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Journal Article
Philosophical transactions. Biological sciences, ISSN 1471-2970, 2012, Volume 367, Issue 1607, pp. 3353 - 3363
Human tissues express cannabinoid CB₁ and CB₂ receptors that can be activated by endogenously released 'endocannabinoids' or exogenously administered compounds... 
Receptors | Cannabinoids | Animal models | Pain | Medical treatment | Agonists | Morphine | Drug design | Endocannabinoids | Cannabinoid receptors | health and disease and epidemiology | Articles | And CB2 | Blood-brain barrier | Cannabinoid receptor agonists | Δ9-tetrahydrocannabinol | Cannabinoid CB1 | Therapeutic applications and strategies | blood-brain barrier | Delta-tetrahydrocannabinol | cannabinoid CB1 and CB2 receptors | CB2 RECEPTOR | LIVER-DISEASES | AMYOTROPHIC-LATERAL-SCLEROSIS | ANXIETY-LIKE BEHAVIOR | MU-OPIOID RECEPTOR | RAT FORMALIN TEST | therapeutic applications and strategies | cannabinoid receptor agonists | NEUROPATHIC PAIN | MOUSE MODEL | BIOLOGY | PENTYLENETETRAZOLE-INDUCED SEIZURE | CENTRAL-NERVOUS-SYSTEM | Endocannabinoids - metabolism | Analgesics - pharmacology | Receptor, Cannabinoid, CB2 - agonists | Cardiovascular Diseases - drug therapy | Humans | Cannabinoid Receptor Agonists - pharmacology | Neurodegenerative Diseases - drug therapy | Pain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Pain - drug therapy | Cannabinoid Receptor Agonists - therapeutic use | Dronabinol - pharmacology | Analgesics - therapeutic use | Cardiovascular Diseases - metabolism | Risk Assessment | Analgesics - administration & dosage | Clinical Trials as Topic | Neurodegenerative Diseases - metabolism | Blood-Brain Barrier - drug effects | Cannabinoid Receptor Agonists - administration & dosage | Drug Discovery | Blood-Brain Barrier - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Dronabinol - therapeutic use | Review
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1744-7658, 2014, Volume 23, Issue 8, pp. 1123 - 1140
Introduction: Commercially available cannabinoids are subject to psychotomimetic and addiction (cannabinomimetic) adverse effects largely through activation of... 
enzyme | endocannabinoid | pain | receptor | ethanolamine | orphan cannabinoid receptor | cannabinoid | bifunctional | peroxisome proliferator-activated receptor | arachidonoyl | Bifunctional | Ethanolamine | Pain | Endocannabinoid | Peroxisome proliferator-activated receptor | Enzyme | Receptor | Orphan cannabinoid receptor | Arachidonoyl | Cannabinoid | BONE-TUMOR PAIN | ENDOCANNABINOID SYSTEM | PACLITAXEL-INDUCED NEUROPATHY | CONTROLLED CLINICAL-TRIAL | AGONIST WIN 55,212-2 | ACID AMIDE HYDROLASE | CHRONIC CONSTRICTION INJURY | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | N-ARACHIDONOYL GLYCINE | Endocannabinoids - metabolism | Analgesics - pharmacology | Analgesics - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Cannabinoid Receptor Antagonists - adverse effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Cannabinoid Receptor Antagonists - therapeutic use | Cannabinoids - adverse effects | Cannabinoids - pharmacology | Cannabinoids - therapeutic use | Animals | Receptor, Cannabinoid, CB1 - agonists | Pain - drug therapy | Pain - physiopathology | Cannabinoid Receptor Agonists - adverse effects | Cannabinoid Receptor Agonists - therapeutic use | Drug Design | Cannabinoid Receptor Antagonists - pharmacology | Ligands | Receptor, Cannabinoid, CB1 - antagonists & inhibitors
Journal Article
ACS chemical neuroscience, ISSN 1948-7193, 07/2015, Volume 6, Issue 9, pp. 1546 - 1559
Synthetic cannabinoid (SC) designer drugs based on indole and indazole scaffolds and featuring l-valinamide or l-tert-leucinamide side chains are encountered... 
FUBINACA | JWH-018 | Cannabinoid | PINACA | THC | SR 144528 | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1ST POTENT | RATS | ILLEGAL PRODUCTS | ALPHA-PVT | NEUROSCIENCES | RECEPTOR ANTAGONIST | INTERNATIONAL UNION | DERIVATIVES | SR141716A | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | Body Temperature - drug effects | Indazoles - chemical synthesis | Humans | Indoles - chemical synthesis | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - chemistry | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Dose-Response Relationship, Drug | Heart Rate - drug effects | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Membrane Potentials - drug effects | Designer Drugs - pharmacology | Indazoles - chemistry | Cannabinoid Receptor Agonists - chemical synthesis | Designer Drugs - chemical synthesis | Indazoles - pharmacology | Designer Drugs - chemistry | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Cell Line, Tumor | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Indoles - chemistry | Cohort Studies
Journal Article
Philosophical transactions. Biological sciences, ISSN 1471-2970, 2012, Volume 367, Issue 1607, pp. 3216 - 3228
The endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle,... 
Enzymes | Receptors | Cannabinoids | Neuroscience | Neurons | Agonists | Ligands | Biosynthesis | Endocannabinoids | Cannabinoid receptors | physiology | cellular biology | neuroscience | Articles | biochemistry | Transient receptor potential vanilloid type-1 | Cannabinoid receptor type-1 | Cannabinoid receptor type-2 | Endocannabinoid | Cannabinoid | Endovanilloid | endovanilloid | endocannabinoid | cannabinoid | transient receptor potential vanilloid type-1 | cannabinoid receptor type-1 | cannabinoid receptor type-2 | NERVE GROWTH-FACTOR | CB1 RECEPTOR | VANILLOID TYPE-1 RECEPTORS | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | CALCIUM-CHANNELS | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | BIOLOGY | SMOOTH-MUSCLE-CELLS | PRIMARY SENSORY NEURONS | TRPV1 CHANNELS | Endocannabinoids - metabolism | Cannabinoid Receptor Agonists - metabolism | Endocannabinoids - pharmacology | Receptor, Cannabinoid, CB2 - agonists | Humans | Cannabinoid Receptor Agonists - pharmacology | Synaptic Transmission | Brain - metabolism | TRPV Cation Channels - metabolism | Arachidonic Acids - metabolism | Pain Perception - drug effects | Receptor, Cannabinoid, CB1 - agonists | TRPV Cation Channels - antagonists & inhibitors | Neuralgia - physiopathology | Receptor Cross-Talk | Signal Transduction | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Arachidonic Acids - pharmacology | Neuralgia - drug therapy | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Glycerides - pharmacology | Animals | Polyunsaturated Alkamides - pharmacology | 133 | 202 | Review
Journal Article
Journal Article