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1. Full Text Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases
by Del Prete, Sonia and Vullo, Daniela and Fisher, Gillian M and Andrews, Katherine T and Poulsen, Sally-Ann and Capasso, Clemente and Supuran, Claudiu T
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2014, Volume 24, Issue 18, pp. 4389 - 4396
The genome of the protozoan parasite , the causative agent of the most lethal type of human malaria, contains a single gene annotated as encoding a carbonic... 
η-CA-class enzyme | Plasmodium falciparum | Inhibitor | Carbonic anhydrase | Anion | Plasmodium falciparum - enzymology | Amino Acid Sequence | Carbonic Anhydrase Inhibitors - chemistry | Humans | Molecular Sequence Data | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Phylogeny | Zinc - chemistry | Drug Discovery | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Sequence Alignment | Isoenzymes - metabolism | Organometallic Compounds - chemical synthesis | Organometallic Compounds - chemistry | Plasmodium falciparum - metabolism | Molecular Structure | Isoenzymes - antagonists & inhibitors | Organometallic Compounds - pharmacology
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2. Full Text Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
by Capasso, Clemente and Supuran, Claudiu T
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 6/2014, Volume 29, Issue 3, pp. 379 - 387
Abstract Recent advances in microbial genomics, synthetic organic chemistry and X-ray crystallography provided opportunities to identify novel antibacterial... 
carbonic anhydrase | Antibacterial | dihydropteroate synthase | sulfa drug | trimethoprim | dihydrofolate reductase | Trimethoprim | Dihydropteroate synthase | Sulfa drug | Dihydrofolate reductase | Carbonic anhydrase | HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHATE | CHEMISTRY, MEDICINAL | BACTERIUM VIBRIO-CHOLERAE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SULFONAMIDE RESISTANCE | ATMOSPHERIC CO2 | SOIL-MICROORGANISMS | PLASMODIUM-FALCIPARUM | STAPHYLOCOCCUS-AUREUS | HELICOBACTER-PYLORI | ENZYMATIC SYNTHESIS | Trimethoprim - chemical synthesis | Bacterial Proteins - antagonists & inhibitors | Trimethoprim - pharmacology | Tetrahydrofolate Dehydrogenase - chemistry | Antimetabolites - chemical synthesis | Dihydropteroate Synthase - antagonists & inhibitors | Bacteria - drug effects | Bacterial Proteins - chemistry | Enzyme Inhibitors - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Enzyme Inhibitors - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Trimethoprim - analogs & derivatives | Dihydropteroate Synthase - chemistry | Bacteria - enzymology | Anti-Bacterial Agents - pharmacology | Folic Acid Antagonists - chemical synthesis | Sulfanilamides - chemical synthesis | Folic Acid Antagonists - pharmacology | Antimetabolites - pharmacology | Sulfanilamides - pharmacology
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3. Full Text Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes inhibitors: The novel N,N′‐bis‐cyanomethylamine and alkoxymethylamine derivatives
by Taslimi, Parham and Caglayan, Cuneyt and Farzaliyev, Vagif and Nabiyev, Oruj and Sujayev, Afsun and Turkan, Fikret and Kaya, Ruya and Gulçin, İlhami
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 04/2018, Volume 32, Issue 4, pp. e22042 - n/a
During this investigation, N , N ′‐bis‐azidomethylamines, N , N ′‐bis‐cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to... 
