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1. Full Text Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance
by Silva, Sónia and Negri, Melyssa and Henriques, Mariana and Oliveira, Rosário and Williams, David W and Azeredo, Joana
FEMS Microbiology Reviews, ISSN 0168-6445, 03/2012, Volume 36, Issue 2, pp. 288 - 305
Abstract The incidence of infections caused by Candida species (candidosis) has increased considerably over the past three decades, mainly due to the rise of... 
epidemiology | candidosis | Candida species | virulence factors | antifungal resistance | Antifungal resistance | Candidosis | Virulence factors | Epidemiology | CELL-SURFACE HYDROPHOBICITY | YEAST PATHOGEN | MICROBIOLOGY | NON-ALBICANS-CANDIDA | IN-VITRO SUSCEPTIBILITIES | SECRETED ASPARTIC PROTEINASE | POLYMERASE-CHAIN-REACTION | INTENSIVE-CARE-UNIT | BLOOD-STREAM INFECTIONS | INVASIVE CANDIDIASIS | BIOFILM FORMATION | Antifungal Agents - pharmacology | Candida - genetics | Candida - metabolism | Candida glabrata - pathogenicity | Humans | Candida tropicalis - pathogenicity | Candidiasis - epidemiology | Candida tropicalis - drug effects | Candidiasis - microbiology | Candida glabrata - metabolism | Antifungal Agents - therapeutic use | Animals | Candida tropicalis - genetics | Candida - pathogenicity | Candidiasis - drug therapy | Candida tropicalis - metabolism | Candida - drug effects | Candida glabrata - genetics | Drug Resistance, Fungal | Candida glabrata - drug effects
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2. Full Text Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations
by Barbara D. Alexander and Melissa D. Johnson and Christopher D. Pfeiffer and Cristina Jiménez-Ortigos and Jelena Catania and Rachel Booker and Mariana Castanheira and Shawn A. Messer and David S. Perlin and Michael A. Pfaller
Clinical Infectious Diseases, ISSN 1058-4838, 6/2013, Volume 56, Issue 12, pp. 1724 - 1732
Background. Fluconazole (FLC) resistance is common in C. glabrata and echinocandins are often used as first-line therapy. Resistance to echinocandin therapy... 
Antifungals | Azoles | Health outcomes | Microbial sensitivity tests | Mortality | Polyenes | Infections | Candida glabrata | ARTICLES AND COMMENTARIES | Genetic mutation | Blood | susceptibility | micafungin | resistance | echinocandin | CASPOFUNGIN | INFECTIOUS DISEASES | ASPERGILLUS-FUMIGATUS | MICROBIOLOGY | IMMUNOLOGY | CHANGING EPIDEMIOLOGY | IN-VITRO | ANTIFUNGAL AGENTS | 1,3-BETA-D-GLUCAN SYNTHASE | ALBICANS | BLOOD-STREAM INFECTIONS | INVASIVE CANDIDIASIS | Humans | Middle Aged | Child, Preschool | Infant | Male | Candidiasis - microbiology | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Candidiasis - drug therapy | Aged, 80 and over | Adult | Female | Retrospective Studies | Child | Drug Resistance, Fungal | Echinocandins - pharmacology | Infant, Newborn | Glucosyltransferases - genetics | Antifungal Agents - pharmacology | Membrane Proteins - genetics | Treatment Outcome | Fungal Proteins - genetics | Mutation - genetics | Adolescent | Echinocandins - therapeutic use | Aged | Candida glabrata - genetics | Candida glabrata - drug effects | Complications and side effects | Drug resistance in microorganisms | Candidiasis | Gene mutations | Echinocandins | Dosage and administration | Genetic aspects | Research | Drug therapy | Risk factors | and Commentaries
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3. Full Text Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
by Healey, Kelley R and Zhao, Yanan and Perez, Winder B and Lockhart, Shawn R and Sobel, Jack D and Farmakiotis, Dimitrios and Kontoyiannis, Dimitrios P and Sanglard, Dominique and Taj-Aldeen, Saad J and Alexander, Barbara D and Jimenez-Ortigosa, Cristina and Shor, Erika and Perlin, David S
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, p. 11128
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles... 
