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Psychopharmacology, ISSN 0033-3158, 12/2012, Volume 224, Issue 3, pp. 363 - 376
Pupillometry can be used to characterize autonomic drug effects.This study was conducted to determine the autonomic effects of... 
Pupil | Neurosciences | Biomedicine | Serotonin | Pupillometry | Pupillary reflex | Norepinephrine | Pharmacology/Toxicology | Psychiatry | MDMA | YOHIMBINE | PSYCHIATRY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE ECSTASY | PHARMACODYNAMICS | CLINICAL PHARMACOKINETICS | NEUROSCIENCES | ALPHA-ADRENOCEPTOR | FLUCTUATIONS | AGONIST CLONIDINE | PAROXETINE | PHARMACOLOGY & PHARMACY | MYDRIASIS | Doxazosin - pharmacology | Autonomic Agents - pharmacokinetics | Humans | Mydriasis - physiopathology | Mydriatics - blood | Miosis - physiopathology | Adrenergic Agonists - pharmacology | Autonomic Agents - pharmacology | Male | N-Methyl-3,4-methylenedioxyamphetamine - blood | Adrenergic alpha-2 Receptor Agonists - pharmacology | Recovery of Function | Mydriatics - pharmacology | Young Adult | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Time Factors | Light | Reaction Time - drug effects | Adult | Body Temperature Regulation - drug effects | Clonidine - pharmacology | Female | Mydriatics - pharmacokinetics | Autonomic Agents - blood | Affect - drug effects | Reflex, Pupillary - drug effects | Dopamine Uptake Inhibitors - pharmacology | Miosis - prevention & control | Morpholines - pharmacology | Thiophenes - pharmacology | Randomized Controlled Trials as Topic | Cross-Over Studies | Mydriasis - chemically induced | Duloxetine Hydrochloride | Adrenergic Uptake Inhibitors - pharmacology | Hemodynamics - drug effects | Carbazoles - pharmacology | Propanolamines - pharmacology | Serotonin Uptake Inhibitors - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - pharmacokinetics | Side effects | Pharmacology | Eyes & eyesight | Index Medicus | Drug abuse | Sympathomimetics | Drug tolerance | clonidine | Duloxetine | Light effects | Parasympathetic nervous system | Reflexes | reboxetine
Journal Article
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | XENOPUS-LAEVIS | BIPOLAR CELLS | PROTEIN-KINASE-C | PHYSIOLOGY | FISH RETINA | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | MT2 MELATONIN | RECEPTORS | NEUROSCIENCES | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Neuroscience
Journal Article
Circulation Research, ISSN 0009-7330, 10/2004, Volume 95, Issue 7, pp. 726 - 733
Altered gap junction coupling of cardiac myocytes during ischemia may contribute to development of lethal arrhythmias. The phosphoprotein connexin 43 (Cx43) is... 
Ischemia | Gap junctions | Glycolysis | Okadaic acid | Protein phosphatases | Connexin43 | Protein phosphorylation | AMP kinase | gap junctions | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | connexin43 | PHOSPHORYLATION | GAP JUNCTIONAL COMMUNICATION | glycolysis | CARDIAC MYOCYTES | ACTIN GENE | protein phosphorylation | okadaic acid | ischemia | IN-VITRO | INTERCELLULAR COMMUNICATION | PERIPHERAL VASCULAR DISEASE | JUN KINASE | protein phosphatases | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | ADRENERGIC REGULATION | Okadaic Acid - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Recombinant Fusion Proteins - physiology | Myocardial Contraction - drug effects | Brefeldin A - pharmacology | Phenanthridines - pharmacology | Antimycin A - pharmacology | Aminoimidazole Carboxamide - pharmacology | Cell Hypoxia | Ribonucleotides - pharmacology | Alkaloids | Protein Processing, Post-Translational - drug effects | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Tacrolimus - pharmacology | Indoles - pharmacology | Flavonoids - pharmacology | Potassium Cyanide - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Ouabain - pharmacology | Cells, Cultured - drug effects | Connexin 43 - metabolism | Rats | Imidazoles - pharmacology | Cycloheximide - pharmacology | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Benzophenanthridines | JNK Mitogen-Activated Protein Kinases - physiology | Myocytes, Cardiac - metabolism | Cells, Cultured - metabolism | Pyridines - pharmacology | Carbazoles - pharmacology | Staurosporine - pharmacology
Journal Article
Life Sciences, ISSN 0024-3205, 11/2017, Volume 188, pp. 1 - 9
The vasorelaxant effects of the anti-diabetic drug, mitiglinide in phenylephrine (Phe)-pre-contracted aortic rings were examined. Arterial tone measurement was... 
