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Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 541 - 554
Elevated concentrations of tumor necrosis factor-α (TNF-α) are detected in pathologies characterized by chronic inflammation. Whether TNF-α plays a role in... 
RECRUITMENT | KILLER-CELL | IMMUNE SUPPRESSION | IMMUNOSUPPRESSION | DOWN-REGULATION | TNF-ALPHA | ACCUMULATION | IMMUNOLOGY | CANCER | T-CELLS | PROGRESSION | Calgranulin B - metabolism | Calgranulin A - metabolism | Tumor Necrosis Factor-alpha - genetics | Immunoblotting | Calgranulin A - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cell Differentiation - genetics | Inflammation - metabolism | Flow Cytometry | Etanercept | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Calgranulin B - immunology | Gene Expression - immunology | Tumor Necrosis Factor-alpha - immunology | Immunoglobulin G - pharmacology | Killer Cells, Natural - immunology | Myeloid Cells - drug effects | Receptors, Antigen, T-Cell - immunology | Calgranulin B - genetics | Mitogen-Activated Protein Kinases - immunology | Calgranulin A - immunology | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Differentiation - immunology | Animals | Receptors, Tumor Necrosis Factor | Cell Differentiation - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Mitogen-Activated Protein Kinases - genetics | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Killer Cells, Natural - metabolism | Chronic Disease | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Hypertension, ISSN 0194-911X, 2014, Volume 63, Issue 6, pp. 1241 - 1250
Connective tissue growth factor (CTGF) is involved in the pathogenesis of various fibrotic disorders. However, its role in the heart is not clear. To... 
Hypertension | Inflammation | S100 proteins | Angiotensin II | MECHANISMS | MYELOID-RELATED PROTEIN-14 | RAGE | MAPK | MYELOID-RELATED-PROTEIN-8/14 | INHIBITION | inflammation | angiotensin II | PERIPHERAL VASCULAR DISEASE | TNF-ALPHA | DYSFUNCTION | hypertension | NF-KAPPA-B | EXPRESSION | Immunohistochemistry | Calgranulin B - metabolism | Oligonucleotide Array Sequence Analysis | Myocytes, Cardiac - immunology | Calgranulin A - genetics | Inflammation - metabolism | Myocardium - metabolism | Antibodies - immunology | Antigens, Ly - metabolism | Calgranulin A - immunology | Hypertension - genetics | Cytokines - genetics | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Fibroblasts - metabolism | Animals, Newborn | Angiotensin II - pharmacology | Neutrophils - drug effects | Toll-Like Receptor 4 - genetics | Hypertension - immunology | Toll-Like Receptor 4 - immunology | Reverse Transcriptase Polymerase Chain Reaction | Toll-Like Receptor 4 - metabolism | Myocytes, Cardiac - drug effects | Fibroblasts - drug effects | Myocytes, Cardiac - metabolism | Fibroblasts - immunology | Mice | Receptors, Immunologic - genetics | Myocardium - immunology | Calgranulin A - metabolism | Transcriptome - immunology | Calgranulin B - immunology | Hypertension - prevention & control | Calgranulin B - genetics | Receptors, Immunologic - immunology | Cytokines - immunology | CD11b Antigen - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Neutrophils - immunology | Myocardium - pathology | Inflammation - immunology | Transcriptome - drug effects | Angiotensin II - immunology | Antibodies - pharmacology | Animals | Antigens, Ly - immunology | Inflammation - genetics | CD11b Antigen - metabolism | Receptors, Immunologic - metabolism
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 11/2015, Volume 53, Issue 5, pp. 664 - 675
We have previously demonstrated increased airway smooth muscle (ASM) mass and airway hyperresponsiveness in whole-life vitamin D-deficient female mice. In this... 
RNA sequencing | mouse model | inflammation | vitamin D | airway remodeling | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CATENIN | CELL BIOLOGY | RESPONSES | RESPIRATORY SYSTEM | GROWTH | DISEASE | RESISTANCE | ASTHMA | CHECKPOINT | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Bronchial Hyperreactivity - immunology | E1A-Associated p300 Protein - genetics | Calgranulin A - genetics | Bronchial Hyperreactivity - genetics | Matrix Metalloproteinase 9 - genetics | Calgranulin A - immunology | Vitamin D Deficiency - immunology | Neutrophils - metabolism | Disease Models, Animal | Lymphocytes - metabolism | Vitamin D Deficiency - genetics | Signal Transduction | Respiratory Hypersensitivity - metabolism | Respiratory Hypersensitivity - immunology | Peptide Initiation Factors - immunology | Wnt Proteins - immunology | Respiratory Hypersensitivity - genetics | Lymphocytes - pathology | Mice | Bronchoalveolar Lavage Fluid - chemistry | Vitamin D Deficiency - metabolism | Vitamin D Deficiency - complications | E1A-Associated p300 Protein - immunology | Matrix Metalloproteinase 9 - immunology | NF-kappa B - immunology | Muscle, Smooth - immunology | Airway Remodeling - immunology | Lymphocytes - immunology | Wnt Proteins - genetics | Calgranulin B - immunology | Bronchial Hyperreactivity - metabolism | Female | Calgranulin B - genetics | Lung - metabolism | Neutrophils - pathology | Receptor, Epidermal Growth Factor - immunology | Lung - pathology | Gene Expression Regulation | Neutrophils - immunology | Respiratory Hypersensitivity - complications | Muscle, Smooth - metabolism | Bronchial Hyperreactivity - complications | Pregnancy | Peptide Initiation Factors - genetics | Animals | NF-kappa B - genetics | Airway Resistance - immunology | Muscle, Smooth - pathology | Lung - immunology | Studies | Data analysis | Vitamin D | Rodents | Vitamin deficiency | Smooth muscle | Software | Chronic obstructive pulmonary disease | Genetic engineering | Inflammation | Gene expression | Growth factors
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2017, Volume 23, Issue 6, pp. 723 - 732
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2008, Volume 181, Issue 8, pp. 5627 - 5636
S100A8 and S100A9, highly expressed by neutrophils, activated macrophages, and microvascular endothelial cells, are secreted during inflammatory processes. Our... 
