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Journal Article
Science, ISSN 0036-8075, 1/2008, Volume 319, Issue 5860, pp. 195 - 198
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102436 - e102436
Background: We previously reported the role of IL-6 in a murine model of cancer cachexia and currently documented a patient in whom tocilizumab, anti-IL-6... 
PROGNOSIS | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | WEIGHT-LOSS | CASTLEMAN-DISEASE | MECHANISMS | INTERLEUKIN-6 | BEARING MICE | TUMOR-GROWTH | ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY | T-CELLS | Cachexia - drug therapy | Humans | Middle Aged | Male | Antibodies, Monoclonal, Humanized - administration & dosage | Interleukin-6 - blood | Aged, 80 and over | Female | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Interleukin-6 - blood | Carcinoma, Non-Small-Cell Lung - pathology | Kaplan-Meier Estimate | Carcinoma, Lewis Lung - blood | Cachexia - blood | Carcinoma, Lewis Lung - drug therapy | Biomarkers, Tumor - blood | Animals | Cachexia - pathology | Carcinoma, Lewis Lung - pathology | Interleukin-6 - biosynthesis | Carcinoma, Non-Small-Cell Lung - blood | Aged | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Biomarkers, Tumor - biosynthesis | Chemotherapy | Cachexia | Analysis | Lung cancer | Cancer | Animal models | Anorexia | Prognosis | Disease | Lung | Lung transplantation | Clinical trials | Transplantation | Metastasis | Medical diagnosis | Metastases | Interleukin 6 | Lymphocytes | Consent | Interleukin 6 receptors | Tumor necrosis factor-TNF | Measurement methods | Water intakes | Medical research | Cytokines | Anemia | Lung carcinoma | Patients | Survival | Quality of life | Medicine | Food intake | Medical prognosis | Rheumatoid arthritis | Water intake | University faculty | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e40677 - e40677
Background: Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on... 
MHC CLASS-I | DENDRITIC CELLS | NK CELLS | MECHANISM | TUMOR-ANTIGENS | TOLERANCE | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | ANERGY | INDUCTION | CYTOTOXIC T-LYMPHOCYTES | Spleen - immunology | Ovalbumin - immunology | Apoptosis - drug effects | Vaccination | Carcinoma, Lewis Lung - immunology | Antineoplastic Agents - therapeutic use | Spleen - drug effects | Carcinoma, Lewis Lung - blood supply | Neoplasm Metastasis | Myeloid Cells - immunology | T-Lymphocytes - drug effects | Angiogenesis Inhibitors - therapeutic use | Biomarkers, Tumor - metabolism | Killer Cells, Natural - immunology | Bone Marrow Cells - drug effects | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | Cytotoxicity, Immunologic - drug effects | Disease Models, Animal | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Angiogenesis Inhibitors - pharmacology | Treatment Outcome | Tumor Burden | Cell Adhesion - drug effects | Antigen-Presenting Cells - immunology | Carcinoma, Lewis Lung - drug therapy | Animals | Carcinoma, Lewis Lung - pathology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Mice | Myeloid Cells - pathology | Antigens | Lymphocytes | Lung cancer | Comparative analysis | Health aspects | Vascular endothelial growth factor | Tumors | Regulators | Animal models | Leukocyte migration | Laboratories | Veterans | CD8 antigen | Immunocytochemistry | Lung | Cytotoxicity | Lymphocytes T | Suppressor cells | Anticancer properties | Angiogenesis | Cell activation | Immunology | Immunotherapy | Bone marrow | Perforin | Medical research | Immunological memory | Immune response | Inflammation | CD3 antigen | T cell receptors | CXCR3 protein | Adenomatous polyposis coli | Medicine | Depletion | Antigen-presenting cells | γ-Interferon | CXCL10 protein | Interleukin 10 | Antitumor activity | Lymphomas | Cell migration | Apoptosis | Cancer | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 3, pp. 263 - 273
Several hypotheses have been proposed to explain how antiangiogenic drugs enhance the treatment efficacy of cytotoxic chemotherapy, including impairing the... 