Mitiglinide | Voltage-dependent K+ channel | Aortic smooth muscle | SERCA pump | channel | Voltage-dependent K | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHYSIOLOGICAL ROLES | ATPASE | ARTERIES | GENES | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | AGENTS | TYPE-2 DIABETES-MELLITUS | EXPRESSION | MODULATION | Potassium Channels, Voltage-Gated - agonists | Endothelium, Vascular - drug effects | Male | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Muscle, Smooth - drug effects | Drug Interactions | Phenylephrine - pharmacology | Glyburide - pharmacology | Oxadiazoles - pharmacology | Aorta, Thoracic - physiology | Indoles - pharmacology | Muscle, Smooth - physiology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Aorta, Thoracic - drug effects | Isoindoles - pharmacology | 4-Aminopyridine - pharmacology | Rabbits | Nifedipine - pharmacology | Adenine - analogs & derivatives | Vasodilator Agents - pharmacology | Vasodilator Agents - antagonists & inhibitors | Adenine - pharmacology | Barium - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Thapsigargin - pharmacology | Carbazoles - pharmacology | Isoindoles - antagonists & inhibitors | Protein kinase A | Electric potential | Protein kinase G | Smooth muscle | Activation | Potassium conductance | Guanylate cyclase | Channels | Vasodilation | Ca2+-transporting ATPase | Adenylate cyclase | Thapsigargin | Phenylephrine | Measurement methods | Aorta | Life sciences | Potassium channels (voltage-gated) | Inhibition | Pretreatment | Glibenclamide | Diabetes mellitus | Muscles | Cyclopiazonic acid | Endothelium | Nifedipine | Resistance | Signaling | Conductance | Endoplasmic reticulum | Adenosine triphosphatase | Index Medicus
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 03/2017, Volume 133, Issue 3, pp. 168 - 175
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 14, pp. 2984 - 2992
Journal Article
Chemical Reviews, ISSN 0009-2665, 08/2013, Volume 113, Issue 8, pp. 6761 - 6815
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 531, Issue 1, pp. 87 - 95
The possible participation of the nitric oxide (NO)-cyclic GMP-protein kinase G (PKG) pathway on gabapentin-induced spinal antiallodynic activity was assessed... 
Pinacidil | Gabapentin | Nitric oxide | Protein kinase G | Diazoxide | Guanylyl cyclase | K + channel opener | Neuropathic pain | channel opener | SENSITIVE POTASSIUM CHANNELS | nitric oxide | TACTILE ALLODYNIA | K+ channel opener | RANDOMIZED CONTROLLED-TRIAL | NERVE INJURY | VASCULAR SMOOTH-MUSCLE | guanylyl cyclase | neuropathic pain | gabapentin | diazoxide | pinacidil | RABBIT VENTRICULAR MYOCYTES | PHARMACOLOGY & PHARMACY | protein kinase G | UP-REGULATION | CALCIUM-CHANNEL | PERIPHERAL ANTINOCICEPTIVE ACTION | Analgesics - pharmacology | Okadaic Acid - pharmacology | Potassium Channels - physiology | Pinacidil - administration & dosage | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Glyburide - pharmacology | Time Factors | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channel Blockers - pharmacology | Spinal Nerves - injuries | Spinal Nerves - physiopathology | Enzyme Inhibitors - pharmacology | Cyclohexanecarboxylic Acids - administration & dosage | Rats | gamma-Aminobutyric Acid - pharmacology | Indazoles - pharmacology | NG-Nitroarginine Methyl Ester - chemistry | Cyclic GMP - metabolism | Signal Transduction - drug effects | Pain - physiopathology | Nitric Oxide Synthase - metabolism | Carbazoles - pharmacology | Amines - pharmacology | Diazoxide - administration & dosage | Cyclic GMP - antagonists & inhibitors | Diazoxide - pharmacology | Rats, Wistar | Stereoisomerism | Nitric Oxide Synthase - antagonists & inhibitors | gamma-Aminobutyric Acid - administration & dosage | Apamin - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Amines - administration & dosage | Female | Indoles - pharmacology | Injections, Spinal | NG-Nitroarginine Methyl Ester - pharmacology | Pinacidil - pharmacology | Vasodilator Agents - pharmacology | Pain - prevention & control | Nitric Oxide - antagonists & inhibitors | Analgesics - administration & dosage | Animals | Cyclohexanecarboxylic Acids - pharmacology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage
Journal Article
Phytochemistry, ISSN 0031-9422, 09/2015, Volume 117, pp. 317 - 324
Four alkaloids comprising two vallesamine, one strychnan, and pyranopyridine alkaloid were isolated from two Malayan species, and . Several of the isolated... 
