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The American journal of surgical pathology, ISSN 0147-5185, 06/2014, Volume 38, Issue 6, pp. 756 - 767
Journal Article
PloS one, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0136023 - e0136023
.... First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenocarcinoma - pathology | Prognosis | Follow-Up Studies | Lung Neoplasms - mortality | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Carcinoma, Large Cell - mortality | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Squamous Cell - mortality | Neoplasm Grading | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Carcinoma, Squamous Cell - therapy | Programmed Cell Death 1 Receptor - metabolism | Survival Rate | Combined Modality Therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | B7-H1 Antigen - metabolism | Carcinoma, Non-Small-Cell Lung - therapy | Adenocarcinoma - therapy | Aged | Neoplasm Staging | Carcinoma, Large Cell - therapy | Adenocarcinoma - mortality | Care and treatment | Physiological aspects | Genetic aspects | Research | Lung cancer, Non-small cell | Apoptosis | Immunohistochemistry | Thoracic surgery | PD-1 protein | Lung cancer | Clinical trials | Oncology | Cancer therapies | Lymph nodes | Subgroups | Proteins | Rank tests | Regression models | Bcl-x protein | Lymphocytes | Immunotherapy | Medical research | Immunoglobulins | Squamous cell carcinoma | Cell survival | Cytokines | Hematology | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Regression analysis | Patients | Medicine | Pathology | Chemotherapy | Hospitals | Cell death | Medical prognosis | PD-L1 protein | Ligands | Diagnostic systems | Solid tumors | Cancer | Tumors | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e57020 - e57020
.... Therapy resistance of a tumor is thought to be related to cancer stem cells (CSCs) within the tumors. There have been indications that the lung cancer is propagated and maintained by a small population of CSCs... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Cadherins - metabolism | Vimentin - metabolism | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Antigens, CD - genetics | Antigens, CD - metabolism | Octamer Transcription Factor-3 - genetics | Small Cell Lung Carcinoma - metabolism | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Vimentin - genetics | Thy-1 Antigens - genetics | Hyaluronan Receptors - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Cadherins - genetics | Lung Neoplasms - genetics | Carcinoma, Large Cell - metabolism | Nanog Homeobox Protein | Immunophenotyping | Small Cell Lung Carcinoma - genetics | Mice, SCID | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Thy-1 Antigens - metabolism | Small Cell Lung Carcinoma - pathology | Animals | Octamer Transcription Factor-3 - metabolism | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Primary Cell Culture | Care and treatment | Analysis | Stem cells | Cancer cells | Physiological aspects | Research | Cancer | Adenocarcinoma | Vimentin | Cell culture | Therapy | Biotechnology | Thoracic surgery | Mesenchyme | Oct-4 protein | Lung cancer | Radiation | Population studies | Identification | Biology | mRNA | Metastasis | Cancer therapies | CD90 antigen | N-Cadherin | Immunology | CD44 antigen | Population | Medical research | Squamous cell carcinoma | Hematology | Small cell lung carcinoma | Cell division | Tumor cell lines | Gene expression | Cadherin | Spheroids | Morbidity | Medicine | Pathology | Lungs | Medical prognosis | Pancreatic cancer | Irradiation | Prostate | Tumors | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e67466 - e67466
.... However, poor sensitivity has been reported for non-small cell lung cancer (NSCLC). To address this problem, we developed a microcavity array (MCA... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prognosis | Prospective Studies | Neoplastic Cells, Circulating - pathology | Cell Count | Humans | Lung Neoplasms - metabolism | Middle Aged | Neoplastic Cells, Circulating - metabolism | Lung Neoplasms - pathology | Male | Tissue Array Analysis - methods | Small Cell Lung Carcinoma - blood | Epithelial Cell Adhesion Molecule | Small Cell Lung Carcinoma - metabolism | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Cell Adhesion Molecules - metabolism | Small Cell Lung Carcinoma - pathology | Cell Line, Tumor | Carcinoma, Non-Small-Cell Lung - blood | Aged | Lung Neoplasms - blood | Medical research | Care and treatment | Medicine, Experimental | Metastasis | Comparative analysis | Lung cancer, Non-small cell | Prostate cancer | Biotechnology | Epithelial cells | Lung cancer | Oncology | Statistical methods | Metastases | Cell adhesion molecules | Engineering | Colon cancer | Cell adhesion | Peripheral blood | Clusters | Life sciences | Colon | Enumeration | Statistical analysis | Research & development--R&D | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Statistics | Patients | Chemotherapy | Solid tumors | Median (statistics) | Prostate | Tumors | Cancer | Index Medicus | Research & development | R&D
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 07/2017, Volume 77, Issue 13, pp. 3540 - 3550
.... In this study, we evaluated tumor specimens from 65 patients with melanoma, lung nonsquamous, squamous cell lung or head and neck cancers who were treated with the approved PD1-targeting antibodies... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Gene Expression - drug effects | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Squamous Cell Carcinoma of Head and Neck | Melanoma - genetics | Gene Expression - immunology | Aged, 80 and over | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Head and Neck Neoplasms - drug therapy | Gene Expression Profiling - methods | Melanoma - pathology | Head and Neck Neoplasms - pathology | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Carcinoma, Squamous Cell - drug therapy | Melanoma - immunology | Melanoma - drug therapy | Nivolumab | Head and Neck Neoplasms - genetics | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | PD-1 protein | CD8 antigen | Antibodies | Lymphocytes T | Killer cells | Cell activation | Lymphocytes | Natural killer cells | Signatures | Immune system | Squamous cell carcinoma | Head | Immune response | Small cell lung carcinoma | Tumor-infiltrating lymphocytes | Melanoma | Lung carcinoma | Gene expression | Ribonucleic acid--RNA | Patients | CD4 antigen | Immune checkpoint | Reproducibility | PD-L1 protein | Biomarkers | Head and neck cancer | Interferon | Solid tumors | Cancer | Tumors | Index Medicus
Journal Article