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PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175329
Teriparatide [human parathyroid hormone (1-34)], which exerts an anabolic effect on bone, is used for the treatment of osteoporosis in patients who are at a... 
HUMAN PARATHYROID HORMONE(1-34) | MARROW FIBROSIS | OVARIECTOMIZED CYNOMOLGUS MONKEYS | VERTEBRAL FRACTURES | THINNER CORTICES | DISTAL RADIUS | MULTIDISCIPLINARY SCIENCES | TURNOVER MARKERS | POSTMENOPAUSAL WOMEN | FIBROUS DYSPLASIA | MECHANICAL-PROPERTIES | Osteogenesis - physiology | X-Ray Microtomography | Bone and Bones - drug effects | Dose-Response Relationship, Drug | Collagen - drug effects | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Biomechanical Phenomena - drug effects | Bone Resorption - metabolism | Female | Models, Animal | Bone Resorption - chemically induced | Porosity - drug effects | Imaging, Three-Dimensional | Bone and Bones - cytology | Rabbits | Bone Density Conservation Agents - adverse effects | Drug Administration Schedule | Teriparatide - administration & dosage | Teriparatide - blood | Osteogenesis - drug effects | Bone Density Conservation Agents - administration & dosage | Microscopy, Interference | Bone Density Conservation Agents - blood | Collagen - metabolism | Animals | Bone Resorption - pathology | Teriparatide - adverse effects | Microscopy, Fluorescence | Adaptations | Animal models | Spine | Bone (trabecular) | Bisphosphonates | Clinical outcomes | Bone resorption | Proteins | Osteoporosis | Alendronic acid | Bone growth | Computed tomography | Fibrous dysplasia | Bone marrow | Bone dysplasia | Tunneling | Skeleton | Bone density | Bone loss | Bone (cortical) | Drug therapy | Bone strength | Drug dosages | Age | Bone remodelling | Rats | Risk reduction | Endocrine therapy | Pharmacology | Frost | Bone turnover | Metabolism | Bone mass | Fractures | Osteodystrophy | Mice | Bone mineral density | Mutation | Porosity | Pharmacokinetics | Risk management | Kidney transplantation | Bone (cancellous)
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1072 - 1079
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities(1). Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE | IDENTIFICATION | CELL BIOLOGY | OSTEOCLASTOGENESIS | ACTIVATOR | MASS | ESTROGEN | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | In vitro methods and tests | Osteogenesis | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article
by Cui, L and Li, T and Liu, YY and Zhou, L and Li, PH and Xu, BL and Huang, LF and Chen, Y and Liu, YZ and Tian, XY and Jee, WSS and Wu, T
PLOS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34647
Glucocorticoid (GC) induced osteoporosis (GIO) is caused by the long-term use of GC for treatment of autoimmune and inflammatory diseases. The GC related... 
TRABECULAR BONE | CELLS | GLUCOCORTICOIDS | HISTOMORPHOMETRY | MULTIDISCIPLINARY SCIENCES | OSTEOBLASTS | BEAGLE | DIFFERENTIATION | EXPRESSION | OSTEONECROSIS | MILTIORRHIZA | Neovascularization, Physiologic - drug effects | Gene Expression - drug effects | Adipogenesis - drug effects | Benzofurans - administration & dosage | Male | Adipocytes - drug effects | PPAR gamma - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Bone and Bones - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Osteoporosis - metabolism | Bone and Bones - metabolism | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Differentiation | Bone Morphogenetic Proteins - genetics | PPAR gamma - genetics | Prednisone - administration & dosage | Benzofurans - therapeutic use | Osteoporosis - chemically induced | Prednisone - adverse effects | Osteoporosis - prevention & control | Osteoblasts - drug effects | Osteogenesis - drug effects | Stromal Cells - metabolism | Bone and Bones - blood supply | Intercellular Signaling Peptides and Proteins - genetics | Rats | Rats, Sprague-Dawley | beta Catenin - metabolism | beta Catenin - genetics | Animals | Adipocytes - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Osteoporosis | Corticosteroids | Bones | Prednisone | Cell differentiation | Density | Steroids | Oxidative stress | Transcription factors | Glucocorticoids | Laboratories | Differentiation (biology) | Stimulation | Adipocytes | Inflammatory diseases | β-catenin | Angiogenesis | Bone histomorphometry | Biomedical materials | Bone growth | Ischemia | Rodents | Bone marrow | Biocompatibility | Inhibition | Bone loss | Bone strength | Osteopenia | Adipogenesis | Cbfa-1 protein | Research & development--R&D | Medical treatment | Pharmacology | Gene expression | Medicine | Studies | Herbal medicine | Osteoblastogenesis | Bone mass | Acids | Stem cells | Dilation | Bone mineral density | In vivo methods and tests | Dkk1 protein | Osteogenesis | Bone (cancellous) | Apoptosis | Herbal medicines | Guanylate cyclase | Osteoblasts | adipogenesis | stromal cells | Bone morphogenetic proteins | Differentiation | Research & development | R&D
Journal Article
Bone, ISSN 8756-3282, 2016, Volume 93, pp. 86 - 96
Abstract Odanacatib (ODN) a selective and reversible cathepsin K inhibitor, inhibits bone resorption, increases bone mass and reduces fracture risk in women... 
