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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2210 - 2218
Targeting cannabinoid-2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms... 
Adhesion molecules | Inflammation | RhoA | Endothelial activation | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MOLECULE EXPRESSION | ATHEROSCLEROSIS | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | endothelial activation | CANNABINOID RECEPTORS | inflammation | adhesion molecules | NITRIC-OXIDE | THERAPEUTIC TARGETS | PERIPHERAL VASCULAR DISEASE | POTENTIAL ROLE | CB2 RECEPTOR ACTIVATION | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2016, Volume 1861, Issue 6, pp. 491 - 500
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases
Journal Article
Molecular Immunology, ISSN 0161-5890, 07/2013, Volume 54, Issue 3-4, pp. 482 - 492
► Oral treatment with α,β-amyrin ameliorate disease activity in DSS-induced colitis. ► α,β-Amyrin treatment decrease leukocyte influx to the colon. ► The... 
Inflammatory bowel disease | α,β-Amyrin | Dextran sodium sulfate | Inflammatory cytokines | Cannabinoid system | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | alpha,beta-amyrin | MECHANISMS | BETA-AMYRIN | ADHESION MOLECULES | IMMUNOLOGY | PROTIUM-HEPTAPHYLLUM | ALPHA-AMYRIN | INFLAMMATORY-BOWEL-DISEASE | MOUSE MODEL | RECEPTORS | EXPRESSION | P-Selectin - metabolism | Colitis - genetics | Tumor Necrosis Factor-alpha - genetics | Colon - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Male | Interleukin-1beta - genetics | Antigens, CD - genetics | Body Weight - genetics | Antigens, CD - metabolism | Lectins, C-Type - metabolism | Interleukin-1beta - metabolism | Cannabinoids - genetics | Colitis - drug therapy | Cannabinoids - metabolism | Administration, Oral | CD18 Antigens - genetics | Membrane Proteins - genetics | Asialoglycoproteins - metabolism | P-Selectin - genetics | Cell Adhesion Molecules - metabolism | Chemokines - genetics | Colon - metabolism | CD18 Antigens - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Receptor, Cannabinoid, CB1 - genetics | Ki-67 Antigen - genetics | Intercellular Adhesion Molecule-1 - genetics | Colitis - metabolism | Chemokines - metabolism | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dextran Sulfate | Cell Adhesion Molecules - genetics | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | Lectins, C-Type - genetics | Receptor, Cannabinoid, CB2 - genetics | Asialoglycoproteins - genetics | Colitis - chemically induced | Vascular Cell Adhesion Molecule-1 - genetics | Membrane Proteins - metabolism | Interleukin-4 - genetics | Amidohydrolases - metabolism | Amidohydrolases - genetics | Interleukin-4 - metabolism | RNA, Messenger - genetics | Up-Regulation - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Up-Regulation - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Antigens, Differentiation, Myelomonocytic - metabolism | Peroxidase - genetics | Peroxidase - metabolism
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7630, pp. 555 - 559
Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate... 
OXIDATIVE-PHOSPHORYLATION | CATALYTIC SUBUNIT | SOLUBLE ADENYLYL-CYCLASE | METABOLISM | MULTIDISCIPLINARY SCIENCES | ENDOCANNABINOID SYSTEM | SUBCELLULAR-LOCALIZATION | NEURONS | PROTEINS | RECEPTORS | BRAIN | Memory - drug effects | Electron Transport - drug effects | Memory Disorders - metabolism | Male | Hippocampus - drug effects | Cannabinoids - adverse effects | Mitochondrial Membranes - drug effects | Oxidative Phosphorylation - drug effects | Cell Respiration - drug effects | Female | Synaptic Transmission - drug effects | Mitochondrial Membranes - enzymology | Cannabinoids - metabolism | Memory Disorders - pathology | Cyclic AMP-Dependent Protein Kinases - metabolism | Memory Disorders - enzymology | Hippocampus - pathology | Mitochondria - metabolism | Adenylyl Cyclases - metabolism | Mitochondria - drug effects | NADH Dehydrogenase - metabolism | Mitochondrial Membranes - metabolism | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Signal Transduction - drug effects | Mice | Receptor, Cannabinoid, CB1 - deficiency | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Energy Metabolism - drug effects | Memory - physiology | Memory Disorders - chemically induced | Mitochondria | Cannabinoids | Health aspects | Memory | Proteins | Phosphorylation | Rodents | Respiration | Chemical compounds | Life Sciences | Neurons and Cognition | Biochemistry, Molecular Biology
Journal Article
Reviews in the Neurosciences, ISSN 0334-1763, 04/2012, Volume 23, Issue 2, pp. 163 - 177
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2015, Volume 97, Issue 6, pp. 1049 - 1070
Review on the immune effects of cannabinoids and endocannabinoids, and their metabolites. 2‐Arachidonoyl‐glycerol (2‐AG) and arachidonyl‐ethanolamide (AEA) are... 
eicosanoid | MAG lipase | prostaglandin | anandamide | leukotriene | leukocyte | LEGIONELLA-PNEUMOPHILA INFECTION | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATED RECEPTOR-GAMMA | IMMUNOLOGY | CELL BIOLOGY | ISCHEMIA-REPERFUSION INJURY | ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL | TRAUMATIC BRAIN-INJURY | ACID AMIDE HYDROLASE | PROSTAGLANDIN E-2 ETHANOLAMIDE | MACROPHAGE-LIKE CELLS | HEMATOLOGY | NF-KAPPA-B | Endocannabinoids - metabolism | Inflammation - pathology | Obesity - immunology | Dendritic Cells - immunology | Humans | Liver Diseases - pathology | Receptors, Cannabinoid - immunology | Dendritic Cells - pathology | Metabolic Syndrome - metabolism | Pain - immunology | Lipid Metabolism - immunology | Neurodegenerative Diseases - immunology | Pain - metabolism | Receptors, Cannabinoid - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Lymphocytes - immunology | Metabolic Syndrome - immunology | Endocannabinoids - immunology | Dendritic Cells - metabolism | Phosphatidic Acids - immunology | Liver Diseases - immunology | Lymphocytes - metabolism | Neurodegenerative Diseases - pathology | Inflammation - immunology | Neurodegenerative Diseases - metabolism | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Arachidonic Acids - immunology | Pain - pathology | Obesity - metabolism | Obesity - pathology | Lymphocytes - pathology | Animals | Glycerides - immunology | Polyunsaturated Alkamides - immunology | Phosphatidic Acids - metabolism | Metabolic Syndrome - pathology | Liver Diseases - metabolism
Journal Article