PROPHYLAXIS | ANTIFUNGAL DRUG-RESISTANCE | REDUCED SUSCEPTIBILITY | MICAFUNGIN | MULTIDISCIPLINARY SCIENCES | AMPHOTERICIN-B | FKS MUTATIONS | CLINICAL ISOLATE | EPIDEMIOLOGY | ECHINOCANDIN RESISTANCE | ERG6 GENE | Kidney - pathology | Drug Resistance, Multiple - drug effects | Humans | Colony Count, Microbial | Candidiasis - microbiology | Antifungal Agents - therapeutic use | Candidiasis - drug therapy | Gene Deletion | Genes, Fungal | Echinocandins - pharmacology | Disease Models, Animal | Antifungal Agents - pharmacology | Drug Resistance, Multiple - genetics | Kidney - drug effects | Drug Resistance, Fungal - drug effects | Genotype | Drug Resistance, Fungal - genetics | Mutation - genetics | Kidney - microbiology | Phenotype | Animals | Candida glabrata - isolation & purification | Echinocandins - therapeutic use | Mice | Candida glabrata - genetics
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4. Full Text Frequency of Decreased Susceptibility and Resistance to Echinocandins among Fluconazole-Resistant Bloodstream Isolates of Candida glabrata
by M. A. Pfaller and M. Castanheira and S. R. Lockhart and A. M. Ahlquist and S. A. Messer and R. N. Jones
Journal of Clinical Microbiology, ISSN 0095-1137, 04/2012, Volume 50, Issue 4, pp. 1199 - 1203
Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
NON-ALBICANS CANDIDEMIA | RISK-FACTORS | INTENSIVE-CARE-UNIT | DOUBLE-BLIND TRIAL | MICROBIOLOGY | AMPHOTERICIN-B | AZOLE ANTIFUNGAL AGENTS | CRITICALLY-ILL PATIENTS | CASPOFUNGIN RESISTANCE | INVASIVE CANDIDIASIS | FUNGAL-INFECTIONS | Antifungal Agents - pharmacology | Candidemia - microbiology | Fluconazole - pharmacology | Drug Resistance, Multiple, Fungal - genetics | Humans | Middle Aged | Male | Fungal Proteins - genetics | Mutation, Missense | Microbial Sensitivity Tests | Young Adult | Candida glabrata - isolation & purification | Adult | Female | Aged | Candida glabrata - genetics | Echinocandins - pharmacology | Sentinel Surveillance | Candida glabrata - drug effects | Glucosyltransferases - genetics | Mycology
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5. Full Text Comparative genomics of emerging pathogens in the Candida glabrata clade
by Gabaldón, Toni and Martin, Tiphaine and Marcet-Houben, Marina and Durrens, Pascal and Bolotin-Fukuhara, Monique and Lespinet, Olivier and Arnaise, Sylvie and Boisnard, Stéphanie and Aguileta, Gabriela and Atanasova, Ralitsa and Bouchier, Christiane and Couloux, Arnaud and Creno, Sophie and Almeida Cruz, Jose and Devillers, Hugo and Enache-Angoulvant, Adela and Guitard, Juliette and Jaouen, Laure and Ma, Laurence and Marck, Christian and Neuvéglise, Cécile and Pelletier, Eric and Pinard, Amélie and Poulain, Julie and Recoquillay, Julien and Westhof, Eric and Wincker, Patrick and Dujon, Bernard and Hennequin, Christophe and Fairhead, Cécile
BMC Genomics, ISSN 1471-2164, 09/2013, Volume 14, Issue 1, pp. 623 - 623
Background: Candida glabrata follows C. albicans as the second or third most prevalent cause of candidemia worldwide. These two pathogenic yeasts are distantly... 
Fungal pathogens | Candida glabrata | Yeast evolution | Yeast genomes | Nakaseomyces | MAXIMUM-LIKELIHOOD | MULTIPLE SEQUENCE ALIGNMENT | SACCHAROMYCES-CEREVISIAE | SCALE PHYLOGENETIC ANALYSES | DUPLICATION EVENTS | YEAST | TRANSFER-RNA GENES | CELL-WALL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN FAMILIES | GENETICS & HEREDITY | SP-NOV | Saccharomycetales - genetics | Candida glabrata - classification | DNA, Fungal - genetics | Genome, Fungal | Selection, Genetic | Saccharomycetales - classification | Phylogeny | Candida glabrata - genetics | Sequence Analysis, DNA | Evolution, Molecular | Genetic aspects | Pathogenic microorganisms | Research | Genomics | Candida | Genomes | Virulence (Microbiology) | Comparative analysis | Proteins | Phylogenetics | Microbiology | Adaptations | Genètica | Llevats | Genòmica | Càndida | Life Sciences | Biochemistry, Molecular Biology
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6. Full Text Role of FKS mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance
by Pham, Cau D and Iqbal, Naureen and Bolden, Carol B and Kuykendall, Randall J and Harrison, Lee H and Farley, Monica M and Schaffner, William and Beldavs, Zintars G and Chiller, Tom M and Park, Benjamin J and Cleveland, Angela A and Lockhart, Shawn R
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 8, pp. 4690 - 4696
Candida glabrata is the second leading cause of candidemia in U.S. hospitals. Current guidelines suggest that an echinocandin be used as the primary therapy... 
