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Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects | Index Medicus
Journal Article
Environmental Monitoring and Assessment, ISSN 0167-6369, 1/2016, Volume 188, Issue 1, pp. 1 - 14
The aim of this study was to determine the behaviour of strobilurin and carbocyamides commonly used in chemical protection of lettuce depending on carefully... 
LC-MS/MS | Microorganisms | Lettuce | Ecotoxicology | Fungicides | Environment | Ecology | Chronic risk analysis | Environmental Monitoring/Analysis | Atmospheric Protection/Air Quality Control/Air Pollution | Environmental Management | ENVIRONMENTAL SCIENCES | IN-VITRO | SOILS | GRAIN | PESTICIDE-RESIDUES | AZOXYSTROBIN | DERIVATIVES | Humans | Mucor - metabolism | Methacrylates - chemistry | Biphenyl Compounds - metabolism | Carbamates - chemistry | Pyrimidines - metabolism | Fungicides, Industrial - metabolism | Saccharomyces cerevisiae - metabolism | Pyrazoles - chemistry | Methacrylates - analysis | Lettuce - microbiology | Chromatography, Liquid | Rhodobacteraceae - metabolism | Biphenyl Compounds - chemistry | Niacinamide - analysis | Carbamates - analysis | Hydantoins - metabolism | Tandem Mass Spectrometry - methods | Environmental Monitoring | Lettuce - chemistry | Fungicides, Industrial - analysis | Niacinamide - metabolism | Risk Assessment | Methacrylates - metabolism | Biphenyl Compounds - analysis | Fungicides, Industrial - chemistry | Pesticide Residues - chemistry | Aminoimidazole Carboxamide - analogs & derivatives | Hydantoins - chemistry | Niacinamide - analogs & derivatives | Pesticide Residues - metabolism | Penicillium - metabolism | Lactobacillales - metabolism | Pyrimidines - chemistry | Carbamates - metabolism | Streptomyces - metabolism | Niacinamide - chemistry | Aminoimidazole Carboxamide - chemistry | Pesticide Residues - analysis | Pesticides - metabolism | Aminoimidazole Carboxamide - metabolism | Pyrazoles - analysis | Pyrimidines - analysis | Strobilurins | Aminoimidazole Carboxamide - analysis | Pesticides - analysis | Pyrazoles - metabolism | Aspergillus - metabolism | Pesticides - chemistry | Hydantoins - analysis | Liquid chromatography | Vegetables | Health aspects | Mass spectrometry | Risk assessment | Index Medicus | LC-MS
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2016, Volume 301, pp. 31 - 41
Hypertension is accompanied by perturbations to the endocannabinoid and antioxidant systems. Thus, potential pharmacological treatments for hypertension should... 
Hypertension | URB597 | Oxidative stress | Endocannabinoid system | Liver | LIPID-PEROXIDATION | NADPH OXIDASE ACTIVITY | BLOOD-PRESSURE | CELL-DEATH | ACID AMIDE HYDROLASE | INDUCED OXIDATIVE STRESS | CARDIOVASCULAR FUNCTION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NF-KAPPA-B | SUPEROXIDE-DISMUTASE | Amidohydrolases - metabolism | Endocannabinoids - metabolism | Glutathione Peroxidase - metabolism | Reactive Oxygen Species - metabolism | Rats, Wistar | Glutathione - metabolism | Glutathione Transferase - metabolism | Amidohydrolases - antagonists & inhibitors | Desoxycorticosterone Acetate | Male | Phospholipases A2 - metabolism | Glutathione Disulfide - metabolism | Hypertension - metabolism | Catalase - metabolism | Monoacylglycerol Lipases - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Liver - drug effects | Hypertension - chemically induced | Benzamides - pharmacology | Superoxide Dismutase - metabolism | Carbamates - pharmacology | Antioxidants | Lipase | Fatty acids | Index Medicus | OXIDATION | TRANSCRIPTION FACTORS | HOMEOSTASIS | LIPASES | ANTIOXIDANTS | GLYCEROL | RATS | 60 APPLIED LIFE SCIENCES | METABOLISM | GLUTATHIONE | ACTIVITY LEVELS | INFLAMMATION | LIVER | CHRONIC INTAKE | DOPAMINE | CARBOXYLIC ACIDS | MINERALOCORTICOIDS | HYPERTENSION | RECEPTORS | AMIDES | LIPIDS | PEROXIDASES | VITAMIN E
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17558 - 17563
Proinflammatory macrophages are key mediators in several pathologies; thus, controlling their activation is necessary. The endocannabinoid system is implicated... 
