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Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin
Journal Article
Pain, ISSN 0304-3959, 2005, Volume 117, Issue 1, pp. 171 - 181
Protein kinase C (PKC) is able to phosphorylate several cellular components that serve as key regulatory components in signal transduction pathways of... 
Nociception | Protein kinase C | Substance P | Phorbol ester | MAP kinase | Mice | Glutamate | phorbol ester | PRIMARY AFFERENT NEURONS | INFLAMMATORY HYPERALGESIA | nociception | VANILLOID RECEPTOR | NECROSIS-FACTOR-ALPHA | RAT SENSORY NEURONS | mice | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | IN-VITRO | SCIATIC-NERVE | ANESTHESIOLOGY | substance P | UP-REGULATION | protein kinase C | glutamate | Bradykinin - analogs & derivatives | Analgesics - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Capsaicin - pharmacology | Nociceptors - physiology | Tetradecanoylphorbol Acetate - analogs & derivatives | Male | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pain - chemically induced | Dose-Response Relationship, Drug | Salicylates - pharmacology | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Drug Interactions | Pain - enzymology | Time Factors | Pain - drug therapy | Protein Kinase C - metabolism | Sympatholytics - pharmacology | Behavior, Animal - drug effects | Indoles - pharmacology | Bradykinin - pharmacology | Blotting, Western - methods | Protein Kinase C - physiology | Calcitonin Gene-Related Peptide - pharmacology | Dipeptides - pharmacology | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Chelating Agents - pharmacology | Enzyme Activation - drug effects | Antibodies - pharmacology | Pain Measurement - methods | Animals | Egtazic Acid - pharmacology | Ruthenium Red - pharmacology | Dizocilpine Maleate - pharmacology | Excitatory Amino Acid Antagonists | Guanethidine - pharmacology | Nociceptors - drug effects | Methyl aspartate | Nerve growth factor | Cell research | Protein kinases
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 209 - 215
N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance... 
Na+/Ca2+ exchanger | Vasorelaxation | Nitric oxide | N-arachidonoyl glycine | Hypotensive | Ca | exchanger | ANANDAMIDE-INDUCED VASORELAXATION | RAT | IDENTIFICATION | VASCULAR ENDOTHELIUM | CORONARY-ARTERIES | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ABNORMAL-CANNABIDIOL | GPR18 | Glycine - analogs & derivatives | Kidney - blood supply | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Endothelium, Vascular - drug effects | Male | Thiourea - pharmacology | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Regional Blood Flow - drug effects | Piperidines - pharmacology | Oxadiazoles - pharmacology | Blood Pressure - drug effects | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Rats | Capsaicin - analogs & derivatives | Arachidonic Acids - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Glycine - pharmacology | Endothelium, Vascular - metabolism | Anilides - pharmacology | Endothelium, Vascular - pathology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | Medical colleges | Dilatation | Vasodilators | Blood vessels | Indomethacin | Glycine | Endothelium
Journal Article
Journal of Urology, The, ISSN 0022-5347, 2013, Volume 190, Issue 2, pp. 746 - 756
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 03/2017, Volume 133, Issue 3, pp. 168 - 175
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 699 - 708
Background and purpose: Studies in isolated preparations of vascular tissue (mainly resistance vessels) provide evidence that anandamide exerts vasorelaxation.... 
vasorelaxation | anandamide | rat aorta | Rat aorta | Vasorelaxation | Anandamide | PHARMACOLOGICAL CHARACTERIZATION | SENSORY NERVES MEDIATE | OXIDATIVE-METABOLISM | PROSTANOID RECEPTORS | CANNABINOID RECEPTOR | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | PROSTAGLANDIN E-2 ETHANOLAMIDE | VANILLOID RECEPTORS | CARDIOVASCULAR FUNCTION | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Bornanes - pharmacology | Endothelium, Vascular - drug effects | Male | Peptide Fragments - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Apamin - pharmacology | Aorta, Abdominal - drug effects | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Piperidines - pharmacology | Charybdotoxin - pharmacology | Benzamides - pharmacology | Vasodilation - physiology | Isoindoles - pharmacology | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Calcitonin Gene-Related Peptide - pharmacology | Nitric Oxide - antagonists & inhibitors | Rats | Capsaicin - analogs & derivatives | Aorta, Abdominal - physiology | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Pyrazoles - administration & dosage | Animals | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Research Papers
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2009, Volume 34, Issue 3, pp. 593 - 606
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 2004, Volume 46, Issue 1, pp. 133 - 149
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in... 
TRPV | Pain | TRPV1 | VR1 | Ion channel | Capsaicin | pain | PROTEIN-KINASE-C | 1 VR1 | RAT | ROOT GANGLION NEURONS | INTRACELLULAR CALCIUM | IODO-RESINIFERATOXIN | SPINAL-CORD | NEUROSCIENCES | CAPSAICIN RECEPTOR | NEUROPATHIC PAIN | ACTIVATED ION-CHANNEL | ion channel | capsaicin | PHARMACOLOGY & PHARMACY | Norepinephrine - pharmacology | Aniline Compounds - metabolism | Calcium - metabolism | Capsaicin - pharmacology | Embryo, Mammalian | Humans | Anilides - chemistry | Excitatory Postsynaptic Potentials - drug effects | Kidney | Patch-Clamp Techniques - methods | N-Methylaspartate - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Xanthenes - metabolism | Carrier Proteins - pharmacology | Neuropeptides - pharmacology | Protein Binding - drug effects | Radioligand Assay - methods | Cinnamates - chemistry | Acids - pharmacology | Membrane Potentials - drug effects | Cell Line | Orexins | Intracellular Signaling Peptides and Proteins | Rats | Capsaicin - analogs & derivatives | Excitatory Amino Acid Agonists - pharmacology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Hot Temperature | Cinnamates - pharmacology | Receptors, Drug - chemistry | Animals | Anilides - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Receptors, Drug - antagonists & inhibitors
Journal Article