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1. Full Text Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans
by Yoneshiro, Takeshi and Aita, Sayuri and Kawai, Yuko and Iwanaga, Toshihiko and Saito, Masayuki
The American journal of clinical nutrition, ISSN 0002-9165, 04/2012, Volume 95, Issue 4, pp. 845 - 850
Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Biological and medical sciences | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Single-Blind Method | Fluorodeoxyglucose F18 - pharmacokinetics | Humans | Contrast Media - pharmacokinetics | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Capsaicin - administration & dosage | Tissue Distribution | Young Adult | Multimodal Imaging | Adult | Basal Metabolism | Skin Temperature | Cold Temperature | Anti-Obesity Agents - administration & dosage | TRPV Cation Channels - agonists | Capsaicin - analogs & derivatives | Membrane Transport Modulators - administration & dosage | Cross-Over Studies | Thermogenesis | Energy Metabolism | Adipose Tissue, Brown - metabolism | Kinetics | Dietary Supplements | Usage | PET imaging | Capsaicin | Physiological aspects | Brown adipose tissue | Research | Health aspects | Bioenergetics | Diet | Cold | Nutrition | Tissues | Index Medicus | Abridged Index Medicus
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2. Full Text t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists
by Lee, Sunho and Kang, Dong Wook and Ryu, HyungChul and Kim, Changhoon and Ann, Jihyae and Lee, Hobin and Kim, Eunhye and Hong, Sunhye and Choi, Sun and Blumberg, Peter M and Frank-Foltyn, Robert and Bahrenberg, Gregor and Stockhausen, Hannelore and Christoph, Thomas and Lee, Jeewoo
Bioorganic & medicinal chemistry, ISSN 0968-0896, 04/2017, Volume 25, Issue 8, pp. 2451 - 2462
Vanilloid receptor 1 | TRPV1 antagonists | Analgesic | Amides - pharmacology | Animals | Pyridines - chemistry | TRPV Cation Channels - antagonists & inhibitors | Humans | Amides - chemistry | Molecular Docking Simulation | Structure-Activity Relationship | Pyridine | Alkaloids | Analysis | Pharmacy | Index Medicus
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3. Full Text Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells
by Chen, Di and Pamu, Sreedhar and Cui, Qiuzhi and Chan, Tak Hang and Dou, Q. Ping
Bioorganic & medicinal chemistry, ISSN 0968-0896, 05/2012, Volume 20, Issue 9, pp. 3031 - 3037
Cell proliferation | EGCG analogs | Breast cancer | AMP-activated protein kinase | Cancer stem cells | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Up-Regulation | AMP-Activated Protein Kinases - metabolism | Neoplastic Stem Cells - drug effects | Antineoplastic Agents - chemical synthesis | Benzoates - chemistry | Down-Regulation | Humans | Catechin - chemical synthesis | Benzoates - chemical synthesis | Antineoplastic Agents - chemistry | Naphthalenes - pharmacology | Signal Transduction - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antineoplastic Agents - pharmacology | Catechin - analogs & derivatives | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Catechin - pharmacology | Catechin - chemistry | Catechin | Protein kinases | Stem cells | Cancer | Index Medicus | Cell survival | epigallocatechin gallate | Capsaicin | Genistein | green tea | Protein biosynthesis | Drug development | Energy balance | epigallocatechin-3-gallate | natural products | Cyclin-dependent kinase inhibitor p21 | Cell cycle | Quercetin | Metformin | Tumors | breast cancer | cancer stem cells | cell proliferation
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4. Full Text Capsaicin analogues derived from n-3 polyunsaturated fatty acids (PUFAs) reduce inflammatory activity of macrophages and stimulate insulin secretion by β-cells in vitro
by Cione, Erika and Plastina, Pierluigi and Pingitore, Attilio and Perri, Mariarita and Caroleo, Maria Cristina and Fazio, Alessia and Witkamp, Renger and Meijerink, Jocelijn
Nutrients, ISSN 2072-6643, 2019, Volume 11, Issue 4, p. 915
Vanillylamide | Obesity | Inflammation | Diabetes | Fatty acid amides | PUFA | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Calcium - metabolism | Capsaicin - pharmacology | Eicosapentaenoic Acid - analogs & derivatives | Fatty Acids, Omega-3 - chemistry | Capsaicin - chemistry | Inflammation - metabolism | Insulin-Secreting Cells - metabolism | Eicosapentaenoic Acid - pharmacology | Molecular Structure | Cell Survival - drug effects | Docosahexaenoic Acids - chemical synthesis | Eicosapentaenoic Acid - chemistry | Docosahexaenoic Acids - chemistry | Rats | Capsaicin - analogs & derivatives | Eicosapentaenoic Acid - chemical synthesis | Docosahexaenoic Acids - analogs & derivatives | Gene Expression Regulation - drug effects | Docosahexaenoic Acids - pharmacology | Insulin - metabolism | Macrophages - metabolism | Animals | Insulin-Secreting Cells - drug effects | Cell Line, Tumor | Macrophages - drug effects | RAW 264.7 Cells | Mice | Adipose tissue | Polyunsaturated fatty acids | Capsaicin | Interleukin | Vanillylamine | Prostaglandin E2 | Adipocytes | Glucose | Macrophages | Adiponectin | Interleukin 6 | Proteins | Pain | Tumor necrosis factor-TNF | Pancreas | Invasiveness | Diabetes mellitus | Breast cancer | Tumor necrosis factor-α | Metabolism | Secretions | Gene expression | Insulin | Fatty acids | Olvanil | Beta cells | Properties (attributes) | Monocytes | Eicosapentaenoic acid | Monocyte chemoattractant protein 1 | Apoptosis | Index Medicus | fatty acid amides | vanillylamide | inflammation | diabetes | obesity
