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physical sciences (352) 352
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biological and medical sciences (286) 286
dose-response relationship, drug (273) 273
enzymes (260) 260
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sulfonamides (242) 242
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isoenzymes - antagonists & inhibitors (203) 203
sulfonamide (192) 192
chemistry, organic (190) 190
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models, molecular (180) 180
isoenzymes - metabolism (161) 161
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drug design (142) 142
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kinetics (138) 138
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proteins (127) 127
antigens, neoplasm - metabolism (126) 126
protein binding (119) 119
carbonic anhydrase inhibitors (114) 114
tumors (114) 114
carbon dioxide (113) 113
enzyme inhibition (112) 112
chemistry, multidisciplinary (109) 109
binding sites (103) 103
mice (103) 103
antineoplastic agents - pharmacology (102) 102
hypoxia (102) 102
inhibitors (102) 102
crystallography, x-ray (100) 100
organic chemistry (99) 99
therapeutics. pharmacology (97) 97
carbonic anhydrase ii - chemistry (93) 93
male (93) 93
carbonic anhydrase inhibitors - metabolism (92) 92
ligands (90) 90
antineoplastic agents - chemistry (89) 89
inhibition (89) 89
antineoplastic agents - chemical synthesis (88) 88
carbonic anhydrases - genetics (85) 85
fundamental and applied biological sciences. psychology (85) 85
cattle (82) 82
isoforms (81) 81
miscellaneous (80) 80
life sciences (75) 75
amino acid sequence (74) 74
molecular docking simulation (74) 74
acetylcholinesterase (73) 73
inhibitor (73) 73
acetazolamide (72) 72
gene expression (72) 72
glaucoma (72) 72
physiology (72) 72
hydrogen-ion concentration (71) 71
research paper (71) 71
antigens, neoplasm - chemistry (70) 70
research article (70) 70
cell line, tumor (69) 69
erythrocytes - enzymology (69) 69
carbonic anhydrases (68) 68
molecular sequence data (66) 66
neoplasms - enzymology (66) 66
carbonic anhydrases - drug effects (65) 65
female (65) 65
metabolism (65) 65
research (65) 65
cell biology (64) 64
isoenzymes - chemistry (64) 64
rabbits (64) 64
biology (62) 62
medicine (62) 62
synthesis (62) 62
carbonic anhydrase ix - metabolism (61) 61
science & technology - other topics (61) 61
carbonic anhydrase ix - antagonists & inhibitors (60) 60
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1. Full Text Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases
by Del Prete, Sonia and Vullo, Daniela and Fisher, Gillian M and Andrews, Katherine T and Poulsen, Sally-Ann and Capasso, Clemente and Supuran, Claudiu T
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 09/2014, Volume 24, Issue 18, pp. 4389 - 4396
η-CA-class enzyme | Plasmodium falciparum | Inhibitor | Carbonic anhydrase | Anion | Plasmodium falciparum - enzymology | Amino Acid Sequence | Carbonic Anhydrase Inhibitors - chemistry | Humans | Molecular Sequence Data | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Phylogeny | Zinc - chemistry | Drug Discovery | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Sequence Alignment | Isoenzymes - metabolism | Organometallic Compounds - chemical synthesis | Organometallic Compounds - chemistry | Plasmodium falciparum - metabolism | Molecular Structure | Isoenzymes - antagonists & inhibitors | Organometallic Compounds - pharmacology | Index Medicus
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2. Full Text Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
by Capasso, Clemente and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 6/2014, Volume 29, Issue 3, pp. 379 - 387
carbonic anhydrase | Antibacterial | dihydropteroate synthase | sulfa drug | trimethoprim | dihydrofolate reductase | Trimethoprim | Dihydropteroate synthase | Sulfa drug | Dihydrofolate reductase | Carbonic anhydrase | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Trimethoprim - chemical synthesis | Bacterial Proteins - antagonists & inhibitors | Trimethoprim - pharmacology | Tetrahydrofolate Dehydrogenase - chemistry | Antimetabolites - chemical synthesis | Dihydropteroate Synthase - antagonists & inhibitors | Bacteria - drug effects | Bacterial Proteins - chemistry | Enzyme Inhibitors - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Enzyme Inhibitors - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Trimethoprim - analogs & derivatives | Dihydropteroate Synthase - chemistry | Bacteria - enzymology | Anti-Bacterial Agents - pharmacology | Folic Acid Antagonists - chemical synthesis | Sulfanilamides - chemical synthesis | Folic Acid Antagonists - pharmacology | Antimetabolites - pharmacology | Sulfanilamides - pharmacology | Index Medicus
