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Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 515 - 526
Innate resistance to in mucosal tissues requires the production of interleukin-17A (IL-17A) by tissue-resident cells early during infection, but the mechanism... 
HOST-DEFENSE | CONTACT HYPERSENSITIVITY | INDEPENDENT GENERATION | DELTA T-CELLS | MICE | IMMUNOLOGY | ALBICANS | CHRONIC MUCOCUTANEOUS CANDIDIASIS | SKIN INFLAMMATION | LANGERHANS CELLS | TH17 CELLS | Candidiasis - genetics | Skin - microbiology | Oligonucleotide Array Sequence Analysis | Skin - metabolism | Dendritic Cells - immunology | Sensory Receptor Cells - immunology | Interleukin-17 - immunology | Lectins, C-Type - immunology | Receptors, Antigen, T-Cell, gamma-delta - genetics | Transcriptome - immunology | Candidiasis - microbiology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Host-Pathogen Interactions - immunology | Interleukin-23 - genetics | Lectins, C-Type - metabolism | Flow Cytometry | Interleukin-23 - metabolism | T-Lymphocytes - metabolism | Candida albicans - physiology | Sensory Receptor Cells - metabolism | Candidiasis - immunology | Dermis - cytology | Dendritic Cells - metabolism | Skin - immunology | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Cells, Cultured | Immunity - immunology | Interleukin-17 - genetics | Mice, Transgenic | Receptors, Antigen, T-Cell, gamma-delta - immunology | Transcriptome - genetics | Candida albicans - immunology | Mice, Inbred Strains | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-23 - immunology | Mice, Knockout | Interleukin-17 - metabolism | Animals | Receptors, Calcitonin Gene-Related Peptide - immunology | Receptors, Calcitonin Gene-Related Peptide - genetics | T-Lymphocytes - immunology | Immunity - genetics | Flow cytometry | Immunology | Dendritic cells | Lymphocytes | Colleges & universities | Infections | Grants | Gene expression | Experiments | Index Medicus
Journal Article
PLoS Medicine, ISSN 1549-1277, 2006, Volume 3, Issue 7, pp. 1152 - 1164
Background: The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM... 
DIABETES-MELLITUS | MYASTHENIA-GRAVIS PATIENTS | MEDICINE, GENERAL & INTERNAL | INTERFERON-ALPHA | SYNDROME TYPE-I | NEUTRALIZING ANTIBODIES | DENDRITIC CELLS | IFN-GAMMA | DISEASE | EXPRESSION | T-CELLS | Antibody Specificity | Polyendocrinopathies, Autoimmune - diagnosis | Alopecia - immunology | Autoantibodies - blood | Dendritic Cells - immunology | Humans | Middle Aged | Child, Preschool | Male | Interferon Type I - immunology | Interferons - immunology | Lymphocyte Subsets - immunology | Palatine Tonsil - immunology | Autoimmunity - immunology | Polyendocrinopathies, Autoimmune - genetics | Thymoma - immunology | HLA Antigens - immunology | Genotype | Polyendocrinopathies, Autoimmune - immunology | Lymphoid Tissue - pathology | Thymus Gland - ultrastructure | Norway - epidemiology | Adolescent | Cell Line, Tumor | Candidiasis, Chronic Mucocutaneous - etiology | Interferons - physiology | Finland - epidemiology | Self Tolerance - immunology | Transcription Factors - deficiency | Alopecia - etiology | Neutralization Tests | Keratoconjunctivitis - immunology | Keratoconjunctivitis - etiology | Myasthenia Gravis - etiology | Lymphoid Tissue - immunology | Thymus Neoplasms - immunology | Antigen Presentation | Immunoglobulin G - immunology | Self Tolerance - genetics | Interleukins - immunology | Adult | Female | Candidiasis, Chronic Mucocutaneous - immunology | Transcription Factors - genetics | Polyendocrinopathies, Autoimmune - epidemiology | Interferon-alpha - immunology | Thymus Neoplasms - complications | Autoantibodies - immunology | Interferons - classification | Thymus Gland - immunology | Myasthenia Gravis - immunology | Thymoma - complications | Development and progression | Genetic aspects | Research | Autoimmune diseases | Index Medicus | Allergy | Immunology | Gene Therapy | Genomics | Autoimmune Diseases | Genetics | Immunology and Allergy
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-17 RECEPTOR | TARGET GENES | CANDIDA-ALBICANS | C/EBP-BETA | GENE-EXPRESSION | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | MESSENGER-RNA STABILITY | T-CELL | IMMUNOLOGY | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2908, 2016, Volume 17, Issue 4, pp. 406 - 413
The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is... 
