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PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167240 - e0167240
Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions... 
SIGNAL-TRANSDUCTION | IN-VITRO | ALLOSTERIC MODULATORS | HUMAN-BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | INVERSE AGONIST | CELL-GROWTH | RAT-BRAIN | ADENYLATE-CYCLASE | ESTROGEN-RECEPTOR | CB1 RECEPTOR | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Humans | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Isomerism | Breast Neoplasms - metabolism | Indoles - metabolism | Cyclohexanols - metabolism | Receptor, Cannabinoid, CB1 - agonists | Colforsin - metabolism | Tamoxifen - chemistry | Cannabinoid Receptor Antagonists - pharmacology | Female | Indoles - pharmacology | Cyclohexanols - pharmacology | Cyclic AMP - metabolism | CHO Cells | Binding, Competitive | Tamoxifen - metabolism | Cricetinae | Colforsin - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Adenylyl Cyclases - metabolism | Breast Neoplasms - drug therapy | Selective Estrogen Receptor Modulators - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Cannabinoid Receptor Antagonists - metabolism | Tamoxifen - pharmacology | Tamoxifen - analogs & derivatives | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Selective Estrogen Receptor Modulators - pharmacology | GTP-Binding Proteins - metabolism | Cell receptors | Patient outcomes | Drug metabolism | Development and progression | Genetic aspects | Breast cancer | Tamoxifen | Drug therapy | Health aspects | Cytochrome | Drugs | Estrogens | Estrogen receptors | Drug development | Isomers | Proteins | Adenylate cyclase | Osteoporosis | Receptors | Toxicology | Cell growth | Metabolites | Cannabinoid CB2 receptors | Cannabinoid receptors | Medical treatment | Cytochrome P450 | Pharmacology | Cannabinoid CB1 receptors | FDA approval | Medicine | Studies | Inverse agonists | Affinity | Selective estrogen receptor modulators | Cancer | Index Medicus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2012, Volume 287, Issue 44, pp. 36944 - 36967
The alpha-hemoglobin-derived dodecapeptide RVD-hemopressin (RVDPVNFKLLSH) has been proposed to be an endogenous agonist for the cannabinoid receptor type 1... 
SPECTROMETRY-BASED QUANTIFICATION | HEMOGLOBIN-DERIVED PEPTIDES | SIGNAL-TRANSDUCTION | MOUSE-BRAIN | INHIBITION | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANNABINOID CB1 | ADENYLATE-CYCLASE | BINDING | AGONIST | Cannabinoid Receptor Modulators - metabolism | Epitope Mapping | Cannabinoid Receptor Modulators - blood | Allosteric Regulation | Humans | Molecular Sequence Data | Male | Brain - metabolism | Tandem Mass Spectrometry | Cyclohexanols - metabolism | Receptor, Cannabinoid, CB1 - agonists | Peptide Fragments - immunology | Peptide Fragments - blood | Cannabinoid Receptor Modulators - chemical synthesis | Female | Hemoglobins - biosynthesis | CHO Cells | Binding, Competitive | Amino Acid Sequence | Cricetinae | Peptide Fragments - metabolism | Signal Transduction | Mice, Inbred C57BL | Hemoglobins - immunology | Hemoglobins - metabolism | Rats | Mice, Inbred NZB | Peptide Fragments - biosynthesis | Protein Transport | Antibodies, Monoclonal, Murine-Derived - biosynthesis | Hemoglobins - chemical synthesis | Peptide Fragments - chemical synthesis | Receptor, Cannabinoid, CB1 - metabolism | Hemoglobins - chemistry | Animals | HL-60 Cells | Protein Binding | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Cannabinoid Receptor Modulators - immunology | Sus scrofa | Index Medicus | CB Cannabinoid Receptors | Peptides | Antibody | Neurobiology | Peptide Endocannabinoids | Endocannabinoid System | Monoclonal Antibodies | Negative Allosteric Modulators | Cannabinoids | CB1 | Hemoglobin | Pepcans | Antagonist
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2010, Volume 13, Issue 9, pp. 1113 - 1119
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system.... 