carbonic anhydrase | bis‐cyanomethylamine | acetylcholinesterase | butyrylcholinesterase | enzyme inhibition | N,N′-bis-cyanomethylamine | PROFILES | ISOENZYMES I | (3,4-DIHYDROXYPHENYL)(2,3,4-TRIHYDROXYPHENYL)METHANONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N,N '-bis-cyanomethylamine | GLUCOSIDASE INHIBITORS | II INHIBITION | ERYTHROCYTES IN-VITRO | ANTIOXIDANT | HCA I | TOXICOLOGY | BROMOPHENOLS | ESTERASE | Glycoside Hydrolase Inhibitors - chemical synthesis | Animals | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Glycoside Hydrolase Inhibitors - chemistry | Laboratory tests | Enzymes | Inhibitors | Carbonic anhydrase | Isoenzymes | Diabetes mellitus | Isoforms | Acetylcholine receptors | Pharmacology | Carbonic anhydrase I | Derivatives | Acetylcholinesterase | Index Medicus
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4. Full Text Structure-based drug discovery of carbonic anhydrase inhibitors
by Supuran, Claudiu T
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 12/2012, Volume 27, Issue 6, pp. 759 - 772
Inhibition of the metalloenzyme carbonic anhydrase (CA; EC 4.2.1.1) has pharmacologic applications in the field of anti-glaucoma, anti-convulsant and... 
sulphonamide | x-ray crystallography | imaging of hypoxic tumours | Carbonic anhydrase | glaucoma | anti-cancer agent | dithiocarbamate | Glaucoma | X-ray crystallography | Anti-cancer agent | Dithiocarbamate | Sulphonamide | Imaging of hypoxic tumours | MYCOBACTERIUM-TUBERCULOSIS | INCORPORATING 1,3,5-TRIAZINE MOIETIES | CHEMISTRY, MEDICINAL | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC APPLICATIONS | CRYSTALLOGRAPHIC ANALYSIS | PH-DEPENDENT ACTIVITY | X-RAY | ISOZYME-II | CRYPTOCOCCUS-NEOFORMANS | Fungal Proteins - chemistry | Anti-Infective Agents - pharmacology | Humans | Bacteria - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Fungal Proteins - antagonists & inhibitors | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Carbonic Anhydrases - metabolism | Bacteria - growth & development | Thiocarbamates - pharmacology | Isoenzymes - metabolism | Fungi - growth & development | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Fungi - drug effects | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Sulfonamides - pharmacology | Drug Discovery | Anti-Infective Agents - chemical synthesis | Sulfonamides - chemical synthesis | Thiocarbamates - chemical synthesis | Bacterial Proteins - metabolism | Molecular Docking Simulation | Isoenzymes - antagonists & inhibitors | Fungal Proteins - metabolism
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5. Carbonic anhydrases - A overview
by Supuran, Claudiu T
Current Pharmaceutical Design, ISSN 1381-6128, 03/2008, Volume 14, Issue 7, pp. 603 - 614
Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread metalloenzymes all over the phylogenetic tree, with at least 4 distinct gene families encoding for them.... 
ARCHAEON METHANOSARCINA-THERMOPHILA | METHANOBACTERIUM-THERMOAUTOTROPHICUM | SULFAMATE INHIBITORS | ACTIVE-SITE | CRYSTAL-STRUCTURE | X-RAY | HUMAN ISOZYME-II | PHARMACOLOGY & PHARMACY | ISOFORM-II | HELICOBACTER-PYLORI | RAY CRYSTALLOGRAPHIC STRUCTURE | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrases - therapeutic use | Carbonic Anhydrases - chemistry | Anti-Obesity Agents - therapeutic use | Carbonic Anhydrases - metabolism | Antineoplastic Agents - metabolism | Animals | Anti-Obesity Agents - chemical synthesis | Carbonic Anhydrase Inhibitors - metabolism | Anti-Obesity Agents - metabolism | Carbonic Anhydrase Inhibitors - therapeutic use
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6. Full Text Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties
by Boztaş, Murat and Çetinkaya, Yasin and Topal, Meryem and Gülçin, Ilhami and Menzek, Abdullah and Şahin, Ertan and Tanc, Muhammet and Supuran, Claudiu T
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 2, pp. 640 - 650
Cyclopropylcarboxylic acids and esters and cyclopropylmethanols incorporating bromophenol moieties were investigated as inhibitors of the carbonic anhydrase... 
