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Clinical Pharmacology in Drug Development, ISSN 2160-763X, 11/2015, Volume 4, Issue 6, pp. 407 - 417
LCZ696 is a first‐in‐class angiotensin receptor neprilysin inhibitor in development for treatments of hypertension and heart failure indications. In 3 separate... 
LCZ696 | pharmacokinetic drug–drug interaction | amlodipine | hydrochlorothiazide | carvedilol | Pharmacokinetic drug-drug interaction | Amlodipine | Hydrochlorothiazide | Carvedilol | STEADY-STATE PHARMACOKINETICS | ANTAGONIST | NATRIURETIC PEPTIDES | pharmacokinetic drug-drug interaction | HEART-FAILURE | EXCRETION | PHARMACOLOGY & PHARMACY | DYSFUNCTION | VALSARTAN | Hydrochlorothiazide - pharmacokinetics | Diuretics - pharmacokinetics | Humans | Middle Aged | Male | Metabolic Clearance Rate | Tetrazoles - blood | Adrenergic beta-Antagonists - pharmacokinetics | Drug Interactions | Tetrazoles - administration & dosage | Adrenergic beta-Antagonists - adverse effects | Amlodipine - administration & dosage | Arizona | Diuretics - blood | Hydrochlorothiazide - adverse effects | Diuretics - administration & dosage | Administration, Oral | Amlodipine - adverse effects | Propanolamines - adverse effects | Antihypertensive Agents - adverse effects | Antihypertensive Agents - blood | Cross-Over Studies | Models, Biological | Calcium Channel Blockers - administration & dosage | Protease Inhibitors - blood | Calcium Channel Blockers - blood | Propanolamines - administration & dosage | Diuretics - adverse effects | Tetrazoles - pharmacokinetics | Angiotensin Receptor Antagonists - adverse effects | Angiotensin Receptor Antagonists - pharmacokinetics | Calcium Channel Blockers - adverse effects | Area Under Curve | Protease Inhibitors - pharmacokinetics | Carbazoles - administration & dosage | Aminobutyrates - adverse effects | Antihypertensive Agents - administration & dosage | Healthy Volunteers | Propanolamines - pharmacokinetics | Amlodipine - pharmacokinetics | Aminobutyrates - pharmacokinetics | Protease Inhibitors - administration & dosage | Protease Inhibitors - adverse effects | Adult | Female | Carbazoles - blood | Aminobutyrates - administration & dosage | Drug Therapy, Combination | Propanolamines - blood | Hydrochlorothiazide - blood | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - blood | Carbazoles - adverse effects | Amlodipine - blood | Drug Administration Schedule | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Neprilysin - metabolism | Aminobutyrates - blood | Angiotensin Receptor Antagonists - blood | Carbazoles - pharmacokinetics | Neprilysin - antagonists & inhibitors | Tetrazoles - adverse effects | Calcium Channel Blockers - pharmacokinetics | Angiotensin Receptor Antagonists - administration & dosage | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 11/2017, Volume 109, pp. 200 - 208
Journal Article
Journal Article
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 11/2017, Volume 109, pp. S108 - S115
Journal Article
Journal Article
Journal Article
Journal of NeuroVirology, ISSN 1355-0284, 8/2017, Volume 23, Issue 4, pp. 603 - 614
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 09/2016, Volume 128, pp. 184 - 190
Journal Article
Critical Reviews in Toxicology, ISSN 1040-8444, 11/2012, Volume 42, Issue 10, pp. 854 - 876
Clinical outcome following 3,4-methylenedioxymethamphetamine (MDMA) intake ranges from mild entactogenic effects to a life-threatening intoxication. Despite... 
Clinical toxicology | norepinephrine | treatment | ecstasy | cytochrome P450 | intoxication | serotonin | neurotoxicity | receptor | poisoning | CYP2D6 | transporter | metabolism | neurotransmitter | dopamine | CYP2D6 POOR METABOLIZER | IN-VITRO | UPTAKE INHIBITOR CITALOPRAM | INDUCED DOPAMINE RELEASE | TOXICOLOGY | LONG-TERM POTENTIATION | DARK-AGOUTI RATS | SEROTONIN TRANSPORTER GENE | CATECHOL-O-METHYLTRANSFERASE | 5-HT NERVE-ENDINGS | RECEPTOR GENE POLYMORPHISMS | Serotonin Uptake Inhibitors - pharmacokinetics | Body Temperature - drug effects | Humans | N-Methyl-3,4-methylenedioxyamphetamine - blood | Propanolamines - pharmacokinetics | Brain - metabolism | Heart Rate - drug effects | Drug Interactions | Glutathione Transferase - genetics | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Models, Animal | Blood Pressure - drug effects | Serotonin Syndrome - physiopathology | Haloperidol - pharmacology | Neurotransmitter Transport Proteins - genetics | Cytochrome P-450 CYP2D6 - genetics | Ketanserin - pharmacology | Haloperidol - pharmacokinetics | Ketanserin - pharmacokinetics | Polymorphism, Genetic | Brain - drug effects | Serotonin Syndrome - chemically induced | Animals | Carbazoles - pharmacokinetics | Receptors, Neurotransmitter - metabolism | Carbazoles - pharmacology | Propanolamines - pharmacology | Serotonin Uptake Inhibitors - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - pharmacokinetics | Index Medicus
Journal Article