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The New England Journal of Medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 23, pp. 2171 - 2179
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2005, Volume 353, Issue 21, pp. 2262 - 2269
Basal-cell carcinoma is the most common malignant tumor, and its incidence is increasing. This review explains the treatment options, including four surgical... 
Skin Neoplasms - pathology | Carcinoma, Basal Cell - therapy | Carcinoma, Basal Cell - genetics | Skin Neoplasms - therapy | Humans | Risk Factors | Skin Neoplasms - genetics | Carcinoma, Basal Cell - pathology | Mutation | Care and treatment | Basal cell carcinoma | Health aspects | Cancer | Transplants & implants | Sunburn & sun tanning | Skin cancer
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 152 - 165
Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely variable clinical outcomes and responses to conventional chemotherapy.... 
BREAST-CANCER | CELLS | ONCOLOGY | PROGNOSIS | UROTHELIAL CARCINOMA | RADICAL CYSTECTOMY | GENE-EXPRESSION | CLASSIFICATION | MICROARRAYS | P63 | PROGRESSION | CELL BIOLOGY | Receptors, Estrogen - metabolism | Urinary Bladder Neoplasms - classification | Cell Proliferation | Prognosis | Carcinoma, Squamous Cell - pathology | Humans | Muscle Neoplasms - pathology | Muscle Neoplasms - classification | Male | Gene Expression Profiling | Vinblastine - administration & dosage | PPAR gamma - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Tumor Suppressor Protein p53 - genetics | Cisplatin - administration & dosage | Urinary Bladder Neoplasms - pathology | Female | Neoadjuvant Therapy | Cell Differentiation | Muscle Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | Doxorubicin - administration & dosage | PPAR gamma - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Receptors, Estrogen - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | Carcinoma, Basal Cell - pathology | Urinary Bladder Neoplasms - drug therapy | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Carcinoma, Squamous Cell - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Basal Cell - drug therapy | Methotrexate - administration & dosage | Aged | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Neoplasm Staging | Clinical Trials, Phase II as Topic | Cohort Studies | Chemotherapy | Anthracyclines | Estrogen | Methotrexate | Tumor proteins | Bladder cancer | Cancer
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2008, Volume 26, Issue 15, pp. 2568 - 2581
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2013, Volume 15, Issue 3, pp. 274 - 283
A key issue in cancer biology is whether oncogenic transformation of different cell types of origin within an adult tissue gives rise to distinct tumour... 
STEM-CELLS | SUBPOPULATION | SUBTYPES | INITIATION | ARCHITECTURE | IDENTIFICATION | LUMINAL CELLS | TUMORIGENESIS | PROGRESSION | MURINE | CELL BIOLOGY | Prostatic Neoplasms - metabolism | Phosphorylation | Cell Proliferation | Epithelial Cells - metabolism | Oligonucleotide Array Sequence Analysis | Humans | PTEN Phosphohydrolase - physiology | Male | Gene Expression Profiling | Neoplasm Recurrence, Local - mortality | Immunoenzyme Techniques | Prostate - metabolism | Neoplasm Recurrence, Local - pathology | Carcinoma, Basal Cell - mortality | Flow Cytometry | Biomarkers, Tumor - metabolism | Adult | Cell Differentiation | Epithelial Cells - cytology | Real-Time Polymerase Chain Reaction | Genes, Reporter | Prostatic Neoplasms - pathology | Neoplasm Recurrence, Local - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Mice, Transgenic | Survival Rate | Carcinoma, Basal Cell - pathology | Keratin-5 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Carcinoma, Basal Cell - metabolism | Prostatic Neoplasms - mortality | Cell Lineage | Animals | Fluorescent Antibody Technique | Prostate - cytology | Keratin-5 - metabolism | Biomarkers, Tumor - genetics | Mice | Cell Transformation, Neoplastic - pathology | Apoptosis | Stem cells | Homeostasis | Physiological aspects | Development and progression | Genetic aspects | Research | Health aspects | Prostate cancer | Risk factors
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 6, pp. 716 - 728
Journal Article
Journal Article