PRECIPITATED WITHDRAWAL | NEUROPATHIC PAIN | ACID AMIDE HYDROLASE | IN-VIVO | ANANDAMIDE | DELTA-TETRAHYDROCANNABINOL | CANNABINOID RECEPTOR ADAPTATION | MICE | RAT-BRAIN | NEUROSCIENCES | KNOCKOUT MOUSE | Cannabinoid Receptor Modulators - metabolism | Analgesics - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | Neuronal Plasticity - drug effects | Male | Benzodioxoles - administration & dosage | Pain - metabolism | Brain - physiology | Monoacylglycerol Lipases - genetics | Enzyme Inhibitors - administration & dosage | Monoacylglycerol Lipases - metabolism | Neuronal Plasticity - physiology | Piperidines - pharmacology | Pain - drug therapy | Female | Models, Animal | Endocannabinoids | Amidohydrolases - metabolism | Synapses - drug effects | Piperidines - administration & dosage | Synapses - physiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Analgesics - administration & dosage | Amidohydrolases - antagonists & inhibitors | Mice, Transgenic | Mice, Knockout | Brain - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Animals | Cannabinoid Receptor Modulators - antagonists & inhibitors | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Complications and side effects | Cannabinoids | Drug tolerance | Physiological aspects | Neuropharmacology | Research | Properties | Drug receptors | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 10/2010, Volume 13, Issue 10, pp. 1265 - 1270
Peripheral cannabinoid receptors exert a powerful inhibitory control over pain initiation, but the endocannabinoid signal that normally engages this intrinsic... 
CANNABINOID RECEPTORS | SYSTEM | NEUROPATHIC PAIN | CB2 RECEPTORS | ACID AMIDE HYDROLASE | INFLAMMATION | IN-VIVO | INJURY | NEUROSCIENCES | RAT MODEL | ANALGESIA | Cannabinoid Receptor Modulators - metabolism | Pyrazoles - therapeutic use | Male | Sciatica - drug therapy | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Cannabinoid Receptor Modulators - therapeutic use | Pain - genetics | Time Factors | Statistics, Nonparametric | Escape Reaction - drug effects | Amidohydrolases - deficiency | Endocannabinoids | Disease Models, Animal | Drug Administration Routes | Rats | Pain - pathology | Rats, Sprague-Dawley | Cannabinoids - pharmacology | Mice, Knockout | Ethylene Glycols - metabolism | Cannabinoids - therapeutic use | Arachidonic Acids - therapeutic use | Hyperalgesia - genetics | Indoles - therapeutic use | Mice | Carrageenan | Enzyme Inhibitors | Spinal Cord - metabolism | Polyunsaturated Alkamides - therapeutic use | Motor Activity - drug effects | Tritium | Pain - chemically induced | Formaldehyde | Pain Threshold - drug effects | Amidohydrolases - metabolism | Oncogene Proteins v-fos - metabolism | Tissue Distribution - drug effects | Drug Administration Schedule | Pain - prevention & control | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Pain Measurement - drug effects | Polyunsaturated Alkamides - metabolism | Feeding Behavior - drug effects | Gene Expression Regulation - drug effects | PPAR alpha - deficiency | Animals | Hyperalgesia - drug therapy | Peripheral Nervous System Diseases | Piperidines - therapeutic use | Cannabinoid Receptor Modulators - antagonists & inhibitors | Chromatography, Liquid - methods | Mass Spectrometry - methods | Cannabinoids | Care and treatment | Pain | Analgesics | Evoked potentials (Electrophysiology) | Physiological aspects | Dosage and administration | Research | Methods | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases | Animal models | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 06/2012, Volume 74, Issue 5, pp. 801 - 808
The steroid 17β-estradiol (E2) is well known to influence hippocampal functions such as memory, affective behaviors, and epilepsy. There is growing awareness... 
CA1 | EXCITABILITY | STEROIDS | SYNAPSES | ESTROGEN-RECEPTOR-ALPHA | SYNAPTIC-TRANSMISSION | NEURONS | RELEASE | BINDING | NEUROSCIENCES | Cannabinoid Receptor Modulators - metabolism | CA1 Region, Hippocampal - cytology | Electric Stimulation | Estrogens - pharmacology | Male | Receptors, Metabotropic Glutamate - metabolism | Pyridazines - pharmacology | Lactones - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Castration | Piperidines - pharmacology | Excitatory Amino Acid Agents - pharmacology | Neurons - physiology | Female | Neurons - drug effects | Endocannabinoids | Estradiol - pharmacology | Pyrazoles - pharmacology | Enzyme Inhibitors - pharmacology | NAD - pharmacology | Cannabinoid Receptor Modulators - agonists | Morpholines - pharmacology | Rats | Biophysics | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Naphthalenes - pharmacology | Patch-Clamp Techniques | Animals | Benzoxazines - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Phenols | In Vitro Techniques | Neural Inhibition - drug effects | Benzodioxoles - pharmacology | Inhibitory Postsynaptic Potentials - drug effects | Brain | Epilepsy | Estrogen | GABA | Hormones, Sex | Estradiol | Studies | Rodents | Gender differences | Behavior | Males | Females | Index Medicus | Presynapse | Emotional behavior | gamma -Aminobutyric acid | Neurosteroids | Memory | Sex | Estrogen receptors | Cannabinoid CB1 receptors | Anandamide | Synaptic transmission | Hippocampus | Steroid hormones | Synapses
Journal Article