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Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 10, pp. 2077 - 2086
In a clinical trial for adeno-associated virus serotype 1 (AAV-1)-mediated gene transfer to muscle for lipoprotein lipase (LPL) deficiency, 1 subject from the... 
RESPONSES | AAV VECTOR | LIPOPROTEIN-LIPASE DEFICIENCY | ADENOASSOCIATED VIRAL VECTOR | LONG-TERM CORRECTION | VIRUS | BENEFICIAL MUTATION | CANINE HEMOPHILIA-B | FACTOR-IX | HEMATOLOGY | LEBERS CONGENITAL AMAUROSIS | Dependovirus - genetics | Genetic Therapy | Dose-Response Relationship, Immunologic | Immunoglobulin G - blood | Humans | Male | Antibodies, Viral - blood | Immunoenzyme Techniques | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Muscle, Skeletal - immunology | Immunoglobulin G - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Capsid - metabolism | Creatine Kinase - immunology | Muscle, Skeletal - enzymology | Transduction, Genetic | Lipoprotein Lipase - genetics | Transgenes - genetics | CD4-Positive T-Lymphocytes - metabolism | Hyperlipoproteinemia Type I - enzymology | Dependovirus - immunology | Lipoprotein Lipase - biosynthesis | Hyperlipoproteinemia Type I - genetics | Capsid - immunology | B-Lymphocytes - immunology | Creatine Kinase - biosynthesis | Hyperlipoproteinemia Type I - immunology | Interferon-gamma - immunology | Lipoprotein Lipase - immunology | Triglycerides - blood | Antibodies, Viral - immunology | Hyperlipoproteinemia Type I - therapy | CD8-Positive T-Lymphocytes - immunology | Transgenes - immunology | Interferon-gamma - biosynthesis | Gene Therapy
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e61101
Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent... 
3-DIMENSIONAL STRUCTURE | B-CELLS | VISUALIZATION | PROTECTIVE IMMUNITY | CRYOELECTRON MICROSCOPY | PROTEIN-STRUCTURE | MULTIDISCIPLINARY SCIENCES | VIRUS-LIKE PARTICLES | CRYO-EM | MASS-SPECTROMETRY | YOUNG-CHILDREN | Antibodies, Viral - metabolism | Antigens, Viral - metabolism | Epitopes - metabolism | Virus Replication - genetics | Humans | Rotavirus - physiology | Rotavirus - immunology | Molecular Sequence Data | Virion - genetics | Antigens, Viral - genetics | Neutralization Tests | Host-Pathogen Interactions - immunology | Epitopes - immunology | Rotavirus - metabolism | HEK293 Cells | B-Lymphocytes - virology | Capsid Proteins - immunology | Transcription, Genetic | Rotavirus Infections - virology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Caco-2 Cells | Protein Structure, Tertiary | Virion - immunology | Amino Acid Sequence | Cell Line | Immunoglobulin A - metabolism | Capsid Proteins - metabolism | Models, Molecular | Virus Replication - immunology | Protein Binding - immunology | Virion - metabolism | Rotavirus Infections - immunology | Sequence Homology, Amino Acid | Antigens, Viral - immunology | Animals | B-Lymphocytes - immunology | Immunoglobulin A - immunology | Antibodies, Viral - immunology | Epitopes - chemistry | Antibodies, Monoclonal - metabolism | Capsid Proteins - genetics | Genetic aspects | Genetic transcription | B cells | Vaccines | Immunoglobulin A | Pediatrics | Transcription | Mucosa | Antibodies | Viruses | Infections | Biochemistry | Immunity | Crystallography | Proteins | Immunology | Physiology | Immunoglobulins | Automation | Quaternary | Particulates | Biophysics | Medicine | Pathology | Lymphocytes B | Quaternary structure | Scientific imaging | Intracellular | Human behavior | Mass spectrometry | Protein structure | Immunoassays | Neutralization
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42788
Group A Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The aim of the present work was to evaluate protection... 
SECRETING CELL RESPONSES | EGG-YOLK IMMUNOGLOBULIN | WA HUMAN ROTAVIRUS | NEWBORN CALVES | CLINICAL-TRIAL | BOVINE ROTAVIRUS | IMMUNE-RESPONSES | NASAL IMMUNIZATION | MULTIDISCIPLINARY SCIENCES | VIRUS-LIKE PARTICLES | MATERNAL ANTIBODIES | Germ-Free Life - immunology | Immunoglobulins - immunology | Cell Count | Humans | Rotavirus - immunology | Sus scrofa - blood | Diarrhea - prevention & control | Neutralization Tests | Virus Shedding | Diarrhea - blood | Antibody Specificity - immunology | Immunoglobulin G - immunology | Diarrhea - immunology | Capsid Proteins - immunology | Rotavirus Infections - virology | Disease Models, Animal | Animals, Newborn | Duodenum - immunology | Duodenum - virology | Antibody Formation - immunology | Enzyme-Linked Immunosorbent Assay | Administration, Oral | Egg Yolk - immunology | Diarrhea - virology | Rotavirus Infections - blood | Sus scrofa - virology | Rotavirus Infections - immunology | Antigens, Viral - immunology | Animals | Antibody-Producing Cells - immunology | Chickens | Duodenum - pathology | Immunoglobulin A - immunology | Antibodies, Viral - immunology | Sus scrofa - immunology | Rotavirus Infections - prevention & control | Swine | Analysis | Immunoglobulin G | Diarrhea | Infants | Immunoglobulin A | Enzyme-linked immunosorbent assay | Milk | Neonates | Poultry | Antibodies | Viruses | Vaccines | Dehydration | Cow's milk | Intestine | Children | Supplementation | Immune system | Yolk | Immunoglobulins | Immune response | Duodenum | Dietary supplements | Oral administration | Preventive medicine | Hogs | Neutralization
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 5, pp. 2019 - 2026
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e67748
Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that... 
HEPATOCYTES | ACTIVATION | ELIMINATE | INNATE IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-TRANSFER | VECTORS | ADENOVIRUS | T-CELLS | HEMOPHILIA | Recombinant Fusion Proteins - immunology | Dependovirus - genetics | Inflammation - pathology | Liver - pathology | Interleukin-12 - genetics | Hepatocytes - pathology | Liver - immunology | Gene Expression - immunology | Killer Cells, Natural - immunology | Female | Interferon-gamma - genetics | Genetic Vectors - immunology | Mice, Inbred C57BL | Dependovirus - immunology | Inflammation - immunology | Hepatocytes - immunology | Capsid - immunology | Killer Cells, Natural - cytology | Animals | T-Lymphocytes - cytology | Interferon-gamma - immunology | Interleukin-12 - immunology | Inflammation - genetics | Recombinant Fusion Proteins - genetics | Transcription, Genetic - immunology | T-Lymphocytes - immunology | Mice | Transgenes - immunology | Genetic Therapy - methods | Interleukin-12 | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | Dependoviruses | Gene therapy | Transcription | Liver | Cytotoxicity | Viruses | Genomes | Lymphocytes T | Immunity | Immunity (cell-mediated) | Lymphocytes | Hepatology | Interleukin 1 | Deoxyribonucleic acid--DNA | Recombinant | Expression vectors | Immune system | Medical research | Antigens | Antiinflammatory agents | Immune response | Immunostimulation | Therapeutic applications | Interleukin 12 | Vectors (Biology) | Hepatocytes | γ-Interferon | Interferon | Deoxyribonucleic acid | DNA
Journal Article
PLoS Medicine, ISSN 1549-1277, 2006, Volume 3, Issue 9, pp. 1637 - 1653
Journal Article
Journal Article