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Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 288 - 297
Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS) has been linked to heterozygous deletion of RPS14; which encodes... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN 5Q-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | DELETION 5Q | RISK MYELODYSPLASTIC SYNDROME | CELL BIOLOGY | HEMATOPOIETIC STEM-CELLS | MOUSE MODEL | DIAMOND-BLACKFAN ANEMIA | MYELOID-LEUKEMIA | SUPPRESSOR-CELLS | UP-REGULATION | Immunohistochemistry | Calgranulin A - metabolism | Humans | Immunity, Innate - genetics | Calgranulin A - genetics | Tumor Suppressor Protein p53 - genetics | Anemia - genetics | Flow Cytometry | Mass Spectrometry | Calgranulin B - genetics | Megakaryocytes | Cytokines - immunology | Disease Models, Animal | Erythropoiesis - genetics | Haploinsufficiency - genetics | Anemia - immunology | Ribosomal Proteins - genetics | In Situ Hybridization, Fluorescence | Blotting, Western | Mice, Knockout | Immunity, Innate - immunology | Microscopy, Confocal | Animals | Bone Marrow - pathology | Fluorescent Antibody Technique | Erythroid Precursor Cells - metabolism | Mice | Myelodysplastic Syndromes - genetics | In Vitro Techniques | Myelodysplastic Syndromes - pathology | Myelodysplastic Syndromes - immunology | Erythropoiesis - immunology | Hematopoietic Stem Cells | Erythropoiesis | Physiological aspects | Genetic aspects | Research | Cell differentiation | Hematopoietic stem cells | Proteins | Gene expression | Anemia | Erythrocytes | Apoptosis | Immune system
Journal Article
BMC Pregnancy and Childbirth, ISSN 1471-2393, 07/2014, Volume 14, Issue 1, pp. 241 - 241
Background: Elucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective... 
Pregnancy | Parturition | Inflammation | Uterus | RIBONUCLEIC-ACID ABUNDANCE | TROPHOBLAST CELLS | ENDOPEROXIDE-H SYNTHASE-1 | MESSENGER-RNA EXPRESSION | MYOMETRIAL CELLS | HUMAN DECIDUA | HUMAN FETAL MEMBRANES | OBSTETRICS & GYNECOLOGY | HISTOLOGIC CHORIOAMNIONITIS | INTRAUTERINE INFECTION | 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE | Interleukin-1 - genetics | Up-Regulation | Aldehyde Reductase - genetics | Toll-Like Receptor 2 - genetics | Humans | Obstetric Labor, Premature - genetics | 3-Hydroxysteroid Dehydrogenases - analysis | Prostaglandins - analysis | Calgranulin A - genetics | Intramolecular Oxidoreductases - analysis | Alcohol Oxidoreductases - genetics | Chorioamnionitis - genetics | Young Adult | Obstetric Labor, Premature - metabolism | Organic Anion Transporters - genetics | Cyclooxygenase 2 - genetics | Alcohol Oxidoreductases - analysis | Adult | Female | Multidrug Resistance-Associated Proteins - genetics | Placenta - chemistry | Prostaglandins - genetics | Cytochrome P-450 Enzyme System - analysis | Gene Expression | Multidrug Resistance-Associated Proteins - analysis | Interleukin-1 - analysis | Calgranulin A - analysis | Down-Regulation | Aldehyde Reductase - analysis | Signal Transduction - genetics | Amnion - chemistry | Gestational Age | Cyclooxygenase 2 - analysis | Hydroxyprostaglandin Dehydrogenases - genetics | Labor, Obstetric - metabolism | Organic Anion Transporters - analysis | Intramolecular Oxidoreductases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Chorion - chemistry | Prostaglandin-E Synthases | Cytochrome P-450 Enzyme System - genetics | Toll-Like Receptor 2 - analysis | Hydroxyprostaglandin Dehydrogenases - analysis | Labor, Obstetric - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Decidua - chemistry | Prostaglandins - metabolism | Studies | Placenta | Cytokines | Gene expression | Premature birth | Cesarean section
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 11/2015, Volume 53, Issue 5, pp. 664 - 675
We have previously demonstrated increased airway smooth muscle (ASM) mass and airway hyperresponsiveness in whole-life vitamin D-deficient female mice. In this... 
