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Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 34, pp. 56126 - 56142
Here, we report new mechanistic insight into how chronic hypoxia increases 'stemness' in cancer cells. Using chemical inhibitors, we provide direct... 
Anti-angiogenic therapy | Cancer stem-like cells (CSCs) | Anti-oxidant | Chronic hypoxia | Doxycycline | OXIDATION | anti-angiogenic therapy | MITOCHONDRIAL BIOGENESIS | anti-oxidant | cancer stem-like cells (CSCs) | VALPROIC ACID | HIF1-ALPHA | FIBROBLASTS | CELL BIOLOGY | HETEROGENEITY | INVASION | chronic hypoxia | METABOLISM | EXPRESSION | PROMOTES
Journal Article
Journal Article
Journal Article
Aging, ISSN 1945-4589, 02/2018, Volume 10, Issue 2, pp. 230 - 240
Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signal (MTS) in living cells. Here, we... 
Tri-phenyl-phosphonium (TPP) | Mitochondrial targeting signal | Cancer stem cells (CSCs) | Cancer therapy | cancer therapy | mitochondrial targeting signal | MASS | cancer stem cells (CSCs) | tri-phenyl-phosphonium (TPP) | THERAPEUTIC IMPLICATIONS | PROPAGATION | CELL BIOLOGY | GERIATRICS & GERONTOLOGY
Journal Article
ONCOTARGET, ISSN 1949-2553, 09/2017, Volume 8, Issue 40, pp. 67269 - 67286
Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment... 
SURVIVAL | vitamin C | mitochondrial DNA (mt-DNA) | cancer stem-like cells (CSCs) | AUTOPHAGY | doxycycline | mitochondrial biogenesis | CELL BIOLOGY | BREAST-CANCER | ASCORBATE | WOMEN | OXIDATIVE MITOCHONDRIAL METABOLISM | BIOGENESIS | PHARMACOKINETICS | TUMOR-GROWTH | PROPAGATION
Journal Article