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Clinical cancer research, ISSN 1557-3265, 10/2008, Volume 14, Issue 20, pp. 6456 - 6468
Purpose: It was the aim of our study to establish an extensive panel of non-small cell lung cancer (NSCLC) xenograft models useful for the testing of novel... 
xenograft | NSCLC | erlotinib | mutational analysis | anti-EGFR therapy | cetuximab | biomarker | Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Large Cell - drug therapy | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Adenocarcinoma - pathology | Oligonucleotide Array Sequence Analysis | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Middle Aged | Drug Resistance, Neoplasm | Immunoblotting | Male | Gene Expression Profiling | Adenocarcinoma - metabolism | Biomarkers, Tumor - metabolism | Cetuximab | Disease Models, Animal | Genes, ras - genetics | Antibodies, Monoclonal - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | Etoposide - pharmacology | Mutation - genetics | Adenocarcinoma - drug therapy | Small Cell Lung Carcinoma - pathology | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Carboplatin - pharmacology | Quinazolines - pharmacology | Deoxycytidine - analogs & derivatives | Erlotinib Hydrochloride | Paclitaxel - pharmacology | Prognosis | Carcinoma, Squamous Cell - metabolism | Deoxycytidine - pharmacology | Lung Neoplasms - pathology | Small Cell Lung Carcinoma - drug therapy | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Vinblastine - analogs & derivatives | Polymerase Chain Reaction | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Radiation-Sensitizing Agents - pharmacology | Tumor Suppressor Protein p53 - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Protein Kinase Inhibitors - pharmacology | Vinblastine - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Antineoplastic Agents, Phytogenic - pharmacology | Index Medicus
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 05/2004, Volume 96, Issue 10, pp. 739 - 749
Background. Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients with metastatic breast cancers... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Up-Regulation | Cyclophosphamide - analogs & derivatives | Paclitaxel - pharmacology | Taxoids - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Receptor, ErbB-2 - metabolism | Deoxycytidine - pharmacology | Transplantation, Heterologous | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Vinblastine - analogs & derivatives | Female | Gene Expression Regulation, Neoplastic - drug effects | Receptor, ErbB-2 - drug effects | Disease Models, Animal | Floxuridine - pharmacology | Cell Survival - drug effects | Tumor Stem Cell Assay | Proto-Oncogene Proteins - drug effects | Enzyme-Linked Immunosorbent Assay | Antibodies, Monoclonal - pharmacology | Docetaxel | Breast Neoplasms - drug therapy | DNA, Neoplasm - drug effects | Guanine Nucleotide Exchange Factors | Drug Synergism | Animals | Mice, Nude | Cyclophosphamide - pharmacology | Cell Line, Tumor | Mice | Vinblastine - pharmacology | Carboplatin - pharmacology | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Trastuzumab | Vinorelbine | Epirubicin - pharmacology | Chemotherapy | Care and treatment | Breast cancer | Research | Health aspects | Drug therapy | Medical treatment | Index Medicus
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 0027-8874, 03/2012, Volume 104, Issue 6, pp. 476 - 487
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 05/2017, Volume 19, Issue 8, pp. 1669 - 1684
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established... 
lung cancer | histone methylation | taxane-platin chemotherapy | JIB-04 | GSK-J4 | KDM | histone demethylases | demethylase inhibitors | Jumonji demethylases | drug resistance | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Transcription, Genetic - drug effects | Taxoids - pharmacology | Benzazepines - adverse effects | Humans | Aminopyridines - adverse effects | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Taxoids - therapeutic use | Hydrazones - adverse effects | Aminopyridines - therapeutic use | Carboplatin - therapeutic use | Hydrazones - therapeutic use | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Bridged-Ring Compounds - pharmacology | Neoadjuvant Therapy | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Bridged-Ring Compounds - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Enzyme Inhibitors - pharmacology | Benzazepines - pharmacology | Pyrimidines - pharmacology | Enzyme Inhibitors - therapeutic use | Hydrazones - pharmacology | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Benzazepines - therapeutic use | Pyrimidines - therapeutic use | Aminopyridines - pharmacology | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Histones - metabolism | Carboplatin - pharmacology | Methylation | Jumonji Domain-Containing Histone Demethylases - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Clinical cancer research, ISSN 1078-0432, 04/2014, Volume 20, Issue 8, pp. 2104 - 2114
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 11/2010, Volume 28, Issue 31, pp. 4769 - 4777
In patients with metastatic colorectal cancer, the predictive value of KRAS mutational status in the selection of patients for treatment with anti–epidermal... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Predictive Value of Tests | Receptor, Epidermal Growth Factor - genetics | Translocation, Genetic | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Paclitaxel - pharmacology | Microtubule-Associated Proteins - genetics | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | ras Proteins - metabolism | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Patient Selection | Antibodies, Monoclonal, Humanized | Protein-Tyrosine Kinases - genetics | Receptor, Epidermal Growth Factor - metabolism | Serine Endopeptidases - genetics | Biomarkers, Tumor - metabolism | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Cetuximab | Precision Medicine | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Antibodies, Monoclonal - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | Cisplatin - pharmacology | Carcinoma, Non-Small-Cell Lung - mortality | Receptor Protein-Tyrosine Kinases | Survival Analysis | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Carboplatin - pharmacology | Quinazolines - pharmacology | Deoxycytidine - analogs & derivatives | Index Medicus
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0146256 - e0146256
We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Methotrexate - pharmacology | Cisplatin - pharmacokinetics | Glutathione - metabolism | Humans | Apoptosis - genetics | Deoxycytidine - pharmacology | Gene Expression Profiling | DNA Repair - genetics | DNA Adducts - metabolism | Organoplatinum Compounds - pharmacology | Urinary Bladder Neoplasms - genetics | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Mass Spectrometry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Biological Transport - genetics | DNA Damage - drug effects | Cisplatin - pharmacology | Urinary Bladder Neoplasms - drug therapy | Carboplatin - metabolism | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Vinblastine - pharmacology | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | RNA sequencing | Complications and side effects | Care and treatment | DNA damage | Development and progression | Genetic aspects | Research | Gene expression | Bladder cancer | Cell culture | Cytotoxicity | Biochemistry | Drug resistance | Inactivation | Cancer therapies | Doxorubicin | Ovarian cancer | Proteins | Urinary bladder | Methotrexate | Repair | Deoxyribonucleic acid--DNA | Efflux | Vinblastine | Internal medicine | Cell division | Mass spectroscopy | Polymerase chain reaction | Chemotherapy | Carboplatin | DNA adducts | Mass spectrometry | Drugs | Biotechnology | Gemcitabine | Laboratories | Toxicity | Chemoresistance | Bladder | Oncology | DNA repair | Urology | Oxaliplatin | Scintillation counters | Platinum | Cell cycle | Glutathione | Deactivation | Hematology | Resistance factors | Cisplatin | Medicine | Signaling | Intracellular | Apoptosis | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES | Deoxyribonucleic acid | DNA
Journal Article