PROLONGED THERAPY | MICAFUNGIN | RISK-FACTOR | SPECIES IDENTIFICATION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ANTIFUNGAL SUSCEPTIBILITY | AMPHOTERICIN-B | CASPOFUNGIN RESISTANCE | BLOOD-STREAM INFECTIONS | POPULATION-BASED SURVEILLANCE | INVASIVE CANDIDIASIS | Antifungal Agents - pharmacology | Candida glabrata - pathogenicity | Candidemia - microbiology | Fluconazole - pharmacology | Lipopeptides - pharmacology | United States | Drug Resistance, Multiple, Fungal - genetics | Fungal Proteins - genetics | Microbial Sensitivity Tests | Glucosyltransferases - metabolism | Candidemia - drug therapy | Candida glabrata - isolation & purification | Mutation | Candida glabrata - genetics | Echinocandins - pharmacology | Candida glabrata - drug effects | Fungal Proteins - metabolism | Glucosyltransferases - genetics | Epidemiology and Surveillance
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7. Full Text Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β-d-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint
by Guillermo Garcia-Effron and Samuel Lee and Steven Park and John D. Cleary and David S. Perlin
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2009, Volume 53, Issue 9, pp. 3690 - 3699
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CANDIDA-GLABRATA | ANTIFUNGAL AGENTS | BLOOD-STREAM | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | SP-NOV | MESSENGER-RNA DECAY | SURROGATE MARKER | FLUCONAZOLE-RESISTANT | SACCHAROMYCES-CEREVISIAE | PREDICT SUSCEPTIBILITY | INVASIVE CANDIDIASIS | Antifungal Agents - pharmacology | Drug Resistance, Fungal - physiology | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Glucosyltransferases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Glucosyltransferases - metabolism | Fungal Proteins - physiology | Candida glabrata - genetics | Candida glabrata - enzymology | Echinocandins - pharmacology | Candida glabrata - drug effects | Fungal Proteins - metabolism | Glucosyltransferases - genetics | Mechanisms of Resistance
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8. Full Text FKS mutant Candida glabrata: Risk factors and outcomes in patients with candidemia
by Beyda, Nicholas D and John, Julie and Kilic, Abdullah and Alam, Mohammad J and Lasco, Todd M and Garey, Kevin W
Clinical Infectious Diseases, ISSN 1058-4838, 09/2014, Volume 59, Issue 6, pp. 819 - 825
Background. Echinocandins are recommended for Candia glabrata candidemia. Mutations in the FKS1 and FKS2 genes are associated with echinocandin resistance. Few... 
Antifungal resistance | Echinocandins | Systemic candidiasis | Candida glabrata | Micafungin | CLSI | CASPOFUNGIN | INFECTIOUS DISEASES | SUSCEPTIBILITY | systemic candidiasis | MICROBIOLOGY | IMMUNOLOGY | FAILURE | antifungal resistance | ECHINOCANDIN RESISTANCE | SPP | THERAPY | echinocandins | MUTATIONS | micafungin | Prognosis | Lipopeptides - pharmacology | Lipopeptides - therapeutic use | Humans | Middle Aged | Male | Candidiasis - microbiology | Candidiasis - diagnosis | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Young Adult | Candidiasis - drug therapy | Treatment Failure | Aged, 80 and over | Adult | Female | Echinocandins - pharmacology | Antifungal Agents - pharmacology | Risk Factors | Treatment Outcome | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Patient Outcome Assessment | Echinocandins - therapeutic use | Aged | Candidemia | Mutation | Candida glabrata - genetics | Candida glabrata - drug effects | Complications and side effects | Candidiasis | Care and treatment | Candida | Analysis | Outcome and process assessment (Health Care) | Genetic aspects | Research
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9. Full Text The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
by Inglis, Diane O and Arnaud, Martha B and Binkley, Jonathan and Shah, Prachi and Skrzypek, Marek S and Wymore, Farrell and Binkley, Gail and Miyasato, Stuart R and Simison, Matt and Sherlock, Gavin
Nucleic Acids Research, ISSN 0305-1048, 1/2012, Volume 40, Issue D1, pp. D667 - D674
The Candida Genome Database (CGD, http://www.candidagenome.org/) is an internet-based resource that provides centralized access to genomic sequence data and... 
ANNOTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EVOLUTION | Candida albicans - genetics | Fungal Proteins - chemistry | Candida - genetics | Genome, Fungal | Genomics | Databases, Genetic | Genes, Fungal | Software | Candida glabrata - genetics | Pathogens | Databases | Nucleotide sequence | Feedback | orthology | Data processing | genomics | Genomes | Physicochemical properties
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10. Full Text Rapid detection of FKS-associated echinocandin resistance in Candida glabrata
by Zhao, Yanan and Nagasaki, Yoji and Kordalewska, Milena and Press, Ellen G and Shields, Ryan K and Nguyen, M. Hong and Clancy, Cornelius J and Perlin, David S
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6573 - 6577
A novel and highly accurate diagnostic assay platform was established for rapid identification of FKS mutations associated with echinocandin resistance in... 
