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1. Full Text Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice Fed a High-fat Diet
by Kang, Ji‐Hye and Tsuyoshi, Goto and Han, In‐Seob and Kawada, Teruo and Kim, Young Min and Yu, Rina
Obesity, ISSN 1930-7381, 04/2010, Volume 18, Issue 4, pp. 780 - 787
Obesity‐induced inflammation contributes to the development of obesity‐related metabolic disorders such as insulin resistance, type 2 diabetes, fatty liver... 
CRUCIAL ROLE | PPAR-ALPHA | METABOLIC SYNDROME | ACTIVATION | NUTRITION & DIETETICS | ADIPONECTIN | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | RECEPTOR | TNF-ALPHA | ADIPOSE-TISSUE | Glucose Intolerance - metabolism | Dietary Fats - metabolism | Obesity - drug therapy | Capsaicin - pharmacology | Capsaicin - therapeutic use | Male | Insulin - blood | RNA, Messenger - metabolism | Adipose Tissue - metabolism | TRPV Cation Channels - metabolism | Flow Cytometry | Leptin - blood | Glucose Intolerance - etiology | Adiponectin - genetics | Dietary Fats - administration & dosage | Anti-Inflammatory Agents - therapeutic use | Adiponectin - metabolism | Disease Models, Animal | Hypoglycemic Agents - therapeutic use | Gene Expression | Fatty Liver - metabolism | Anti-Inflammatory Agents - pharmacology | Obesity - complications | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | PPAR alpha - genetics | Reverse Transcriptase Polymerase Chain Reaction | Fatty Liver - drug therapy | TRPV Cation Channels - genetics | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Triglycerides - metabolism | Animals | Lipid Metabolism - drug effects | Inflammation - genetics | Mice, Obese | Mice | PPAR alpha - metabolism | Blood Glucose - metabolism | Dietary Supplements | PPAR alpha - chemistry | Fatty Liver - etiology
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2. Full Text Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis
by Ma, Liqun and Zhong, Jian and Zhao, Zhigang and Luo, Zhidan and Ma, Shuangtao and Sun, Jing and He, Hongbo and Zhu, Tianqi and Liu, Daoyan and Zhu, Zhiming and Tepel, Martin
Cardiovascular Research, ISSN 0008-6363, 12/2011, Volume 92, Issue 3, pp. 504 - 513
Aims Activation of transient receptor potential vanilloid type-1 (TRPV1) channels may affect lipid storage and the cellular inflammatory response. Now, we... 
Transient receptor potential vanilloid type-1 | Capsaicin | Vascular smooth muscle cells | Atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | DEPENDENT PROTEIN-KINASE | RECEPTOR | MECHANISMS | DEFICIENT MICE | CHOLESTEROL EFFLUX | CALCINEURIN | SMOOTH-MUSCLE-CELLS | CHANNELS | EXPRESSION | Immunohistochemistry | Dietary Fats - metabolism | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Capsaicin - pharmacology | Atherosclerosis - genetics | Aorta - metabolism | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | Aortic Diseases - metabolism | TRPV Cation Channels - deficiency | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Time Factors | Dietary Fats - administration & dosage | Polymerase Chain Reaction | ATP-Binding Cassette Transporters - metabolism | Aortic Diseases - prevention & control | ATP Binding Cassette Transporter 1 | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Diterpenes - pharmacology | Atherosclerosis - pathology | Tumor Suppressor Proteins - metabolism | Aorta - drug effects | Mice, Inbred C57BL | TRPV Cation Channels - agonists | Cells, Cultured | Receptors, LDL - metabolism | Atherosclerosis - metabolism | Blotting, Western | TRPV Cation Channels - genetics | Mice, Knockout | Aortic Diseases - genetics | Animals | Apolipoproteins E - genetics | Lipid Metabolism - drug effects | Mice | Atherosclerosis - prevention & control | Calcineurin - metabolism
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3. Full Text Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma β-cells
by De Petrocellis, Luciano and Marini, Pietro and Matias, Isabel and Moriello, Aniello Schiano and Starowicz, Katarzyna and Cristino, Luigia and Nigam, Santosh and Di Marzo, Vincenzo
Experimental Cell Research, ISSN 0014-4827, 2007, Volume 313, Issue 14, pp. 2993 - 3004
In RIN m5F rat insulinoma β-cells, agonists at cannabinoid CB receptors modulate insulin release. Here we investigated in these cells the effect of the... 
