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1. Full Text AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
by Seely, Kathryn A and Brents, Lisa K and Franks, Lirit N and Rajasekaran, Maheswari and Zimmerman, Sarah M and Fantegrossi, William E and Prather, Paul L
Neuropharmacology, ISSN 0028-3908, 10/2012, Volume 63, Issue 5, pp. 905 - 915
Analgesia | Morphine | Marijuana | G-protein | Adenylyl cyclase | CB1 receptors | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Pyrazoles - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Analgesics, Opioid - pharmacology | Receptors, Opioid, mu - agonists | Piperidines - pharmacology | Cannabinoid Receptor Agonists - therapeutic use | Recombinant Proteins - antagonists & inhibitors | Piperidines - metabolism | Receptors, Opioid, mu - metabolism | Morpholines - metabolism | Analgesics, Non-Narcotic - metabolism | Drug Inverse Agonism | Mice | Analgesics, Opioid - metabolism | Kinetics | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Analgesics, Opioid - antagonists & inhibitors | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Analgesics, Non-Narcotic - pharmacology | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Analgesics, Opioid - adverse effects | Narcotic Antagonists - metabolism | Receptor, Cannabinoid, CB1 - agonists | Analgesics, Non-Narcotic - adverse effects | Cannabinoid Receptor Agonists - adverse effects | Morpholines - adverse effects | CHO Cells | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cricetinae | Morpholines - pharmacology | Narcotic Antagonists - adverse effects | Recombinant Proteins - agonists | Analgesics, Non-Narcotic - therapeutic use | Pyrazoles - metabolism | Mice, Inbred Strains | Receptors, Opioid, mu - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Piperidines - therapeutic use | Narcotic Antagonists - pharmacology | Piperidines - adverse effects | Receptors, Opioid, mu - genetics | Index Medicus | Drugs | Pain perception | Opioid receptors | Cyclic AMP | Opioid receptors (type mu) | Antagonists | Cannabinoid CB1 receptors | Guanine nucleotide-binding protein | Antagonism | Cell activation | Side effects | Inverse agonists | CB1 Receptors | Adenylyl Cyclase
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2. Full Text Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
by Thomas, A and Baillie, G L and Phillips, A M and Razdan, R K and Ross, R A and Pertwee, R G
British journal of pharmacology, ISSN 0007-1188, 03/2007, Volume 150, Issue 5, pp. 613 - 623
cannabidiol | CB2 receptor | CP55940 | O‐2654 | GTPγS assay | CB1 receptor | mouse brain | inverse agonism | neutral antagonism | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cricetulus | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cyclohexanes - pharmacology | Humans | Bornanes - pharmacology | Anti-Inflammatory Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Transfection | Piperidines - pharmacology | Morpholines - antagonists & inhibitors | Phenols - antagonists & inhibitors | Cyclohexanes - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Cell Membrane - metabolism | Cell Membrane - drug effects | Receptors, Cannabinoid - genetics | CHO Cells | Phenols - pharmacology | Pyrazoles - pharmacology | Cricetinae | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Cannabidiol - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Brain - drug effects | Cannabinoid Receptor Agonists | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Benzoxazines - pharmacology | Protein Binding | Mice | Cannabidiol - metabolism | In Vitro Techniques | Naphthalenes - antagonists & inhibitors | Index Medicus | O-2654 | Research Papers
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3. Full Text CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system
by Romero, Thiago R. L and Resende, Livia C and Guzzo, Luciana S and Duarte, Igor D. G
Anesthesia and analgesia, ISSN 0003-2999, 02/2013, Volume 116, Issue 2, pp. 463 - 472
Life Sciences & Biomedicine | Anesthesiology | Science & Technology | Analgesics - pharmacology | Ethanolamines - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | Norepinephrine - physiology | Sympathetic Nervous System - drug effects | Dinoprostone | Male | Cannabinoid Receptor Agonists - pharmacology | Peripheral Nerves - drug effects | Yohimbine - pharmacology | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Receptor, Cannabinoid, CB1 - agonists | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Prazosin - pharmacology | Palmitic Acids - pharmacology | Palmitic Acids - antagonists & inhibitors | Morpholines - pharmacology | Rats | Pain Measurement - drug effects | Ethanolamines - antagonists & inhibitors | Polyunsaturated Alkamides - antagonists & inhibitors | Adrenergic alpha-2 Receptor Antagonists - pharmacology | Arachidonic Acids - pharmacology | Animals | Arachidonic Acids - antagonists & inhibitors | Polyunsaturated Alkamides - pharmacology | Adrenergic Uptake Inhibitors - pharmacology | Endocannabinoids - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
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4. Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
by Pertwee, R.G
Current medicinal chemistry, ISSN 0929-8673, 05/2010, Volume 17, Issue 14, pp. 1360 - 1381
Transmitter gated and ion channels | tetrahydrocannabinol | G protein-coupled receptors | Δ | Rimonabant | AM251 | GPR55 | The nuclear receptors PPARα | PPARγ | Cannabinoid receptors | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Piperidines - chemistry | Receptors, G-Protein-Coupled - metabolism | Cannabinoid Receptor Antagonists | Receptors, Cannabinoid - metabolism | Cannabinoid Receptor Agonists | Pyrazoles - chemistry | Ion Channels - metabolism | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Ligands | Dronabinol - pharmacology | Pyrazoles - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism
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5. Full Text The highs and lows of cannabinoid receptor expression in disease: Mechanisms and their therapeutic implications
by Miller, Lydia K and Devi, Lakshmi A
Pharmacological reviews, ISSN 0031-6997, 09/2011, Volume 63, Issue 3, pp. 461 - 470
