, ISSN 1550-4131, 2013, Volume 18, Issue 6, pp. 803 - 815
Journal Article
Diabetes, ISSN 0012-1797, 12/2012, Volume 61, Issue 12, pp. 3314 - 3321
Journal Article
by Tsoi, H and Lam, K.C and Dong, Y and Zhang, X and Lee, C.K and Zhang, J and Ng, S.C and Ng, S.S.M and Zheng, S and Chen, Y and Fang, J and Yu, J
Oncogene, ISSN 0950-9232, 11/2017, Volume 36, Issue 44, pp. 6109 - 6118
.... Knockdown of pre-45s rRNA inhibits G1/S cell-cycle transition by stabilizing p53 through inducing murine double minute 2 (MDM2... 
RNA-POLYMERASE-I | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | UPSTREAM BINDING-FACTOR | CELL BIOLOGY | INHIBITION | ONCOLOGY | SIGNALING PATHWAY | CALCIUM | GENETICS & HEREDITY | MDM2 | STRESS | Proto-Oncogene Proteins c-mdm2 - genetics | Calcium - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | RNA, Ribosomal - genetics | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Pol1 Transcription Initiation Complex Proteins - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Female | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Cell Proliferation - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Ribosomal Proteins - genetics | HCT116 Cells | RNA, Ribosomal - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Disease-Free Survival | Protein Interaction Maps - genetics | Aged | Colorectal Neoplasms - pathology | Care and treatment | Colon cancer | Ribosomal RNA | Cancer cells | Cell cycle | Diagnosis | Research | Protein kinases | Cell proliferation | Transcription | Pathogenesis | p53 Protein | Colorectal carcinoma | Colorectal cancer | Kinases | Calcium signalling | Cell growth | Calcium-binding protein | Calmodulin | MDM2 protein | Cell survival | RNA-mediated interference | rRNA 45S | Tumor cell lines | Metabolism | Ribonucleic acid--RNA | Protein L11 | Adenomatous polyposis coli | Ribosomal protein S6 kinase | Ribosomal protein L11 | Endoplasmic reticulum | Calcium (reticular) | Cytoplasm | Ca2+/calmodulin-dependent protein kinase II | Original
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 10, pp. 2925 - 2941
... through a pathway involving calcium/calmodulin-dependent protein kinase II gamma (CaMKII gamma) and JNK. Remarkably, CaMKII gamma was also responsible for processes involved... 
ADVANCED ATHEROSCLEROTIC LESIONS | MEDICINE, RESEARCH & EXPERIMENTAL | TARGETED DISRUPTION | INHIBITION PROTECTS | CHOLESTEROL-LOADED MACROPHAGES | CARDIAC RYANODINE RECEPTOR | ENDOPLASMIC-RETICULUM STRESS | C-JUN | CELL-DEATH | MEMBRANE PERMEABILIZATION | PARKINSONS-DISEASE | RNA, Small Interfering - genetics | Calcium - metabolism | Humans | Stress, Physiological | Endoplasmic Reticulum - metabolism | Mitogen-Activated Protein Kinase 9 - genetics | fas Receptor - metabolism | Macrophages, Peritoneal - cytology | Epithelial Cells - physiology | STAT1 Transcription Factor - metabolism | fas Receptor - genetics | Membrane Potential, Mitochondrial - physiology | Epithelial Cells - cytology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Cholesterol - metabolism | STAT1 Transcription Factor - genetics | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Kidney Tubules - cytology | Animals | Thapsigargin - metabolism | Mice | Apoptosis - physiology | Enzyme Activation | Macrophages, Peritoneal - metabolism | RNA, Small Interfering - metabolism | Mitochondria | Cell physiology | Research | Properties | Observations | Protein kinases | Endoplasmic reticulum | Apoptosis
Journal Article
Annals of the rheumatic diseases, ISSN 0003-4967, 12/2014, Volume 73, Issue 12, pp. 2130 - 2136
Journal Article