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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 22, pp. 9976 - 9999
Due to the emergence of highly pathogenic and oseltamivir-resistant influenza viruses, there is an urgent need to develop new anti-influenza agents. Herein,... 
H5N1 | DESIGN | CHEMISTRY, MEDICINAL | REVERSE-TRANSCRIPTASE INHIBITORS | SMALL-MOLECULE INHIBITORS | POLYMERASE | DYNAMICS | NEURAMINIDASE-INHIBITOR | INFLUENZA-VIRUS | IDENTIFICATION | H1N1 | 4 acetamido 5 [(4 isopropylbenzyl)amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | Medical and Health Sciences | pharmacokinetic parameters | drug potency | drug structure | ethyl 4 acetamido 5 [[4 (benzo[b]thiophen 5 yl)benzyl]amino] 3 (pentan 3 yloxy) cyclohex 1 ene 1 carboxylate | oseltamivir derivative | MDCK cell line | virus sialidase | ethyl 4 acetamido 3 (pentan 3 yloxy) 5 [[4 (phenylthio)benzyl]amino]cyclohex 1 ene 1 carboxylate | 4 acetamido 5 [[4 (isobutylthio)benzyl]amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | 4 acetamido 3 (pentan 3 yloxy) 5 [(4 phenoxybenzyl)amino]cyclohex 1 ene 1 carboxylic acid | animal model | 4 acetamido 3 (pentan 3 yloxy) 5 [[4 (thiophen 2 yl thio)benzyl]amino]cyclohex 1 ene 1 carboxylic acid | Basic Medicine | ribavirin | rat | Influenza A virus (H5N6) | antivirus agent | 4 acetamido 5 [[4 (cyclopentyl)benzyl]amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | human cell | Influenza A virus (H5N2) | antiviral activity | animal experiment | 4 acetamido 5 [[4 (benzo[b]thiophen 2 yl)benzyl)amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | 4 acetamido 5 [[4 (cyclohexylthio)benzyl]amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | 4 acetamido 5 [[4 (sec butylthio)benzyl]amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | zanamivir | nonhuman | 4 acetamido 3 (pentan 3 yloxy) 5 [[4 (pentan 3 yloxy)benzyl]amino]cyclohex 1 ene 1 carboxylic acid | maximum concentration | diclofenac | 4 acetamido 3 (pentan 3 yloxy) 5 [[4 (phenylsulfonyl)benzyl]amino]cyclohex 1 ene 1 carboxylic acid | drug clearance | drug stability | 4 acetamido 5 [[3 (cyclopentyl)benzyl]amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | unclassified drug | molecular model | plasma concentration-time curve | Medicin och hälsovetenskap | metabolic stability | 4 acetamido 5 [[3 (sec butylthio)benzyl]amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | Article | drug synthesis | Influenza A virus (H5N1) | 4 acetamido 5 amino 3 (1 ethylpropoxy) 1 cyclohexene 1 carboxylic acid | 4 acetamido 5 [(4 benzylbenzyl)amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | propafenone | time to maximum plasma concentration | human | Influenza A virus (H5N8) | 4 acetamido 5 [(4 ethylbenzyl)amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | testosterone | 4 acetamido 5 [(4 methoxybenzyl)amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | bioassay | area under the curve | drug half life | Influenza A virus (H3N2) | 4 acetamido 5 [(4 benzoylbenzyl)amino] 3 (pentan 3 yloxy)cyclohex 1 ene 1 carboxylic acid | controlled study | Influenza A virus | Medicinska och farmaceutiska grundvetenskaper | oseltamivir | unindexed drug | 4 acetamido 3 (pentan 3 yloxy) 5 [[4 (phenylthio)benzyl]amino]cyclohex 1 ene 1 carboxylic acid
Journal Article
Synthesis, ISSN 0039-7881, 02/2016, Volume 48, Issue 8, pp. 1122 - 1130
We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted... 
tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 methylbutyl]hydrazine 1 carboxylic acid | tert butyl 2 [2 methyl 1 (1 phenethyl 1h tetrazol 5 yl)propyl]hydrazine 1 carboxylic acid | unclassified drug | proton transport | Ugi reaction | Ugi tetrazole reaction | tert butyl 2[1 (1 tert butyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid | hydrazine | drug isolation | electrospray mass spectrometry | isocyanides | benzyl 4 [2 (tert butoxycarbonyl)hydrazino] 4[1 [2 (1h indol 3 yl)ethyl] 1h tetrazol 5 yl]piperidine 1 carboxylic acid | deprotection reaction | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 phenylethyl]hydrazine 1 carboxylic acid | tert butyl 2 [2 [1 (1 methoxy 4 methyl 1 oxopentan 2 yl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid | mass spectrometry | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 methylpropyl]hydrazine 1 carboxylic acid | tert butyl 2 [cyclohexyl(1 cyclohexyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid | proton nuclear magnetic resonance | hydrazine derivative | drug screening | chemical reaction | supercritical fluid chromatography | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl)(cyclohexyl)methyl]hydrazine 1 carboxylic acid | tert butyl 2 [1 (1 phenethyl 1h tetrazol 5 yl)cyclohexyl]hydrazine 1 carboxylic acid | article | carbon nuclear magnetic resonance | To be checked by Faculty | tert butyl 2 [3 methyl 1 (1 phenethyl 1h tetrazol 5 yl)butyl]hydrazine 1 carboxylic acid | one pot synthesis | tetrazoles | tert butyl 2 [1 chloro 2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid | tert butyl 2 [2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]butan 2 yl]hydrazine 1 carboxylic acid | tert butyl 2 [1 [1 benzyl 4 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]piperidin 4 yl]]hydrazine 1 carboxylic acid | tert butyl 2 [cyclohexyl (1 phenethyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid | multicomponent reaction | tert butyl 2 [2 chloro 1 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]ethyl]hydrazine 1 carboxylic acid | paper | 3-COMPONENT REACTION | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | MULTICOMPONENT REACTIONS | DIASTEREOSELECTIVE SYNTHESIS | CHEMISTRY | DIVERSITY | LEWIS-ACIDS | 4-COMPONENT CONDENSATION | EFFICIENT
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2014, Volume 136, Issue 38, pp. 13217 - 13225
The complex [Ru­(Triphos)­(TMM)] (Triphos = 1,1,1-tris­(diphenylphosphinomethyl)­ethane, TMM = trimethylene methane) provides an efficient catalytic system for... 
ALCOHOLS | TRANSFORMATION | DECARBONYLATION | METHANOL | REDUCTION | AMINES | DIOXIDE | ESTERS | RUTHENIUM | CHEMISTRY, MULTIDISCIPLINARY | AMIDES | Ruthenium | Carboxylic acids | Chemical properties | Hydrogenation | Analysis
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 09/2017, Volume 262, pp. 10 - 17
Journal Article
1969, Chemistry of functional groups, xiv, 1155 p. illus.
Book
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2014, Volume 53, Issue 33, pp. 8722 - 8726
Journal Article
Environment International, ISSN 0160-4120, 09/2014, Volume 70, pp. 62 - 75
We quantify global emissions of C –C perfluoroalkyl carboxylic acid (PFCA) homologues during the life-cycle of products based on perfluorooctanoic acid (PFOA),... 
Geographical shift of industrial sources | PFOA | Perfluoroalkyl carboxylic acids (PFCAs) | Global emission inventory | Per- and polyfluorinated alkyl substances | Air Pollutants - analysis | Environmental Monitoring | Air Pollution - analysis | Carboxylic Acids - analysis | Fluorocarbons - analysis
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2017, Volume 23, Issue 31, pp. 7382 - 7401
Journal Article