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Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2017, Volume 314, pp. 39 - 47
The farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays important roles in regulating bile acid homeostasis. The aim of the... 
Inflammation | Farnesoid X receptor (FXR) | Acute liver injury | Obeticholic acid | Carbon tetrachloride (CCl4) | Carbon tetrachloride (CCl | FIBROSIS | HEPATOCYTE APOPTOSIS | STELLATE CELLS | NECROSIS-FACTOR-ALPHA | NONALCOHOLIC STEATOHEPATITIS | MECHANISMS | FAILURE | HEPATIC INFLAMMATION | FARNESOID-X-RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | AGONIST | Chemical and Drug Induced Liver Injury - prevention & control | Apoptosis - drug effects | Male | Alanine Transaminase - blood | Carbon Tetrachloride Poisoning - complications | Extracellular Signal-Regulated MAP Kinases - metabolism | Carbon Tetrachloride Poisoning - prevention & control | Inflammation - etiology | Chenodeoxycholic Acid - analogs & derivatives | Animals | Chemical and Drug Induced Liver Injury - complications | Chenodeoxycholic Acid - pharmacology | Hepatocytes - chemistry | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Hepatocytes - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Bile acids | Liver | Analysis | Carbon tetrachloride | Index Medicus | APOPTOSIS | TRANSLOCATION | PHOSPHORYLATION | 60 APPLIED LIFE SCIENCES | NECROSIS | LIGANDS | GENES | LIVER CELLS | MICE | BILE | TRANSCRIPTION FACTORS | HOMEOSTASIS | CARBON | INJURIES | LABELLING | NEOPLASMS | MACROPHAGES | TRANSCRIPTION | MONOCYTES | LYMPHOKINES | CARBON TETRACHLORIDE | INFLAMMATION | LIVER | PHOSPHOTRANSFERASES | RECEPTORS | BILE ACIDS
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2013, Volume 191, Issue 4, pp. 1835 - 1844
Liver fibrosis is a severe, life-threatening clinical condition resulting from nonresolving hepatitis of different origins. IL-17A is critical in inflammation,... 
NEUTROPHIL INFILTRATION | TGF-BETA | INTERLEUKIN-17 | PULMONARY INFLAMMATION | ALLERGIC-ASTHMA | DISEASE | SMOOTH-MUSCLE-CELLS | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | T-CELLS | MAP Kinase Signaling System - physiology | Humans | Middle Aged | Interleukin-17 - physiology | Hepatic Stellate Cells - metabolism | Male | Interleukin-17 - pharmacology | Transforming Growth Factor beta - biosynthesis | Hepatectomy | Receptors, Interleukin-17 - deficiency | Hepatitis, Animal - metabolism | Th17 Cells - metabolism | Carcinoma, Hepatocellular - chemistry | Collagen - biosynthesis | Cytokines - genetics | Hepatitis, Animal - pathology | Hemangioma - surgery | Liver Cirrhosis - complications | Interleukin-17 - genetics | Hemangioma - chemistry | Mice, Knockout | Chemical and Drug Induced Liver Injury - metabolism | Liver Cirrhosis - pathology | Th17 Cells - immunology | Mice | Interleukin-17 - analysis | Carbon Tetrachloride Poisoning - complications | Liver Neoplasms - chemistry | Actins - genetics | Liver Cirrhosis - metabolism | Adult | Female | Carcinoma, Hepatocellular - etiology | Collagen - genetics | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Hepatic Stellate Cells - pathology | Hepatitis, Animal - chemically induced | Liver Cirrhosis - etiology | Actins - biosynthesis | Gene Expression Regulation - immunology | Neutrophils - physiology | Carcinoma, Hepatocellular - surgery | Liver Neoplasms - surgery | Interleukin-17 - biosynthesis | Recombinant Proteins - pharmacology | Gene Expression Regulation - drug effects | Animals | Hepatitis B, Chronic - complications | MAP Kinase Signaling System - drug effects | Transforming Growth Factor beta - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - analysis | Protein Kinase Inhibitors - pharmacology | Cytokines - biosynthesis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0121365 - e0121365
Carbon tetrachloride (CCl4) is widely used as an animal model of hepatotoxicity and the mechanisms have been arduously studied, however, the contribution of... 