MYCOBACTERIUM-TUBERCULOSIS | ODONTHALIA-CORYMBIFERA | NMDA RECEPTOR ANTAGONISTS | THERAPEUTIC APPLICATIONS | BROMOPHENOL DERIVATIVES | CHEMISTRY, MEDICINAL | ENZYME-ACTIVITY | PHENOLIC-COMPOUNDS | SELECTIVE INHIBITORS | TROUT ONCORHYNCHUS-MYKISS | RED ALGA | Antigens, Neoplasm | Carbonic Anhydrase I - antagonists & inhibitors | Carbonic Anhydrases | Humans | Cyclopropanes | Crystallography, X-Ray | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Carbonic Anhydrase IX
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7. Full Text Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis
by Bua, Silvia and Di Cesare Mannelli, Lorenzo and Vullo, Daniela and Ghelardini, Carla and Bartolucci, Gianluca and Scozzafava, Andrea and Supuran, Claudiu T and Carta, Fabrizio
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2017, Volume 60, Issue 3, pp. 1159 - 1170
We report the synthesis of a series of hybrid compounds incorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with... 
ISOFORMS IX | CHEMISTRY, MEDICINAL | DISEASES | MECHANISM | TRANSMEMBRANE | SELECTIVE INHIBITORS | XII | COUMARINS | NEUROPEPTIDES | TH17 CELLS | Analgesics - therapeutic use | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Arthritis, Rheumatoid - drug therapy | Carbonic Anhydrase Inhibitors - chemistry | Humans | Drug Design | Rats | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Carbonic Anhydrase Inhibitors - therapeutic use | Index Medicus
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8. Full Text Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): A class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases
by Tars, Kaspars and Vullo, Daniela and Kazaks, Andris and Leitans, Janis and Lends, Alons and Grandane, Aiga and Zalubovskis, Raivis and Scozzafava, Andrea and Supuran, Claudiu T
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 293 - 300
Coumarins were recently shown to constitute a novel class of mechanism-based carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. We demonstrate that sulfocoumarins... 
Carbonic Anhydrase Inhibitors - chemistry | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Coumarins - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Triazoles - chemical synthesis | Molecular Structure | Carbonic Anhydrase IX | Catalytic Domain | Click Chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase I - chemistry | Antineoplastic Agents - chemistry | Hydrolysis | Carbonic Anhydrase I - antagonists & inhibitors | Coumarins - chemical synthesis | Protein Binding | Isoenzymes - antagonists & inhibitors | Carbonic Anhydrase II - chemistry
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9. Full Text Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
by Özbey, Fadime and Taslimi, Parham and Gülçin, İlhami and Maraş, Ahmet and Göksu, Süleyman and Supuran, Claudiu T
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 11/2016, Volume 31, Issue sup2, pp. 79 - 85
A series of diaryl ethers were synthesized and their human (h) carbonic anhydrase (CA) isoenzymes hCA I and II, acetylcholinesterase (AChE), and... 
carbonic anhydrase | butyrylcholinesterase | enzyme inhibition | Acetylcholinesterase | diaryl ethers | CHEMISTRY, MEDICINAL | ENZYME-ACTIVITY | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOZYMES I | ERYTHROCYTES IN-VITRO | SULFONAMIDE DERIVATIVES | BROMOPHENOL DERIVATIVES | ANTIOXIDANT | ISOENZYMES HCA I | BIOLOGICAL EVALUATION | TROUT ONCORHYNCHUS-MYKISS | Ethers - chemical synthesis | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Ethers - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Isoenzymes - isolation & purification | Dose-Response Relationship, Drug | Ethers - pharmacology | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Carbonic Anhydrase I - antagonists & inhibitors | Isoenzymes - metabolism | Carbonic Anhydrase I - isolation & purification | Molecular Structure | Carbonic Anhydrase II - isolation & purification | Acetylcholinesterase - metabolism | Isoenzymes - antagonists & inhibitors
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10. Full Text Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: Novel sulfamoylcarbamates and sulfamides derived from acetophenones
by Akıncıoğlu, Hülya and Akıncıoğlu, Akın and Gülçin, İlhami and Durdagi, Serdar and Supuran, Claudiu T and Göksu, Süleyman
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3592 - 3602
In this study, several novel sulfamides were synthesized and evaluated for their acetylcholine esterase (AChE) and human carbonic anhydrase I, and II... 
