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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14621 - 14626
A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous... 
Community structure | Datasets | Communities | Genes | Cell lines | Antineoplastics | Signatures | Dosage | Gene expression | Mode of action | Drug repurposing | Chemotherapy | Systems biology | Computational drug discovery | systems biology | TARGET | NETWORK | computational drug discovery | MULTIDISCIPLINARY SCIENCES | CONNECTIVITY MAP | EXPRESSION PROFILES | KAPPA-B | AUTOPHAGY | chemotherapy | CANCER | CELL-DEATH | drug repurposing | CAMPTOTHECIN | DISEASE | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Drug Discovery - methods | Gene Expression Profiling | RNA Polymerase II - metabolism | Autophagy - drug effects | Neoplasms - genetics | Piperidines - pharmacology | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Antineoplastic Agents - classification | Fuzzy Logic | Camptothecin - analogs & derivatives | Pyrazoles - pharmacology | Drug Screening Assays, Antitumor - methods | Blotting, Western | Pyrroles - pharmacology | Algorithms | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | HeLa Cells | Neoplasms - pathology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Dose-response relationship (Biochemistry) | Physiological aspects | Research | Observations | Methods | Cancer | Pharmacology | Biochemistry | Kinases | Research & development--R&D | Index Medicus | Cyclin-dependent kinase 2 | Drugs | Enhancers | Neurodegenerative diseases | Transcription | Drug discovery | Nodes | Phagocytosis | Rho-associated kinase | Biological Sciences
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2004, Volume 109, Issue 1, pp. 1 - 8
Heme oxygenase‐1 (HO‐1), an inducible enzyme that catalyzes oxidative degradation of heme to form biliverdin, carbon monoxide and free iron, may protect tumor... 
heme oxygenase‐1 | zinc protoporphyrin | macromolecular therapeutics | tumor targeting/EPR effect | D‐amino acid oxidase | Macromolecular therapeutics | D-amino acid oxidase | Tumor targeting/EPR effect | Heme oxygenase-1 | Zinc protoporphyrin | HUMAN BRAIN-TUMORS | CANCER-CHEMOTHERAPY | INDUCED APOPTOSIS | NITRIC-OXIDE SYNTHASE | heme oxygenase-1 | MACROMOLECULAR DRUGS | MESSENGER-RNA | ONCOLOGY | GENE-EXPRESSION | SOLID TUMOR | HYDROGEN-PEROXIDE PRODUCTION | TARGETED DELIVERY | Oxidants - pharmacology | Body Weight | Reactive Oxygen Species - metabolism | Oxidative Stress | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Male | Metalloporphyrins - pharmacology | Oxygen - metabolism | Dose-Response Relationship, Drug | Antineoplastic Agents - pharmacology | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Polyethylene Glycols - pharmacology | Oxidation-Reduction | Hydrogen Peroxide - pharmacology | Etoposide - pharmacology | Tetrazolium Salts - pharmacology | Cisplatin - pharmacology | Hydrogen Peroxide - metabolism | Mitomycin - pharmacology | Neoplasms - drug therapy | Proline - chemistry | Drug Synergism | Animals | Cell Line, Tumor | Mice | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Treatment with the DNA topoisomerase inhibitors etoposide, doxorubicin, and camptothecin, and with the alkylating agents cisplatin and melphalan, caused... 
OXYGEN | SUPEROXIDE ANION | BUTHIONINE SULFOXIMINE | INHIBITION | U937 CELLS | NEURONAL DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | SENSITIVITY | HYDROGEN-PEROXIDE | STRESS | Buthionine Sulfoximine - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Reactive Oxygen Species | Glutathione - metabolism | Alkylating Agents - pharmacology | Humans | Topoisomerase I Inhibitors | Antineoplastic Agents, Alkylating - pharmacology | Immunoblotting | Monocytes - metabolism | Oxygen - metabolism | Antineoplastic Agents - toxicity | Necrosis | Dose-Response Relationship, Drug | Flow Cytometry | Time Factors | U937 Cells | Adenosine Triphosphate - metabolism | Cell Death | Radiation-Protective Agents - pharmacology | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Membrane Potentials - drug effects | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Etoposide - pharmacology | Spectrometry, Fluorescence | Glutathione - antagonists & inhibitors | Mitochondria - metabolism | Antioxidants - pharmacology | Cisplatin - pharmacology | Hypoxia | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Dose-Response Relationship, Radiation | Doxorubicin - pharmacology | Apoptosis | butylated hydroxyanisole | melphelan | N-Acetyl-L-cysteine | cisplatin | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 02/2012, Volume 11, Issue 2, pp. 427 - 438
Journal Article
British Journal of Cancer, ISSN 0007-0920, 2017, Volume 117, Issue 12, pp. 1777 - 1786
Background: Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and... 
