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Hepatology, ISSN 0270-9139, 01/2018, Volume 67, Issue 1, pp. 247 - 259
Journal Article
Oncogene, ISSN 0950-9232, 03/2017, Volume 36, Issue 13, pp. 1770 - 1778
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2017, Volume 32, Issue 5, pp. 654 - 668.e5
Journal Article
Journal Article
Journal Article
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 8/2012, Volume 120, Issue 8, pp. 1177 - 1182
Journal Article
Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 640 - 648
Bortezomib (bort) has improved overall survival in patients with multiple myeloma (MM), but the majority of them develop drug resistance. In this study, we... 
CYTOKINES | LYMPHOMA-CELLS | CANCER-ASSOCIATED FIBROBLASTS | MICROENVIRONMENT | ONCOLOGY | INDUCED APOPTOSIS | GROWTH | DEGRADATION | DRUG-RESISTANCE | STROMAL CELLS | HEMATOLOGY | EXPRESSION | RNA-Binding Proteins - genetics | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Multiple Myeloma - mortality | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bortezomib - pharmacology | Autophagy - drug effects | Plasma Cells - pathology | Plasma Cells - drug effects | Multiple Myeloma - drug therapy | TOR Serine-Threonine Kinases - genetics | Aged, 80 and over | Transforming Growth Factor beta - antagonists & inhibitors | Bone Marrow Cells - drug effects | Female | Plasma Cells - metabolism | Antineoplastic Agents - pharmacology | Fibroblasts - metabolism | Pyrazoles - pharmacology | Signal Transduction | Bone Marrow Cells - pathology | Fibroblasts - pathology | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Multiple Myeloma - pathology | Pyrroles - pharmacology | Animals | Transforming Growth Factor beta - genetics | Fibroblasts - drug effects | Survival Analysis | Aged | Mice | Primary Cell Culture | Transforming Growth Factor beta - metabolism | Bone Marrow Cells - metabolism | Drug Combinations | Multiple Myeloma - genetics | RNA-Binding Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 18, pp. 5142 - 5157
Cancer-associated fibroblasts (CAF) have been suggested to originate from mesenchymal stromal cells (MSC), but their relationship with MSCs is not clear. Here,... 
SURVIVAL | STEM-CELLS | MICROENVIRONMENT | ONCOLOGY | ACTIVATION PROTEIN | STAT3 | TUMOR-ASSOCIATED MACROPHAGES | MYOFIBROBLASTS | NEUROBLASTOMA | DRUG-RESISTANCE | INTERLEUKIN-6 | Apoptosis - drug effects | Cancer-Associated Fibroblasts - metabolism | Humans | Cancer-Associated Fibroblasts - drug effects | Culture Media, Conditioned - pharmacology | Male | Janus Kinase 2 - metabolism | Biomarkers, Tumor - metabolism | Bone Marrow Cells - drug effects | Female | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Neuroblastoma - pathology | STAT3 Transcription Factor - metabolism | Pyrazoles - pharmacology | Tumor Microenvironment - drug effects | Mesenchymal Stromal Cells - drug effects | Bone Marrow Cells - pathology | Mesenchymal Stromal Cells - metabolism | MAP Kinase Kinase 1 - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Cancer-Associated Fibroblasts - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Neuroblastoma - drug therapy | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Neuroblastoma - metabolism | Mesenchymal Stromal Cells - pathology | Bone Marrow Cells - metabolism | Pyridones - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Cell survival | Mesenchyme | Immunodeficiency | Stat3 protein | Extracellular signal-regulated kinase | Etoposide | Bone tumors | Neuroblastoma | Macrophages | Survival | Neuroblastoma cells | Chemotherapy | Stromal cells | Janus kinase 2 | Xenografts | Bone marrow | Fibroblasts | Cancer | Tumors | Immune system | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 05/2016, Volume 15, Issue 6, pp. 1175 - 1189
Journal Article
Cell Cycle, ISSN 1538-4101, 10/2012, Volume 11, Issue 19, pp. 3599 - 3610
Here, we investigated the compartment-specific role of cell cycle arrest and senescence in breast cancer tumor growth. For this purpose, we generated a number... 
PD0332991 | cancer metabolism | cancer-associated fibroblast | senescence | mitophagy | autophagy | glycolysis | aging | tumor stroma | CDK inhibitors | cell cycle arrest | tumor initiation | Cancer-associated fibroblast | Senescence | Cancer metabolism | Tumor stroma | Aging | Cell cycle arrest | Glycolysis | Tumor initiation | Mitophagy | Autophagy | OXIDATIVE STRESS | KETONE PRODUCTION | MITOCHONDRIAL METABOLISM | STROMAL CAVEOLIN-1 | HUMAN BREAST-CANCER | CELL BIOLOGY | PREMATURE SENESCENCE | INDEPENDENT CELL-DEATH | PRIMARY BILIARY-CIRRHOSIS | AEROBIC GLYCOLYSIS | HYDROGEN-PEROXIDE | Humans | Lactic Acid - metabolism | Hydrogen Peroxide - pharmacology | Cellular Senescence - drug effects | Breast Neoplasms - blood supply | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p19 - metabolism | Fibroblasts - pathology | Piperazines - pharmacology | Autophagy - drug effects | Neovascularization, Pathologic - pathology | Animals | Breast Neoplasms - pathology | Models, Biological | Fibroblasts - drug effects | Paracrine Communication - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Cell Cycle - drug effects | Fibroblasts - metabolism | Index Medicus
Journal Article
Cancer Science, ISSN 1347-9032, 02/2015, Volume 106, Issue 2, pp. 134 - 142
Given the close interaction between tumor cells and stromal cells in the tumor microenvironment ( TME ), TME ‐targeted strategies would be promising for... 
tranilast | Cancer‐associated fibroblasts | dendritic cell‐based vaccine immunotherapy | suppressor immune cells | tumor microenvironment | Suppressor immune cells | Cancer-associated fibroblasts | Dendritic cell-based vaccine immunotherapy | Tranilast | Tumor microenvironment | PROMOTE TUMOR-GROWTH | ACTIVATION PROTEIN | PROLIFERATION | INHIBITION | MICROENVIRONMENT | ONCOLOGY | COLLAGEN-SYNTHESIS | REGULATORY T-CELLS | STROMAL FIBROBLASTS | dendritic cell-based vaccine immunotherapy | PROGRESSION | Immunotherapy - methods | ortho-Aminobenzoates - pharmacology | Immunity, Humoral - immunology | Dendritic Cells - immunology | T-Lymphocytes, Regulatory - immunology | Immunity, Cellular - drug effects | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Tumor Microenvironment - drug effects | Antineoplastic Agents - immunology | Mice, Inbred C57BL | Lymph Nodes - immunology | Mice, SCID | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Cancer Vaccines - immunology | Immunity, Cellular - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Immunity, Humoral - drug effects | Fibroblasts - immunology | Killer Cells, Natural - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Index Medicus | Original
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2016, Volume 15, Issue 10, pp. 1376 - 1385
Journal Article