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Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 288 - 297
Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS) has been linked to heterozygous deletion of RPS14; which encodes... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN 5Q-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | DELETION 5Q | RISK MYELODYSPLASTIC SYNDROME | CELL BIOLOGY | HEMATOPOIETIC STEM-CELLS | MOUSE MODEL | DIAMOND-BLACKFAN ANEMIA | MYELOID-LEUKEMIA | SUPPRESSOR-CELLS | UP-REGULATION | Immunohistochemistry | Calgranulin A - metabolism | Humans | Immunity, Innate - genetics | Calgranulin A - genetics | Tumor Suppressor Protein p53 - genetics | Anemia - genetics | Flow Cytometry | Mass Spectrometry | Calgranulin B - genetics | Megakaryocytes | Cytokines - immunology | Disease Models, Animal | Erythropoiesis - genetics | Haploinsufficiency - genetics | Anemia - immunology | Ribosomal Proteins - genetics | In Situ Hybridization, Fluorescence | Blotting, Western | Mice, Knockout | Immunity, Innate - immunology | Microscopy, Confocal | Animals | Bone Marrow - pathology | Fluorescent Antibody Technique | Erythroid Precursor Cells - metabolism | Mice | Myelodysplastic Syndromes - genetics | In Vitro Techniques | Myelodysplastic Syndromes - pathology | Myelodysplastic Syndromes - immunology | Erythropoiesis - immunology | Hematopoietic Stem Cells | Erythropoiesis | Physiological aspects | Genetic aspects | Research | Cell differentiation | Hematopoietic stem cells | Proteins | Gene expression | Anemia | Erythrocytes | Apoptosis | Immune system
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 541 - 554
Elevated concentrations of tumor necrosis factor-α (TNF-α) are detected in pathologies characterized by chronic inflammation. Whether TNF-α plays a role in... 
RECRUITMENT | KILLER-CELL | IMMUNE SUPPRESSION | IMMUNOSUPPRESSION | DOWN-REGULATION | TNF-ALPHA | ACCUMULATION | IMMUNOLOGY | CANCER | T-CELLS | PROGRESSION | Calgranulin B - metabolism | Calgranulin A - metabolism | Tumor Necrosis Factor-alpha - genetics | Immunoblotting | Calgranulin A - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cell Differentiation - genetics | Inflammation - metabolism | Flow Cytometry | Etanercept | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Calgranulin B - immunology | Gene Expression - immunology | Tumor Necrosis Factor-alpha - immunology | Immunoglobulin G - pharmacology | Killer Cells, Natural - immunology | Myeloid Cells - drug effects | Receptors, Antigen, T-Cell - immunology | Calgranulin B - genetics | Mitogen-Activated Protein Kinases - immunology | Calgranulin A - immunology | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Differentiation - immunology | Animals | Receptors, Tumor Necrosis Factor | Cell Differentiation - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Mitogen-Activated Protein Kinases - genetics | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Killer Cells, Natural - metabolism | Chronic Disease | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Clinical & Experimental Metastasis, ISSN 0262-0898, 8/2016, Volume 33, Issue 6, pp. 609 - 627
The dynamic interaction between tumor cells and their microenvironment induces a proinflammatory milieu that drives cancer development and progression. The... 
NF-κB | Biomedicine | ALCAM | Hematology | MCAM | Malignant melanoma | Cancer Research | Oncology | S100A8/A9 | RAGE | Surgical Oncology | Biomedicine general | MIGRATION | CELL-ADHESION MOLECULE | CANCER | S100 PROTEINS | NF-kappa B | CIRCULATING TUMOR-CELLS | ONCOLOGY | INFLAMMATION | CARBOXYLATED GLYCANS | EXPRESSION | CD146 | Calgranulin B - metabolism | Cell Proliferation | Reactive Oxygen Species - metabolism | Calgranulin A - metabolism | Humans | Lung Neoplasms - metabolism | Tumor Microenvironment | Male | NF-kappa B - metabolism | CD146 Antigen - genetics | Fetal Proteins - metabolism | Calgranulin A - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Lung Neoplasms - secondary | Melanoma - genetics | Calgranulin B - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Receptor for Advanced Glycation End Products - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Melanoma - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptor for Advanced Glycation End Products - metabolism | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Cell Adhesion Molecules, Neuronal - genetics | Xenograft Model Antitumor Assays | Animals | CD146 Antigen - metabolism | NF-kappa B - genetics | Mice, Nude | Fetal Proteins - genetics | Mice | Apoptosis | Cell Movement
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2018, Volume 24, Issue 2, pp. 154 - 164
Hemophagocytic syndrome (HPS) is a fatal hyperinflammatory disease with a poorly understood mechanism that occurs most frequently in extranodal natural... 