Bombesin | Anandamide, TRPV1 | Cannabinoid receptor | Calcium, insulinoma β-cells | SIGNAL-TRANSDUCTION PATHWAYS | VANILLOID VR1 RECEPTORS | BOMBESIN-LIKE PEPTIDES | PHOSPHOLIPASE-C | G-PROTEINS | ENDOCANNABINOID SYSTEM | CA2+ SIGNALS | CELL BIOLOGY | insulinoma beta-cells | ENERGY-BALANCE | ONCOLOGY | anandamide | TRPV1cannabinoid receptor bombesin calcium | CB1 RECEPTORS | Receptor, Cannabinoid, CB2 - agonists | Calcium - metabolism | Capsaicin - metabolism | Cell Line, Tumor - drug effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - genetics | Neuroprotective Agents - metabolism | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Arachidonic Acids - metabolism | Receptor, Cannabinoid, CB1 - agonists | Colforsin - metabolism | TRPV Cation Channels - antagonists & inhibitors | Dronabinol - analogs & derivatives | Pyrrolidinones - metabolism | Estrenes - metabolism | Phosphoinositide Phospholipase C - metabolism | Sensory System Agents - metabolism | Cannabinoids - metabolism | Cell Line, Tumor - metabolism | Phosphoinositide Phospholipase C - antagonists & inhibitors | Enzyme Inhibitors - metabolism | TRPV Cation Channels - agonists | Neurotransmitter Agents - metabolism | Pertussis Toxin - metabolism | Rats | TRPV Cation Channels - genetics | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Insulinoma - metabolism | Thapsigargin - metabolism | Signal Transduction - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dronabinol - metabolism | Bombesin - metabolism
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4. Full Text The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption
by Rossi, F and Siniscalco, D and Luongo, L and De Petrocellis, L and Bellini, G and Petrosino, S and Torella, M and Santoro, C and Nobili, B and Perrotta, S and Di Marzo, V and Maione, S
Bone, ISSN 8756-3282, 2008, Volume 44, Issue 3, pp. 476 - 484
Abstract Recent studies suggest a role for the endocannabinoid/endovanilloid anandamide in the regulation of bone resorption/formation balance in mice. Here,... 
Orthopedics | Osteoclasts | Bone turnover | Calcium | Vanilloids/cannabinoids receptors | Anandamide | EPITHELIAL CA2 | CHANNELS TRPV5 | ENDOCANNABINOID SYSTEM | SENSORY NEURONS | CB1 RECEPTOR | CELL BIOLOGY | CAPSAICIN RECEPTOR | ENDOCRINOLOGY & METABOLISM | NONPSYCHOACTIVE CANNABINOID ACID | VANILLOID RECEPTOR-1 | AJULEMIC ACID | Cannabinoid Receptor Modulators - metabolism | Osteogenesis - physiology | Calcium - metabolism | Capsaicin - metabolism | Humans | Tartrate-Resistant Acid Phosphatase | Osteoclasts - cytology | TRPV Cation Channels - metabolism | Acid Phosphatase - metabolism | Arachidonic Acids - metabolism | Isoenzymes - metabolism | Bone and Bones - metabolism | Cell Differentiation | Osteoclasts - physiology | Endocannabinoids | Bone and Bones - cytology | Amidohydrolases - metabolism | Bone Resorption | Cathepsin K | Isoenzymes - genetics | Cells, Cultured | Polyunsaturated Alkamides - metabolism | Phospholipase D - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Cathepsins - metabolism | Mice | Acid Phosphatase - genetics | Cathepsins | Osteoporosis | Phospholipases | Fatty acids
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5. Full Text NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
by Zhang, Xuming and McNaughton, Peter A and Huang, Jiehong
The EMBO Journal, ISSN 0261-4189, 12/2005, Volume 24, Issue 24, pp. 4211 - 4223
Nociceptors, or pain‐sensitive receptors, are unique among sensory receptors in that their sensitivity is increased by noxious stimulation. This process,... 
