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The New England Journal of Medicine, ISSN 0028-4793, 08/2017, Volume 377, Issue 9, pp. 829 - 838
Alectinib, a potent ALK tyrosine kinase inhibitor, was more effective and somewhat less toxic than crizotinib when used as primary therapy in patients with ALK... 
RESISTANT | MEDICINE, GENERAL & INTERNAL | MODELS | ANTITUMOR-ACTIVITY | INHIBITOR ALECTINIB | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Central Nervous System Neoplasms - secondary | Young Adult | Pyridines - adverse effects | Anaplastic Lymphoma Kinase | Antineoplastic Agents - adverse effects | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Receptor Protein-Tyrosine Kinases - analysis | Pyrazoles - adverse effects | Pyridines - therapeutic use | Crizotinib | Carbazoles - adverse effects | Kaplan-Meier Estimate | Carcinoma, Non-Small-Cell Lung - mortality | Disease-Free Survival | Animals | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Intention to Treat Analysis | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Central Nervous System Neoplasms - drug therapy | Drugs | Care and treatment | Analysis | Comparative analysis | Lung cancer, Non-small cell | Health aspects | Systemic diseases | Toxicity | Lung cancer | Central nervous system | Oncology | Nervous system | Metastasis | Radiation therapy | Patients | Lymphoma | Cancer therapies | Survival | Mutation | Protein-tyrosine kinase | Drug dosages | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Chemical Research, ISSN 1747-5198, 01/2011, Volume 35, Issue 1, pp. 53 - 59
  2-Furylmethylene-2,3,4,9-tetrahydrocarbazol-1-ones were obtained from the mixed aldol condensation of 2,3,4,9-tetrahydrocarbazole-1-ones and... 
Carbazoles
Journal Article
Journal of Chemical Research, ISSN 1747-5198, 01/2011, Volume 35, Issue 1, pp. 1 - 3
  Reaction of pyrrole, indole or carbazole with dialkyl acetylenedicarboxylates catalysed by N-methylimidazole provides a simple and efficient route for the... 
Carbazoles
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 17010 - 17015
Journal Article
Science, ISSN 0036-8075, 8/2012, Volume 337, Issue 6098, pp. 1094 - 1097
Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock... 
Molecules | Carbazoles | Hepatocytes | HEK293 cells | Chronobiology | Genes | REPORTS | Cell lines | Luminescence | Fibroblasts | Resins | HOMEOSTASIS | CHEMICAL BIOLOGY | METABOLISM | RHYTHMS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PERIOD | DEGRADATION | MAMMALIAN CIRCADIAN CLOCK | OSCILLATIONS | REVEALS | Glucose-6-Phosphatase - genetics | Carbazoles - chemistry | Gluconeogenesis - drug effects | Humans | Molecular Sequence Data | Hepatocytes - metabolism | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | Proteolysis - drug effects | Sulfonamides - isolation & purification | Liver - drug effects | HEK293 Cells | Cryptochromes - agonists | Hepatocytes - drug effects | Cryptochromes - metabolism | Carbazoles - isolation & purification | Amino Acid Sequence | Circadian Clocks - drug effects | Sulfonamides - chemistry | Liver - metabolism | Sulfonamides - pharmacology | Animals | Gluconeogenesis - genetics | Small Molecule Libraries | Protein Stability - drug effects | Cell Line, Tumor | Liver - cytology | Mice | Carbazoles - pharmacology | 3T3 Cells | Circadian rhythms | Ubiquitin | Molecular dynamics | Physiological aspects | Research | Proteins | Biochemistry | Circadian rhythm | Molecular biology | Index Medicus | Biotechnology | Biomedical materials | Medical services | Disorders | Derivatives | Chemical compounds | Culture | Biological clocks
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 97, pp. 13039 - 13042
We report the C4-selective C-H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium... 
Carbazoles | Activation | Ruthenium | Alkylation
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2019, Volume 55, Issue 68, pp. 10162 - 10165
Peripheral π-expansion of carbazole-based porphyrins was achieved for the first time by the Pt-catalyzed cyclization and the incorporation of a benzocarbazole... 
Carbazoles | Conjugation | Crystallography | Porphyrins
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2019, Volume 55, Issue 31, pp. 4558 - 4561
Macrocycles built of carbazole and pyridine fragments with alkene/alkane linkers constitute a helical structure as documented structurally and... 
Carbazoles | Alkanes | Cyclobutane | Crystallography
Journal Article
Archives of Toxicology, ISSN 0340-5761, 10/2017, Volume 91, Issue 10, pp. 3365 - 3372
The maintenance of cellular homeostasis is a complex process that is governed by the receipt of prototypical growth and death signals. The endogenous functions... 
Biomedicine, general | Cell growth | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | 6-Formylindolo[3,2- b ]carbazole (FICZ) | Pharmacology/Toxicology | Mitochondrial-dependent pathway | Apoptosis | 6-Formylindolo[3,2-b]carbazole (FICZ) | OXIDATIVE STRESS | AH RECEPTOR | HEPATOMA-CELLS | 6-Formylindolo[3,2-b] carbazole ( FICZ) | CYTOCHROME-C | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)-INDUCED IMMUNOTOXICITY | CYCLE CONTROL | IMMUNE-SYSTEM | RETINOBLASTOMA PROTEIN | ARYL-HYDROCARBON RECEPTOR | TOXICOLOGY | T-CELLS | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Glutathione - metabolism | Cytochromes c - metabolism | Humans | Carbazoles - administration & dosage | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Cytochrome P-450 CYP1A1 - metabolism | Membrane Potential, Mitochondrial - drug effects | Hep G2 Cells | Dose-Response Relationship, Drug | Cell Proliferation - drug effects | Flavonoids - pharmacology | Carbazoles - pharmacology | Carbazoles - metabolism | Flavonoids | Flavones | Growth | Bioflavonoids | Analysis | Cytochrome P-450 | Cytochrome | Oxidative stress | Enzyme activity | Low concentrations | Toxicity | Cytochrome P450 | Homeostasis | Hepatoma | Carbazole | Mitochondria | Enzymatic activity | Aromatic compounds | Cell death | Trace levels | Biocompatibility | Kinetics | Viability | Growth kinetics | Index Medicus
Journal Article
Journal Article
Journal Article