Nuclear internalisation | Acquired resistance | IGF-1R | Colorectal cancer | BRAF mutation | colorectal cancer | I RECEPTOR | TUMOR-CELLS | COMBINATION | acquired resistance | INSULIN | nuclear internalisation | MUTATION STATUS | ONCOLOGY | POOR-PROGNOSIS | KRAS | INHIBITOR | TRANSCRIPTION FACTOR | EXPRESSION | Leucovorin - administration & dosage | Receptor, IGF Type 1 - metabolism | Molecular Chaperones - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Panitumumab | Drug Resistance, Neoplasm | Male | Protein Inhibitors of Activated STAT - metabolism | Protein Transport - drug effects | Cell Nucleus - metabolism | Colorectal Neoplasms - drug therapy | Protein Inhibitors of Activated STAT - genetics | Camptothecin - administration & dosage | Camptothecin - analogs & derivatives | Cell Survival - drug effects | Bevacizumab - administration & dosage | Antibodies, Monoclonal - pharmacology | HCT116 Cells | Curcumin - pharmacology | Molecular Chaperones - genetics | Pyrimidines - pharmacology | Dasatinib - pharmacology | Signal Transduction - drug effects | Sorafenib | Fluorouracil - pharmacology | Niacinamide - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Molecular Targeted Therapy | Organoplatinum Compounds - pharmacology | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Oxaliplatin | Female | Antineoplastic Agents - pharmacology | Gene Silencing | Fatty Acids, Unsaturated - pharmacology | HT29 Cells | Pyrroles - pharmacology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cetuximab - administration & dosage | Aged | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Colorectal Neoplasms - pathology | Immunohistochemistry | Medical research | Cell survival | Insulin-like growth factor I | RNA-mediated interference | Colorectal carcinoma | Chemoresistance | Clinical trials | Insulin-like growth factors | Metastasis | Insulin | Patients | Survival | Metastases | Proteins | SUMO protein | Chemotherapy | Cell lines | Monoclonal antibodies | Tumors | Cancer | Index Medicus | Translational Therapeutics
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2006, Volume 12, Issue 8, pp. 2640 - 2646
Purpose: Tumor necrosis factor-related apoptosis–inducing ligand (TRAIL/Apo2L) exhibits potent antitumor activity on systemic administration in nonhuman... 
apoptosis | TRAIL | primary human hepatocytes | chemotherapy | HEPATOCELLULAR-CARCINOMA CELLS | APOPTOSIS-INDUCING LIGAND | ONCOLOGY | HUMAN HEPATOCYTES | IN-VIVO | RECEPTOR | TUMORICIDAL ACTIVITY | MONOCLONAL-ANTIBODY | DEATH | NF-KAPPA-B | FAMILY | Immunohistochemistry | Apoptosis Regulatory Proteins - pharmacology | Apoptosis - drug effects | Gene Expression - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | GPI-Linked Proteins | Apoptosis - genetics | Deoxycytidine - pharmacology | Hepatocytes - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand | Organoplatinum Compounds - pharmacology | Receptors, Tumor Necrosis Factor, Member 10c | Dose-Response Relationship, Drug | Tumor Necrosis Factor Decoy Receptors | Hepatocytes - cytology | TNF-Related Apoptosis-Inducing Ligand | Time Factors | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Hepatocytes - drug effects | Camptothecin - analogs & derivatives | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | Cell Survival - drug effects | Membrane Glycoproteins - pharmacology | Cells, Cultured | Etoposide - pharmacology | Cisplatin - pharmacology | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Membrane Glycoproteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Fluorouracil - pharmacology | Camptothecin - pharmacology | Deoxycytidine - analogs & derivatives | Index Medicus | in-vivo | tumoricidal activity | monoclonal-antibody | hepatocellular-carcinoma cells | human hepatocytes | receptor | death | nf-kappa-b | family | apoptosis-inducing ligand
Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2012, Volume 30, Issue 3, pp. 1248 - 1256
This study sought to measure the degree of synergy induced by specific small molecule inhibitors of DNA-PK [NU7026 and IC486241 (ICC)], a major component of... 
