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Clinical Cancer Research, ISSN 1078-0432, 07/2016, Volume 22, Issue 13, pp. 3286 - 3297
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 50, pp. 9361 - 9367
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2011, Volume 19, Issue 3, pp. 620 - 626
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 11/2017, Volume 66, Issue 11, pp. 1425 - 1436
The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5+... 
Persistence | Immunology | Medicine & Public Health | Chimeric antigen receptor | Toxicity | Oncology | Cancer Research | T cells | CEA | TARGET | CHIMERIC IMMUNE RECEPTORS | METASTASES | IMMUNOLOGY | CANCER | TRIAL | ONCOLOGY | IMMUNOTHERAPY | LYMPHOMA | GENE-THERAPY | PHASE-I | LYMPHOCYTES | Cyclophosphamide - administration & dosage | Myeloablative Agonists - adverse effects | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Carcinoembryonic Antigen - genetics | Drug Resistance, Neoplasm | Male | Interferon-gamma - metabolism | Myeloablative Agonists - agonists | Cyclophosphamide - adverse effects | T-Lymphocytes - transplantation | Carcinoembryonic Antigen - metabolism | Neoplasms - therapy | Neoplasms - genetics | T-Lymphocytes - metabolism | Adult | Female | Receptors, Antigen, T-Cell - immunology | Lung - metabolism | Interleukin-6 - metabolism | Anemia - etiology | Immunotherapy, Adoptive - adverse effects | Immunotherapy, Adoptive - methods | Abdominal Pain - etiology | GPI-Linked Proteins - immunology | Receptors, Antigen, T-Cell - metabolism | Carcinoembryonic Antigen - immunology | Vidarabine - adverse effects | Treatment Outcome | Vidarabine - analogs & derivatives | GPI-Linked Proteins - metabolism | Neoplasms - immunology | Interferon-gamma - immunology | Interleukin-6 - immunology | Vomiting - etiology | T-Lymphocytes - immunology | Aged | Receptors, Antigen, T-Cell - genetics | Vidarabine - administration & dosage | Cohort Studies | GPI-Linked Proteins - genetics | CEA (Oncology) | Cells | Cytokines | Control methods | Feasibility studies | Lymphocytes T | Malignancy | Epithelium | Patients | Interleukin 6 | Infusion | Carcinoembryonic antigen | Cyclophosphamide | Cell activation | Fludarabine | Interleukin 2 | Lungs | Lymphocytes | Production methods | γ-Interferon | Biocompatibility | Preconditioning | Index Medicus | Original
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2017, Volume 25, Issue 5, pp. 1248 - 1258
Chimeric antigen receptor T (CAR-T) cells have shown promising efficacy in treatment of hematological malignancies, but its applications in solid tumors need... 
safety and efficacy | phase I | dose escalating | colorectal carcinoma | CAR-T | CEA | MEDICINE, RESEARCH & EXPERIMENTAL | CD8(+) | RESPONSE CRITERIA | VIVO | SUBSETS | CELL THERAPY | CHIMERIC ANTIGEN RECEPTOR | ANTITUMOR-ACTIVITY | B-CELL | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CARCINOEMBRYONIC ANTIGEN | Dose-Response Relationship, Immunologic | Humans | Middle Aged | Mutant Chimeric Proteins - genetics | Carcinoembryonic Antigen - genetics | Male | Liver Neoplasms - therapy | Lymphocyte Depletion | T-Lymphocytes - transplantation | Neoplasm Recurrence, Local - immunology | Neoplasm Recurrence, Local - pathology | Colorectal Neoplasms - therapy | Neoplasm Recurrence, Local - diagnostic imaging | Protein Engineering | Female | Receptors, Antigen, T-Cell - immunology | Liver Neoplasms - secondary | Gene Expression | Immunotherapy, Adoptive | Carcinoembryonic Antigen - immunology | Lymphocyte Activation | Adenocarcinoma - immunology | Neoplasm Recurrence, Local - therapy | Liver Neoplasms - immunology | Colorectal Neoplasms - diagnostic imaging | Liver Neoplasms - diagnostic imaging | Adenocarcinoma - secondary | Magnetic Resonance Imaging | Colorectal Neoplasms - immunology | Adenocarcinoma - therapy | T-Lymphocytes - cytology | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Aged | Receptors, Antigen, T-Cell - genetics | Adenocarcinoma - diagnostic imaging | Colorectal Neoplasms - pathology | Cytotoxicity, Immunologic | Cell proliferation | Antigens | Research & development--R&D | Liver | Colorectal carcinoma | Exploration | Lymphocytes T | Metastasis | Radiation therapy | Patients | Embryos | Fever | Metastases | Inflammatory bowel disease | Carcinoembryonic antigen | Magnetic resonance imaging | Computed tomography | Lymphocytes | Peripheral blood | Nonsteroidal anti-inflammatory drugs | Solid tumors | Positron emission tomography | Tumors | Original
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2008, Volume 14, Issue 10, pp. 3060 - 3069
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2018, Volume 115, Issue 19, pp. E4473 - E4482
Prostate cancer is a heterogeneous disease composed of divergent molecular and histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine... 
