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Cell, ISSN 0092-8674, 05/2017, Volume 169, Issue 4, pp. 736 - 749.e18
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2016, Volume 22, Issue 22, pp. 5461 - 5471
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2017, Volume 77, Issue 5, pp. 1075 - 1082
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 13, pp. 1430 - 1437
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 20, pp. 6674 - 6682
Purpose: Immune dysfunction is well documented in renal cell carcinoma (RCC) patients and likely contributes to tumor evasion. This dysfunction includes a... 
Type-1/Type-2 responses | T-regulatory cells | FoxP3 | Immune dysfunction | HEPATOCELLULAR-CARCINOMA | INTERFERON-ALPHA | CANCER-PATIENTS | CYTOKINE PRODUCTION | DENDRITIC CELLS | TUMOR REJECTION | ONCOLOGY | IN-VIVO | PERIPHERAL-BLOOD | ANTITUMOR IMMUNITY | ENDOTHELIAL GROWTH-FACTOR | T-Lymphocytes, Regulatory - metabolism | Humans | Middle Aged | Kidney - immunology | Kidney Neoplasms - immunology | Male | Antineoplastic Agents - therapeutic use | Kidney Neoplasms - metabolism | Th2 Cells - immunology | Interferon-gamma - metabolism | Recombinant Proteins | Th1 Cells - immunology | Th2 Cells - drug effects | Carcinoma, Renal Cell - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Kidney - metabolism | Female | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Th1 Cells - drug effects | Kidney - drug effects | Interleukin-4 - metabolism | CD4-Positive T-Lymphocytes - metabolism | CD3 Complex - metabolism | Th2 Cells - metabolism | Carcinoma, Renal Cell - metabolism | Interleukin-4 - immunology | Immunosuppression | T-Lymphocytes, Regulatory - drug effects | Interferon-gamma - immunology | CD3 Complex - immunology | Indoles - therapeutic use | Kidney Neoplasms - drug therapy | CD4-Positive T-Lymphocytes - drug effects
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4416 - 4428
Purpose: The efficacy of PD-1 checkpoint blockade as adjuvant therapy in localized clear cell renal cell carcinoma (ccRCC) is currently unknown. The... 
MOLECULAR SUBTYPES | SURVIVAL | IMMUNE CONTEXTURE | DENDRITIC CELLS | ONCOLOGY | COLORECTAL-CANCER | IMMUNOSCORE | PROGNOSTIC VALUE | PD-1 | EXPRESSION | LYMPHOCYTES | Prognosis | Carcinoma, Renal Cell - pathology | Dendritic Cells - immunology | Humans | Middle Aged | Neoplasm Proteins - immunology | Carcinoma, Renal Cell - genetics | Dendritic Cells - pathology | Gene Expression Regulation, Neoplastic - immunology | Immunophenotyping | Male | Carcinoma, Renal Cell - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasm Recurrence, Local - immunology | Neoplasm Recurrence, Local - pathology | Lymphocytes, Tumor-Infiltrating - pathology | Female | T-Lymphocytes - immunology | Aged | T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - immunology | Neoplasm Proteins - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Immunohistochemistry | Flow cytometry | Therapy | PD-1 protein | CD8 antigen | Cytotoxicity | Lymphocytes T | CD223 antigen | Blood | Metastases | T-cell receptor | Nephrectomy | Lymphocytes | Risk assessment | Peripheral blood | CD25 antigen | Foxp3 protein | Bioindicators | Tumor-infiltrating lymphocytes | Dendritic cells | Health risks | Inflammation | T cell receptors | Gene expression | Patients | CD4 antigen | Immune checkpoint | Experimental design | ICOS protein | PD-L1 protein | Biomarkers | Infiltration | Clear cell-type renal cell carcinoma | Tumors | Cancer
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5187 - 5201
Purpose: Recent advances in immunotherapy highlight the antitumor effects of immune checkpoint inhibition despite a relatively limited subset of patients... 
HDAC INHIBITORS | ONCOLOGY | IMMUNOTHERAPY | SAFETY | INFLAMMATION | ANTIBODY | IMMUNE CHECKPOINT | CANCER | T-CELLS | Carcinoma, Non-Small-Cell Lung - pathology | Tumor Microenvironment - drug effects | Immunotherapy - methods | Myeloid-Derived Suppressor Cells - immunology | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Renal Cell - pathology | Humans | Histone Deacetylase Inhibitors - administration & dosage | Carcinoma, Renal Cell - genetics | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Carcinoma, Renal Cell - immunology | Carcinoma, Non-Small-Cell Lung - immunology | Tumor Microenvironment - immunology | Benzamides - administration & dosage | Animals | Immune Tolerance - immunology | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Carcinoma, Renal Cell - drug therapy | Disease Models, Animal | Histone deacetylase | Animal models | PD-1 protein | Arginase | Suppressor cells | Anticancer properties | Alterations | Immunotherapy | Inhibition | Cell survival | Immunomodulation | Lung carcinoma | Patients | Survival | Nitric-oxide synthase | Monocytes | Immunosuppression | Inhibitors | Immune checkpoint | Experimental design | Antitumor activity | In vivo methods and tests | Cyclooxygenase-2 | Solid tumors | Clear cell-type renal cell carcinoma | Cancer | program cell death protein 1 inhibition | Renal cell carcinoma | lung carcinoma | myeloid derived suppressor cells | histone deacetylase inhibition
Journal Article