Orthopedics | Osteoporosis | Odanacatib | Bone remodeling | Alendronate | Bone strength | Cathepsin K inhibitor | CORTICAL BONE | RESORPTION | K INHIBITOR ODANACATIB | COMPUTED-TOMOGRAPHY | HIP | MINERAL DENSITY | SPINE | ENDOCRINOLOGY & METABOLISM | ESTROGEN | POSTMENOPAUSAL WOMEN | MONKEYS | Bone and Bones - pathology | Femur - pathology | Tomography, X-Ray Computed | Cancellous Bone - drug effects | Cortical Bone - pathology | Femur - diagnostic imaging | Biphenyl Compounds - therapeutic use | Bone Remodeling - drug effects | Bone and Bones - drug effects | Bone Diseases, Metabolic - drug therapy | Cancellous Bone - diagnostic imaging | Biphenyl Compounds - pharmacology | Bone and Bones - diagnostic imaging | Cancellous Bone - pathology | Female | Lumbar Vertebrae - physiopathology | Disease Models, Animal | Biomarkers - metabolism | Rabbits | Cancellous Bone - physiopathology | Bone Diseases, Metabolic - diagnostic imaging | Ovariectomy | Cortical Bone - physiopathology | Lumbar Vertebrae - drug effects | Femur - physiopathology | Withholding Treatment | Absorptiometry, Photon | Regression Analysis | Biomechanical Phenomena | Bone Density - drug effects | Bone and Bones - physiopathology | Organ Size - drug effects | Animals | Lumbar Vertebrae - pathology | Bone Diseases, Metabolic - physiopathology | Cortical Bone - diagnostic imaging | Cathepsins | Aluminum compounds | Bones | Density | Analysis
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2017, Volume 32, Issue 2, pp. 360 - 372
Journal Article
Bone, ISSN 8756-3282, 2016, Volume 93, pp. 33 - 42
Abstract Aging hypogonadal men are at increased risk of osteoporosis and sarcopenia. Testosterone is a potentially appealing strategy to prevent simultaneous... 
Orthopedics | Testosterone | Androgens | Muscle | Conditional knock-out mice | Disuse osteoporosis | Androgen receptor | CORTICAL BONE | DEGRADES BONE | OSTEOGENIC RESPONSE | BOTULINUM TOXIN | RAT MODEL | SKELETAL-MUSCLE | BONE LOSS | ADULT MALE-MICE | ESTROGEN-RECEPTOR-ALPHA | ENDOCRINOLOGY & METABOLISM | SPINAL-CORD-INJURY | Muscular Disorders, Atrophic - complications | Body Weight | Receptors, Androgen - metabolism | Bone Diseases, Metabolic - pathology | Male | Muscular Disorders, Atrophic - physiopathology | Cancellous Bone - drug effects | Cortical Bone - pathology | X-Ray Microtomography | Bone Remodeling - drug effects | Muscular Disorders, Atrophic - drug therapy | Bone Diseases, Metabolic - drug therapy | Cancellous Bone - diagnostic imaging | Muscular Atrophy - physiopathology | Bone Diseases, Metabolic - complications | Gene Deletion | Cancellous Bone - pathology | Androgens - therapeutic use | Female | Integrases - metabolism | Muscular Disorders, Atrophic - pathology | Muscular Atrophy - complications | Extracellular Matrix Proteins - metabolism | Acute Disease | Bone Resorption - physiopathology | Cancellous Bone - physiopathology | Mice, Inbred C57BL | Muscular Atrophy - pathology | Bone Resorption - drug therapy | Cortical Bone - physiopathology | Organ Size | Bone Resorption - complications | MyoD Protein - metabolism | Muscular Atrophy - drug therapy | Animals | Androgens - pharmacology | Calcification, Physiologic | Bone Resorption - pathology | Cortical Bone - drug effects | Bone Diseases, Metabolic - physiopathology | Cortical Bone - diagnostic imaging | Osteoporosis | Paralysis | Body weight
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2017, Volume 32, Issue 10, pp. 2001 - 2009
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2017, Volume 32, Issue 10, pp. 2116 - 2127
ABSTRACT Macrophages have established roles supporting bone formation. Despite their professional phagocytic nature, the role of macrophage phagocytosis in... 
