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1. Full Text Opposing roles for cannabinoid receptor type-1 (CB 1) and transient receptor potential vanilloid Type-1 channel (TRPV1) on the modulation of panic-like responses in rats
by Casarotto, Plínio C and Terzian, Ana Luisa B and Aguiar, Daniele C and Zangrossi, Hélio and Guimares, Francisco S and Wotjak, Carsten T and Moreira, Fabrício A
Neuropsychopharmacology, ISSN 0893-133X, 01/2012, Volume 37, Issue 2, pp. 478 - 486
The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating anxiety-and panic-related responses. Given the cellular and behavioral... 
vanilloid | anxiety | anandamide | cannabinoid | periaqueductal gray | panic | PSYCHIATRY | ENDOCANNABINOID SYSTEM | GREY-MATTER | NEUROSCIENCES | PREFRONTAL CORTEX | DORSOLATERAL PERIAQUEDUCTAL GRAY | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | BRAIN | Rats, Wistar | Capsaicin - pharmacology | Cinnamates - administration & dosage | Microinjections - methods | Periaqueductal Gray - drug effects | Male | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Capsaicin - administration & dosage | TRPV Cation Channels - metabolism | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Electric Stimulation - methods | Pyrazoles - pharmacology | Panic - drug effects | Piperidines - administration & dosage | TRPV Cation Channels - physiology | Rats | Capsaicin - analogs & derivatives | Cinnamates - pharmacology | Arachidonic Acids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Panic - physiology | Pyrazoles - administration & dosage | Animals | Anilides - administration & dosage | Anilides - pharmacology | Periaqueductal Gray - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Pyrazoles - antagonists & inhibitors | animal models | psychopharmacology | mood | stress disorders | cannabinoids | Original
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2. Full Text The highs and lows of cannabinoid receptor expression in disease: Mechanisms and their therapeutic implications
by Miller, Lydia K and Devi, Lakshmi A
Pharmacological Reviews, ISSN 0031-6997, 09/2011, Volume 63, Issue 3, pp. 461 - 470
Alterations in the endogenous cannabinoid system have been described in almost every category of disease. These changes can alternatively be protective or... 
PERIPHERAL-NERVE INJURY | NEUROPATHIC PAIN BEHAVIORS | RETINOIC ACID | EMERGING ROLE | EMBRYONIC STEM-CELLS | CENTRAL GLUCOCORTICOID-RECEPTORS | HEPATIC CB1 RECEPTORS | ENDOCANNABINOID SYSTEM | PHARMACOLOGY & PHARMACY | UP-REGULATION | PREFRONTAL CORTEX | Cannabinoid Receptor Modulators - metabolism | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cannabinoids - antagonists & inhibitors | Humans | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Cannabinoid, CB2 - genetics | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Neurons - metabolism | Neurons - drug effects | Receptors, Cannabinoid - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - agonists | Cannabinoid Receptor Modulators - agonists | Nerve Tissue Proteins - genetics | Cannabinoids - pharmacology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoid Receptor Agonists | Animals | Receptor, Cannabinoid, CB1 - genetics | Cannabinoid Receptor Modulators - antagonists & inhibitors | Cannabinoids - agonists | Receptor, Cannabinoid, CB1 - antagonists & inhibitors
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3. Full Text AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
by Seely, Kathryn A and Brents, Lisa K and Franks, Lirit N and Rajasekaran, Maheswari and Zimmerman, Sarah M and Fantegrossi, William E and Prather, Paul L
Neuropharmacology, ISSN 0028-3908, 10/2012, Volume 63, Issue 5, pp. 905 - 915
Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects... 
Analgesia | Morphine | Marijuana | G-protein | Adenylyl cyclase | CB1 receptors | AGONIST MORPHINE | ACTIVATION | PROTEIN-KINASE | CB1 CANNABINOID RECEPTOR | SYNERGISTIC INTERACTIONS | NEUROSCIENCES | INHIBITION | KAPPA | FULL AGONIST | ADENYLYL-CYCLASE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Pyrazoles - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Analgesics, Opioid - pharmacology | Receptors, Opioid, mu - agonists | Piperidines - pharmacology | Cannabinoid Receptor Agonists - therapeutic use | Recombinant Proteins - antagonists & inhibitors | Piperidines - metabolism | Receptors, Opioid, mu - metabolism | Morpholines - metabolism | Analgesics, Non-Narcotic - metabolism | Drug Inverse Agonism | Mice | Analgesics, Opioid - metabolism | Kinetics | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Analgesics, Opioid - antagonists & inhibitors | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Analgesics, Non-Narcotic - pharmacology | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Analgesics, Opioid - adverse effects | Narcotic Antagonists - metabolism | Receptor, Cannabinoid, CB1 - agonists | Analgesics, Non-Narcotic - adverse effects | Cannabinoid Receptor Agonists - adverse effects | Morpholines - adverse effects | CHO Cells | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cricetinae | Morpholines - pharmacology | Narcotic Antagonists - adverse effects | Recombinant Proteins - agonists | Analgesics, Non-Narcotic - therapeutic use | Pyrazoles - metabolism | Mice, Inbred Strains | Receptors, Opioid, mu - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Piperidines - therapeutic use | Narcotic Antagonists - pharmacology | Piperidines - adverse effects | Receptors, Opioid, mu - genetics | Index Medicus | Drugs | Pain perception | Opioid receptors | Cyclic AMP | Opioid receptors (type mu) | Antagonists | Cannabinoid CB1 receptors | Guanine nucleotide-binding protein | Antagonism | Cell activation | Side effects | Inverse agonists | CB1 Receptors | Adenylyl Cyclase
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4. Full Text Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5‐HT2A) receptor activity via ERK1/2 signaling
by Franklin, Jade M and Carrasco, Gonzalo A
Synapse, ISSN 0887-4476, 03/2013, Volume 67, Issue 3, pp. 145 - 159
Recent behavioral studies suggest that nonselective agonists of cannabinoid receptors may regulate serotonin 2A (5‐HT2A) receptor neurotransmission. Two... 
