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Nature medicine, ISSN 1546-170X, 01/2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | Index Medicus | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
Journal Article
Nature medicine, ISSN 1546-170X, 05/2017, Volume 23, Issue 6, pp. 733 - 741
Blood vessels in the central nervous system (CNS) are controlled by neuronal activity. For example, widespread vessel constriction (vessel tone) is induced by... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Capillaries - pathology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, Adrenergic, alpha-2 - metabolism | Transcriptome | Capillaries - drug effects | RNA, Messenger - metabolism | Oxygen - metabolism | Hypoxia - metabolism | Receptors, Serotonin, 5-HT1 - metabolism | Spinal Cord Injuries - pathology | Receptor, Serotonin, 5-HT1B - metabolism | Aromatic-L-Amino-Acid Decarboxylases - metabolism | Tyramine - metabolism | Capillaries - metabolism | Locomotion - drug effects | Injections, Spinal | Capillaries - physiopathology | Spinal Cord Injuries - metabolism | Pericytes - metabolism | Vasoconstriction | Rats | Microscopy, Interference | Oxygen Inhalation Therapy | Microscopy, Confocal | Animals | Norepinephrine - metabolism | Tryptamines - metabolism | Serotonin - metabolism | Spinal Cord Injuries - physiopathology | Biogenic Monoamines - metabolism | Locomotion - physiology | Enzymes | Care and treatment | Analysis | Tryptophan | Spinal cord injuries | Dosage and administration | Drug therapy | Health aspects | Noradrenaline | Blood flow | Index Medicus | spinal cord injury | AADC | hypoxia | pericyte | capillary | locomotion | Trace amines | neurovascular coupling | 5-HT1B receptor | motoneurons | ischemia
Journal Article
Nature (London), ISSN 1476-4687, 08/2012, Volume 490, Issue 7418, pp. 107 - 111
Detection of microbial products by host inflammasomes is an important mechanism of innate immune surveillance. Inflammasomes activate the caspase-1 (CASP1)... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e35905 - e35905
Hematopoietic progenitor CD133(+)/c-kit(+) cells have been shown to be involved in myocardial healing following myocardial infarction (MI). Previously we... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Up-Regulation | Capillaries - pathology | Receptors, Notch - metabolism | Cardiomegaly - pathology | Angiopoietin-1 - metabolism | Antigens, CD - metabolism | Peptides - metabolism | Serrate-Jagged Proteins | Bone Marrow - metabolism | Myocardium - metabolism | Endomyocardial Fibrosis - complications | Myocardial Infarction - physiopathology | Capillaries - metabolism | Apelin | Jagged-1 Protein | Capillaries - physiopathology | Signal Transduction | Cardiomegaly - physiopathology | Myocardial Infarction - metabolism | Receptors, CXCR4 - metabolism | Chemokine CXCL12 - metabolism | Hematopoietic Stem Cells - cytology | Endomyocardial Fibrosis - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Cardiomegaly - metabolism | Cell Movement | Actins - metabolism | Glycoproteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Myocardial Infarction - pathology | Endomyocardial Fibrosis - pathology | Membrane Proteins - metabolism | Heart Function Tests | Diabetes Mellitus, Type 2 - complications | Calcium-Binding Proteins - metabolism | Myocardium - pathology | Adipokines | AC133 Antigen | Cardiomegaly - complications | Myocardial Infarction - complications | Animals | Diabetes Mellitus, Type 2 - physiopathology | Bone Marrow - pathology | Receptor, Notch3 | Endomyocardial Fibrosis - physiopathology | Apoptosis | Advertising executives | Vascular endothelial growth factor | Adenoviruses | Heart attack | Myocardial infarction | Heart | Diabetic retinopathy | Heart attacks | Angiopoietin | Recovery of function | Smooth muscle | Cardiovascular disease | Recruitment | Angiogenesis | Toxicology | Cell growth | Ischemia | Data recovery | Rodents | Bone marrow | Repair | Heart diseases | Immunoglobulins | Diabetes mellitus | Coronary artery | Muscles | Pharmacology | c-Kit protein | Hemopoiesis | Studies | Ostomy | Coronary vessels | Fibrosis | Stem cells | Myocardium | Infarction | Diabetes | Laboratory animals | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 03/2018, Volume 13, Issue 3, pp. e0193967 - e0193967
Objectives A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Multivariate Analysis | Myocardial Ischemia - metabolism | Cardiomyopathy, Dilated - pathology | Cardiomyopathy, Dilated - surgery | Humans | Middle Aged | Male | Young Adult | Netherlands | Myocardium - metabolism | Ventricular Dysfunction, Left - pathology | Aged, 80 and over | Electrocardiography | Myocardial Ischemia - diagnostic imaging | Adult | Female | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | Ventricular Dysfunction, Left - epidemiology | Heart Transplantation | Myocardium - pathology | Cardiomyopathy, Dilated - metabolism | Switzerland | Ventricular Dysfunction, Left - diagnostic imaging | Heart - diagnostic imaging | Myocardial Ischemia - pathology | Ventricular Dysfunction, Left - metabolism | Cardiomyopathy, Dilated - diagnostic imaging | Aged | Myocardial Ischemia - surgery | Cohort Studies | Physiological aspects | Development and progression | Calcium-binding proteins | Heart enlargement | Health aspects | Heart muscle | Health care | Heart | Nephrology | Cardiomyopathy | Antibodies | Interstitial cells | Epidemiology | Proteins | Ischemia | Measurement methods | Population | Blood pressure | Capillaries | Cardiology | Heart diseases | Enzyme-linked immunosorbent assay | Vitamin K | Hypertension | Research & development--R&D | Hospitals | Dilated cardiomyopathy | Calcification | Myocardium | Microvasculature | Ventricle | Integrity | Index Medicus | Research & development | R&D
Journal Article