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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 08/2010, Volume 107, Issue 33, pp. 14621 - 14626
.... Available methods are inefficient and are not able to support network pharmacology. We developed an automatic and robust approach that exploits similarity in gene... 
Community structure | Datasets | Communities | Genes | Cell lines | Antineoplastics | Signatures | Dosage | Gene expression | Mode of action | Drug repurposing | Chemotherapy | Systems biology | Computational drug discovery | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Drug Discovery - methods | Gene Expression Profiling | RNA Polymerase II - metabolism | Autophagy - drug effects | Neoplasms - genetics | Piperidines - pharmacology | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Antineoplastic Agents - classification | Fuzzy Logic | Camptothecin - analogs & derivatives | Pyrazoles - pharmacology | Drug Screening Assays, Antitumor - methods | Blotting, Western | Pyrroles - pharmacology | Algorithms | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | HeLa Cells | Neoplasms - pathology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Dose-response relationship (Biochemistry) | Physiological aspects | Research | Observations | Methods | Cancer | Index Medicus | Cyclin-dependent kinase 2 | Drugs | Enhancers | Neurodegenerative diseases | Transcription | Pharmacology | Drug discovery | Nodes | Phagocytosis | Rho-associated kinase | systems biology | Biological Sciences | drug repurposing | computational drug discovery | chemotherapy
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Journal Article
Journal Article
Clinical cancer research, ISSN 1557-3265, 04/2006, Volume 12, Issue 8, pp. 2640 - 2646
Purpose: Tumor necrosis factor-related apoptosis–inducing ligand (TRAIL/Apo2L) exhibits potent antitumor activity on systemic administration in nonhuman... 
apoptosis | TRAIL | primary human hepatocytes | chemotherapy | in-vivo | tumoricidal activity | monoclonal-antibody | hepatocellular-carcinoma cells | human hepatocytes | receptor | death | nf-kappa-b | family | apoptosis-inducing ligand | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Apoptosis Regulatory Proteins - pharmacology | Apoptosis - drug effects | Gene Expression - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | GPI-Linked Proteins | Apoptosis - genetics | Deoxycytidine - pharmacology | Hepatocytes - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand | Organoplatinum Compounds - pharmacology | Receptors, Tumor Necrosis Factor, Member 10c | Dose-Response Relationship, Drug | Tumor Necrosis Factor Decoy Receptors | Hepatocytes - cytology | TNF-Related Apoptosis-Inducing Ligand | Time Factors | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Hepatocytes - drug effects | Camptothecin - analogs & derivatives | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | Cell Survival - drug effects | Membrane Glycoproteins - pharmacology | Cells, Cultured | Etoposide - pharmacology | Cisplatin - pharmacology | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Membrane Glycoproteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Fluorouracil - pharmacology | Camptothecin - pharmacology | Deoxycytidine - analogs & derivatives | Index Medicus
Journal Article
Investigational new drugs, ISSN 0167-6997, 6/2012, Volume 30, Issue 3, pp. 1248 - 1256
This study sought to measure the degree of synergy induced by specific small molecule inhibitors of DNA-PK [NU7026 and IC486241 (ICC)], a major component of... 
Anthracyclines | DNA-PK | Medicine & Public Health | Homologous recombination | Non-homologous end joining | Oncology | DNA-damage | Breast cancer | Pharmacology/Toxicology | DNA-repair | Drug synergism | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | DNA-Activated Protein Kinase - antagonists & inhibitors | Cell Survival - drug effects | HCT116 Cells | Humans | Morpholines - pharmacology | Cisplatin - pharmacology | Comet Assay | Organoplatinum Compounds - pharmacology | Drug Synergism | HT29 Cells | Topoisomerase I Inhibitors - pharmacology | Cell Cycle Checkpoints - drug effects | Colonic Neoplasms - pathology | Acridones - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Chromones - pharmacology | Camptothecin - pharmacology | Camptothecin - analogs & derivatives | Antimitotic agents | Complications and side effects | Colon cancer | DNA damage | Dosage and administration | Research | Antineoplastic agents | Drug therapy | Studies | Pharmacology | Deoxyribonucleic acid--DNA | Colorectal cancer | Index Medicus | Drugs | Flow cytometry | Phosphorylation | Data processing | Tumor cell lines | Synergism | Comet assay | Western blotting | Homologous recombination repair | Irinotecan | Rad51 protein | DNA-dependent protein kinase | homologous recombination | Cell cycle | oxaliplatin
Journal Article
Journal Article
Clinical cancer research, ISSN 1078-0432, 04/2014, Volume 20, Issue 8, pp. 2104 - 2114
Journal Article
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 12/2014, Volume 74, Issue 6, pp. 1125 - 1137
Journal Article