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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3841 - 3846
The S100A8/S100A9 heterodime/calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn²⁺ and... 
Proteins | Pathogens | Antimicrobials | Superoxides | Neutrophils | Bacteria | Infections | Titration | Immunity | Crystal structure | Bacterial pathogenesis | Isothermal titration calorimetry | Protein crystal structure | Staphylococcus aureus | Antibiotic resistance | CALCIUM-BINDING PROTEINS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | protein crystal structure | ESCHERICHIA-COLI | PSORIASIN S100A7 | isothermal titration calorimetry | STRUCTURE VALIDATION | antibiotic resistance | STAPHYLOCOCCUS-AUREUS | METAL | bacterial pathogenesis | SUPEROXIDE-DISMUTASE | ZINC-BINDING | EF-HAND PROTEINS | Zinc - metabolism | Humans | Protein Multimerization | Crystallography, X-Ray | Calgranulin A - genetics | Leukocyte L1 Antigen Complex - immunology | Host-Pathogen Interactions - immunology | Calgranulin A - chemistry | Calgranulin B - immunology | Calgranulin B - genetics | Leukocyte L1 Antigen Complex - pharmacology | Calgranulin A - immunology | Binding Sites | Calgranulin B - chemistry | Mutagenesis, Site-Directed | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Immunity, Innate | Manganese - metabolism | Recombinant Proteins - immunology | Leukocyte L1 Antigen Complex - chemistry | Leukocyte L1 Antigen Complex - genetics | Staphylococcus aureus - immunology | Histidine - chemistry | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Amino Acid Substitution | Molecular dynamics | Host-parasite relationships | Immune response | Research | Health aspects | Manganese compounds | Bacterial infections | Binding sites | Medical immunity | Index Medicus | Biological Sciences
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2018, Volume 24, Issue 2, pp. 154 - 164
Hemophagocytic syndrome (HPS) is a fatal hyperinflammatory disease with a poorly understood mechanism that occurs most frequently in extranodal natural... 
MEDICINE, RESEARCH & EXPERIMENTAL | LYMPHOHISTIOCYTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-FEATURES | KAPPA-B | ARACHIDONIC-ACID | THALIDOMIDE | CANCER | CELL BIOLOGY | PHARMACOKINETICS | NASAL-TYPE | INFLAMMATION | S100A9 | Adaptor Proteins, Signal Transducing - chemistry | Inflammation - pathology | Humans | Lymphohistiocytosis, Hemophagocytic - physiopathology | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Calgranulin A - genetics | Transcription Factor RelA - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Calgranulin A - chemistry | Heterografts | Lymphoma, Extranodal NK-T-Cell - drug therapy | Inflammation - drug therapy | Protein Multimerization - genetics | Adult | Female | Calgranulin B - genetics | Interferon-gamma - genetics | Lymphohistiocytosis, Hemophagocytic - genetics | Calgranulin B - chemistry | Dexamethasone - administration & dosage | Signal Transduction | Lymphohistiocytosis, Hemophagocytic - drug therapy | Thalidomide - administration & dosage | Gene Knock-In Techniques | Lymphohistiocytosis, Hemophagocytic - complications | Whole Exome Sequencing | NF-kappa B - genetics | Lymphoma, Extranodal NK-T-Cell - physiopathology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Mutation | Lymphoma, Extranodal NK-T-Cell - complications | Physiological aspects | Development and progression | Genetic aspects | Research | Non-Hodgkin's lymphomas | Gene mutations | Cell culture | Oxidase | Activation | Macrophages | NAD(P)H oxidase | Immunosuppressive agents | Lipopolysaccharides | Cell activation | Xenografts | Tumor necrosis factor-TNF | Natural killer cells | Thalidomide | NF-κB protein | Dexamethasone | Cell survival | Secretion | Tumor cell lines | Tumor necrosis factor-α | Survival | Lymphoma | Cells | Hemophagocytic syndrome | Signaling | Medical prognosis | Cell lines | Mice | Lymphomas | Interferon | T-cell lymphoma | Peritoneum | Index Medicus
Journal Article
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 11/2016, Volume 1864, Issue 11, pp. 1558 - 1569
Human S100A9 (Calgranulin B) is a Ca -binding protein, from the S100 family, that often presents as a homodimer in myeloid cells. It becomes an important... 