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3. Full Text Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
by Özbey, Fadime and Taslimi, Parham and Gülçin, İlhami and Maraş, Ahmet and Göksu, Süleyman and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 11/2016, Volume 31, Issue sup2, pp. 79 - 85
carbonic anhydrase | butyrylcholinesterase | enzyme inhibition | Acetylcholinesterase | diaryl ethers | Ethers - chemical synthesis | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Ethers - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Isoenzymes - isolation & purification | Dose-Response Relationship, Drug | Ethers - pharmacology | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Carbonic Anhydrase I - antagonists & inhibitors | Isoenzymes - metabolism | Carbonic Anhydrase I - isolation & purification | Molecular Structure | Carbonic Anhydrase II - isolation & purification | Acetylcholinesterase - metabolism | Isoenzymes - antagonists & inhibitors | Index Medicus
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4. Full Text Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
by Turkan, Fikret and Cetin, Adnan and Taslimi, Parham and Karaman, Muhammet and Gulçin, İlhami
Bioorganic chemistry, ISSN 0045-2068, 05/2019, Volume 86, pp. 420 - 427
Substituted pyrazole | Enzyme inhibition | Carbonic anhydrase | Acetylcholinesterase | Carbonic Anhydrase Inhibitors - chemistry | Pyrazoles - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Electrophorus | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Dose-Response Relationship, Drug | Pyrazoles - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Carbonic Anhydrase I - antagonists & inhibitors | Carbonic Anhydrase I - isolation & purification | Molecular Docking Simulation | Molecular Structure | Acetylcholinesterase - metabolism | Pyrazoles - pharmacology | Nuclear magnetic resonance spectroscopy | Enzyme inhibitors | Molecular biology | Analysis | Index Medicus
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5. Full Text Structure-based drug discovery of carbonic anhydrase inhibitors
by Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 12/2012, Volume 27, Issue 6, pp. 759 - 772
sulphonamide | x-ray crystallography | imaging of hypoxic tumours | Carbonic anhydrase | glaucoma | anti-cancer agent | dithiocarbamate | Glaucoma | X-ray crystallography | Anti-cancer agent | Dithiocarbamate | Sulphonamide | Imaging of hypoxic tumours | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Fungal Proteins - chemistry | Anti-Infective Agents - pharmacology | Humans | Bacteria - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Fungal Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Carbonic Anhydrases - metabolism | Bacteria - growth & development | Thiocarbamates - pharmacology | Isoenzymes - metabolism | Fungi - growth & development | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Fungi - drug effects | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Sulfonamides - pharmacology | Drug Discovery | Anti-Infective Agents - chemical synthesis | Sulfonamides - chemical synthesis | Thiocarbamates - chemical synthesis | Bacterial Proteins - metabolism | Molecular Docking Simulation | Isoenzymes - antagonists & inhibitors | Fungal Proteins - metabolism | Index Medicus
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6. Full Text Carbonic anhydrase inhibitors: The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors
by Nishimori, Isao and Minakuchi, Tomoko and Kohsaki, Takuhiro and Onishi, Saburo and Takeuchi, Hiroaki and Vullo, Daniela and Scozzafava, Andrea and Supuran, Claudiu T
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2007, Volume 17, Issue 13, pp. 3585 - 3594
Sulfonamide | Carbonic anhydrase | Helicobacter pylori | Sulfamate | Enzyme inhibitor | β-class enzyme | Catalytic/inhibition mechanism | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Antibacterial agents | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Recombinant Proteins - metabolism | Amino Acid Sequence | Chemistry, Pharmaceutical - methods | Sulfonamides - antagonists & inhibitors | Sulfonamides - chemistry | Humans | Enzyme Inhibitors - pharmacology | Stomach Ulcer - drug therapy | Molecular Sequence Data | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Stomach Neoplasms - drug therapy | Carbonic Anhydrases - chemistry | Enzyme Inhibitors - chemical synthesis | Sequence Homology, Amino Acid | Helicobacter pylori - enzymology | Cloning, Molecular | Drug Design | Index Medicus