pain | sensory transduction | neurotrophic factor | membrane trafficking | tyrosine kinase | Neurotrophic factor | Tyrosine kinase | Membrane trafficking | Pain | Sensory transduction | PROTEIN-KINASE-C | TYROSINE PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAPSAICIN-RECEPTOR | SENSORY NEURONS | NERVE GROWTH-FACTOR | CELL BIOLOGY | NOCICEPTIVE NEURONS | ADULT-RAT | VANILLOID RECEPTOR-1 | NOXIOUS HEAT | Immunohistochemistry | Phosphorylation | Ion Channels | Calcium - metabolism | Capsaicin - pharmacology | Humans | Electrophysiology | Molecular Sequence Data | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | TRPV Cation Channels - metabolism | Transfection | Nerve Growth Factor - physiology | Time Factors | Vanadates - pharmacology | src-Family Kinases - metabolism | Neurons - metabolism | Tyrosine - chemistry | Amino Acid Sequence | Cell Line | Sodium - pharmacology | Nerve Growth Factor - metabolism | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Glutathione Transferase - metabolism | DNA - metabolism | Hot Temperature | Plasmids - metabolism | Sequence Homology, Amino Acid | Animals | Receptor, trkA - metabolism | Models, Biological | Protein Binding | Mice | Mutation | DNA, Complementary - metabolism
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6. Full Text Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance
by Lee, Eunjung and Jung, Dae Young and Kim, Jong Hun and Patel, Payal R and Hu, Xiaodi and Lee, Yongjin and Azuma, Yoshihiro and Wang, Hsun-Fan and Tsitsilianos, Nicholas and Shafiq, Umber and Kwon, Jung Yeon and Lee, Hyong Joo and Lee, Ki Won and Kim, Jason K
FASEB Journal, ISSN 0892-6638, 08/2015, Volume 29, Issue 8, pp. 3182 - 3192
Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism is unclear. Recent studies have shown a metabolic... 
Aging | Glucose metabolism | Capsaicin | Hyperinsulinemic-euglycemic clamp | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRP CHANNELS | LOCOMOTOR-ACTIVITY | PAIN SENSATION | hyperinsulinemic-euglycemic clamp | MICE LACKING | CELL BIOLOGY | CAPSAICIN RECEPTOR | SKELETAL-MUSCLE | BODY-WEIGHT | IMPAIRED NOCICEPTION | ENERGY HOMEOSTASIS | capsaicin | CALCIUM | BIOLOGY | aging | glucose metabolism | Dietary Fats - metabolism | Leptin - metabolism | Mice, Inbred C57BL | Cells, Cultured | Diet, High-Fat - adverse effects | Male | Diabetes Mellitus, Type 2 - metabolism | Obesity - metabolism | TRPV Cation Channels - metabolism | Insulin - metabolism | Animals | Insulin Resistance - physiology | Glucose - metabolism | Adipose Tissue, Brown - metabolism | Mice | Energy Metabolism - physiology | Aging - metabolism | Research Communication
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7. Full Text Regulation of Ca2+-dependent Desensitization in the Vanilloid Receptor TRPV1 by Calcineurin and cAMP-dependent Protein Kinase
by Durga Prasanna Mohapatra and Carla Nau
Journal of Biological Chemistry, ISSN 0021-9258, 04/2005, Volume 280, Issue 14, pp. 13424 - 13432
The vanilloid receptor TRPV1 is a polymodal nonselective cation channel of nociceptive sensory neurons involved in the perception of inflammatory pain. TRPV1... 
CA2+-SENSITIVE INACTIVATION | THERMAL HYPERALGESIA | INHIBITION | CALCIUM-CHANNELS | VR1 | ROOT GANGLION NEURONS | CALMODULIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+ CHANNELS | CAPSAICIN-ACTIVATED CURRENTS | DIRECT PHOSPHORYLATION | Cyclic AMP-Dependent Protein Kinases - metabolism | Cyclophilin A - metabolism | Protons | Cell Line | Phosphorylation | Calmodulin - metabolism | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | Calcium - metabolism | Capsaicin - metabolism | TRPV Cation Channels | Humans | Ion Channels - genetics | Rats | Alanine - metabolism | Patch-Clamp Techniques | Animals | Ion Channels - metabolism | Protein Kinase C - metabolism | Sulfonamides - metabolism | Cyclosporine - metabolism | Calcineurin - metabolism
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8. Full Text Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy
by Silva, M and Martins, D and Charrua, A and Piscitelli, F and Tavares, I and Morgado, C and Di Marzo, V
Neuropharmacology, ISSN 0028-3908, 08/2016, Volume 107, pp. 49 - 57
The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation by the brain remains understudied. The rostroventromedial medulla... 