MEDICINE, RESEARCH & EXPERIMENTAL | LYMPHOHISTIOCYTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-FEATURES | KAPPA-B | ARACHIDONIC-ACID | THALIDOMIDE | CANCER | CELL BIOLOGY | PHARMACOKINETICS | NASAL-TYPE | INFLAMMATION | S100A9 | Adaptor Proteins, Signal Transducing - chemistry | Inflammation - pathology | Humans | Lymphohistiocytosis, Hemophagocytic - physiopathology | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Calgranulin A - genetics | Transcription Factor RelA - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Calgranulin A - chemistry | Heterografts | Lymphoma, Extranodal NK-T-Cell - drug therapy | Inflammation - drug therapy | Protein Multimerization - genetics | Adult | Female | Calgranulin B - genetics | Interferon-gamma - genetics | Lymphohistiocytosis, Hemophagocytic - genetics | Calgranulin B - chemistry | Dexamethasone - administration & dosage | Signal Transduction | Lymphohistiocytosis, Hemophagocytic - drug therapy | Thalidomide - administration & dosage | Gene Knock-In Techniques | Lymphohistiocytosis, Hemophagocytic - complications | Whole Exome Sequencing | NF-kappa B - genetics | Lymphoma, Extranodal NK-T-Cell - physiopathology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Mutation | Lymphoma, Extranodal NK-T-Cell - complications | Physiological aspects | Development and progression | Genetic aspects | Research | Non-Hodgkin's lymphomas | Gene mutations | Cell culture | Oxidase | Activation | Macrophages | NAD(P)H oxidase | Immunosuppressive agents | Lipopolysaccharides | Cell activation | Xenografts | Tumor necrosis factor-TNF | Natural killer cells | Thalidomide | NF-κB protein | Dexamethasone | Cell survival | Secretion | Tumor cell lines | Tumor necrosis factor-α | Survival | Lymphoma | Cells | Hemophagocytic syndrome | Signaling | Medical prognosis | Cell lines | Mice | Lymphomas | Interferon | T-cell lymphoma | Peritoneum
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3841 - 3846
The S100A8/S100A9 heterodime/calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn²⁺ and... 
Proteins | Pathogens | Antimicrobials | Superoxides | Neutrophils | Bacteria | Infections | Titration | Immunity | Crystal structure | Bacterial pathogenesis | Isothermal titration calorimetry | Protein crystal structure | Staphylococcus aureus | Antibiotic resistance | CRYSTAL-STRUCTURE | PROTEINS 8 | MULTIDISCIPLINARY SCIENCES | protein crystal structure | ESCHERICHIA-COLI | PSORIASIN S100A7 | ZINC | isothermal titration calorimetry | STRUCTURE VALIDATION | antibiotic resistance | CALCIUM | STAPHYLOCOCCUS-AUREUS | bacterial pathogenesis | SUPEROXIDE-DISMUTASE | BINDING | Zinc - metabolism | Humans | Protein Multimerization | Crystallography, X-Ray | Calgranulin A - genetics | Leukocyte L1 Antigen Complex - immunology | Host-Pathogen Interactions - immunology | Calgranulin A - chemistry | Calgranulin B - immunology | Calgranulin B - genetics | Leukocyte L1 Antigen Complex - pharmacology | Calgranulin A - immunology | Binding Sites | Calgranulin B - chemistry | Mutagenesis, Site-Directed | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Immunity, Innate | Manganese - metabolism | Recombinant Proteins - immunology | Leukocyte L1 Antigen Complex - chemistry | Leukocyte L1 Antigen Complex - genetics | Staphylococcus aureus - immunology | Histidine - chemistry | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Amino Acid Substitution | Molecular dynamics | Host-parasite relationships | Immune response | Research | Health aspects | Biological Sciences
Journal Article
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 11/2015, Volume 53, Issue 5, pp. 664 - 675
We have previously demonstrated increased airway smooth muscle (ASM) mass and airway hyperresponsiveness in whole-life vitamin D-deficient female mice. In this... 
RNA sequencing | mouse model | inflammation | vitamin D | airway remodeling | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CATENIN | CELL BIOLOGY | RESPONSES | RESPIRATORY SYSTEM | GROWTH | DISEASE | RESISTANCE | ASTHMA | CHECKPOINT | EXPRESSION | Receptor, Epidermal Growth Factor - genetics | Bronchial Hyperreactivity - immunology | E1A-Associated p300 Protein - genetics | Calgranulin A - genetics | Bronchial Hyperreactivity - genetics | Matrix Metalloproteinase 9 - genetics | Calgranulin A - immunology | Vitamin D Deficiency - immunology | Neutrophils - metabolism | Disease Models, Animal | Lymphocytes - metabolism | Vitamin D Deficiency - genetics | Signal Transduction | Respiratory Hypersensitivity - metabolism | Respiratory Hypersensitivity - immunology | Peptide Initiation Factors - immunology | Wnt Proteins - immunology | Respiratory Hypersensitivity - genetics | Lymphocytes - pathology | Mice | Bronchoalveolar Lavage Fluid - chemistry | Vitamin D Deficiency - metabolism | Vitamin D Deficiency - complications | E1A-Associated p300 Protein - immunology | Matrix Metalloproteinase 9 - immunology | NF-kappa B - immunology | Muscle, Smooth - immunology | Airway Remodeling - immunology | Lymphocytes - immunology | Wnt Proteins - genetics | Calgranulin B - immunology | Bronchial Hyperreactivity - metabolism | Female | Calgranulin B - genetics | Lung - metabolism | Neutrophils - pathology | Receptor, Epidermal Growth Factor - immunology | Lung - pathology | Gene Expression Regulation | Neutrophils - immunology | Respiratory Hypersensitivity - complications | Muscle, Smooth - metabolism | Bronchial Hyperreactivity - complications | Pregnancy | Peptide Initiation Factors - genetics | Animals | NF-kappa B - genetics | Airway Resistance - immunology | Muscle, Smooth - pathology | Lung - immunology | Studies | Data analysis | Vitamin D | Rodents | Vitamin deficiency | Smooth muscle | Software | Chronic obstructive pulmonary disease | Genetic engineering | Inflammation | Gene expression | Growth factors
Journal Article