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7. Full Text The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes
by Bayrak, Çetin and Taslimi, Parham and Gülçin, İlhami and Menzek, Abdullah
Bioorganic chemistry, ISSN 0045-2068, 06/2017, Volume 72, pp. 359 - 366
Bromophenols | Carbonic anhydrase | Bromination | Natural products | Enzyme inhibition | Phenylbutenone | Acetylcholinesterase | Butyrylcholinesterase | Phenols - chemical synthesis | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Biological Products - pharmacology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase I - metabolism | Butanones - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Dose-Response Relationship, Drug | Butanones - chemical synthesis | Butyrylcholinesterase - metabolism | Molecular Structure | Phenols - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Butanones - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Cholinesterase Inhibitors - pharmacology | Carbonic Anhydrase I - antagonists & inhibitors | Phenols - chemistry | Acetylcholinesterase - metabolism | Enzymes | Isoenzymes | Biological products | Index Medicus
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8. Full Text Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases
by Tars, Kaspars and Vullo, Daniela and Kazaks, Andris and Leitans, Janis and Lends, Alons and Grandane, Aiga and Zalubovskis, Raivis and Scozzafava, Andrea and Supuran, Claudiu T
Journal of medicinal chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 293 - 300
Carbonic Anhydrase Inhibitors - chemistry | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Coumarins - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Triazoles - chemical synthesis | Molecular Structure | Carbonic Anhydrase IX | Catalytic Domain | Click Chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase I - chemistry | Antineoplastic Agents - chemistry | Hydrolysis | Carbonic Anhydrase I - antagonists & inhibitors | Coumarins - chemical synthesis | Protein Binding | Isoenzymes - antagonists & inhibitors | Carbonic Anhydrase II - chemistry | Index Medicus
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9. Full Text Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies
by Mollica, Adriano and Costante, Roberto and Akdemir, Atilla and Carradori, Simone and Stefanucci, Azzurra and Macedonio, Giorgia and Ceruso, Mariangela and Supuran, Claudiu T
Bioorganic & medicinal chemistry, ISSN 0968-0896, 09/2015, Volume 23, Issue 17, pp. 5311 - 5318
Selective carbonic anhydrase IX inhibitors | Selective carbonic anhydrase XII inhibitors | Molecular modeling | Tertiary sulfonamides | Probenecid | Catalytic Domain | Carbonic Anhydrase Inhibitors - chemistry | Humans | Probenecid - pharmacology | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase I - chemistry | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Carbonic Anhydrases - metabolism | Carbonic Anhydrase I - antagonists & inhibitors | Probenecid - analogs & derivatives | Antigens, Neoplasm - metabolism | Probenecid - chemical synthesis | Molecular Docking Simulation | Carbonic Anhydrase II - chemistry | Carbonic Anhydrase IX | Drugstores | Amino acids | Sulfonamides | Analysis | Pharmacy | Index Medicus
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10. Full Text Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors
by Angeli, Andrea and Carta, Fabrizio and Bartolucci, Gianluca and Supuran, Claudiu T
Bioorganic & medicinal chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 13, pp. 3567 - 3573
Inhibitors | Selenium | Acylseleno-urea | Carbonic anhydrase | Metalloenzymes | Carbonic Anhydrase IX - antagonists & inhibitors | Organoselenium Compounds - chemical synthesis | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Sulfonamides - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Sulfonamides - chemical synthesis | Carbonic Anhydrase I - antagonists & inhibitors | Antigens, Neoplasm - metabolism | Carbonic Anhydrase IX - metabolism | Molecular Structure | Antioxidants | Glaucoma | Enzyme inhibitors | Epilepsy | Index Medicus