CELLCYCLE | BREAST-CANCER | LUNG-CANCER | RECRUITMENT | THERAPY | ONCOLOGY | VEGF | CHEMOKINE | GROWTH-FACTOR | TUMOR ANGIOGENESIS | NEOVASCULARIZATION | METRONOMIC CHEMOTHERAPY | CELL BIOLOGY | Paclitaxel - pharmacology | Apoptosis - drug effects | Humans | Melanoma, Experimental - drug therapy | Antibodies, Monoclonal - therapeutic use | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Deoxycytidine - therapeutic use | Neoplasms - blood | Angiogenesis Inhibitors - therapeutic use | Bone Marrow Cells - drug effects | Female | Antineoplastic Agents - pharmacology | Drug Therapy, Combination | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Vascular Endothelial Growth Factor A - blood | Angiogenesis Inhibitors - pharmacology | Melanoma, Experimental - pathology | Carcinoma, Lewis Lung - blood | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Carcinoma, Lewis Lung - drug therapy | Neoplasms - drug therapy | Animals | Tumor Burden - drug effects | Breast Neoplasms - pathology | Chemokine CXCL12 - blood | Breast Neoplasms - blood | Carcinoma, Lewis Lung - pathology | Stem Cells - drug effects | Stem Cells - pathology | Cell Proliferation - drug effects | Melanoma, Experimental - blood | Mice | Mice, Inbred BALB C | Endothelial Cells - pathology | Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Endothelial Cells - drug effects | Antimitotic agents | Chemotherapy | Antineoplastic agents | Antitank weapons | Cancer | Tumors | Endothelium | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2006, Volume 116, Issue 10, pp. 2610 - 2621
Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVE REGENERATION | BASAL LAMINA | ANGIOGENESIS INHIBITORS | BLOOD-VESSELS | EXTRACELLULAR-MATRIX | MUSCLE ACTIN EXPRESSION | ENDOTHELIAL SPROUTS | BASEMENT-MEMBRANES | GROWTH IN-VIVO | ESTABLISHED TUMORS | Basement Membrane - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Actins - metabolism | Endothelium, Vascular - drug effects | Vascular Endothelial Growth Factor A - metabolism | Basement Membrane - pathology | Carcinoma, Lewis Lung - blood supply | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Insulinoma - blood supply | Pericytes - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Organic Chemicals - pharmacology | Angiogenesis Inhibitors - therapeutic use | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Imidazoles - therapeutic use | Collagen Type IV - immunology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Collagen Type IV - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Pericytes - metabolism | Insulinoma - drug therapy | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Neoplasms - blood supply | Treatment Outcome | Imidazoles - pharmacology | Basement Membrane - metabolism | Carcinoma, Lewis Lung - drug therapy | Neoplasms - drug therapy | Indazoles - pharmacology | Animals | Endothelium, Vascular - metabolism | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Carcinoma, Lewis Lung - pathology | Matrix Metalloproteinase Inhibitors | Endothelium, Vascular - pathology | Insulinoma - pathology | Mice | Neovascularization, Pathologic - metabolism | Neoplasms - pathology | Indazoles - therapeutic use | Care and treatment | Research | Vascular endothelial growth factor | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e110869 - e110869
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2005, Volume 113, Issue 5, pp. 752 - 760
The role of platelets in tumor progression and metastasis has been recognized but the mechanism of their action remains unclear. Five human lung cancer cell... 
lung cancer | platelet microvesicles | metastasis | matrix metalloproteinases | exosomes | Matrix metalloproteinases | Metastasis | Platelet microvesicles | Exosomes | Lung cancer | SURVIVAL | VESICLES | MEMBRANE-TYPE-1 MATRIX-METALLOPROTEINASE | ADHESION | IN-VITRO | ONCOLOGY | GROWTH | SURFACE | RHABDOMYOSARCOMA CELLS | GENERATION | ENDOTHELIAL MICROPARTICLES | Phosphorylation | Cell Proliferation | Humans | Lung Neoplasms - metabolism | Carcinoma, Lewis Lung - secondary | Lung Neoplasms - pathology | Metalloendopeptidases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Carcinoma, Lewis Lung - blood supply | Cyclin D2 | Neovascularization, Pathologic - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinases, Membrane-Associated | Cyclins - metabolism | Neoplasm Invasiveness - pathology | Bone Marrow - metabolism | Platelet Membrane Glycoproteins - metabolism | Female | Interleukin-8 - metabolism | Tumor Cells, Cultured | Lung Neoplasms - blood supply | Matrix Metalloproteinase 14 | Endothelial Cells - metabolism | Mice, Inbred C57BL | Umbilical Veins | Carcinoma, Lewis Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Chemotaxis | Disease Progression | Hepatocyte Growth Factor - metabolism | Animals | Blood Platelets - metabolism | Endothelial Cells - cytology | Platelet Activation | Bone Marrow - pathology | Fibrinogen - metabolism | Mice | Neovascularization, Pathologic - metabolism | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 953 - 967
Journal Article