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5. Full Text Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases
by Basith, Shaherin and Cui, Minghua and Hong, Sunhye and Choi, Sun
Molecules (Basel, Switzerland), ISSN 1420-3049, 08/2016, Volume 21, Issue 8, p. 966
Therapeutic | Desensitization | Analogues | Capsaicin | Neuropathic pain | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Capsicum - classification | Capsaicin - pharmacology | Capsaicin - therapeutic use | Humans | Capsaicin - chemistry | Sensory System Agents - chemistry | Capsaicin - analogs & derivatives | Clinical Trials as Topic | Structure-Activity Relationship | Pain - metabolism | Sensory System Agents - pharmacology | TRPV Cation Channels - metabolism | Signal Transduction - drug effects | Pain - drug therapy | Pain - etiology | Molecular Structure | Sensory System Agents - therapeutic use | Capsicum - chemistry | Index Medicus | therapeutic | analogues | neuropathic pain | desensitization | capsaicin
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6. Full Text The response of PKD1L3 / PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs
by Ishii, Sho and Kurokawa, Azusa and Kishi, Mikiya and Yamagami, Keigo and Okada, Shinji and Ishimaru, Yoshiro and Misaka, Takumi
The FEBS journal, ISSN 1742-464X, 05/2012, Volume 279, Issue 10, pp. 1857 - 1870
acid | calcium imaging | transient receptor potential channel | capsaicin | PKD1L3/PKD2L1 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Calcium Channels - metabolism | Capsaicin - pharmacology | TRPP Cation Channels - antagonists & inhibitors | Humans | Cells, Cultured | Molecular Sequence Data | Receptors, Cell Surface - metabolism | Male | Receptors, Cell Surface - antagonists & inhibitors | Sensory System Agents - pharmacology | Animals | HEK293 Cells | Mice | Mice, Inbred BALB C | Tongue - metabolism | TRPP Cation Channels - metabolism | Taste Buds - drug effects | Proteins | Biochemistry | Phytochemicals | Kidney diseases | Gene expression | Index Medicus | PKD2L1 | PKD1L3 | Original
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7. Capsaicin and its analogues: Structure-activity relationship study
by Huang, X.-F and Xue, J.-Y and Jiang, A.-Q and Zhu, H.-L
Current medicinal chemistry, ISSN 0929-8673, 07/2013, Volume 20, Issue 21, pp. 2661 - 2672
Gastroprotection | Analgesic | Anti-cancer | Vasorelaxation | Capsaicin | Structure and activity relationship | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Analgesics - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Capsaicin - pharmacology | Humans | Capsaicin - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Capsaicin - analogs & derivatives | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neoplasms - drug therapy | Animals | Analgesics - chemical synthesis | Analgesics - chemistry | Cell Proliferation - drug effects | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasms - pathology
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8. Full Text Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists
by Ryu, HyungChul and Seo, Sejin and Lee, Jee-Young and Ha, Tae-Hwan and Lee, Sunho and Jung, Aeran and Ann, Jihyae and Kim, Sung-Eun and Yoon, Suyoung and Hong, Mannkyu and Blumberg, Peter M and Frank-Foltyn, Robert and Bahrenberg, Gregor and Schiene, Klaus and Stockhausen, Hannelore and Christoph, Thomas and Frormann, Sven and Lee, Jeewoo
European journal of medicinal chemistry, ISSN 0223-5234, 03/2015, Volume 93, pp. 101 - 108
Vanilloid receptor 1 | TRPV1 antagonists | Analgesic | Analgesics - pharmacology | Analgesics - therapeutic use | Sulfonamides - chemistry | Pyridines - chemistry | Structure-Activity Relationship | Sulfonamides - pharmacology | Benzeneacetamides - chemical synthesis | Sulfonamides - chemical synthesis | Animals | Benzeneacetamides - therapeutic use | Sulfonamides - therapeutic use | Analgesics - chemical synthesis | Analgesics - chemistry | Pain - drug therapy | TRPV Cation Channels - antagonists & inhibitors | Benzeneacetamides - chemistry | Mice | Molecular Structure | Pain Measurement | Benzeneacetamides - pharmacology | Alkaloids | Pyridine | Analgesics | Analysis | Formaldehyde | Index Medicus
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9. Full Text Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists
by Ann, Jihyae and Jung, Aeran and Kim, Mi-Yeon and Kim, Hyuk-Min and Ryu, HyungChul and Kim, Sunjoo and Kang, Dong Wook and Hong, Sunhye and Cui, Minghua and Choi, Sun and Blumberg, Peter M and Frank-Foltyn, Robert and Bahrenberg, Gregor and Stockhausen, Hannelore and Christoph, Thomas and Lee, Jeewoo
Bioorganic & medicinal chemistry, ISSN 0968-0896, 11/2015, Volume 23, Issue 21, pp. 6844 - 6854
Vanilloid receptor 1 | TRPV1 antagonists | Analgesic | Amides - chemical synthesis | Humans | Molecular Conformation | Capsaicin - toxicity | Amides - therapeutic use | Structure-Activity Relationship | Hypothermia - chemically induced | TRPV Cation Channels - metabolism | Animals | Hypothermia - drug therapy | Analgesics - chemical synthesis | Analgesics - chemistry | TRPV Cation Channels - antagonists & inhibitors | Amides - chemistry | Mice | Molecular Docking Simulation | Binding Sites | Drugstores | Alkaloids | Pyridine | Analysis | Pharmacy | Index Medicus
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