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11. Full Text Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
by Abdoli, Morteza and Angeli, Andrea and Bozdag, Murat and Carta, Fabrizio and Kakanejadifard, Ali and Saeidian, Hamid and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 01/2017, Volume 32, Issue 1, pp. 1071 - 1078
Carbonic anhydrase | inhibitor | sulfonamide | scaffold | benzo[d]thiazole | Carbonic Anhydrase IX - antagonists & inhibitors | Sulfonamides - chemistry | Benzothiazoles - pharmacology | Carbonic Anhydrase Inhibitors - chemistry | Humans | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Sulfonamides - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Sulfonamides - chemical synthesis | Benzothiazoles - chemical synthesis | Carbonic Anhydrase I - antagonists & inhibitors | Benzothiazoles - chemistry | Carbonic Anhydrase IX - metabolism | Molecular Structure | Carbonic anhydrase I | Sulfonamides | Investigations | Isoforms | Index Medicus
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12. Full Text Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities
by Garibov, Emin and Taslimi, Parham and Sujayev, Afsun and Bingol, Zeynebe and Çetinkaya, Songul and Gulçin, İlhami and Beydemir, Sukru and Farzaliyev, Vagif and Alwasel, Saleh H and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 11/2016, Volume 31, Issue sup3, pp. 1 - 9
carbonic anhydrase | butyrylcholinesterase | enzyme inhibition | Acetylcholinesterase | antioxidant activity | Antioxidants - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Carbonic Anhydrase Inhibitors - pharmacology | Pyrimidines - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Carbonic Anhydrase I - antagonists & inhibitors | Molecular Structure | Acetylcholinesterase - metabolism | Index Medicus
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13. Full Text The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
by Bayrak, Cetin and Taslimi, Parham and Karaman, Halide Sedef and Gulcin, Ilhami and Menzek, Abdullah
Bioorganic chemistry, ISSN 0045-2068, 04/2019, Volume 85, pp. 128 - 139
Enzyme inhibition | Carbonic anhydrase | Acetylcholinesterase | Bromination | Bromophenol | Molecular docking | Bromobenzenes - chemical synthesis | Cholinesterase Inhibitors - pharmacokinetics | Carbonic Anhydrase Inhibitors - pharmacokinetics | Cholinergic Antagonists - chemical synthesis | Biological Products - pharmacokinetics | Phenols - chemical synthesis | Humans | Carbonic Anhydrase II - metabolism | Cholinesterase Inhibitors - chemical synthesis | Carbonic Anhydrase I - metabolism | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Cholinergic Antagonists - pharmacokinetics | Bromobenzenes - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Phenols - metabolism | Bromobenzenes - pharmacokinetics | Cholinergic Antagonists - metabolism | Biological Products - chemical synthesis | Phenols - pharmacokinetics | Biological Products - metabolism | Protein Binding | Molecular Docking Simulation | Carbonic Anhydrase Inhibitors - metabolism | Acetylcholinesterase - metabolism | Carbonic Anhydrase II - chemistry | Hydroxides | Isoenzymes | Benzene | Resveratrol | Index Medicus
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14. Full Text Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies
by Eldehna, Wagdy M and Al-Ansary, Ghada H and Bua, Silvia and Nocentini, Alessio and Gratteri, Paola and Altoukhy, Ayman and Ghabbour, Hazem and Ahmed, Hanaa Y and Supuran, Claudiu T
European journal of medicinal chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 521 - 530
Synthesis | Carbonic anhydrase | 4-(2-Aminoethyl)benzenesulfonamide | Isatin | Catalytic Domain | Chemistry Techniques, Synthetic | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Carbonic Anhydrase Inhibitors - chemical synthesis | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Sulfonamides - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Carbonic Anhydrases - metabolism | Sulfonamides - chemical synthesis | Carbonic Anhydrase I - antagonists & inhibitors | Isoenzymes - metabolism | Drug Design | Sulfonamides - metabolism | Molecular Docking Simulation | Carbonic Anhydrase IV - antagonists & inhibitors | Carbonic Anhydrase Inhibitors - metabolism | Indoles - chemistry | Isoenzymes - antagonists & inhibitors | Drugstores | Genetic engineering | Functional foods | Sulfonamides | Pharmacy | Analysis | Index Medicus
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