Sulfamide | Acetylcholine esterase | Carbonic anhydrase | Enzyme inhibition | Sulfamoylcarbamate | Molecular docking | Hybrid molecules | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | PHENOLIC-COMPOUNDS | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | VITRO INHIBITION | ISOENZYMES INHIBITORS | ERYTHROCYTE ISOZYMES I | SULFONAMIDE DERIVATIVES | BIOLOGICAL EVALUATION | REDUCTIVE AMINATION | CHOLINESTERASE INHIBITOR | Isocyanates | Oxidation-Reduction | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Sulfonamides - chemical synthesis | Acetophenones - chemistry | Amination | Carbonic Anhydrase I - antagonists & inhibitors | Molecular Docking Simulation | Molecular Structure | Kinetics | Carbonic Anhydrase II - chemistry | Acetylcholine | Medicine, Experimental | Medical colleges | Medical research | Isoenzymes
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11. Full Text Synthesis, molecular modeling, and biological evaluation of 4‐[5‐aryl‐3‐(thiophen‐2‐yl)‐4,5‐dihydro‐1H‐pyrazol‐1‐yl] benzenesulfonamides toward acetylcholinesterase, carbonic anhydrase I and II enzymes
by Yamali, Cem and Gul, Halise Inci and Ece, Abdulilah and Taslimi, Parham and Gulcin, Ilhami
Chemical Biology & Drug Design, ISSN 1747-0277, 04/2018, Volume 91, Issue 4, pp. 854 - 866
In this study, 4‐[5‐aryl‐3‐(thiophen‐2‐yl)‐4,5‐dihydro‐1 H ‐pyrazol‐1‐yl] benzenesulfonamides were synthesized, and inhibition effects on AC hE, hCA I, and hCA... 
carbonic anhydrase | docking | acetylcholinesterase | modeling | pyrazoline | sulfonamide | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG CANDIDATES | PARAMETERS | ACCURATE DOCKING | AGENTS | INHIBITORS | DERIVATIVES | BIOACTIVITIES | MANNICH-BASES | Protein Structure, Tertiary | Sulfonamides - chemistry | Humans | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Carbonic Anhydrase I - metabolism | Pyrazoles - chemistry | Cholinesterase Inhibitors - metabolism | Hydrogen Bonding | Sulfonamides - metabolism | Molecular Docking Simulation | Carbonic Anhydrase Inhibitors - metabolism | Binding Sites | Acetylcholinesterase - metabolism | Carbonic Anhydrase II - chemistry | Enzymes | Analysis | Models
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12. Full Text Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors
by Touisni, Nadia and Maresca, Alfonso and McDonald, Paul C and Lou, Yuanmei and Scozzafava, Andrea and Dedhar, Shoukat and Winum, Jean-Yves and Supuran, Claudiu T
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 24, pp. 8271 - 8277
A series of 7-substituted coumarins incorporating various glycosyl moieties were synthesized and investigated for the inhibition of the zinc enzyme carbonic... 
THERAPEUTIC APPLICATIONS | CHEMISTRY, MEDICINAL | METASTASIS | TRANSMEMBRANE | ACTIVATORS | ISOZYME-IX | HYPOXIA | CANCER | EXPRESSION | BENZENE SULFONAMIDES | Carbonic Anhydrase Inhibitors - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Coumarins - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Carbonic Anhydrases - metabolism | Cell Hypoxia | Coumarins - pharmacology | Xenograft Model Antitumor Assays | Animals | Coumarins - chemical synthesis | Antigens, Neoplasm - metabolism | Female | Antineoplastic Agents - pharmacology | Mice | Mice, Inbred BALB C | Carbonic Anhydrase IX | Organic chemistry | Chemical Sciences
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13. Full Text Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives
by Güney, Murat and Coşkun, Ahmet and Topal, Fevzi and Daştan, Arif and Gülçin, İlhami and Supuran, Claudiu T
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2014, Volume 22, Issue 13, pp. 3537 - 3543
The oxidation of some cyanocycloheptatrienes with CrO and pyridine was investigated and a few new nitrile functionalised benzotropone derivatives were... 