Cell surface antigens | Prostate cancer | Immunotherapy | CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | ANTIANDROGEN RESISTANCE | LINEAGE PLASTICITY | NEUROENDOCRINE DIFFERENTIATION | MONOCLONAL-ANTIBODY | TUMORS | prostate cancer | cell surface antigens | immunotherapy | CARCINOMAS | CARCINOEMBRYONIC ANTIGEN | EXPRESSION | Prostatic Neoplasms - metabolism | Humans | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - immunology | Transcriptome | Carcinoembryonic Antigen - genetics | Carcinoma, Neuroendocrine - therapy | Male | Neoplasm Proteins - metabolism | Prostate - metabolism | T-Lymphocytes - transplantation | Carcinoembryonic Antigen - metabolism | Prostatic Neoplasms - immunology | Prostatic Neoplasms - therapy | Prostate - immunology | Prostatic Neoplasms - genetics | Proteome - immunology | Cell Differentiation | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Carcinoma, Neuroendocrine - metabolism | GPI-Linked Proteins - immunology | Carcinoembryonic Antigen - immunology | Membrane Proteins - genetics | Cells, Cultured | Carcinoma, Neuroendocrine - genetics | Membrane Proteins - immunology | Proteome - analysis | GPI-Linked Proteins - metabolism | Carcinoma, Neuroendocrine - immunology | T-Lymphocytes - cytology | T-Lymphocytes - immunology | Antigens, Surface - immunology | Antigens, Surface - analysis | GPI-Linked Proteins - genetics | Care and treatment | Methods | Cancer | Biological Sciences | PNAS Plus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0161820
Gamma delta (γδ) T cells and cytokine-induced killer (CIK) cells, which are a heterogeneous population of T lymphocytes and natural killer T (NKT) cells, have... 
Recombinant Fusion Proteins - immunology | B7-2 Antigen - genetics | Cell Proliferation | Receptor, ErbB-2 - genetics | Humans | Carcinoembryonic Antigen - genetics | Receptors, Antigen, T-Cell, gamma-delta - genetics | Antigens, CD19 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Burkitt Lymphoma - mortality | Burkitt Lymphoma - pathology | Receptors, IgG - genetics | Burkitt Lymphoma - immunology | Receptor, ErbB-2 - immunology | B7-2 Antigen - immunology | Antigens, CD19 - immunology | Burkitt Lymphoma - therapy | Gene Expression | Immunotherapy, Adoptive - methods | Carcinoembryonic Antigen - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Receptors, Antigen, T-Cell, gamma-delta - immunology | Receptors, IgG - immunology | Feeder Cells - immunology | Cytokine-Induced Killer Cells - immunology | Xenograft Model Antitumor Assays | Animals | T-Lymphocytes - cytology | Cytokine-Induced Killer Cells - transplantation | K562 Cells | Survival Analysis | Cytokine-Induced Killer Cells - cytology | Feeder Cells - cytology | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Mice | Primary Cell Culture | Cytotoxicity, Immunologic | Bioengineering | Cell culture | Therapy | CD86 antigen | Toxicity | Interleukin | Clinical trials | Cytotoxicity | Leukocytes (mononuclear) | Lymphocytes T | Cancer therapies | Carcinoembryonic antigen | Killer cells | Immunology | Interleukin 2 | Lymphocytes | Immunotherapy | Zoledronic acid | Peripheral blood mononuclear cells | Biocompatibility | Natural killer cells | Expansion | Immune system | Medical research | Antigens | CD19 antigen | Cytokines | Tumor cells | Feasibility studies | CD3 antigen | T cell receptors | ErbB-2 protein | Major histocompatibility complex | γ-Interferon | Interferon | Gene therapy | Laboratory animals | Histocompatibility | Nanotechnology | Cancer | Tumors
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2013, Volume 133, Issue 3, pp. 624 - 636
Journal Article