EFFEROCYTOSIS | TRABECTEDIN | PARATHYROID HORMONE | MACROPHAGES | OSTEOIMMUNOLOGY | TRAIL | IN-VITRO | APOPTOTIC CELLS | GROWTH | ENDOCRINOLOGY & METABOLISM | PARATHYROID-HORMONE | OSTEAL MACROPHAGES | DIFFERENTIATION | RECEPTORS | POLARIZATION | MODULATION | Male | Parathyroid Hormone - pharmacology | Cancellous Bone - drug effects | Cortical Bone - pathology | Osteoclasts - cytology | Bone and Bones - anatomy & histology | Cancellous Bone - pathology | Dioxoles - pharmacology | Osteoblasts - cytology | Tetrahydroisoquinolines - pharmacology | Phagocytosis - drug effects | Calcification, Physiologic - drug effects | Mice, Inbred C57BL | Osteoblasts - drug effects | Osteogenesis - drug effects | Macrophages - cytology | Osteoclasts - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Organ Size - drug effects | Animals | Cortical Bone - drug effects | Macrophages - drug effects | Osteoblasts - metabolism | Osteoclasts - drug effects | Chemotherapy | Parathyroid hormone | Analysis | Bone morphogenetic proteins | Bones | Mice | Macrophages | Transforming growth factors | Gene expression | Density | Cancer | Cbfa-1 protein | Flow cytometry | Transcription factors | Homeostasis | Bone turnover | Bone (trabecular) | Osteoblasts | Mimicry | Phagocytes | Bone growth | Bone mass | Mineralization | Bone marrow | Bone mineral density | Osteogenesis | Phagocytosis | Apoptosis | parathyroid hormone | macrophages | trabectedin | efferocytosis | osteoimmunology
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2012, Volume 27, Issue 6, pp. 1252 - 1262
As they age, mice deficient for the β2‐adrenergic receptor (Adrb2−/−) maintain greater trabecular bone microarchitecture, as a result of lower bone resorption... 
β‐ADRENERGIC | ISOPROTERENOL | MECHANICAL LOADING | PEAK BONE MASS ACQUISITION | β-ADRENERGIC | ss-ADRENERGIC | SYMPATHETIC-NERVOUS-SYSTEM | BETA-2-ADRENERGIC RECEPTORS | OSTEOBLAST-LIKE CELLS | FRACTURE RISK | NORADRENERGIC REGULATION | LEPTIN DEFICIENCY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | PARATHYROID-HORMONE | ADAPTIVE RESPONSE | GROWTH-FACTOR-I | Bone and Bones - pathology | Femur - pathology | Stress, Mechanical | Male | Bone Remodeling - drug effects | Bone and Bones - drug effects | Body Composition - drug effects | Bone and Bones - metabolism | Gene Deletion | Biomechanical Phenomena - drug effects | Receptors, Adrenergic, beta-2 - deficiency | Receptors, Adrenergic, beta-1 - deficiency | Femur - metabolism | Receptors, Adrenergic, beta-2 - genetics | Osteoblasts - drug effects | Osteogenesis - drug effects | Femur - drug effects | Receptors, Adrenergic, beta-1 - metabolism | Femur - physiopathology | Receptors, Adrenergic, beta-2 - metabolism | Gene Expression Regulation - drug effects | Bone and Bones - physiopathology | Organ Size - drug effects | Phenotype | Animals | Isoproterenol - pharmacology | Receptors, Adrenergic, beta-1 - genetics | Mice | Osteoblasts - metabolism | Insulin-Like Growth Factor I - metabolism | Femur | Vertebrae | Insulin-like growth factor I | Spine | Insulin-like growth factors | isoproterenol | Bone (trabecular) | Bone resorption | Bone histomorphometry | Bone growth | NF- Kappa B protein | Bone mass | Loading | Tibia | Adrenergic receptors | Bone mineral density | Mechanical stimuli | Osteogenesis | Bone (cancellous)
Journal Article
Bone, ISSN 8756-3282, 09/2016, Volume 90, pp. 168 - 180
Glucocorticoids are extensively used to treat patients with Duchenne muscular dystrophy because of their ability to delay muscle damage, prolong ambulation and... 