Anthracyclines | DNA-PK | Medicine & Public Health | Homologous recombination | Non-homologous end joining | Oncology | DNA-damage | Breast cancer | Pharmacology/Toxicology | DNA-repair | Drug synergism | DOUBLE-STRAND BREAKS | DEPENDENT PROTEIN-KINASE | RANDOMIZED CONTROLLED-TRIAL | METASTATIC COLORECTAL-CANCER | DAMAGE | REPAIR | ONCOLOGY | COMBINATION CHEMOTHERAPY | PHARMACOLOGY & PHARMACY | ATM | IONIZING-RADIATION | CYTOTOXICITY | DNA-Activated Protein Kinase - antagonists & inhibitors | Cell Survival - drug effects | HCT116 Cells | Humans | Morpholines - pharmacology | Cisplatin - pharmacology | Comet Assay | Organoplatinum Compounds - pharmacology | Drug Synergism | HT29 Cells | Topoisomerase I Inhibitors - pharmacology | Cell Cycle Checkpoints - drug effects | Colonic Neoplasms - pathology | Acridones - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Chromones - pharmacology | Camptothecin - pharmacology | Camptothecin - analogs & derivatives | Antimitotic agents | Complications and side effects | Colon cancer | DNA damage | Dosage and administration | Research | Antineoplastic agents | Drug therapy | Studies | Pharmacology | Deoxyribonucleic acid--DNA | Colorectal cancer | Index Medicus | Drugs | Flow cytometry | Phosphorylation | Data processing | Tumor cell lines | Synergism | Comet assay | Western blotting | Homologous recombination repair | Irinotecan | Rad51 protein | DNA-dependent protein kinase | homologous recombination | Cell cycle | oxaliplatin
Journal Article
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 11/2012, Volume 9, Issue 11, pp. 3147 - 3159
23-O-(1,4'-Bipiperidine-1-carbonyl)betulinic acid (BBA), a synthetic derivative of 23-hydroxybetulinic acid (23-HBA), shows a reversal effect on multidrug... 
BBA | multidrug resistance | ABCB1 | ABCG2 | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA CELLS | MEDIATED MULTIDRUG-RESISTANCE | TRANSPORTERS | VINCRISTINE RESISTANCE | HUMAN P-GLYCOPROTEIN | GENE | PHARMACOLOGY & PHARMACY | ANTICANCER DRUGS | BINDING | CYTOTOXICITY | Paclitaxel - pharmacology | Triterpenes - pharmacology | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Breast Neoplasms - metabolism | Triterpenes - chemistry | Carcinoma, Hepatocellular - drug therapy | Piperidines - pharmacology | Triterpenes - chemical synthesis | Female | Antineoplastic Agents - pharmacology | Real-Time Polymerase Chain Reaction | Camptothecin - analogs & derivatives | RNA, Messenger - genetics | Cells, Cultured | Liver Neoplasms - drug therapy | Models, Molecular | Cisplatin - pharmacology | KB Cells - drug effects | Calcium Channel Blockers - pharmacology | Piperidines - chemical synthesis | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Verapamil - pharmacology | Blotting, Western | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Mice, Nude | Fluorescent Antibody Technique | Liver Neoplasms - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Cell Proliferation - drug effects | Mice | Molecular Docking Simulation | Antineoplastic Agents, Phytogenic - pharmacology | In Vitro Techniques | Camptothecin - pharmacology | Doxorubicin - pharmacology | Carcinoma, Hepatocellular - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2014, Volume 134, Issue 11, pp. 2717 - 2725
Journal Article
Journal of Biotechnology, ISSN 0168-1656, 07/2015, Volume 205, pp. 14 - 23
Journal Article