OXIDATIVE STRESS | LIPID-PEROXIDATION | INDUCED APOPTOSIS | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CHEMICAL SYMPATHECTOMY | GENE-EXPRESSION | KUPFFER CELLS | MOUSE-LIVER | HEPATIC STEATOSIS | INDUCED LIVER-INJURY | Carbon Tetrachloride Poisoning - drug therapy | Chemokines - blood | Liver - pathology | Systemic Inflammatory Response Syndrome - physiopathology | Mice, Inbred C57BL | Male | Carbon Tetrachloride Poisoning - complications | Sympathetic Nervous System - physiopathology | Chemokine CCL2 - blood | Carbon Tetrachloride Poisoning - blood | Dexamethasone - therapeutic use | Systemic Inflammatory Response Syndrome - blood | Animals | Systemic Inflammatory Response Syndrome - etiology | Transaminases - blood | Carbon Tetrachloride Poisoning - physiopathology | Mice | Systemic Inflammatory Response Syndrome - drug therapy | Alkaline Phosphatase - blood | Cytokines - blood | Inflammation | Analysis | Liver | Carbon tetrachloride | Neurophysiology | Alkaline phosphatase | Pathogenesis | Interleukin | Lipid peroxidation | Inflammatory response | Nervous system | Eotaxin | Metastases | Interleukin 6 | Granulocyte colony-stimulating factor | Rodents | Hepatology | Gastroenterology | Colony-stimulating factor | Pretreatment | Hepatotoxicity | Drug dosages | Peroxidation | Medical research | Immune response | Dexamethasone | Cytokines | Internal medicine | 6-Hydroxydopamine | Interleukin 12 | Gene expression | Sympathetic nervous system | CCL4 protein | Immune systems | Medicine | Pathology | Injury prevention | Hospitals | FasL protein | Monocyte chemoattractant protein | Infiltration | Intoxication | Leukocytes (granulocytic) | Laboratory animals | Chemokines | Monocyte chemoattractant protein 1 | Denervation | Index Medicus
Journal Article
Journal Article
Journal Article
Phytomedicine, ISSN 0944-7113, 2010, Volume 17, Issue 3, pp. 282 - 288
This study was carried out to investigate whether rosmarinic acid (RA) has antifibrotic effect on experimental liver fibrosis and its possible mechanism.... 
Connective transforming growth factor | In vivo | Rosmarinic acid | Liver fibrosis | Transforming growth factor-β1 | In vitro | CHEMISTRY, MEDICINAL | TGF-BETA | ANGIOGENESIS | RAT | MARKERS | HYALURONAN | PLANT SCIENCES | HEPATIC STELLATE CELLS | TISSUE GROWTH-FACTOR | INTEGRATIVE & COMPLEMENTARY MEDICINE | Transforming growth factor-beta 1 | PHARMACOLOGY & PHARMACY | EXPRESSION | Carbon Tetrachloride Poisoning - drug therapy | Liver - pathology | Transforming Growth Factor beta1 - antagonists & inhibitors | Plant Extracts - pharmacology | Actins - metabolism | Male | Carbon Tetrachloride Poisoning - complications | Depsides - pharmacology | Liver - drug effects | Depsides - therapeutic use | Liver Cirrhosis - metabolism | Phytotherapy | Disease Models, Animal | Hepatic Stellate Cells - drug effects | Liver Cirrhosis - drug therapy | Liver Cirrhosis - etiology | Connective Tissue Growth Factor - antagonists & inhibitors | Liver - metabolism | Cells, Cultured | Rats | Antioxidants - pharmacology | Cinnamates - pharmacology | Rats, Sprague-Dawley | Antioxidants - therapeutic use | Animals | Cell Proliferation - drug effects | Cinnamates - therapeutic use | Plant Extracts - therapeutic use | Care and treatment | Polyvinylidene fluoride | Tumor necrosis factor | Carbon tetrachloride | Research | Hyaluronic acid | Health aspects | Liver cirrhosis | Enzyme-linked immunosorbent assay | Index Medicus
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2005, Volume 96, Issue 3, pp. 529 - 535
In the present study, we investigated the protective effect of Miller (Solanaceae) fruit (LFE) against CCl -induced hepatotoxicity and the mechanism underlying... 
CCl 4 | Cytochrome P450 2E1 (CYP2E1) | Antioxidative activity | Hepatoprotection | Fruit | Lycium chinense | CCl 4-Induced hepatotoxicity | Induced hepatotoxicity | CCl | CCl4-induced hepatotoxicity | cytochrome P450 2E1 (CYP2E1) | CHEMISTRY, MEDICINAL | ACID | fruit | RATS | PREVENTION | HUMAN LIVER-MICROSOMES | HEPATIC-INJURY | PLANT SCIENCES | INHIBITION | CYTOCHROME-P450 2E1 EXPRESSION | METABOLISM | INTEGRATIVE & COMPLEMENTARY MEDICINE | CCl4 | PHARMACOLOGY & PHARMACY | antioxidative activity | MICE | hepatoprotection | Free Radical Scavengers - pharmacology | Liver - pathology | Glutathione - metabolism | Plant Extracts - pharmacology | Alkaline Phosphatase - metabolism | Male | Carbon Tetrachloride Poisoning - complications | Cytochrome P-450 CYP2E1 - metabolism | Carbon Tetrachloride Poisoning - prevention & control | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Liver - drug effects | Lipid Peroxidation - drug effects | Superoxides - metabolism | Chemical and Drug Induced Liver Injury - etiology | Chemical and Drug Induced Liver Injury - prevention & control | Lycium | Liver - metabolism | Rats | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Aspartate Aminotransferases - metabolism | Catalase - metabolism | Animals | Alanine Transaminase - metabolism | Alanine | Hydroxides | Phosphatases | RNA | Analysis | Medicine, Botanic | Carbon tetrachloride | Cytochrome P-450 | Aspartate | Medicine, Herbal | Glutathione | Index Medicus
Journal Article
Journal of Applied Toxicology, ISSN 0260-437X, 03/2008, Volume 28, Issue 2, pp. 147 - 155
The importance of hydroxyl groups in the antioxidant and hepatoprotective properties of resveratrol was investigated. To achieve this, resveratrol or its... 
liver injury | necrosis | inflammation | glutathione | carbon tetrachloride | resveratrol | lipid peroxidation | resveratrol analogs | liver damage |