Bone mineral density | Glucocorticoids | Creatine kinase | Bisphosphonates | Bone strength | Duchenne muscular dystrophy | MUSCLE | OSTEOPOROSIS | ALENDRONATE | MINERAL DENSITY | VERTEBRAL FRACTURES | METABOLISM | GROWTH | ENDOCRINOLOGY & METABOLISM | BOYS | EXPRESSION | Cartilage - pathology | Muscles - physiopathology | Body Weight - drug effects | Male | Cartilage - drug effects | Cortical Bone - pathology | Muscles - pathology | X-Ray Microtomography | Bone Remodeling - drug effects | Muscular Dystrophy, Duchenne - diagnostic imaging | Femur Neck - diagnostic imaging | Cancellous Bone - diagnostic imaging | Mice, Inbred mdx | Cancellous Bone - pathology | Diphosphonates - therapeutic use | Bone Resorption - chemically induced | Glucocorticoids - adverse effects | Diaphyses - pathology | Disease Models, Animal | Femur Neck - pathology | Cancellous Bone - physiopathology | Osteoclasts - pathology | Calcification, Physiologic - drug effects | Muscular Dystrophy, Duchenne - drug therapy | Mice, Inbred C57BL | Osteogenesis - drug effects | Bone Resorption - drug therapy | Cortical Bone - physiopathology | Muscular Dystrophy, Duchenne - pathology | Muscular Dystrophy, Duchenne - complications | Bone Resorption - prevention & control | Gene Expression Regulation - drug effects | Bone Resorption - diagnostic imaging | Biomechanical Phenomena | Animals | Diaphyses - drug effects | Diaphyses - physiopathology | Muscles - drug effects | Femur Neck - physiopathology | Cortical Bone - diagnostic imaging | Femur Neck - drug effects | Diphosphonates - pharmacology | Osteoclasts - drug effects | Corticosteroids | Bones | Prednisone | Density | Steroids | Phosphonates | Creatine | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 02/2017, Volume 22, Issue 2, pp. 197 - 197
Cistanoside A (Cis A), an active phenylethanoid glycoside isolated from Cistanche deserticola Y. C. Ma, has received our attention because of its possible role... 
Cistanoside A | RANKL | Antiosteoporotic | Ovariectomized mice | TRAF6 | ANTIOSTEOPOROTIC ACTIVITY | DIAGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | antiosteoporotic | OSTEOPOROSIS | cistanoside A | ovariectomized mice | OSTEOBLASTS | PHENYLETHANOIDS | ECHINACOSIDE | EXTRACT | Bone and Bones - pathology | Mechanical Phenomena - drug effects | Cancellous Bone - metabolism | Ovariectomy | Osteogenesis - drug effects | Osteoporosis - drug therapy | Cancellous Bone - drug effects | Glycosides - pharmacology | Osteoporosis - etiology | X-Ray Microtomography | Bone and Bones - drug effects | Bone Density - drug effects | Animals | Cancellous Bone - diagnostic imaging | Osteoporosis - metabolism | Osteoporosis - pathology | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Biomarkers | Bone Resorption - metabolism | Cancellous Bone - pathology | Catechols - pharmacology | Female | Mice | Intervention | Alkaline phosphatase | Body weight | AKT protein | Bone (trabecular) | Inactivation | Phosphatase | Osteoprotegerin | Bone resorption | Osteoporosis | Bone growth | Rodents | Deoxypyridinoline | TRANCE protein | Bone strength | NF-κB protein | Cathepsin K | TRAF6 protein | Bone turnover | Metabolism | Biological activity | 1-Phosphatidylinositol 3-kinase | Molecular modelling | Lymphocytes B | Tumor necrosis factor | Ligands | Bone mineral density | Acid phosphatase (tartrate-resistant) | Osteogenesis
Journal Article