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Diabetes, obesity & metabolism, ISSN 1462-8902, 1999
Journal
Journal of hepatology, ISSN 0168-8278, 2011, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20944
... the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX... 
BACTERIAL COMMUNITY | INSULIN | IN-VITRO | LIPID-METABOLISM | PLASMA | MECHANISM | LINOLEIC-ACID | GLUCOSE | MULTIDISCIPLINARY SCIENCES | LIVER | GUT MICROBIOTA | Intestines - drug effects | Obesity - diet therapy | Molecular Weight | Xylans - pharmacology | Diet - adverse effects | Cholesterol - blood | Body Weight - drug effects | Male | Linoleic Acids, Conjugated - metabolism | Obesity - microbiology | Metagenome - physiology | Bacterial Load - drug effects | Subcutaneous Fat - metabolism | Prevotella - physiology | Subcutaneous Fat - drug effects | Obesity - etiology | Bifidobacterium - physiology | Biomarkers - metabolism | Dietary Fats - adverse effects | Metagenome - drug effects | Mice, Inbred C57BL | Bacteroides - physiology | Insulin Resistance | Obesity - metabolism | Prebiotics | Gene Expression Regulation - drug effects | Animals | Intestines - microbiology | Xylans - chemistry | Xylans - therapeutic use | Mice | Triticum - chemistry | Microbiota (Symbiotic organisms) | Diet | Analysis | Body weight | Physiological aspects | Insulin resistance | Wheat | Fatty acids | Dysbacteriosis | Adipose tissue | Fat metabolism | Enzyme activity | Lipids | Glucose | Molecular weight | High fat diet | Proteins | Microbiota | Enzymatic activity | Rodents | Nutrients | Bacteria | Oxidation | Colon | Lipid metabolism | Supplementation | Arabinoxylans | Food | Carbohydrates | Obesity | Dietary supplements | Polymerization | Inflammation | Ecology | Metabolism | Fermentation | Gene expression | Insulin | Body weight gain | Cholesterol | Studies | Nutrition research | Correlation analysis | Laboratory animals
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 10654 - 15
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2016, Volume 65, Issue 5, pp. 1190 - 1195
Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release. In type 2 diabetes (T2D), along with decrements in... 
INSULIN | SGLT2 | ENDOCRINOLOGY & METABOLISM | Glucose Intolerance - metabolism | Glycosuria - chemically induced | Carbohydrate Metabolism - drug effects | Lipolysis - drug effects | Benzhydryl Compounds - administration & dosage | Humans | Glucagon-Like Peptide 1 - blood | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Glucagon - blood | Glucose Intolerance - blood | Glucose Intolerance - drug therapy | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Time Factors | Glucosides - therapeutic use | C-Reactive Protein - analysis | Benzhydryl Compounds - therapeutic use | Insulin Secretion | Glucosides - adverse effects | Hypoglycemic Agents - therapeutic use | 3-Hydroxybutyric Acid - blood | Sodium-Glucose Transporter 2 - metabolism | Glucose Intolerance - urine | 3-Hydroxybutyric Acid - agonists | Renal Elimination - drug effects | Sodium-Glucose Transporter 2 Inhibitors | Membrane Transport Modulators - administration & dosage | Diabetes Mellitus, Type 2 - urine | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Algorithms | Glucosides - administration & dosage | 3-Hydroxybutyric Acid - metabolism | Lipid Metabolism - drug effects | Membrane Transport Modulators - therapeutic use | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Membrane Transport Modulators - adverse effects | Hypoglycemic Agents - adverse effects | Energy Metabolism - drug effects | Type 2 diabetes | Care and treatment | Glucagon | Dosage and administration | Triglycerides | Research | Insulin
Journal Article
The Plant cell, ISSN 1532-298X, 2015, Volume 27, Issue 8, pp. 2244 - 2260
... reprogram primary C- and N-metabolism. In particular, gluconeogenesis and amino acid catabolism are affected by these transcription factors... 
Datasets | Transcriptomes | Salts | RESEARCH ARTICLES | Genes | Plant roots | Amino acids | Carbohydrate metabolism | Plants | Amino acid metabolism | Plant cells | ASPARAGINE SYNTHETASE | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGHT | DROUGHT | PLANT SCIENCES | CELL BIOLOGY | AMINO-ACID-METABOLISM | STRESS RESPONSES | GENE | ELECTRON-TRANSFER FLAVOPROTEIN | TRANSCRIPTION FACTOR | MOLECULAR-BASIS | Carbohydrate Metabolism - drug effects | Basic-Leucine Zipper Transcription Factors - metabolism | Salt-Tolerant Plants - drug effects | Calcium - metabolism | Sodium Chloride - pharmacology | Gluconeogenesis - drug effects | Protein-Serine-Threonine Kinases | Carbohydrate Metabolism - genetics | Plant Roots - genetics | Immunoblotting | Promoter Regions, Genetic - genetics | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Protein Binding - drug effects | Salt-Tolerant Plants - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Plant Roots - metabolism | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Gluconeogenesis - genetics | Signal Transduction - drug effects | Mutation | Plant Growth Regulators - pharmacology | Salt-Tolerant Plants - genetics | Arabidopsis thaliana | Genetic aspects | Plant-soil relationships
Journal Article
European journal of pharmacology, ISSN 0014-2999, 2011, Volume 668, Issue 3, pp. 497 - 506
.... In this study we sought to determine the effect of Ilepatril treatment of high fat fed/low dose streptozotocin-diabetic rats, a model for type 2 diabetes, on vascular and neural complications... 