RVM | Descending pain modulation | FAAH | TRPV1 | Diabetic neuropathic pain | Periaqueductal grey | PERIAQUEDUCTAL GRAY | PERIPHERAL INFLAMMATION | NEUROSCIENCES | ACID AMIDE HYDROLASE | NUCLEUS RAPHE MAGNUS | DESCENDING PAIN | PHARMACOLOGY & PHARMACY | POTENTIAL VANILLOID TYPE-1 | ROSTRAL VENTROMEDIAL MEDULLA | FORMALIN TEST | C-FOS EXPRESSION | TRPV1 CHANNELS | Amidohydrolases - metabolism | Endocannabinoids - metabolism | Chronic Pain - drug therapy | Rats, Wistar | Capsaicin - pharmacology | TRPV Cation Channels - agonists | Analgesics, Non-Narcotic - pharmacology | Medulla Oblongata - metabolism | Male | Diabetic Neuropathies - drug therapy | Nociceptive Pain - drug therapy | Polyunsaturated Alkamides - metabolism | RNA, Messenger - metabolism | Formaldehyde | Nociceptive Pain - metabolism | Oleic Acids - metabolism | Chronic Pain - metabolism | TRPV Cation Channels - metabolism | Arachidonic Acids - metabolism | Animals | Ethanolamines - metabolism | Diabetes Mellitus, Experimental - metabolism | Diabetic Neuropathies - metabolism | Palmitic Acids - metabolism | Enzymes | Diabetic neuropathies | Care and treatment | Pain | RNA | Streptozocin | Analysis | Hydrolases | Fatty acids | Chronic pain
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9. Full Text Vanilloid receptors—do they have a role in whole body metabolism? Evidence from TRPV1
by Zsombok, Andrea
Journal of Diabetes and Its Complications, ISSN 1056-8727, 2013, Volume 27, Issue 3, pp. 287 - 292
Abstract With increasing lifespan, therapeutic interventions for the treatment of disorders such as type 2 diabetes mellitus are in great demand. Despite... 
Endocrinology & Metabolism | GLP-1 | TRPV1 | Glucose | Hypothalamus | Insulin | GENE-RELATED PEPTIDE | IMMUNOHISTOCHEMICAL LOCALIZATION | BROWN ADIPOSE-TISSUE | GLUCAGON-LIKE PEPTIDE-1 | PARAVENTRICULAR NUCLEUS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | CAPSICUM-FRUTESCENS | LIVER-RELATED NEURONS | CAPSAICIN-DESENSITIZED RATS | GLUCOSE-PRODUCTION | Obesity - diet therapy | Adipose Tissue, White - immunology | Capsaicin - metabolism | Capsaicin - therapeutic use | Hypoglycemic Agents - metabolism | Obesity - immunology | Humans | Adipose Tissue, White - metabolism | Diabetes Mellitus, Type 2 - diet therapy | Glucagon-Like Peptide 1 - blood | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | TRPV Cation Channels - metabolism | Insulin-Secreting Cells - metabolism | Liver - immunology | Diabetes Mellitus, Type 2 - immunology | Autonomic Nervous System - metabolism | Insulin Secretion | Hypoglycemic Agents - therapeutic use | Hypothalamus - immunology | Glucagon-Like Peptide 1 - metabolism | Liver - metabolism | TRPV Cation Channels - agonists | Insulin Resistance | Insulin-Secreting Cells - immunology | Obesity - metabolism | Insulin - metabolism | Animals | Hypothalamus - metabolism | Energy Metabolism | Autonomic Nervous System - immunology | Dietary Supplements | Type 2 diabetes | Glucose metabolism | Glucagon | Dietary supplements | Physiological aspects | Health aspects | Dextrose | glucose | insulin | hypothalamus
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10. Full Text Reversal of pathological pain through specific spinal GABAA receptor subtypes
by Knabl, Julia and Witschi, Robert and Hösl, Katharina and Reinold, Heiko and Zeilhofer, Ulrike B and Ahmadi, Seifollah and Brockhaus, Johannes and Sergejeva, Marina and Hess, Andreas and Brune, Kay and Fritschy, Jean-Marc and Rudolph, Uwe and Möhler, Hanns and Zeilhofer, Hanns Ulrich
Nature, ISSN 0028-0836, 01/2008, Volume 451, Issue 7176, pp. 330 - 334
Inflammatory diseases and neuropathic insults are frequently accompanied by severe and debilitating pain, which can become chronic and often unresponsive to... 
