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Lancet, The, ISSN 0140-6736, 2015, Volume 387, Issue 10021, pp. 849 - 856
Summary Background Ductal carcinoma in situ is currently managed with excision, radiotherapy, and adjuvant hormone therapy, usually tamoxifen. We postulated... 
Internal Medicine | INTRADUCTAL BREAST-CANCER | MEDICINE, GENERAL & INTERNAL | SURGICAL ADJUVANT BREAST | RADIATION-THERAPY | B-17 | Breast Neoplasms - surgery | Triazoles - administration & dosage | Triazoles - adverse effects | Thrombosis - chemically induced | Age Factors | Humans | Middle Aged | Tamoxifen - administration & dosage | Nitriles - administration & dosage | Antineoplastic Agents, Hormonal - adverse effects | Aromatase Inhibitors - adverse effects | Carcinoma, Ductal, Breast - drug therapy | Mastectomy, Segmental | Antineoplastic Agents, Hormonal - therapeutic use | Postmenopause | Female | Embolism - chemically induced | Aromatase Inhibitors - therapeutic use | Triazoles - therapeutic use | Aromatase Inhibitors - administration & dosage | Carcinoma, Ductal, Breast - surgery | Double-Blind Method | Administration, Oral | Antineoplastic Agents, Hormonal - administration & dosage | Combined Modality Therapy | Breast Neoplasms - drug therapy | Breast Neoplasms - radiotherapy | Carcinoma, Ductal, Breast - radiotherapy | Tamoxifen - therapeutic use | Tamoxifen - adverse effects | Nitriles - adverse effects | Nitriles - therapeutic use | Lumpectomy | Medical colleges | Carcinoma | Radiation | Clinical trials | Postmenopausal women | Hormones | Tamoxifen | Radiotherapy | Biometry | Health maintenance organizations | Product development | Cancer | Chemotherapy | Womens health | Older people | Breast cancer | Radiation therapy | Cancer surgery | Index Medicus | Abridged Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 7, pp. 609 - 618
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2008, Volume 26, Issue 8, pp. 1275 - 1281
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2011, Volume 29, Issue 25, pp. 3366 - 3373
Journal Article
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8760 - 8760
Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic... 
HETEROGENEITY | ACTIVATION | VARIANTS | PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE | ACQUIRED-RESISTANCE | SEQUENCING DATA | Carcinoma, Ductal, Breast - genetics | Receptors, Estrogen - metabolism | Humans | Receptor, ErbB-2 - metabolism | Clonal Evolution - genetics | Tamoxifen - administration & dosage | Case-Control Studies | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Carcinoma, Ductal, Breast - drug therapy | Neoplasm Metastasis | Lung Neoplasms - secondary | Adult | Carcinoma, Ductal, Breast - pathology | Female | Quinazolines - administration & dosage | Liver Neoplasms - secondary | Carcinoma, Ductal, Breast - metabolism | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Deoxycytidine - administration & dosage | Brain Neoplasms - genetics | Trastuzumab - administration & dosage | Breast Neoplasms - drug therapy | Sequence Analysis, DNA | Spinal Neoplasms - secondary | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Spinal Neoplasms - genetics | Bayes Theorem | DNA, Neoplasm - genetics | Mutation | Deoxycytidine - analogs & derivatives | Biological evolution | Breast cancer | Genomes | Metastasis | ErbB-2 protein | Patients | Metastases | Heterogeneity | Biopsy | Breast | Evolution | Deoxyribonucleic acid--DNA | Cancer | Tumors | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 79, Issue 3, pp. 808 - 817
Purpose To present 5-year data on treatment efficacy, cosmetic results, and toxicities for patients enrolled on the American Society of Breast Surgeons... 
