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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 35, pp. 15427 - 15430
Many drugs are amphiphiles that, in addition to binding to a particular target protein, adsorb to cell membrane lipid bilayers and alter intrinsic bilayer... 
Sodium channels | Elasticity | Lipids | Biochemistry | Physiological regulation | Curvature | Lipid bilayers | Membrane proteins | Spring constant | Hydrophobic coupling | Bilayer elasticity | Hydrophobic matching | MEMBRANE-PROTEIN FUNCTION | PERMEABILITY | MECHANISM | MULTIDISCIPLINARY SCIENCES | bilayer elasticity | ENERGETICS | GRAMICIDIN CHANNELS | hydrophobic matching | DISCOVERY | ELASTICITY | LIPID-BILAYERS | hydrophobic coupling | DEFORMATIONS | THICKNESS | Capsaicin - pharmacology | Humans | Isoflavones - pharmacology | Protein Conformation - drug effects | Capsaicin - chemistry | Octoxynol - chemistry | Isoflavones - chemistry | Ion Channels - physiology | Cell Membrane - physiology | Cell Membrane - chemistry | Gramicidin - pharmacology | Ion Channel Gating - physiology | Phloretin - pharmacology | Ion Channels - chemistry | Cell Membrane - drug effects | Membrane Potentials - drug effects | Cell Line | Gramicidin - chemistry | Capsaicin - analogs & derivatives | Genistein - chemistry | Phosphatidylcholines - chemistry | Algorithms | Membrane Proteins - chemistry | Phloretin - chemistry | Genistein - pharmacology | Hydrophobic and Hydrophilic Interactions | Kinetics | Lipid Bilayers - chemistry | Octoxynol - pharmacology | Hydrogen-Ion Concentration | Ion Channel Gating - drug effects | Lipid membranes | Chemical properties | Research | Health aspects | Protein binding | Biological Sciences
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 10/2012, Volume 82, Issue 2, pp. 291 - 298
Sustained nonivamide permeation is achieved by film forming emulsions containing Eudragit polymers. Film forming emulsions containing Eudragit® NE 30D (NE)... 
Mechanical properties | Film adhesion | Topical delivery | Water resistance | Nonivamide | Elongation | RELEASE | BIOADHESIVE PATCH | FORMULATION | ELASTICITY | IN-VITRO | 5-AMINOLEVULINIC ACID | PHARMACOLOGY & PHARMACY | SKIN | ABSORPTION | PLASTICIZERS | Polymers - administration & dosage | Polyvinyl Alcohol - chemistry | Polysorbates - chemistry | Skin - metabolism | Glass | Capsaicin - chemistry | Methylcellulose - analogs & derivatives | Administration, Cutaneous | Methacrylates - chemistry | Capsaicin - administration & dosage | Emulsions - administration & dosage | Swine | Skin Cream - administration & dosage | Polysorbates - administration & dosage | Methylcellulose - administration & dosage | Povidone - administration & dosage | Polycarboxylate Cement - chemistry | Emulsions - chemistry | Methacrylates - administration & dosage | Capsaicin - analogs & derivatives | Polyvinyl Alcohol - administration & dosage | Permeability | Acrylic Resins - chemistry | Chemistry, Pharmaceutical | Methylcellulose - chemistry | Povidone - chemistry | Animals | Surface-Active Agents - administration & dosage | Hypromellose Derivatives | Skin Cream - chemistry | Acrylic Resins - administration & dosage | Polymers - chemistry | Surface-Active Agents - chemistry | Delayed-Action Preparations | Transition Temperature | Motion pictures
Journal Article
Journal Article
CURRENT MEDICINAL CHEMISTRY, ISSN 0929-8673, 2017, Volume 24, Issue 14, pp. 1453 - 1468
Background: Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family that plays a key role in the inflammatory process. It has been... 
plant metabolites | OXIDATIVE STRESS | SIGNALING PATHWAYS | CHEMISTRY, MEDICINAL | INFLAMMATORY RESPONSES | plant extracts | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED MCP-1 EXPRESSION | PHENETHYL ESTER SUPPRESSES | CAFFEIC ACID | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | Diabetes | TNF-ALPHA | monocyte chemoattractant protein-1 (MCP-1) | NF-KAPPA-B | CCR2 | ADIPOSE-TISSUE | Phenols - isolation & purification | Plant Extracts - chemistry | Anthocyanins - isolation & purification | Capsaicin - pharmacology | Plant Extracts - pharmacology | Humans | Alkaloids - isolation & purification | Capsaicin - chemistry | Stilbenes - chemistry | Diabetes Mellitus, Type 2 - metabolism | Stilbenes - pharmacology | Terpenes - pharmacology | Terpenes - chemistry | Chemokine CCL2 - metabolism | Flavonoids - pharmacology | Phenols - pharmacology | Sterols - pharmacology | Anthocyanins - pharmacology | Alkaloids - pharmacology | Terpenes - isolation & purification | Sterols - chemistry | Diabetes Complications - metabolism | Diabetes Complications - drug therapy | Plant Extracts - isolation & purification | Capsaicin - isolation & purification | Anthocyanins - chemistry | Sterols - isolation & purification | Animals | Stilbenes - isolation & purification | Chemokine CCL2 - biosynthesis | Phenols - chemistry | Flavonoids - isolation & purification | Diabetes Mellitus, Type 2 - drug therapy | Flavonoids - chemistry | Alkaloids - chemistry | Adipose tissues | CC chemokine receptors | Saponins | Adipose tissue | Capsaicin | Macrophages | Phenolic acids | Alkaloids | Metabolites | CCR2 protein | Sterols | Diabetes mellitus (non-insulin dependent) | Obesity | Complications | Diabetes mellitus | Pharmacology | Inflammation | Plants | Insulin | Fatty acids | Chemical compounds | Plant extracts | Flavonoids | Molecular modelling | Monocyte chemoattractant protein | Phenols | Anthocyanins | Infiltration | Terpenes | Chemokines | Monocyte chemoattractant protein 1
Journal Article