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cannabinoid Receptor Modulators - metabolism | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cannabinoids - antagonists & inhibitors | Humans | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Cannabinoid, CB2 - genetics | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Neurons - metabolism | Neurons - drug effects | Receptors, Cannabinoid - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - agonists | Cannabinoid Receptor Modulators - agonists | Nerve Tissue Proteins - genetics | Cannabinoids - pharmacology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoid Receptor Agonists | Animals | Receptor, Cannabinoid, CB1 - genetics | Cannabinoid Receptor Modulators - antagonists & inhibitors | Cannabinoids - agonists | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Index Medicus
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6. Full Text Astrocyte signaling controls spike timing-dependent depression at neocortical synapses
by Min, Rogier and Nevian, Thomas
Nature neuroscience, ISSN 1097-6256, 03/2012, Volume 15, Issue 5, pp. 746 - 53
Astrocytes/drug effects | Electric Stimulation | Rats, Wistar | 2-Amino-5-phosphonovalerate/pharmacology | Calcium/metabolism | Synapses/drug effects | Time Factors | Naphthalenes/pharmacology | Sodium Channel Blockers/pharmacology | Thalamus/cytology | Long-Term Synaptic Depression/drug effects | Animals, Newborn | Calcium Channel Blockers/pharmacology | Excitatory Amino Acid Antagonists/pharmacology | Dizocilpine Maleate/pharmacology | Excitatory Postsynaptic Potentials/drug effects | Probability | Rats | Benzoxazines/pharmacology | Biophysics | Signal Transduction/drug effects | Neocortex/cytology | Patch-Clamp Techniques | Animals | Glutamic Acid/metabolism | Morpholines/pharmacology | Pyrazoles/pharmacology | Piperidines/pharmacology | Tetrodotoxin/pharmacology | In Vitro Techniques | Receptor, Cannabinoid, CB1/antagonists & inhibitors | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Piperidines - pharmacology | Tetrodotoxin - pharmacology | Pyrazoles - pharmacology | Astrocytes - drug effects | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Synapses - physiology | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Naphthalenes - pharmacology | Astrocytes - ultrastructure | Astrocytes - physiology | Signal Transduction - drug effects | Benzoxazines - pharmacology | Thalamus - cytology | Neocortex - cytology | Signal Transduction - physiology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dizocilpine Maleate - pharmacology | Methyl aspartate | Depression, Mental | Physiological aspects | Genetic aspects | Research | Risk factors | Synapses | Index Medicus
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7. Full Text GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum
by Nazir, Mamona and Harms, Henrik and Loef, Irene and Kehraus, Stefan and El Maddah, Fayrouz and Arslan, Idris and Rempel, Viktor and Müller, Christa E and König, Gabriele M
Planta medica, ISSN 0032-0943, 08/2015, Volume 81, Issue 12/13, pp. 1141 - 1145
Natural Product Chemistry | Onygenaceae | marine-derived fungi | GPR18 receptor inhibition | Auxarthron reticulatum | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Humans | Alkaloids - isolation & purification | Ascomycota - chemistry | Glycosides - antagonists & inhibitors | Indoles - isolation & purification | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Antagonists - isolation & purification | Animals | Triterpenes - antagonists & inhibitors | Alkaloids - antagonists & inhibitors | Cannabinoid Receptor Antagonists - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Porifera - microbiology | Molecular Structure | Indoles - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Indoles - chemistry | Alkaloids - chemistry | Ascomycota | Fungi | Research
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8. Full Text The pharmacology of cannabinoid receptors and their ligands: an overview
by Pertwee, R.G and Pertwee, R.G
International Journal of Obesity, ISSN 0307-0565, 04/2006, Volume 30, Issue S1, pp. S13 - S18
Cannabinoid CB | Therapeutic targets and strategies | Cannabinoid receptor inverse agonists and neutral antagonists | receptors | Allosteric site | and CB | Endocannabinoids | Autoprotection and autoimpairment | Cannabinoid Receptor Modulators - metabolism | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Humans | Nerve Endings - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Pain - metabolism | Receptors, Cannabinoid - metabolism | Cannabinoid Receptor Agonists | Animals | Receptor, Cannabinoid, CB1 - agonists | Pain - drug therapy | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Multiple Sclerosis - drug therapy | Multiple Sclerosis - metabolism | Obesity | Cannabinoids | Cell receptors | Care and treatment | Research | Health aspects | Index Medicus
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9. Full Text Opposing roles for cannabinoid receptor type-1 (CB 1) and transient receptor potential vanilloid Type-1 channel (TRPV1) on the modulation of panic-like responses in rats
by Casarotto, Plínio C and Terzian, Ana Luisa B and Aguiar, Daniele C and Zangrossi, Hélio and Guimares, Francisco S and Wotjak, Carsten T and Moreira, Fabrício A
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 01/2012, Volume 37, Issue 2, pp. 478 - 486
vanilloid | anxiety | anandamide | cannabinoid | periaqueductal gray | panic | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Rats, Wistar | Capsaicin - pharmacology | Cinnamates - administration & dosage | Microinjections - methods | Periaqueductal Gray - drug effects | Male | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Capsaicin - administration & dosage | TRPV Cation Channels - metabolism | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Electric Stimulation - methods | Pyrazoles - pharmacology | Panic - drug effects | Piperidines - administration & dosage | TRPV Cation Channels - physiology | Rats | Capsaicin - analogs & derivatives | Cinnamates - pharmacology | Arachidonic Acids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Panic - physiology | Pyrazoles - administration & dosage | Animals | Anilides - administration & dosage | Anilides - pharmacology | Periaqueductal Gray - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Pyrazoles - antagonists & inhibitors | Index Medicus | animal models | psychopharmacology | mood | stress disorders | cannabinoids | Original
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