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Journal of Controlled Release, ISSN 0168-3659, 02/2017, Volume 247, pp. 28 - 54
...: structural analogues and nanomedicines. In this review, we summarize recent advances in the design, synthesis and development of camptothecin molecular derivatives and supramolecular vehicles, following a systematic classification... 
Stimuli-responsive | Clinical trials | Camptothecin nanomedicines | Camptothecin analogues | Structure-activity relationship | TOPOISOMERASE-I INHIBITOR | LINKED DNA BREAKS | LOADED POLYMERIC MICELLES | DRUG-DELIVERY | MESOPOROUS SILICA NANOPARTICLES | PLANT ANTITUMOR AGENTS | CHEMISTRY, MULTIDISCIPLINARY | STIMULI-RESPONSIVE NANOCARRIERS | HUMAN BREAST-CARCINOMA | PHARMACOLOGY & PHARMACY | PHASE-I | INORGANIC NANOPARTICLES | Camptothecin - pharmacokinetics | Topoisomerase I Inhibitors - pharmacokinetics | Camptothecin - adverse effects | Nanoparticles - chemistry | Humans | Topoisomerase I Inhibitors - administration & dosage | Models, Molecular | Antineoplastic Agents, Phytogenic - chemistry | Delayed-Action Preparations - chemistry | Clinical Trials as Topic | Antineoplastic Agents, Phytogenic - administration & dosage | Topoisomerase I Inhibitors - adverse effects | Animals | Drug Liberation | Camptothecin - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Drug Delivery Systems - methods | Nanomedicine | Topoisomerase I Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - adverse effects | Camptothecin - analogs & derivatives | Magnetic fields | Enzymes | Therapeutics | Homeopathy | Materia medica and therapeutics | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2017, Volume 45, Issue 11, pp. 1166 - 1177
Journal Article
Journal Article
Journal Article
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 06/2017, Volume 11, pp. 1859 - 1870
.... In the present study, a quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of withanolide analogs against human breast cancer... 
Breast cancer | Withanolides | QSAR | ADMET | Molecular docking | WITHAFERIN-A | SEMISYNTHESIS | CHEMISTRY, MEDICINAL | IMMUNOMODULATORY ACTIVITY | breast cancer | CELL-LINES | ACID-DERIVATIVES | ANTICANCER ACTIVITY | molecular docking | IN-VITRO EVALUATION | GROWTH | STEROIDAL LACTONES | WITHANIA-SOMNIFERA | PHARMACOLOGY & PHARMACY | withanolides | Reproducibility of Results | Cell Proliferation | Models, Chemical | Withanolides - chemistry | Humans | Molecular Conformation | Antineoplastic Agents, Phytogenic - chemistry | Breast Neoplasms - drug therapy | Tubulin - metabolism | MCF-7 Cells | Withanolides - pharmacology | Withanolides - pharmacokinetics | Antimetabolites, Antineoplastic - pharmacology | Female | Fluorouracil - pharmacology | Molecular Docking Simulation | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - pharmacokinetics | Camptothecin - pharmacology | Quantitative Structure-Activity Relationship | Drugs | Care and treatment | Plant products | Usage | Structure-activity relationship (Pharmacology) | Development and progression | Structure-activity relationships | Health aspects | Testing | Medicinal plants | Regression coefficients | Camptothecin | 5-Fluorouracil | Immunomodulation | Pharmacology | Lactones | Anticancer properties | Analogs | Leaves | Tubulin | Chemical bonds | Antitumor activity | Sulfate | Ginseng | Cancer | Withania | ADME/T
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138607 - e0138607
Journal Article