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American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2011, Volume 301, Issue 3, pp. C559 - C565
Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol 301: C559-C565, 2011.... 
Calcium imaging | Microinjection | Cytosolic calcium concentration | Endoplasmic reticulum | CYCLIC ADP-RIBOSE | PHYSIOLOGY | ANG-II | LIVER LYSOSOMES | RECEPTOR | microinjection | METABOLIC-CLEARANCE | BLOOD-PRESSURE | UTERINE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | RENAL ENDOSOMES | SMOOTH-MUSCLE-CELLS | calcium imaging | cytosolic calcium concentration | endoplasmic reticulum | Myometrium - drug effects | Type C Phospholipases - metabolism | Brefeldin A - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Autophagy - drug effects | Endosomes - metabolism | Angiotensin II Type 2 Receptor Blockers - pharmacology | Macrocyclic Compounds - pharmacology | Saralasin - pharmacology | Endoplasmic Reticulum - drug effects | Estrenes - pharmacology | Myometrium - metabolism | Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors | Ryanodine - pharmacology | Angiotensin II - pharmacology | Pyridines - administration & dosage | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Saralasin - administration & dosage | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Calcium Signaling - drug effects | Models, Biological | Receptor, Angiotensin, Type 1 - metabolism | Oxazoles - pharmacology | Losartan - administration & dosage | Angiotensin II - administration & dosage | Calcium Signaling - physiology | Endoplasmic Reticulum - metabolism | Imidazoles - administration & dosage | Type C Phospholipases - antagonists & inhibitors | Lysosomes - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Pyrrolidinones - pharmacology | Macrolides - pharmacology | NADP - analogs & derivatives | Female | NADP - metabolism | Heparin - pharmacology | Angiotensin II - metabolism | Arsenicals - pharmacology | Cells, Cultured | Sirolimus - pharmacology | Myometrium - cytology | Animals | Egtazic Acid - pharmacology | Uterus - cytology | Signal Transduction - physiology | Pyridines - pharmacology | Carbolines - pharmacology | Myometrium | Cell receptors | Calcium channels | Genetic aspects | Properties | Angiotensin | Receptors and Signal Transduction
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as... 
LISTERIA-MONOCYTOGENES | SRTA GENE | CHEMISTRY, MEDICINAL | CELL-WALL | STREPTOCOCCUS-PNEUMONIAE | SORTING SIGNAL | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | A INHIBITORS | PROTEIN ANCHORING TRANSPEPTIDASE | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 41 - 52
Ferroptosis has recently been identified as a mode of programmed cell death. However, little is yet known about the signaling mechanism. Here, we report that... 
Acute leukemia | Redox | Ferroptosis | Cell death | ROS | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | NECROPTOSIS | 5-LIPOXYGENASE INHIBITOR | ARACHIDONIC-ACID | PEROXIDATION | ZILEUTON | ANTIOXIDANT | RESISTANCE | PHARMACOLOGY & PHARMACY | Masoprocol - pharmacology | Reactive Oxygen Species - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Glutathione Peroxidase - antagonists & inhibitors | Humans | Arachidonate 12-Lipoxygenase - chemistry | Arachidonate 15-Lipoxygenase - chemistry | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cyclohexylamines - pharmacology | Lipid Peroxidation - drug effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | alpha-Tocopherol - pharmacology | Arachidonate 12-Lipoxygenase - genetics | Fas-Associated Death Domain Protein - genetics | Glutathione Peroxidase - metabolism | Flavanones - pharmacology | Fas-Associated Death Domain Protein - metabolism | Carbolines - antagonists & inhibitors | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Arachidonate 15-Lipoxygenase - metabolism | Glutathione Peroxidase - genetics | Reactive Oxygen Species - antagonists & inhibitors | Arachidonate 15-Lipoxygenase - genetics | Cell Line, Tumor | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Phenylenediamines - pharmacology | Kinetics | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Carbolines - pharmacology | Biochemistry | Peroxidase | Acute lymphocytic leukemia | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 616, Issue 1, pp. 73 - 80
Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor... 