Carbonic anhydrase inhibition | Oxidation | Nitrile-substituted drugs | Benzocycloheptatriene | Benzotropone | Rearrangement | CONVENIENT SYNTHESIS | ESTER ANALOGS | CYCLOADDITION REACTIONS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ERYTHROCYTE ISOZYMES I | SULFONAMIDE DERIVATIVES | ANTITUMOR AGENTS | THERAPEUTIC APPLICATIONS | SINGLET OXYGEN | ISOFORMS I | BICYCLIC ENDOPEROXIDES | Oxidation-Reduction | Carbonic Anhydrase Inhibitors - chemistry | Humans | Tropolone - analogs & derivatives | Carbonic Anhydrase II - metabolism | Models, Molecular | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Tropolone - chemical synthesis | Tropolone - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Photochemical Processes | Dose-Response Relationship, Drug | Carbonic Anhydrase I - antagonists & inhibitors | Isoenzymes - metabolism | Tropolone - chemistry | Molecular Structure | Isoenzymes - antagonists & inhibitors | Isoenzymes | Analysis | Chemical properties
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14. Full Text Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies
by Eldehna, Wagdy M and Abo-Ashour, Mahmoud F and Nocentini, Alessio and Gratteri, Paola and Eissa, Ibrahim H and Fares, Mohamed and Ismael, Omnia E and Ghabbour, Hazem A and Elaasser, Mahmoud M and Abdel-Aziz, Hatem A and Supuran, Claudiu T
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 250 - 262
Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino)benzenesulfonamides ( and ). All the... 
Carbonic anhydrase inhibitors | Anticancer | Isatin | Benzenesulfonamide | Apoptosis | DESIGN | CHEMISTRY, MEDICINAL | ANTIPROLIFERATIVE AGENTS | SULFONAMIDES | ANTITUMOR-ACTIVITY | VITRO BIOLOGICAL EVALUATION | THERAPEUTIC APPLICATIONS | ISOFORMS IX | POTENT | SELECTIVE INHIBITORS | XII | Caco-2 Cells | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Models, Molecular | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Sulfonamides - chemical synthesis | MCF-7 Cells | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Indoles - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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15. Full Text Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies
by Eldehna, Wagdy M and Al-Ansary, Ghada H and Bua, Silvia and Nocentini, Alessio and Gratteri, Paola and Altoukhy, Ayman and Ghabbour, Hazem and Ahmed, Hanaa Y and Supuran, Claudiu T
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 521 - 530
Herein we present the design, synthesis, and biological evaluation of three different series of novel sulfonamides ( , and ) incorporating substituted... 
Synthesis | Carbonic anhydrase | 4-(2-Aminoethyl)benzenesulfonamide | Isatin | DESIGN | CHEMISTRY, MEDICINAL | ISOZYMES IX | ACTIVATORS | MOIETIES | DISCOVERY | BENZENESULFONAMIDES | XII | AGENTS | DERIVATIVES | HYBRIDS | Catalytic Domain | Chemistry Techniques, Synthetic | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Carbonic Anhydrase Inhibitors - chemical synthesis | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Sulfonamides - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Carbonic Anhydrases - metabolism | Sulfonamides - chemical synthesis | Carbonic Anhydrase I - antagonists & inhibitors | Isoenzymes - metabolism | Drug Design | Sulfonamides - metabolism | Molecular Docking Simulation | Carbonic Anhydrase IV - antagonists & inhibitors | Carbonic Anhydrase Inhibitors - metabolism | Indoles - chemistry | Isoenzymes - antagonists & inhibitors | Drugstores | Genetic engineering | Functional foods | Sulfonamides | Pharmacy | Analysis
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