Enzymes | Receptors | Antiinflammatories | Messenger RNA | Cell lines | Macrophage activation | Inflammation | Macrophages | Endocannabinoids | Cannabinoid receptors | FAAH | Glyceryl prostaglandin | COX-2 | Anandamide | Prostaglandin synthase | prostaglandin synthase | CELLS | MONOACYLGLYCEROL LIPASE | 2-ARACHIDONYL GLYCEROL | MULTIDISCIPLINARY SCIENCES | ARACHIDONIC-ACID | INTERNATIONAL-UNION | CANNABINOID RECEPTORS | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | ACID AMIDE HYDROLASE | glyceryl prostaglandin | INHIBITORS | BLOCKADE | anandamide | Endocannabinoids - metabolism | Inflammation - chemically induced | Endocannabinoids - pharmacology | Gene Expression - drug effects | Monoacylglycerol Lipases - antagonists & inhibitors | Male | Interleukin-1beta - genetics | Monoacylglycerol Lipases - genetics | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Cyclooxygenase 2 - genetics | Esters - chemistry | Interleukin-1beta - metabolism | Lipocalins - genetics | Prostaglandin D2 - metabolism | Female | Glycerol - chemistry | Intramolecular Oxidoreductases - metabolism | Carbamates - pharmacology | Lipocalins - metabolism | Cell Line | Lipopolysaccharides - toxicity | Enzyme-Linked Immunosorbent Assay | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Glycerides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Arachidonic Acids - pharmacology | Prostaglandin D2 - chemistry | Glycerides - pharmacology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Intramolecular Oxidoreductases - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Inflammation - prevention & control | Mice | Prostaglandin D2 - pharmacology | Macrophage Activation - drug effects | Prostaglandins | Physiological aspects | Lipid metabolism | Research | Health aspects | Lipids | Side effects | Metabolites | Rodents | Index Medicus | Biological Sciences
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 10/2016, Volume 200, pp. 47 - 55
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2017, Volume 45, Issue 7, pp. 755 - 764
To assess drug-drug interaction (DDI) potential for the three directacting antiviral (3D) regimen of ombitasvir, dasabuvir, and paritaprevir, in vitro studies... 
METABOLISM | PHARMACOKINETICS | INTERACTION PROFILE | TRANSPORTERS | DIGOXIN | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | INHIBITOR | DISPOSITION | P-GLYCOPROTEIN | RITONAVIR | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Male | Antiviral Agents - metabolism | Macrocyclic Compounds - pharmacology | Carbamates - metabolism | Uracil - pharmacology | HEK293 Cells | Female | Membrane Transport Proteins - metabolism | Ritonavir - pharmacology | Carbamates - pharmacology | Hepacivirus - drug effects | Cell Line | Antiviral Agents - pharmacology | Anilides - metabolism | Macrocyclic Compounds - metabolism | Sulfonamides - pharmacology | Ritonavir - metabolism | Anilides - pharmacology | Drug Interactions - physiology | Sulfonamides - metabolism | Uracil - metabolism | Uracil - analogs & derivatives | Plasma | Ritonavir | Viruses | Hepatitis | Dynamic models | Drug interaction | P-Glycoprotein | Static models | Inducers | Glucuronosyltransferase | Antiviral agents | UDP-glucuronosyltransferase | Drug interactions | Glycoprotein | Substrate inhibition | Breast cancer | Pharmacology | Exposure | Substrates | Organic anion transporting polypeptide | Liability | Inhibitors | Predictions | Hepatitis C virus | Hepatitis C | Transporter | Cancer | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2007, Volume 13, Issue 10, pp. 1176 - 1184
Post- translational modification and functional impairment of proteins through carbamylation is thought to promote vascular dysfunction during end- stage renal... 
ATHEROSCLEROTIC LESIONS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | MYELOPEROXIDASE-CATALYZED OXIDATION | CELL BIOLOGY | HEMOGLOBIN CARBAMYLATION | CYANATE | CARDIOVASCULAR-DISEASE | NITRIC-OXIDE | THIOCYANATE | EOSINOPHIL PEROXIDASE | APOLIPOPROTEIN-A-I | Inflammation - pathology | Predictive Value of Tests | Citrulline - analogs & derivatives | Humans | Cyanates - metabolism | Male | Blood Proteins - metabolism | Foam Cells - cytology | Carbamates - metabolism | Dose-Response Relationship, Drug | Coronary Artery Disease - pathology | Female | Lipoproteins, LDL - metabolism | Citrulline - blood | Atherosclerosis - pathology | Coronary Artery Disease - etiology | Oxidation-Reduction | Jurkat Cells | Mice, Inbred C57BL | Lipoproteins, LDL - pharmacology | Receptors, LDL - metabolism | Mice, Transgenic | Clinical Trials as Topic | Atherosclerosis - metabolism | Mice, Knockout | Smoking - metabolism | Macrophages - metabolism | Animals | Citrulline - biosynthesis | Models, Biological | Uremia - blood | Mice | Protein Processing, Post-Translational | Cholesterol - biosynthesis | Scavenger Receptors, Class A - metabolism | Peroxidase - metabolism | Proteins | Medical research | Cardiovascular disease | Oxidation | Biochemistry | Cholesterol | Smoking | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 12, pp. 8505 - 8518
Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of cholesteryl esters in steroidogenic tissues and, thus, facilitates cholesterol availability for... 
