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Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 12/2012, Volume 367, Issue 1607, pp. 3353 - 3363
Human tissues express cannabinoid CB₁ and CB₂ receptors that can be activated by endogenously released 'endocannabinoids' or exogenously administered compounds... 
Receptors | Cannabinoids | Animal models | Pain | Medical treatment | Agonists | Morphine | Drug design | Endocannabinoids | Cannabinoid receptors | health and disease and epidemiology | Articles | And CB2 | Blood-brain barrier | Cannabinoid receptor agonists | Δ9-tetrahydrocannabinol | Cannabinoid CB1 | Therapeutic applications and strategies | blood-brain barrier | Delta-tetrahydrocannabinol | cannabinoid CB1 and CB2 receptors | CB2 RECEPTOR | LIVER-DISEASES | AMYOTROPHIC-LATERAL-SCLEROSIS | ANXIETY-LIKE BEHAVIOR | MU-OPIOID RECEPTOR | RAT FORMALIN TEST | therapeutic applications and strategies | cannabinoid receptor agonists | NEUROPATHIC PAIN | MOUSE MODEL | BIOLOGY | PENTYLENETETRAZOLE-INDUCED SEIZURE | CENTRAL-NERVOUS-SYSTEM | Endocannabinoids - metabolism | Analgesics - pharmacology | Receptor, Cannabinoid, CB2 - agonists | Cardiovascular Diseases - drug therapy | Humans | Cannabinoid Receptor Agonists - pharmacology | Neurodegenerative Diseases - drug therapy | Pain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Pain - drug therapy | Cannabinoid Receptor Agonists - therapeutic use | Dronabinol - pharmacology | Analgesics - therapeutic use | Cardiovascular Diseases - metabolism | Risk Assessment | Analgesics - administration & dosage | Clinical Trials as Topic | Neurodegenerative Diseases - metabolism | Blood-Brain Barrier - drug effects | Cannabinoid Receptor Agonists - administration & dosage | Drug Discovery | Blood-Brain Barrier - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Dronabinol - therapeutic use | Review
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2012, Volume 63, Issue 5, pp. 905 - 915
Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects... 
Analgesia | Morphine | Marijuana | G-protein | Adenylyl cyclase | CB1 receptors | AGONIST MORPHINE | ACTIVATION | PROTEIN-KINASE | CB1 CANNABINOID RECEPTOR | SYNERGISTIC INTERACTIONS | NEUROSCIENCES | INHIBITION | KAPPA | FULL AGONIST | ADENYLYL-CYCLASE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Pyrazoles - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Analgesics, Opioid - pharmacology | Receptors, Opioid, mu - agonists | Piperidines - pharmacology | Cannabinoid Receptor Agonists - therapeutic use | Recombinant Proteins - antagonists & inhibitors | Piperidines - metabolism | Receptors, Opioid, mu - metabolism | Morpholines - metabolism | Analgesics, Non-Narcotic - metabolism | Drug Inverse Agonism | Mice | Analgesics, Opioid - metabolism | Kinetics | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Analgesics, Opioid - antagonists & inhibitors | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Analgesics, Non-Narcotic - pharmacology | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Analgesics, Opioid - adverse effects | Narcotic Antagonists - metabolism | Receptor, Cannabinoid, CB1 - agonists | Analgesics, Non-Narcotic - adverse effects | Cannabinoid Receptor Agonists - adverse effects | Morpholines - adverse effects | CHO Cells | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cricetinae | Morpholines - pharmacology | Narcotic Antagonists - adverse effects | Recombinant Proteins - agonists | Analgesics, Non-Narcotic - therapeutic use | Pyrazoles - metabolism | Mice, Inbred Strains | Receptors, Opioid, mu - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Piperidines - therapeutic use | Narcotic Antagonists - pharmacology | Piperidines - adverse effects | Receptors, Opioid, mu - genetics | Index Medicus | Drugs | Pain perception | Opioid receptors | Cyclic AMP | Opioid receptors (type mu) | Antagonists | Cannabinoid CB1 receptors | Guanine nucleotide-binding protein | Antagonism | Cell activation | Side effects | Inverse agonists | CB1 Receptors | Adenylyl Cyclase
Journal Article
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2012, Volume 63, Issue 4, pp. 653 - 666
Cannabinoids have been shown to exert neuroprotective effects in a plethora of neurodegenerative conditions. Over the past decade, some studies demonstrate... 
Neuroinflammation | CB2 | CB1 | WIN55212-2 | PPAR-γ | Beta-amyloid | CB | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | NEUROSCIENCES | PPAR-gamma | CELL-DEATH | CASPASE-3 ACTIVATION | CORTICAL-NEURONS | SIGNALING PATHWAY | DNA FRAGMENTATION | IN-VIVO | PHARMACOLOGY & PHARMACY | INFLAMMATORY RESPONSE | NF-KAPPA-B | Receptor, Cannabinoid, CB2 - agonists | Neuroglia - pathology | Injections, Intraventricular | Male | PPAR gamma - metabolism | Alzheimer Disease - pathology | Cannabinoid Receptor Agonists - therapeutic use | Neuroglia - immunology | Nootropic Agents - antagonists & inhibitors | Cannabinoid Receptor Antagonists - pharmacology | Neurons - metabolism | Alzheimer Disease - immunology | Morpholines - therapeutic use | Receptors, Cannabinoid - chemistry | Disease Models, Animal | Benzoxazines - administration & dosage | Nerve Tissue Proteins - agonists | Alzheimer Disease - drug therapy | Rats | Hippocampus - pathology | Random Allocation | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Naphthalenes - therapeutic use | Neurons - pathology | Rats, Wistar | Hippocampus - drug effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - chemistry | Neuroglia - drug effects | Receptors, Cannabinoid - metabolism | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - agonists | Morpholines - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Neurons - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Hippocampus - immunology | Morpholines - administration & dosage | Neurons - immunology | Nootropic Agents - therapeutic use | Cannabinoid Receptor Agonists - administration & dosage | Benzoxazines - therapeutic use | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Nootropic Agents - administration & dosage | Naphthalenes - administration & dosage | Alzheimer Disease - metabolism | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | PPAR gamma - agonists | Neuroglia - metabolism | Naphthalenes - antagonists & inhibitors
Journal Article