RNA sequencing | mouse model | inflammation | vitamin D | airway remodeling | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CATENIN | CELL BIOLOGY | RESPONSES | RESPIRATORY SYSTEM | GROWTH | DISEASE | RESISTANCE | ASTHMA | CHECKPOINT | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Bronchial Hyperreactivity - immunology | E1A-Associated p300 Protein - genetics | Calgranulin A - genetics | Bronchial Hyperreactivity - genetics | Matrix Metalloproteinase 9 - genetics | Calgranulin A - immunology | Vitamin D Deficiency - immunology | Neutrophils - metabolism | Disease Models, Animal | Lymphocytes - metabolism | Vitamin D Deficiency - genetics | Signal Transduction | Respiratory Hypersensitivity - metabolism | Respiratory Hypersensitivity - immunology | Peptide Initiation Factors - immunology | Wnt Proteins - immunology | Respiratory Hypersensitivity - genetics | Lymphocytes - pathology | Mice | Bronchoalveolar Lavage Fluid - chemistry | Vitamin D Deficiency - metabolism | Vitamin D Deficiency - complications | E1A-Associated p300 Protein - immunology | Matrix Metalloproteinase 9 - immunology | NF-kappa B - immunology | Muscle, Smooth - immunology | Airway Remodeling - immunology | Lymphocytes - immunology | Wnt Proteins - genetics | Calgranulin B - immunology | Bronchial Hyperreactivity - metabolism | Female | Calgranulin B - genetics | Lung - metabolism | Neutrophils - pathology | Receptor, Epidermal Growth Factor - immunology | Lung - pathology | Gene Expression Regulation | Neutrophils - immunology | Respiratory Hypersensitivity - complications | Muscle, Smooth - metabolism | Bronchial Hyperreactivity - complications | Pregnancy | Peptide Initiation Factors - genetics | Animals | NF-kappa B - genetics | Airway Resistance - immunology | Muscle, Smooth - pathology | Lung - immunology | Studies | Data analysis | Vitamin D | Rodents | Vitamin deficiency | Smooth muscle | Software | Chronic obstructive pulmonary disease | Genetic engineering | Inflammation | Gene expression | Growth factors
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 541 - 554
Elevated concentrations of tumor necrosis factor-α (TNF-α) are detected in pathologies characterized by chronic inflammation. Whether TNF-α plays a role in... 
RECRUITMENT | KILLER-CELL | IMMUNE SUPPRESSION | IMMUNOSUPPRESSION | DOWN-REGULATION | TNF-ALPHA | ACCUMULATION | IMMUNOLOGY | CANCER | T-CELLS | PROGRESSION | Calgranulin B - metabolism | Calgranulin A - metabolism | Tumor Necrosis Factor-alpha - genetics | Immunoblotting | Calgranulin A - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cell Differentiation - genetics | Inflammation - metabolism | Flow Cytometry | Etanercept | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Calgranulin B - immunology | Gene Expression - immunology | Tumor Necrosis Factor-alpha - immunology | Immunoglobulin G - pharmacology | Killer Cells, Natural - immunology | Myeloid Cells - drug effects | Receptors, Antigen, T-Cell - immunology | Calgranulin B - genetics | Mitogen-Activated Protein Kinases - immunology | Calgranulin A - immunology | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Differentiation - immunology | Animals | Receptors, Tumor Necrosis Factor | Cell Differentiation - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Mitogen-Activated Protein Kinases - genetics | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Killer Cells, Natural - metabolism | Chronic Disease | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Clinical & Experimental Metastasis, ISSN 0262-0898, 8/2016, Volume 33, Issue 6, pp. 609 - 627
The dynamic interaction between tumor cells and their microenvironment induces a proinflammatory milieu that drives cancer development and progression. The... 
NF-κB | Biomedicine | ALCAM | Hematology | MCAM | Malignant melanoma | Cancer Research | Oncology | S100A8/A9 | RAGE | Surgical Oncology | Biomedicine general | MIGRATION | CELL-ADHESION MOLECULE | CANCER | S100 PROTEINS | NF-kappa B | CIRCULATING TUMOR-CELLS | ONCOLOGY | INFLAMMATION | CARBOXYLATED GLYCANS | EXPRESSION | CD146 | Calgranulin B - metabolism | Cell Proliferation | Reactive Oxygen Species - metabolism | Calgranulin A - metabolism | Humans | Lung Neoplasms - metabolism | Tumor Microenvironment | Male | NF-kappa B - metabolism | CD146 Antigen - genetics | Fetal Proteins - metabolism | Calgranulin A - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Lung Neoplasms - secondary | Melanoma - genetics | Calgranulin B - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Receptor for Advanced Glycation End Products - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Melanoma - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptor for Advanced Glycation End Products - metabolism | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Cell Adhesion Molecules, Neuronal - genetics | Xenograft Model Antitumor Assays | Animals | CD146 Antigen - metabolism | NF-kappa B - genetics | Mice, Nude | Fetal Proteins - genetics | Mice | Apoptosis | Cell Movement | Development and progression | Chemical properties | Metastasis | Cells | Melanoma
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 11/2015, Volume 53, Issue 5, pp. 601 - 606
We report that S100 proteins were reduced in patients with chronic rhinosinusitis (CRS). S100A8/9, which is important in epithelial barrier function, was... 