B TYPE-I | SCAVENGER RECEPTOR | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHOLESTEROL ESTER | TUMOR-CELLS | DIFFERENTIAL REGULATION | LIVER-X-RECEPTOR | HIGH-DENSITY-LIPOPROTEIN | MOLECULAR-MECHANISMS | MEDIATED REGULATION | RNA, Small Interfering - genetics | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Leydig Cells - enzymology | Cholesterol - blood | Sterol Esterase - metabolism | Male | Orphan Nuclear Receptors - metabolism | Phosphoproteins - metabolism | Cholesterol Esters - blood | Gene Knockdown Techniques | Cholesterol Side-Chain Cleavage Enzyme - genetics | Cyclic AMP - physiology | ATP-Binding Cassette Transporters - genetics | Leydig Cells - metabolism | Oxadiazoles - pharmacology | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Progesterone - biosynthesis | ATP Binding Cassette Transporter 1 | Cyclic AMP - metabolism | Retinoid X Receptors - metabolism | Second Messenger Systems | Sterol Regulatory Element Binding Protein 1 - metabolism | Carbamates - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Promoter Regions, Genetic | Orphan Nuclear Receptors - agonists | Cells, Cultured | Gene Expression Regulation | Scavenger Receptors, Class B - genetics | Nicotinic Acids - pharmacology | Phosphoproteins - genetics | Orphan Nuclear Receptors - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Sterol Esterase - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Retinoid X Receptors - agonists | Tetrahydronaphthalenes - pharmacology | Sterol Esterase - physiology | Bucladesine - pharmacology | Mice | Scavenger Receptors, Class B - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Perilipin-1 | Index Medicus | Testis | Signal Transduction | Molecular Cell Biology | Cell Signaling | StAR Protein | Steroidogenesis | Steroidogenic Tissues | Cyclic AMP (cAMP)
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2007, Volume 3, Issue 2, pp. 117 - 125
Journal Article
Journal Article
Blood, ISSN 0006-4971, 02/2006, Volume 107, Issue 3, pp. 931 - 939
Delta-like 4 (DII4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and... 
VASCULAR DEVELOPMENT | SIGNALING PATHWAYS | DROSOPHILA-NOTCH | MAMMALIAN NOTCH | SEMAPHORIN-III | EMBRYONIC LETHALITY | GROWTH-FACTOR | HEMATOLOGY | TUBE FORMATION | MOUSE EMBRYO | ACTIVATED NOTCH4 | Neovascularization, Physiologic - drug effects | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Blood Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Blood Proteins - genetics | Aspartic Acid Endopeptidases | Up-Regulation - physiology | Amyloid Precursor Protein Secretases | Umbilical Veins - cytology | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Repressor Proteins - metabolism | Carbamates - pharmacology | Proto-Oncogene Proteins - metabolism | Endopeptidases - metabolism | Dipeptides - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Umbilical Veins - physiology | Receptor, Notch1 - metabolism | Up-Regulation - drug effects | Neovascularization, Physiologic - physiology | Endothelial Cells - cytology | Protein Binding | Ligands | Receptor, Notch4 | Index Medicus | Abridged Index Medicus | Hemostasis, Thrombosis, and Vascular Biology
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 12/2009, Volume 34, Issue 13, pp. 2733 - 2745
Endocannabinoids inhibit hypothalamic-pituitary-adrenal (HPA) axis activity; however, the neural substrates and pathways subserving this effect are not well... 
Anxiety | HPA axis | Amygdala | Cannabinoid | Corticosterone | Stress | stress | amygdala | RAT BASOLATERAL AMYGDALA | PSYCHIATRY | cannabinoid | N-ARACHIDONYLETHANOLAMINE ANANDAMIDE | SYNAPTIC-TRANSMISSION | ANTIDEPRESSANT TREATMENT | PROJECTION NEURONS | CONDITIONED FEAR | LIMBIC STIMULATION | NEUROSCIENCES | anxiety | RESTRAINT STRESS | CANNABINOID RECEPTOR | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | corticosterone | Cannabinoid Receptor Modulators - metabolism | Amygdala - drug effects | Male | Carbamates - administration & dosage | Arachidonic Acids - metabolism | Benzamides - administration & dosage | Amygdala - enzymology | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Stress, Psychological - metabolism | Restraint, Physical | Benzamides - pharmacology | Corticosterone - blood | Dronabinol - pharmacology | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Piperidines - administration & dosage | Microinjections | Pituitary-Adrenal System - metabolism | Amygdala - metabolism | Rats | Polyunsaturated Alkamides - metabolism | Rats, Sprague-Dawley | Hypothalamo-Hypophyseal System - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Pyrazoles - administration & dosage | Animals | Signal Transduction - drug effects | Dronabinol - administration & dosage | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Index Medicus
Journal Article