Inflammation - chemically induced | Analgesics - pharmacology | Spinal Cord - drug effects | Spinal Cord - metabolism | Diazepam - metabolism | Rats, Wistar | Capsaicin - pharmacology | Analgesics - metabolism | Male | Ganglia, Spinal - cytology | Pain - chemically induced | Receptors, GABA-A - chemistry | Pain - metabolism | Brain - physiology | Formaldehyde | Protein Subunits - metabolism | Diazepam - pharmacology | Fluorobenzenes - pharmacology | Protein Isoforms - metabolism | Inflammation - drug therapy | Pain - drug therapy | Protein Isoforms - chemistry | Neurons - metabolism | Spinal Cord - cytology | Neurons - drug effects | Chronic Disease - drug therapy | Disease Models, Animal | Analgesics - therapeutic use | Fluorobenzenes - metabolism | Pain - prevention & control | Diazepam - administration & dosage | Analgesics - administration & dosage | Rats | Hot Temperature | Organ Specificity | Brain - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Animals | Receptors, GABA-A - genetics | Mice | Protein Subunits - chemistry | Receptors, GABA-A - metabolism | Spinal Cord - physiopathology | Ganglia, Spinal - metabolism | Care and treatment | Receptors | Analgesics | GABA | Development and progression | Dosage and administration | Research | Health aspects | Chronic pain | Neurosciences | Neurotransmitters | NMR | Rodents | Pain management | Pharmacology | Nuclear magnetic resonance | Binding sites | Inflammatory diseases | Index Medicus
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11. Full Text The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli
by Brierley, Stuart M and Hughes, Patrick A and Page, Amanda J and Kwan, Kelvin Y and Martin, Christopher M and O'Donnell, Tracey A and Cooper, Nicole J and Harrington, Andrea M and Adam, Birgit and Liebregts, Tobias and Holtmann, Gerald and Corey, David P and Rychkov, Grigori Y and Blackshaw, L. Ashley
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 2084 - 2095.e3
Background & Aims The transient receptor potential (TRP) channel family includes transducers of mechanical and chemical stimuli for visceral sensory neurons.... 
Gastroenterology and Hepatology | SENSITIZATION | PELVIC COLONIC AFFERENTS | INFLAMMATORY PAIN | MICE | HYPERALGESIA | COLD | GASTROENTEROLOGY & HEPATOLOGY | IRRITABLE-BOWEL-SYNDROME | SENSORY NEURONS | BRADYKININ | HYPERSENSITIVITY | Hyperalgesia - chemically induced | Immunohistochemistry | Intestinal Mucosa - metabolism | Intestinal Mucosa - physiopathology | Mechanotransduction, Cellular - drug effects | Capsaicin - pharmacology | Neuroanatomical Tract-Tracing Techniques | Receptor, PAR-2 - metabolism | Colon - drug effects | Afferent Pathways - physiopathology | Colon - innervation | Male | Ganglia, Spinal - physiopathology | Nodose Ganglion - metabolism | Trinitrobenzenesulfonic Acid | Pelvis - innervation | RNA, Messenger - metabolism | Transient Receptor Potential Channels - deficiency | Action Potentials | Nodose Ganglion - physiopathology | Splanchnic Nerves - physiopathology | In Situ Hybridization | Colitis - chemically induced | Nodose Ganglion - drug effects | Colon - physiopathology | Female | Transient Receptor Potential Channels - metabolism | Bradykinin - pharmacology | Disease Models, Animal | Afferent Pathways - metabolism | Hyperalgesia - metabolism | Mice, Inbred C57BL | Reverse Transcriptase Polymerase Chain Reaction | Pressure | Stimulation, Chemical | Colon - metabolism | Hyperalgesia - physiopathology | Mice, Knockout | Animals | Colitis - physiopathology | Transient Receptor Potential Channels - genetics | TRPA1 Cation Channel | Colitis - metabolism | Splanchnic Nerves - metabolism | Mice | Ganglia, Spinal - drug effects | Pain Measurement | Ganglia, Spinal - metabolism | Index Medicus | Abridged Index Medicus
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12.