Cell proliferation | NMR structure | Protein complex | Receptor for advanced glycation end products | NMR spectroscopy | S100A9 | CHAPS | WST-1 assay | STRUCTURAL INSIGHTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | BIOPHYSICS | NEURITE OUTGROWTH | BINDING PROTEINS S100A8 | DISEASE | UP-REGULATION | TUMOR-GROWTH | CHEMICAL-SHIFT PERTURBATION | GLYCATION END-PRODUCTS | Calgranulin B - metabolism | Receptor for Advanced Glycation End Products - chemistry | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Protein Multimerization | Receptor for Advanced Glycation End Products - antagonists & inhibitors | Structure-Activity Relationship | Cholic Acids - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Protein Domains | Antineoplastic Agents - pharmacology | Calgranulin B - genetics | Receptor for Advanced Glycation End Products - genetics | Binding Sites | Calgranulin B - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Protein Structure, Secondary | Receptor for Advanced Glycation End Products - metabolism | Recombinant Proteins - chemistry | Epithelial Cells - pathology | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Cholic Acids - pharmacology | Escherichia coli - genetics | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Protein Binding | Cell Proliferation - drug effects | Molecular Docking Simulation | Mutation | Proteins | Nuclear magnetic resonance spectroscopy | Analysis | Drug interactions | Protein binding
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 12, pp. e115800 - e115800
Objectives: One way to optimize the drug prescription in rheumatoid arthritis (RA) is to identify predictive biomarkers of drug responsiveness. Here, we... 
INFLAMMATORY JOINT DISEASES | THERAPY | SYNOVIAL-FLUID | MULTIDISCIPLINARY SCIENCES | SERUM-LEVELS | CALPROTECTIN | PROTEINS | ETANERCEPT | INFLIXIMAB | MASS-SPECTROMETRY | BLOOD-CELLS | Leukocytes, Mononuclear - metabolism | Calgranulin B - metabolism | Calgranulin A - metabolism | Humans | Leukocyte L1 Antigen Complex - metabolism | Middle Aged | Immunoglobulin G - therapeutic use | Male | Methotrexate - therapeutic use | Receptors, Tumor Necrosis Factor - therapeutic use | Young Adult | Arthritis, Rheumatoid - metabolism | Etanercept | Arthritis, Rheumatoid - drug therapy | Adult | Female | Aged | Proteomics - methods | Biomarkers, Pharmacological - chemistry | Biomarkers, Pharmacological - metabolism | Calgranulin B - chemistry | Drug Combinations | Antirheumatic Agents - therapeutic use | Cohort Studies | Proteins | Rheumatoid factor | Biological products | Analysis | Arthritis | Mass spectrometry | Enzyme-linked immunosorbent assay | Disease | Laboratories | Innovations | Antibodies | Leukocytes (mononuclear) | Identification | Biopolymers | Blood | Immunology | Peripheral blood mononuclear cells | Rheumatism | Tumor necrosis factor-TNF | Bioindicators | Methotrexate | Polymers | Lupus | Autoantibodies | Cytokines | Neutrophils | Rheumatology | Mass spectroscopy | Gene expression | Patients | S100A9 protein | Rheumatoid arthritis | Proteomics | Biomarkers | Autoimmune diseases | S100A8 protein | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e40277 - e40277
S100A8 and S100A9 are two calcium binding Myeloid Related Proteins, and important mediators of inflammatory diseases. They were recently introduced as partners... 
Calgranulin B - metabolism | Calgranulin A - metabolism | Antibodies, Monoclonal - biosynthesis | Cross-Linking Reagents - pharmacology | Cytosol - immunology | Humans | Cytosol - drug effects | Herpesvirus 4, Human - drug effects | NADPH Oxidases - metabolism | Molecular Sequence Data | Protein Transport - drug effects | Structure-Activity Relationship | Cytochrome b Group - metabolism | Calgranulin A - chemistry | Lymphocytes - virology | Bacterial Secretion Systems - drug effects | Pseudomonas aeruginosa - metabolism | Protein Binding - drug effects | Calgranulin B - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Neutrophils - enzymology | Herpesvirus 4, Human - physiology | Neutrophils - drug effects | Recombinant Proteins - chemistry | Enzyme Activation - drug effects | Cell-Free System | NADPH Oxidases - isolation & purification | Cytochrome b Group - isolation & purification | Lymphocytes - drug effects | Lymphocytes - enzymology | Cytochrome | Residues | Enzymes | Phosphorylation | Dehydrogenases | Calcium | Leukemia | Escherichia coli | Neutrophils | Oxidase | Amino acid sequence | Cystic fibrosis | Activation | Kinases | NAD(P)H oxidase | Inflammatory diseases | Proteins | Cytochrome b558 | Acids | Lymphocytes | CYBB protein | Aging | Chimeras | Recombinant | Index Medicus | Calgranulin B | Biotechnology | Bacterial Secretion Systems | Calgranulin A | Recombinant Proteins | Cytosol | Life Sciences | Computer Science | Pseudomonas aeruginosa | Cross-Linking Reagents | Antibodies, Monoclonal | Herpesvirus 4, Human | Protein Transport | Cytochrome b Group | Protein Binding | Enzyme Activation | NADPH Oxidase
Journal Article