CALCIUM-BINDING PROTEINS | MAST-CELL ACTIVATION | HUMAN NEUTROPHILS | TRANSENDOTHELIAL MIGRATION | ENDOTHELIAL-CELLS | NITRIC-OXIDE | NADPH OXIDASE ACTIVATION | MACROPHAGE EXPRESSION | ARACHIDONIC-ACID | IMMUNOLOGY | CHEMOTACTIC PROTEIN | Free Radical Scavengers - pharmacology | Free Radical Scavengers - chemistry | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukocytes - immunology | Calgranulin A - chemistry | Free Radical Scavengers - immunology | Nitric Oxide Synthase Type II - immunology | Protein Processing, Post-Translational - drug effects | Calgranulin B - immunology | Biological Transport - drug effects | Microcirculation - immunology | Calgranulin A - immunology | Protein Processing, Post-Translational - immunology | Calgranulin B - chemistry | Mast Cells - immunology | Nitric Oxide - immunology | Hemoglobins - immunology | Rats | Anti-Inflammatory Agents, Non-Steroidal - immunology | Inflammation - immunology | p-Methoxy-N-methylphenethylamine - pharmacology | Cysteine - chemistry | Biological Transport - immunology | Endothelial Cells - immunology | Oxidants - immunology | Animals | Lipopolysaccharides - pharmacology | Mice | Mice, Inbred BALB C | Interleukin-10 - immunology | Interferon-gamma - pharmacology | Cysteine - immunology
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 489 - 501
The mouse has long served as a paradigm for complex autoimmune and inflammatory disease. Null mutations in which encodes the nonreceptor protein-tyrosine... 
SIGNAL-TRANSDUCTION | VIABLE MOTHEATEN | MACROPHAGES | KINASE | DISEASE | IMMUNOLOGY | SHP-1 | PROTEIN-TYROSINE-PHOSPHATASE | SYSTEMIC AUTOIMMUNITY | T-CELLS | DEFICIENCY | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Calgranulin A - metabolism | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | Autoimmunity - genetics | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Calgranulin A - genetics | Mice, 129 Strain | CD11c Antigen - immunology | Protein-Tyrosine Kinases - immunology | CD11c Antigen - metabolism | Inflammation - metabolism | CD11c Antigen - genetics | Flow Cytometry | Autoimmunity - immunology | Myeloid Differentiation Factor 88 - immunology | src-Family Kinases - metabolism | Female | Calgranulin A - immunology | Neutrophils - metabolism | Syk Kinase | Dendritic Cells - metabolism | Dermis - metabolism | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Neutrophils - immunology | Mice, Transgenic | Inflammation - immunology | src-Family Kinases - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Dermis - immunology | Mice, Knockout | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Cell Line, Tumor | Inflammation - genetics | Dermis - pathology | Mice | Mutation | Myeloid Differentiation Factor 88 - metabolism | Autoimmunity | Dendritic cells | Analysis | Skin diseases | Inflammation | Phosphotransferases | Integrins
Journal Article
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 2015, Volume 67, Issue 12, pp. 3303 - 3313
Journal Article
International Immunology, ISSN 0953-8178, 5/2014, Volume 26, Issue 5, pp. 257 - 267
Tyk2 regulates IL-22/IL-23-induced psoriasis Tyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals triggered by various cytokines,... 
Psoriasis | Tyk2 | IL-23 | IL-22 | IL-17 | IFN-GAMMA | KERATINOCYTES | CYTOKINE | DELTA-T-CELLS | ANTIMICROBIAL PEPTIDES | IMMUNOLOGY | NUCLEAR TRANSLOCATION | psoriasis | INHIBITOR | EXPRESSION | TH17 CELLS | Inflammation - chemically induced | Hyperplasia - immunology | Defensins - genetics | Skin - metabolism | Humans | Interleukin-23 | Interleukin-17 - immunology | Calgranulin A - genetics | Interleukins - metabolism | TYK2 Kinase - immunology | Signal Transduction - immunology | RNA Interference | Interleukins - immunology | Gene Expression - immunology | Inflammation Mediators - metabolism | TYK2 Kinase - antagonists & inhibitors | Calgranulin A - immunology | Interleukins - pharmacology | Psoriasis - prevention & control | Skin - pathology | Cytokines - immunology | Skin - immunology | Inflammation Mediators - immunology | Psoriasis - immunology | Cell Line | Cytokines - metabolism | Enzyme Inhibitors - pharmacology | Inflammation - immunology | Tyrphostins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Keratinocytes - immunology | Mice, Knockout | Interleukin-17 - metabolism | Defensins - immunology | Animals | Keratinocytes - drug effects | Signal Transduction - drug effects | Keratinocytes - metabolism | Psoriasis - chemically induced | Inflammation - prevention & control | Mice, Inbred BALB C | TYK2 Kinase - genetics
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2013, Volume 188, Issue 9, pp. 1137 - 1146
Journal Article