Harmaline | Dopamine | Gabapentin | Primidone | Lithium | Glutamate | Carbamazepine | Valproate | Validity | D 1 receptor | GABA | Propranolol | Essential tremor | ICR mouse | D 2 receptor | γ-Hydroxy-butyrate | D | receptor | GAMMA-HYDROXYBUTYRIC ACID | NUCLEUS-ACCUMBENS DOPAMINE | D-2 receptor | SUBUNIT MESSENGER-RNAS | AMINO-ACIDS | SODIUM-VALPROATE | PHARMACOLOGY & PHARMACY | gamma-Hydroxy-butyrate | AMINOBUTYRIC-ACID | RECEPTOR SUBUNITS | NEUROTRANSMITTER RELEASE | INFERIOR OLIVE | D-1 receptor | DRUG-INDUCED TREMOR | Receptors, Glutamate - metabolism | Muscimol - pharmacology | gamma-Aminobutyric Acid - metabolism | Glutamates - metabolism | Male | Anticonvulsants - pharmacology | Dose-Response Relationship, Drug | Propranolol - pharmacology | Lithium Chloride - pharmacology | Neurotransmitter Agents - pharmacology | Tremor - chemically induced | Behavior, Animal - drug effects | Raclopride - pharmacology | Chlordiazepoxide - pharmacology | Dopamine - metabolism | Baclofen - pharmacology | Harmaline - pharmacology | Affect - drug effects | Benzazepines - pharmacology | Piperazines - pharmacology | Mice, Inbred ICR | Sodium Oxybate - pharmacology | Animals | Mice | Carbolines - pharmacology | Propranolol hydrochloride | Methyl aspartate | Pyridine | Analysis | Gamma-hydroxybutyrate | Chemical properties | Barbiturates | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 11/2004, Volume 110, Issue 19, pp. 3149 - 3155
STABLE ANGINA | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | ORAL SILDENAFIL | PULMONARY-HYPERTENSION | MYOCARDIAL-INFARCTION | PERIPHERAL VASCULAR DISEASE | CONTROLLED CLINICAL-TRIALS | SILDENAFIL-CITRATE | SEXUAL-ACTIVITY | CORONARY-ARTERY-DISEASE | BLOOD-PRESSURE | Myocardial Infarction - mortality | Isosorbide Dinitrate - analogs & derivatives | Phosphodiesterase Inhibitors - adverse effects | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Imidazoles - chemistry | Sulfones - adverse effects | Endothelium, Vascular - drug effects | Male | Piperazines - chemistry | Nitroglycerin - pharmacology | Sildenafil Citrate | Purines | Carbolines - chemistry | Drug Interactions | Imidazoles - therapeutic use | Triazines - pharmacology | Imidazoles - adverse effects | Imidazoles - pharmacology | Piperazines - therapeutic use | Arteriosclerosis - complications | Piperazines - adverse effects | Piperazines - pharmacology | Tadalafil | Cyclic GMP - metabolism | Vardenafil Dihydrochloride | Triazines - adverse effects | Vasodilation - drug effects | Myocardial Infarction - chemically induced | Phosphodiesterase Inhibitors - therapeutic use | Sulfones - therapeutic use | Triazines - therapeutic use | Vasodilator Agents - therapeutic use | Adrenergic alpha-Antagonists - pharmacology | Sulfones - pharmacology | Contraindications | Heart Rate - drug effects | Erectile Dysfunction - drug therapy | Sulfones - chemistry | Coronary Disease - complications | Triazines - chemistry | Blood Pressure - drug effects | Molecular Structure | Nitric Oxide Donors - pharmacology | Phosphodiesterase Inhibitors - chemistry | Carbolines - therapeutic use | Carbolines - adverse effects | Vasodilator Agents - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Phosphoric Diester Hydrolases - drug effects | Hypotension - chemically induced | Isosorbide Dinitrate - pharmacology | Randomized Controlled Trials as Topic | 3',5'-Cyclic-GMP Phosphodiesterases | Vasodilator Agents - chemistry | Vasodilator Agents - adverse effects | Carbolines - pharmacology
Journal Article
Journal Article