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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 35, pp. 9828 - 9833
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 38, pp. 16233 - 16238
Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme family, which is involved in solid tumor acidification. It is a marker of... 
Enzymes | Molecules | Active sites | Memory interference | Crystals | Cell adhesion | Hypoxia | Dimers | Crystal structure | Tumors | CA-IX | ISOZYMES | PROTEIN-TYROSINE-PHOSPHATASES | MULTIDISCIPLINARY SCIENCES | RESOLUTION | INTRACELLULAR PH | EXTRACELLULAR DOMAIN | E-CADHERIN | PROTON-TRANSFER | HYPOXIA | REFINED STRUCTURE | Protons | Carbon Dioxide - chemistry | Carbonic Anhydrases - genetics | Humans | Protein Multimerization | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrases - metabolism | Disulfides - chemistry | Enzyme Inhibitors - chemistry | Drug Design | Water - chemistry | Antigens, Neoplasm - metabolism | Bicarbonates - chemistry | Carbonic Anhydrase IX | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Antigens, Neoplasm - genetics | Catalytic Domain | Carbon Dioxide - metabolism | Enzyme Inhibitors - metabolism | Crystallization | Enzyme Inhibitors - pharmacology | Water - metabolism | Models, Molecular | Neoplasms - enzymology | Recombinant Proteins - chemistry | Neoplasms - drug therapy | Sequence Homology, Amino Acid | Bicarbonates - metabolism | Protein Conformation | Kinetics | Neoplasms - pathology | Hydrogen-Ion Concentration | Structure | Proteins | Membranes | Molecular structure | Chemical compounds | Cell adhesion & migration | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2008, Volume 283, Issue 41, pp. 27799 - 27809
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3988 - 4002
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary... 
CANCER-CELLS | INITIATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GENE SIGNATURE | CARBONIC-ANHYDRASE-IX | STEM-CELLS | STEM/PROGENITOR CELLS | SELF-RENEWAL | GROWTH-FACTOR | EXTRACELLULAR PH | IN-VITRO PROPAGATION | Carbonic Anhydrases - biosynthesis | Carcinoma, Ductal - genetics | Receptors, Notch - metabolism | Carbonic Anhydrases - genetics | Carcinoma, Ductal - pathology | Humans | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Serrate-Jagged Proteins | Female | Carcinoma, Ductal - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Carbonic Anhydrase IX | Jagged-1 Protein | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Calcium-Binding Proteins | Interleukin-6 - genetics | Neoplasm Invasiveness | Intercellular Signaling Peptides and Proteins | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Mammary Glands, Human - pathology | Up-Regulation - genetics | Autocrine Communication - genetics | Membrane Proteins | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Receptor, Notch3 | Cell Hypoxia - genetics | Breast cancer | Genetic aspects | Research | Gene expression | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
by Read, Betsy A and Kegel, Jessica and Klute, Mary J and Kuo, Alan and Lefebvre, Stephane C and Maumus, Florian and Mayer, Christoph and Miller, John and Monier, Adam and Salamov, Asaf and Young, Jeremy and Aguilar, Maria and Claverie, Jean-Michel and Frickenhaus, Stephan and Gonzalez, Karina and Herman, Emily K and Lin, Yao-Cheng and Napier, Johnathan and Ogata, Hiroyuki and Sarno, Analissa F and Shmutz, Jeremy and Schroeder, Declan and De Vargas, Colomban and Verret, Frederic and Von Dassow, Peter and Valentin, Klaus and Van De Peer, Yves and Wheeler, Glen and Dacks, Joel B and Delwiche, Charles F and Dyhrman, Sonya T and Glöckner, Gernot and John, Uwe and Richards, Thomas and Worden, Alexandra Z and Zhang, Xiaoyu and Grigoriev, Igor V and Allen, Andrew E and Bidle, Kay and Borodovsky, Mark and Bowler, Chris and Brownlee, Colin and Mark Cock, J and Elias, Marek and Gladyshev, Vadim N and Groth, Marco and Guda, Chittibabu and Hadaegh, Ahmad and Iglesias-Rodriguez, Maria Debora and Jenkins, Jerry and Jones, Bethan M and Lawson, Tracy and Leese, Florian and Lindquist, Erika and Lobanov, Alexei and Lomsadze, Alexandre and Malik, Shehre-Banoo and Marsh, Mary E and MacKinder, Luke and Mock, Thomas and Mueller-Roeber, Bernd and Pagarete, António and Parker, Micaela and Probert, Ian and Quesneville, Hadi and Raines, Christine and Rensing, Stefan A and Riaño-Pachón, Diego Mauricio and Richier, Sophie and Rokitta, Sebastian and Shiraiwa, Yoshihiro and Soanes, Darren M and Van Der Giezen, Mark and Wahlund, Thomas M and Williams, Bryony and Wilson, Willie and Wolfe, Gordon and Wurch, Louie L and Emiliania Huxleyi Annotation and Emiliania huxleyi Annotation Consortium and Joint Genome Institute (JGI)
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7457, pp. 209 - 213
Journal Article
Plant Physiology, ISSN 0032-0889, 10/2015, Volume 169, Issue 2, pp. 1168 - 1178
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2004, Volume 577, Issue 3, pp. 439 - 445
Acidic extracellular pH (pHe) is a typical attribute of a tumor microenviroment, which has an impact on cancer development and treatment outcome. It was... 
Hypoxia | Carbonic anhydrase IX | Sulfonamide | Tumor microenvironment | Acidosis | pHe, extracellular pH | ΔCA, deletion mutant of CA IX lacking the catalytic domain | CAI, carbonic anhydrase inhibitor | CA, carbonic anhydrase | ΔPG, deletion mutant of CA IX lacking the proteoglycan-like domain | AE, anion exchanger | HIF, hypoxia inducible factor | MAb, monoclonal antibody | LACTIC-ACID | hypoxia | BIOCHEMISTRY & MOLECULAR BIOLOGY | SULFONAMIDES | ISOZYME-IX | CELL-LINES | CANCER | CELL BIOLOGY | ADHESION | carbonic anhydrase IX | BIOPHYSICS | sulfonamide | acidosis | IN-VIVO | TRANSPORT METABOLON | tumor microenvironment | INHIBITORS | VHL | Sequence Deletion | Carbonic Anhydrases - genetics | Humans | Gene Expression Regulation, Neoplastic | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Biomarkers, Tumor | Carbonic Anhydrases - metabolism | Cell Hypoxia | Time Factors | Culture Media | Isoenzymes - metabolism | Enzyme Inhibitors - chemistry | Cloning, Molecular | Antigens, Neoplasm - metabolism | Molecular Structure | Carbonic Anhydrase IX | Protein Structure, Tertiary | Antigens, Neoplasm - genetics | Cell Line | Biotinylation | Acidosis - etiology | Sulfonamides - chemistry | Enzyme Inhibitors - pharmacology | Binding Sites - genetics | Sulfonamides - pharmacology | Precipitin Tests | Animals | Dogs | HeLa Cells | Antigens, Neoplasm - drug effects | Carbonic Anhydrases - drug effects | Hydrogen-Ion Concentration | Index Medicus
Journal Article