Diabetic neuropathy | Diabetes | Neutral endopeptidase | Vasopeptidase inhibitor | Angiotensin converting enzyme | Vascular relaxation | IMPROVES INSULIN SENSITIVITY | ENDOTHELIAL DYSFUNCTION | VASOPEPTIDASE INHIBITOR OMAPATRILAT | INCREASED ENERGY-EXPENDITURE | ANGIOTENSIN-CONVERTING-ENZYME | NEUTRAL ENDOPEPTIDASE ACTIVITY | SKELETAL-MUSCLE | NERVE CONDUCTION-VELOCITY | GLUCOSE-TRANSPORT ACTIVITY | PHARMACOLOGY & PHARMACY | ENDONEURIAL BLOOD-FLOW | Blood Vessels - metabolism | Nervous System - metabolism | Thiobarbiturates - metabolism | Body Weight - drug effects | Male | Tyrosine - analogs & derivatives | Nervous System - pathology | Arterioles - physiopathology | Muscle, Skeletal - drug effects | Nociception - drug effects | Diabetes Mellitus, Experimental - complications | Nerve Fibers - pathology | Nerve Fibers - metabolism | Diabetes Complications - physiopathology | Diabetes Complications - metabolism | Enzyme Inhibitors - pharmacology | Lens, Crystalline - metabolism | Rats | Diabetes Complications - drug therapy | Arterioles - drug effects | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Tyrosine - metabolism | Heterocyclic Compounds, 3-Ring - therapeutic use | Vasodilation - drug effects | Blood Glucose - metabolism | Lens, Crystalline - drug effects | Adipose Tissue - drug effects | Carbohydrate Metabolism - drug effects | Glutathione - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Blood Vessels - pathology | Diet, High-Fat - adverse effects | Sciatic Nerve - physiopathology | Insulin - blood | Nervous System - physiopathology | Blood Vessels - physiopathology | Dose-Response Relationship, Drug | Sciatic Nerve - metabolism | Leptin - blood | Superoxides - metabolism | Sciatic Nerve - drug effects | Diabetes Complications - pathology | Glucose Tolerance Test | Nerve Fibers - drug effects | Organ Size - drug effects | Animals | Nervous System - drug effects | Blood Vessels - drug effects | Muscle, Skeletal - pathology | Complications and side effects | Obesity | Insulin resistance | Angiotensin | Animal models | Arterioles | Streptozocin | Diabetes mellitus | Insulin | Fibers | High fat diet | Calcitonin gene-related peptide | Nerve conduction | Peptidyl-dipeptidase A | Acetylcholine | Neprilysin | Sciatic nerve | vasopeptidase inhibitor | vascular relaxation | angiotensin converting enzyme | neutral endopeptidase | diabetic neuropathy | diabetes
Journal Article
Cell metabolism, ISSN 1550-4131, 2009, Volume 9, Issue 4, pp. 327 - 338
Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD +-dependent protein... 
HUMDISEASE | TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | COACTIVATOR PGC-1 | ENDOCRINOLOGY & METABOLISM | PROTEIN DEACETYLASES | PROLIFERATOR-ACTIVATED-RECEPTOR | CELL-SURVIVAL | LIVER-DISEASE | CALORIE RESTRICTION | ADIPOSE-TISSUE | CELL BIOLOGY | Organ Specificity - drug effects | Transcriptional Activation - drug effects | Fatty Liver - complications | Endoplasmic Reticulum - pathology | Inflammation - complications | Dietary Fats - pharmacology | Sirtuin 1 | Endoplasmic Reticulum - drug effects | Gene Deletion | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Protein Binding - drug effects | Dietary Fats - administration & dosage | Fatty Liver - enzymology | Oxidation-Reduction - drug effects | Homeostasis - drug effects | Sirtuins - genetics | Fatty Acids - metabolism | Hepatocytes - drug effects | Feeding Behavior - drug effects | Animals | Signal Transduction - drug effects | Lipid Metabolism - drug effects | Ligands | Trans-Activators - metabolism | Mice | Transcription Factors | PPAR alpha - metabolism | Inflammation - enzymology | Sirtuins - metabolism | Hepatocytes - enzymology | Starvation | Liver diseases | Atherosclerosis | Environmental health | Physiological aspects | Insulin resistance | Inflammation | Fatty acids | PGC-1α | PPARα | inflammation | SIRT1 | hepatic fatty acid oxidation | hepatic steatosis
Journal Article
Journal Article