chronic rhinosinusitis | nasal polyps | S100A8/9 | aging | soluble gp130 | RESPIRATORY SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALPROTECTIN | EXPRESSION | CELL BIOLOGY | Interleukin-6 - antagonists & inhibitors | Cytokine Receptor gp130 - genetics | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Calgranulin A - genetics | Bronchi - immunology | Bronchi - drug effects | Sinusitis - genetics | Asthma - immunology | Tumor Necrosis Factor-alpha - immunology | Sinusitis - pathology | Calgranulin A - immunology | Bronchi - pathology | Interleukin-6 - genetics | Signal Transduction | Epithelial Cells - pathology | Tumor Necrosis Factor-alpha - pharmacology | Asthma - complications | Interleukin-6 - immunology | Rhinitis - complications | Rhinitis - pathology | Asthma - pathology | Chronic Disease | Age Factors | Epithelial Cells - drug effects | Calgranulin A - agonists | Receptors, Interleukin-6 - antagonists & inhibitors | Case-Control Studies | Sinusitis - complications | Sinusitis - immunology | Calgranulin B - immunology | Nasal Polyps - genetics | Adult | Female | Receptors, Interleukin-6 - immunology | Calgranulin B - genetics | Nasal Polyps - immunology | Rhinitis - immunology | Nasal Polyps - pathology | Receptors, Interleukin-6 - genetics | Cells, Cultured | Gene Expression Regulation | Cytokine Receptor gp130 - immunology | Asthma - genetics | Rhinitis - genetics | Nasal Polyps - complications | Interleukin-6 - pharmacology | Cytokine Receptor gp130 - pharmacology | Epithelial Cells - immunology | Aged | Proteins | Studies | Inflammatory bowel disease | Cell growth | Antibiotics | Surgery | Older people | Population | Antimicrobial agents | Age | Geriatrics | Chronic illnesses
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 1852 - 1866
Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus,... 
MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | CRYSTAL-STRUCTURE | DEFICIENT MICE | TNF-ALPHA | NONCOVALENTLY LINKED TETRAMERS | MOLECULAR-BASIS | MRP14 | S100A9 | DISEASE-ACTIVITY | PROTEIN COMPLEX | Inflammation - pathology | Proto-Oncogene Proteins c-mdm2 - genetics | Calgranulin A - genetics | Arthritis - genetics | Calgranulin A - chemistry | Psoriasis - genetics | Psoriasis - pathology | Calgranulin B - immunology | Arthritis - immunology | Calgranulin B - genetics | Calgranulin A - immunology | Binding Sites | Calgranulin B - chemistry | Psoriasis - immunology | Alarmins - genetics | Arthritis - pathology | Toll-Like Receptor 4 - genetics | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Alarmins - chemistry | Mice, Knockout | Animals | Proto-Oncogene Proteins c-mdm2 - immunology | Inflammation - genetics | Mice | Alarmins - immunology | Prevention | Cellular proteins | Phagocytes | Mediators | Physiological aspects | Development and progression | Inflammation | Health aspects | Psoriasis | Calcium | Disease | Mass spectroscopy | Arthritis | Adaptive immunity | TLR4 protein | Tumor necrosis factor-α | Kinases | Inflammatory diseases | Proteins | Toll-like receptors | Scientific imaging | Autoimmune diseases | Mass spectrometry | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 10/2012, Volume 31, Issue 42, pp. 4550 - 4558
Chronic inflammation is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The causes of inflammation in ESCC, however, are... 
transcriptome profiling | esophageal squamous cell carcinoma | inflammation | zinc deficiency | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | SUPPLEMENTATION | OVEREXPRESSION | CARCINOGENESIS | ONCOLOGY | GENES | GENETICS & HEREDITY | SQUAMOUS-CELL CARCINOMA | NF-KAPPA-B | EXPRESSION | NITROSOMETHYLBENZYLAMINE | PROGRESSION | S100A8 | Esophageal Neoplasms - etiology | Immunohistochemistry | Zinc - administration & dosage | Calgranulin B - metabolism | Esophagus - drug effects | Oligonucleotide Array Sequence Analysis | Calgranulin A - metabolism | Weaning | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Male | Gene Expression Profiling | Calgranulin A - genetics | Inflammation - metabolism | Cyclooxygenase 2 - genetics | Esophageal Neoplasms - metabolism | Calgranulin B - genetics | Receptors, Chemokine - genetics | Receptors, Chemokine - metabolism | Esophagus - metabolism | Rats | Reverse Transcriptase Polymerase Chain Reaction | Chemokines - genetics | Inflammation - etiology | Rats, Sprague-Dawley | Carcinoma, Squamous Cell - etiology | Esophagus - pathology | Animals | Animal Nutritional Physiological Phenomena | Diet | Esophageal Neoplasms - genetics | Dimethylnitrosamine - analogs & derivatives | Cyclooxygenase 2 - metabolism | Inflammation - genetics | Chemokines - metabolism | Cluster Analysis | Zinc - deficiency | Deficiency diseases | Complications and side effects | Zinc in the body | Physiological aspects | Development and progression | Genetic aspects | Research | Esophageal cancer | Risk factors | Vitamin deficiency | Head & neck cancer | Gene expression | Zinc | Esophagus | Immune system | Index Medicus | Nutrient deficiency | Hyperplasia | Mucosa | Inflammation | CC chemokines | Fuels | Chemokine receptors | Carcinogens | Developmental stages | Cyclooxygenase-2 | Bioinformatics | N-Nitrosomethylbenzylamine | Tumors | squamous cell carcinoma
Journal Article
Diabetes Care, ISSN 0149-5992, 09/2013, Volume 36, Issue 9, pp. 2794 - 2802
Journal Article