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European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2018, Volume 151, pp. 363 - 375
Two series of 2-benzylpiperazines have been prepared and tested for the inhibition of physiologically relevant isoforms of human carbonic anhydrases (hCA, EC... 
Glaucoma | Enzyme inhibitors | Carbonic anhydrase | Enantioselectivity | Piperazine | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | SULFONAMIDES | MOIETIES | DISCOVERY | BENZENESULFONAMIDES | GENERATION | DERIVATIVES | TOOL | Intraocular Pressure - drug effects | Carbonic Anhydrase Inhibitors - chemistry | Stereoisomerism | Humans | Carbonic Anhydrase II - metabolism | Crystallography, X-Ray | Male | Piperazines - chemistry | Carbonic Anhydrase I - metabolism | Carbonic Anhydrases - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Carbonic Anhydrases - metabolism | Carbonic Anhydrase IV - metabolism | Carbonic Anhydrase IX - metabolism | Glaucoma - metabolism | Glaucoma - physiopathology | Carbonic Anhydrase Inhibitors - therapeutic use | Carbonic Anhydrase IX - antagonists & inhibitors | Rabbits | Glaucoma - drug therapy | Carbonic Anhydrase Inhibitors - chemical synthesis | Piperazines - therapeutic use | Carbonic Anhydrase I - chemistry | Carbonic Anhydrase Inhibitors - pharmacology | Piperazines - pharmacology | Animals | Carbonic Anhydrase IV - chemistry | Carbonic Anhydrase I - antagonists & inhibitors | Carbonic Anhydrase IX - chemistry | Piperazines - chemical synthesis | Molecular Docking Simulation | Carbonic Anhydrase IV - antagonists & inhibitors | Carbonic Anhydrase II - chemistry | Benzylpiperazine | Functional foods | Analysis | Enantiomers | Nitrogen
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Journal Article
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European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 521 - 530
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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2014, Volume 22, Issue 13, pp. 3537 - 3543
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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3592 - 3602
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Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 11/2016, Volume 31, Issue sup2, pp. 79 - 85
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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2017, Volume 25, Issue 12, pp. 3093 - 3097
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