CASPOFUNGIN | MIC VALUES | THERAPY | SUSCEPTIBILITY | FREQUENCY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MUTATIONS | OUTCOMES | MULTIDRUG-RESISTANCE | MINIMUM INHIBITORY CONCENTRATIONS | FAILURE | DNA, Fungal - genetics | Humans | DNA, Fungal - chemistry | Candidiasis - microbiology | Polymerase Chain Reaction - methods | Microbial Sensitivity Tests | Glucosyltransferases - metabolism | Isoenzymes - metabolism | Sensitivity and Specificity | Echinocandins - pharmacology | Glucosyltransferases - genetics | Antifungal Agents - pharmacology | Nucleic Acid Denaturation | Gene Expression | Isoenzymes - genetics | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Molecular Probes - chemistry | Candida glabrata - isolation & purification | Alleles | Mutation | Candida glabrata - genetics | Candida glabrata - enzymology | Candida glabrata - drug effects | Fungal Proteins - metabolism
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11. Full Text Multicenter Evaluation of the Candida albicans/Candida glabrata Peptide Nucleic Acid Fluorescent In Situ Hybridization Method for Simultaneous Dual-Color Identification of C. albicans and C. glabrata Directly from Blood Culture Bottles
by Janeen R. Shepard and Rachel M. Addison and Barbara D. Alexander and Phyllis Della-Latta and Michael Gherna and Gerhard Haase and Gerri Hall and Jennifer K. Johnson and William G. Merz and Heidrun Peltroche-Llacsahuanga and Henrik Stender and Richard A. Venezia and Deborah Wilson and Gary W. Procop and Fann Wu and Mark J. Fiandaca
Journal of Clinical Microbiology, ISSN 0095-1137, 01/2008, Volume 46, Issue 1, pp. 50 - 55
Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
MORTALITY | DIAGNOSIS | DNA | PNA FISH | SURVEILLANCE PROGRAM | MICROBIOLOGY | STREAM INFECTIONS | SP-NOV | ANTIFUNGAL THERAPY | RAPID IDENTIFICATION | PROBES | Candida albicans - genetics | Peptide Nucleic Acids | Candida albicans - isolation & purification | Candida glabrata - isolation & purification | Humans | Sensitivity and Specificity | Blood - microbiology | Candida glabrata - genetics | In Situ Hybridization, Fluorescence - methods | Candidiasis - diagnosis | Mycology
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12. Full Text Systematic Phenotyping of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes
by Schwarzmüller, Tobias and Ma, Biao and Hiller, Ekkehard and Istel, Fabian and Tscherner, Michael and Brunke, Sascha and Ames, Lauren and Firon, Arnaud and Green, Brian and Cabral, Vitor and Marcet-Houben, Marina and Jacobsen, Ilse D and Quintin, Jessica and Seider, Katja and Frohner, Ingrid and Glaser, Walter and Jungwirth, Helmut and Bachellier-Bassi, Sophie and Chauvel, Murielle and Zeidler, Ute and Ferrandon, Dominique and Gabaldón, Toni and Hube, Bernhard and d'Enfert, Christophe and Rupp, Steffen and Cormack, Brendan and Haynes, Ken and Kuchler, Karl
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, p. e1004211
The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis, causing infections ranging from superficial to life-threatening... 
CELL-WALL INTEGRITY | PROTEIN-KINASE PATHWAY | MICROBIOLOGY | FUNCTIONAL-CHARACTERIZATION | FLUCONAZOLE RESISTANCE | ECHINOCANDIN RESISTANCE | SACCHAROMYCES-CEREVISIAE GENOME | VIROLOGY | TRANSPORTER GENE | AZOLE RESISTANCE | IN-VIVO | TRANSCRIPTION FACTOR | PARASITOLOGY | Antifungal Agents - pharmacology | Osmotic Pressure | Gene Library | Biofilms - growth & development | Cell Wall - genetics | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Azoles - pharmacology | Candida glabrata - growth & development | Gene Knockout Techniques | Microbial Sensitivity Tests | Phenotype | Cell Wall - drug effects | Candidiasis - drug therapy | Gene Deletion | Candida glabrata - genetics | Lipopeptides | Echinocandins - pharmacology | Antifungal agents | Mycoses | Genetic research | Research | Drug therapy | Health aspects | Candidiasis | Mycology | Fungal Proteins | Candida glabrata | Cell Wall | Life Sciences | Microbiology and Parasitology | Azoles | Biofilms | Echinocandins | Antifungal Agents | Drug Resistance, Fungal | Library collections | Infections | Yeast | Genes | Genomics
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