Radiology | Hematology, Oncology and Palliative Medicine | MammoSite | Partial-breast irradiation | Brachytherapy | Breast cancer | Breast-conserving therapy | Radiation | TOXICITY | INITIAL CLINICAL-EXPERIENCE | CANCER | ONCOLOGY | OUTCOMES | CATHETER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RADIATION-THERAPY SYSTEM | Breast Neoplasms - surgery | Carcinoma in Situ - chemistry | Carcinoma in Situ - drug therapy | Follow-Up Studies | Humans | Middle Aged | Receptors, Estrogen - analysis | Carcinoma in Situ - radiotherapy | Carcinoma, Ductal, Breast - chemistry | Breast Neoplasms - chemistry | Carcinoma, Ductal, Breast - drug therapy | Carcinoma in Situ - surgery | Aged, 80 and over | Adult | Carcinoma, Ductal, Breast - pathology | Female | Registries | Radiotherapy Dosage | Esthetics | Carcinoma, Ductal, Breast - surgery | Brachytherapy - instrumentation | Carcinoma in Situ - pathology | Brachytherapy - methods | Treatment Outcome | Tumor Burden | Breast Neoplasms - drug therapy | Breast Neoplasms - radiotherapy | Breast Neoplasms - pathology | Carcinoma, Ductal, Breast - radiotherapy | Aged | Neoplasms, Second Primary - pathology | Brachytherapy - adverse effects | Index Medicus | MAMMARY GLANDS | NEOPLASMS | MEDICINE | NUCLEAR MEDICINE | ORGANS | DISEASES | THERAPY | GLANDS | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | BRACHYTHERAPY | EFFICIENCY | BODY | RADIOLOGY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2011, Volume 29, Issue 25, pp. 3351 - 3357
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 19127 - 19137
Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated... 
INVASION | CARCINOMA CELLS | POOR-PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GROWTH | TUMOR-SUPPRESSOR GENE | DOWN-REGULATION | PTEN | MICRORNA-21 TARGETS | EXPRESSION | Carcinoma, Ductal, Breast - genetics | Gene Silencing - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | G1 Phase - drug effects | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Carcinoma, Ductal, Breast - drug therapy | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | G1 Phase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Antibodies, Monoclonal - pharmacology | PTEN Phosphohydrolase - biosynthesis | MicroRNAs - biosynthesis | Up-Regulation - genetics | Breast Neoplasms - drug therapy | S Phase - genetics | Gene Expression Regulation, Enzymologic | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | RNA, Neoplasm - genetics | MicroRNAs - genetics | S Phase - drug effects | Trastuzumab | Drug Resistance, Neoplasm - drug effects | Index Medicus | Gene Regulation | RNA Silencing | MicroRNA | Gene Therapy | Tumor Therapy | Breast Cancer
Journal Article
American Journal of Pathology, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 1647 - 1656
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream... 
ADJUVANT CHEMOTHERAPY | CELLS | INHIBITION | THERAPY | HUMAN-BREAST-CANCER | MUTATIONS | PATHOLOGY | RECEPTORS | TRASTUZUMAB RESISTANCE | EXPRESSION | CARCINOMA | Lung Neoplasms - drug therapy | Receptors, Estrogen - metabolism | Receptor, ErbB-2 - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Immunoenzyme Techniques | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Ductal, Breast - drug therapy | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Survival Rate | Lymphatic Metastasis | Brain Neoplasms - drug therapy | Mutation - genetics | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases | Carcinoma, Lobular - metabolism | Trastuzumab | Bone Neoplasms - mortality | Phosphorylation | Prognosis | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | In Situ Hybridization | Lung Neoplasms - secondary | Adult | Female | Bone Neoplasms - drug therapy | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - mortality | Aged | Carcinoma, Lobular - drug therapy | Index Medicus | Abridged Index Medicus | Regular
Journal Article
Annals of Oncology, ISSN 0923-7534, 2014, Volume 25, Issue 6, pp. 1128 - 1136
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 387, Issue 10021, pp. 857 - 865
Journal Article