5‐HT receptor | cannabinoid receptors | G protein coupled receptor | prefrontal cortex | ERK | 5-HT receptor | Prefrontal cortex | Cannabinoid receptors | ACTIVATION | PROTEIN-KINASE | NEUROSCIENCES | DRUG-ABUSE | CB2 RECEPTORS | PYRAMIDAL NEURONS | PSYCHOTIC SYMPTOMS | MESSENGER-RNA | IN-VIVO | RAT-BRAIN | CELL-LINE | Transcription, Genetic - drug effects | Up-Regulation | Receptor, Serotonin, 5-HT2A - genetics | Rats | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Rats, Sprague-Dawley | RNA, Messenger - biosynthesis | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | MAP Kinase Signaling System - drug effects | Receptor, Cannabinoid, CB1 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Cyclohexanols - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Receptor, Serotonin, 5-HT2A - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Physiological aspects | Phenols | Messenger RNA | G proteins | Serotonin | Depression, Mental | Index Medicus | ERK MAPK
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5. Full Text Tamoxifen isomers and metabolites exhibit distinct affinity and activity at cannabinoid receptors: Potential scaffold for drug development
by Ford, Benjamin M and Franks, Lirit N and Radominska-Pandya, Anna and Prather, Paul L
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167240 - e0167240
Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions... 
SIGNAL-TRANSDUCTION | IN-VITRO | ALLOSTERIC MODULATORS | HUMAN-BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | INVERSE AGONIST | CELL-GROWTH | RAT-BRAIN | ADENYLATE-CYCLASE | ESTROGEN-RECEPTOR | CB1 RECEPTOR | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Humans | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Isomerism | Breast Neoplasms - metabolism | Indoles - metabolism | Cyclohexanols - metabolism | Receptor, Cannabinoid, CB1 - agonists | Colforsin - metabolism | Tamoxifen - chemistry | Cannabinoid Receptor Antagonists - pharmacology | Female | Indoles - pharmacology | Cyclohexanols - pharmacology | Cyclic AMP - metabolism | CHO Cells | Binding, Competitive | Tamoxifen - metabolism | Cricetinae | Colforsin - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Adenylyl Cyclases - metabolism | Breast Neoplasms - drug therapy | Selective Estrogen Receptor Modulators - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Cannabinoid Receptor Antagonists - metabolism | Tamoxifen - pharmacology | Tamoxifen - analogs & derivatives | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Selective Estrogen Receptor Modulators - pharmacology | GTP-Binding Proteins - metabolism | Cell receptors | Patient outcomes | Drug metabolism | Development and progression | Genetic aspects | Breast cancer | Tamoxifen | Drug therapy | Health aspects | Cytochrome | Drugs | Estrogens | Estrogen receptors | Drug development | Isomers | Proteins | Osteoporosis | Receptors | Toxicology | Cell growth | Metabolites | Cannabinoid CB2 receptors | Medical treatment | Cytochrome P450 | Pharmacology | Cannabinoid CB1 receptors | FDA approval | Medicine | Studies | Inverse agonists | Affinity | Selective estrogen receptor modulators | Index Medicus
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6. The cannabinoid receptors
by Reggio, Patricia H
2009, The receptors, ISBN 1588297128, xiv, 396 p., [6] p. of plates
Here, experts introduce the field with chapters covering, among other subjects, cannabinoid ligand synthesis and structure activity relationships, the... 
Other branches of medicine | Cannabinoids | Endocannabinoids | Neurosciences | Receptors | Molecular Medicine | Biomedicine | Pharmacology/Toxicology | Neurobiology
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7. Full Text Novel cannabinoid receptors
by Brown, A J
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 567 - 575
Cannabinoids have numerous physiological effects. In the years since the molecular identification of the G protein‐coupled receptors CB1 and CB2, the ion... 