SYSTEMIC INFLAMMATION | MESSENGER-RNA TRANSLATION | ACTIVATION | INTERFERON-GAMMA | IFN-GAMMA | MACROPHAGES | SIRTUIN 1 | DYSFUNCTION | IMMUNOLOGY | EXPRESSION | CELLULAR-METABOLISM | Prospective Studies | Humans | Middle Aged | Transcriptome | Immunoblotting | Male | Monocytes - metabolism | Monocytes - immunology | Lipopolysaccharides - immunology | Antifungal Agents - therapeutic use | Leukocytes - immunology | Young Adult | Sepsis - drug therapy | Immune Tolerance - immunology | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Candidiasis, Invasive - drug therapy | Endotoxemia - immunology | Adult | Aspergillosis - metabolism | Female | Macrophages - immunology | NAD - metabolism | Aspergillosis - drug therapy | Cytokines - immunology | Sepsis - immunology | Interferon-gamma - therapeutic use | Lactic Acid - metabolism | Oxidative Phosphorylation | Oxygen Consumption | Energy Metabolism - immunology | Escherichia coli Infections - metabolism | Candidiasis, Invasive - metabolism | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Candidiasis, Invasive - immunology | Glycolysis | Escherichia coli Infections - immunology | Mice | Endotoxemia - metabolism | Leukocytes - metabolism | Aspergillosis - immunology | Complications and side effects | Energy metabolism | Immune response | Bioenergetics | Abnormalities | Sepsis | Regulation | Leukocytes | Properties | Health aspects | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 6, pp. 1197 - 1213
Competition for iron influences host-pathogen interactions. Pathogens secrete small iron binding moieties, siderophores, to acquire host iron. In response, the... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIPOCALIN | CELLS | ESCHERICHIA-COLI | ENTEROBACTIN | SALMONELLA-TYPHIMURIUM | NEUTROPHIL GELATINASE | HEPCIDIN | IRON ACQUISITION | MICE | IMMUNOLOGY | BINDING | Candidiasis - genetics | Oncogene Proteins - genetics | Gentisates - metabolism | Immunity, Innate - genetics | Immunoblotting | Male | Bacterial Infections - genetics | RNA Interference | Lipocalins - genetics | Candida albicans - physiology | Transcription Factors - immunology | Carrier Proteins - immunology | Enterobactin - metabolism | Bacterial Outer Membrane Proteins - immunology | Hydroxybutyrate Dehydrogenase - immunology | Oncogene Proteins - metabolism | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cell Surface - immunology | Mice, Knockout | Gentisates - immunology | Bacterial Outer Membrane Proteins - metabolism | Escherichia coli - genetics | Lipocalin-2 | Lipocalins - immunology | Staphylococcus aureus - immunology | Mice | Bacterial Infections - metabolism | Positive Regulatory Domain I-Binding Factor 1 | Receptors, Cell Surface - genetics | Staphylococcus aureus - physiology | Acute-Phase Proteins - genetics | Mutation - immunology | Hydroxybutyrate Dehydrogenase - genetics | Bacterial Infections - immunology | Female | Candidiasis - immunology | Escherichia coli - physiology | Oncogene Proteins - immunology | Bacterial Outer Membrane Proteins - genetics | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Siderophores - metabolism | Mice, Inbred C57BL | Kaplan-Meier Estimate | Escherichia coli - immunology | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Hydroxybutyrate Dehydrogenase - metabolism | Transcription Factors - metabolism | Candidiasis - metabolism | Carrier Proteins - genetics | Immunity, Innate - immunology | Enterobactin - immunology | Animals | Carrier Proteins - metabolism | Siderophores - immunology | Acute-Phase Proteins - immunology | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2010, Volume 207, Issue 2, pp. 299 - 308
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2010, Volume 6, Issue 1, pp. e1000714 - e1000714
Journal Article
Journal Article
European Journal of Immunology, ISSN 0014-2980, 2011, Volume 41, Issue 8, pp. 2260 - 2268
The Nlrp3 inflammasome has been proposed to play an important role in antifungal host defense. However, studies exploring the role of the inflammasome in... 
T helper cells | Innate immunity | Infectious diseases | Cytokines | Knock-out mice | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | IFN-GAMMA | NLRP3 INFLAMMASOME | IMMUNOLOGY | CUTTING EDGE | INTERLEUKIN-18 | HOST-DEFENSE | MICE | ALBICANS INFECTION | DIFFERENTIATION | Tumor Necrosis Factor-alpha - metabolism | Interleukin-18 - immunology | Inflammasomes - metabolism | Kidney - pathology | Cytoskeletal Proteins - genetics | Dendritic Cells - immunology | Kidney - immunology | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Interleukin-1beta - genetics | Candidiasis - microbiology | Th1 Cells - immunology | Host-Pathogen Interactions - immunology | Th1 Cells - metabolism | Flow Cytometry | Th17 Cells - metabolism | Interleukin-1beta - metabolism | Bone Marrow Cells - immunology | Tumor Necrosis Factor-alpha - immunology | Candida albicans - physiology | Cytoskeletal Proteins - metabolism | Female | Candidiasis - immunology | Dendritic Cells - metabolism | Genetic Predisposition to Disease | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Interleukin-1beta - immunology | Candida albicans - immunology | Inflammasomes - genetics | Mice, Knockout | Immunity, Cellular - immunology | Kidney - microbiology | Animals | Apoptosis Regulatory Proteins | Cytoskeletal Proteins - immunology | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Th17 Cells - immunology | Mice | Interleukin-18 - genetics | Bone Marrow Cells - metabolism | Interleukin-18 - metabolism | Medical research | Immune system | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2015, Volume 42, Issue 2, pp. 356 - 366
Journal Article