Apocynaceae | NMR | Cytotoxicity | Alstonia rostrata | Vasorelaxation | Indole alkaloids | Alstonia pneumatophora | MACROPHYLLA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BISINDOLE ALKALOIDS | MACROLINE-MACROLINE | PLANT SCIENCES | ANGUSTIFOLIA | A-D | SARPAGINE | ALSMAPHORAZINES | DERIVATIVES | Carbazoles - chemistry | Pyridines - chemistry | Humans | Crystallography, X-Ray | Cell Line, Tumor - drug effects | Alstonia - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Phenylephrine - pharmacology | Pyrans - chemistry | Aldehydes - pharmacology | Lactams - pharmacology | Molecular Structure | Indole Alkaloids - chemistry | Pyrans - pharmacology | Drug Evaluation, Preclinical - methods | Alkaloids - pharmacology | Secologanin Tryptamine Alkaloids - chemistry | Secologanin Tryptamine Alkaloids - pharmacology | Vasodilator Agents - pharmacology | Aorta - drug effects | Heterocyclic Compounds, 4 or More Rings - chemistry | Rats | Antineoplastic Agents, Phytogenic - chemistry | Animals | Indolizines - chemistry | Indole Alkaloids - pharmacology | Vasodilator Agents - chemistry | Pyridines - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Carbazoles - pharmacology | Alkaloids - chemistry | Indolizines - pharmacology | Aldehydes - chemistry | Lactams - chemistry | Alkaloids | Analysis | Nuclear nonproliferation
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2005, Volume 8, Issue 2, pp. 164 - 172
Synaptic actions of brain-derived neurotrophic factor (BDNF) are 'gated' by cyclic AMP (cAMP), but the underlying molecular mechanisms remain unclear. Here we... 
POTENTIATION | NEUROTROPHIC FACTOR | EXCITATORY SYNAPSES | SYNAPTIC-TRANSMISSION | SURFACE EXPRESSION | FULL-LENGTH | RELEASE | POSTSYNAPTIC DENSITIES | PRIMARY CULTURES | NEUROSCIENCES | CAMP | Disks Large Homolog 4 Protein | Excitatory Postsynaptic Potentials - radiation effects | Microtubule-Associated Proteins - metabolism | Neurons - cytology | Excitatory Postsynaptic Potentials - drug effects | Dopamine Agonists | Cyclic AMP - physiology | Dose-Response Relationship, Drug | Pseudopodia - drug effects | Brain-Derived Neurotrophic Factor - pharmacology | Drug Interactions | Transfection - methods | Cyclic AMP - analogs & derivatives | Dendritic Spines - drug effects | Neurons - physiology | Indoles - pharmacology | Phosphorylation - drug effects | Electric Stimulation - methods | Animals, Newborn | Green Fluorescent Proteins - metabolism | Blotting, Western - methods | Immunoprecipitation - methods | Colforsin - pharmacology | Fluorescent Antibody Technique - methods | Cells, Cultured | Dendritic Spines - physiology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Adrenergic beta-Agonists - pharmacology | Intracellular Signaling Peptides and Proteins | Rats | Thionucleotides - pharmacology | Hippocampus - cytology | Amino Acids | Cyclic AMP - pharmacology | Membrane Proteins | Nerve Tissue Proteins - metabolism | Pyrroles - pharmacology | Animals | Cell Count - methods | Electrophysiology - methods | Analysis of Variance | Isoproterenol - pharmacology | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Protein Kinase Inhibitors - pharmacology | Carbazoles - pharmacology | In Vitro Techniques | Receptor, trkB - metabolism | Physiological aspects | Phosphorylation | Hippocampus (Brain) | Research | Neurotrophic functions
Journal Article