CB2 | CB1 | GPR119 | cannabinoid | non‐CB1/CB2 | GPR55 | Cannabinoid | Non-CB | CB | ACTIVATION | PALMITOYLETHANOLAMIDE | FOOD-INTAKE | OLEOYLETHANOLAMIDE | IDENTIFICATION | LYSOPHOSPHATIDIC ACID | non-CB1/CB2 | PHARMACOLOGY & PHARMACY | LIGAND | PROTEIN-COUPLED-RECEPTOR | AGONIST | Cannabinoid Receptor Agonists | Animals | Humans | Receptors, Cannabinoid - physiology | Receptors, G-Protein-Coupled - genetics | Phylogeny | Receptors, G-Protein-Coupled - agonists | Receptors, Cannabinoid - genetics | Cannabinoids - pharmacology | Receptors, G-Protein-Coupled - physiology | Reviews | non-CB1
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8. Cannabinoid receptors
by Pertwee, R. G and Bonner, Tom I
1995, Neuroscience perspectives., ISBN 0125514603, xiv, 264
Cannabinoids | Drug receptors
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9. Full Text Why do cannabinoid receptors have more than one endogenous ligand?
by Vincenzo Di Marzo and Luciano De Petrocellis
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 12/2012, Volume 367, Issue 1607, pp. 3216 - 3228
The endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle,... 
Enzymes | Receptors | Cannabinoids | Neuroscience | Neurons | Agonists | Ligands | Biosynthesis | Endocannabinoids | Cannabinoid receptors | physiology | cellular biology | neuroscience | Articles | biochemistry | Transient receptor potential vanilloid type-1 | Cannabinoid receptor type-1 | Cannabinoid receptor type-2 | Endocannabinoid | Cannabinoid | Endovanilloid | endovanilloid | endocannabinoid | cannabinoid | transient receptor potential vanilloid type-1 | cannabinoid receptor type-1 | cannabinoid receptor type-2 | NERVE GROWTH-FACTOR | CB1 RECEPTOR | VANILLOID TYPE-1 RECEPTORS | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | CALCIUM-CHANNELS | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | BIOLOGY | SMOOTH-MUSCLE-CELLS | PRIMARY SENSORY NEURONS | TRPV1 CHANNELS | Endocannabinoids - metabolism | Cannabinoid Receptor Agonists - metabolism | Endocannabinoids - pharmacology | Receptor, Cannabinoid, CB2 - agonists | Humans | Cannabinoid Receptor Agonists - pharmacology | Synaptic Transmission | Brain - metabolism | TRPV Cation Channels - metabolism | Arachidonic Acids - metabolism | Pain Perception - drug effects | Receptor, Cannabinoid, CB1 - agonists | TRPV Cation Channels - antagonists & inhibitors | Neuralgia - physiopathology | Receptor Cross-Talk | Signal Transduction | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Arachidonic Acids - pharmacology | Neuralgia - drug therapy | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Glycerides - pharmacology | Animals | Polyunsaturated Alkamides - pharmacology | 133 | 202 | Review
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10. Full Text Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
by Fuxe, K and Marcellino, D and Rivera, A and Diaz-Cabiale, Z and Filip, M and Gago, B and Roberts, D.C.S and Langel, U and Genedani, S and Ferraro, L and de la Calle, A and Narvaez, J and Tanganelli, S and Woods, A and Agnati, L.F and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för neurokemi
Brain Research Reviews, ISSN 0165-0173, 2007, Volume 58, Issue 2, pp. 415 - 452
Abstract Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson's disease, schizophrenia and drug addiction or drug... 
Neurology | Treatment strategy | Drug addiction | Galanin receptor | Dopamine receptor | Schizophrenia | Depression | Striatum | 5-HT 1A receptor | CB1 receptor | Heteromerization | Adenosine receptor | mGluR5 | Parkinson’s disease | Parkinson's disease | receptor | 5-HT | treatment strategy | CENTRAL CARDIOVASCULAR CONTROL | COCAINE-SEEKING BEHAVIOR | drug addiction | CB1 CANNABINOID RECEPTOR | heteromerization | schizophrenia | NEUROSCIENCES | dopamine receptor | galanin receptor | RAT NUCLEUS-ACCUMBENS | VENTRAL LIMBIC CORTEX | LEVODOPA-INDUCED DYSKINESIA | striatum | ADENOSINE A(2A) RECEPTORS | DOPAMINE D-3 RECEPTOR | adenosine receptor | CENTRAL-NERVOUS-SYSTEM | depression | MEDIUM SPINY NEURONS | 5-HT1A receptor | Animals | Receptors, Cell Surface - drug effects | Humans | Psychopharmacology | Cell Communication - drug effects | Neurons - physiology | Cell Communication - physiology | Neurons - cytology | Receptors, Cell Surface - physiology | Neurons - drug effects | Receptors, Cell Surface - classification | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | NATURAL SCIENCES | NATURVETENSKAP | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
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