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1. Full Text Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma
by Nakashima, Chie and Yamamoto, Kazuhiko and Fujiwara‐Tani, Rina and Luo, Yi and Matsushima, Sayako and Fujii, Kiyomu and Ohmori, Hitoshi and Sasahira, Tomonori and Sasaki, Takamitsu and Kitadai, Yasuhiko and Kirita, Tadaaki and Kuniyasu, Hiroki
Cancer science, ISSN 1347-9032, 06/2018, Volume 109, Issue 6, pp. 2036 - 2045
malic enzyme | cancer invasion | glutamine | prognosis | stemness | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Epithelial-Mesenchymal Transition - drug effects | Transplantation, Heterologous | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Malate Dehydrogenase - genetics | Cytosol - enzymology | Malate Dehydrogenase - antagonists & inhibitors | Oxidation-Reduction - drug effects | Mouth Neoplasms - genetics | Mouth Neoplasms - enzymology | Carcinoma, Squamous Cell - enzymology | Cell Proliferation - genetics | Disease Progression | Cell Movement - drug effects | Oligonucleotides, Antisense - genetics | Lanthanoid Series Elements - pharmacology | Cell Line, Tumor | Mouth Neoplasms - pathology | Cell Proliferation - drug effects | Malate Dehydrogenase - biosynthesis | Lactates | Glucose metabolism | Enzymes | Squamous cell carcinoma | Analysis | Development and progression | Fermentation | Glutamine | Cell proliferation | Tricarboxylic acid cycle | Energy metabolism | Phosphorylation | Dehydrogenases | Mesenchyme | Amino acids | Kinases | Cancer therapies | Cell adhesion & migration | Mitochondria | Cell growth | Feedback | NADP | Lipogenesis | Personal information | Oral carcinoma | Oral squamous cell carcinoma | Citric acid | Malic enzyme | Oxidative phosphorylation | Medical prognosis | Glycolysis | Lactic acid | Tumors | Index Medicus | Original
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2. Full Text Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial
by Soria, Jean-Charles, Prof and Felip, Enriqueta, MD and Cobo, Manuel, MD and Lu, Shun, MD and Syrigos, Konstantinos, Prof and Lee, Ki Hyeong, MD and Göker, Erdem, MD and Georgoulias, Vassilis, Prof and Li, Wei, MD and Isla, Dolores, MD and Guclu, Salih Z, MD and Morabito, Alessandro, MD and Min, Young J, MD and Ardizzoni, Andrea, MD and Gadgeel, Shirish M, Prof and Wang, Bushi, PhD and Chand, Vikram K, MD and Goss, Glenwood D, Prof and LUX-Lung 8 Investigators
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 8, pp. 897 - 907
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Receptor, Epidermal Growth Factor - metabolism | Carcinoma, Squamous Cell - mortality | Time Factors | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Carcinoma, Squamous Cell - enzymology | Lung Neoplasms - enzymology | Kaplan-Meier Estimate | Treatment Outcome | Tumor Burden | Disease Progression | Disease-Free Survival | Carcinoma, Squamous Cell - drug therapy | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Intention to Treat Analysis | Quinazolines - adverse effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Neoplasm Staging | Medical colleges | Squamous cell carcinoma | Care and treatment | Product development | College teachers | Erlotinib | Index Medicus
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3. Full Text High-frequency targetable EGFR mutations in sinonasal squamous cell carcinomas arising from inverted sinonasal papilloma
by Udager, Aaron M and Rolland, Delphine C.M and McHugh, Jonathan B and Betz, Bryan L and Murga-Zamalloa, Carlos and Carey, Thomas E and Marentette, Lawrence J and Hermsen, Mario A and DuRoss, Kathleen E and Lim, Megan S and Elenitoba-Johnson, Kojo S.J and Brown, Noah A
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2015, Volume 75, Issue 13, pp. 2600 - 2606
Life Sciences & Biomedicine | Oncology | Science & Technology | Paranasal Sinus Neoplasms - genetics | Amino Acid Sequence | Carcinoma, Squamous Cell - enzymology | ErbB Receptors - metabolism | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Molecular Sequence Data | Sequence Analysis, DNA | Squamous Cell Carcinoma of Head and Neck | Papilloma, Inverted - genetics | Cell Line, Tumor | Female | Head and Neck Neoplasms - genetics | Aged | Head and Neck Neoplasms - enzymology | Mutation | Paranasal Sinus Neoplasms - enzymology | Papilloma, Inverted - enzymology | Index Medicus | sinonasal | Schneiderian | inverted papilloma | EGFR | squamous cell carcinoma
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4. Full Text Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer
by Chen, Yu-Chih and Chen, Yi-Wei and Hsu, Han-Shui and Tseng, Ling-Ming and Huang, Pin-I and Lu, Kai-Hsi and Chen, Dow-Tien and Tai, Lung-Kuo and Yung, Ming-Chi and Chang, Shih-Ching and Ku, Hung-Hai and Chiou, Shih-Hwa and Lo, Wen-Liang
Biochemical and biophysical research communications, ISSN 0006-291X, 07/2009, Volume 385, Issue 3, pp. 307 - 313
Cancer stem cell | Head and neck squamous cancer | Aldehyde dehydrogenase 1 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Mesenchymal Stromal Cells - enzymology | Carcinoma, Squamous Cell - enzymology | Oligonucleotide Array Sequence Analysis | Isoenzymes - genetics | Humans | Middle Aged | Aldehyde Dehydrogenase - biosynthesis | Aldehyde Dehydrogenase - genetics | Male | Transcription Factors - genetics | Gene Knockdown Techniques | Retinal Dehydrogenase | Transcription Factors - metabolism | Biomarkers, Tumor - metabolism | Female | Aged | Head and Neck Neoplasms - enzymology | Tumor Cells, Cultured | Isoenzymes - biosynthesis | Neoplastic Stem Cells - enzymology | Snail Family Transcription Factors | Medical colleges | Squamous cell carcinoma | Aldehydes | Stem cells | Index Medicus
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5. Full Text FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer
by Hu, Xiaoling and Zhai, Yuanfang and Kong, Pengzhou and Cui, Heyang and Yan, Ting and Yang, Jian and Qian, Yu and Ma, Yanchun and Wang, Fang and Li, Hongyi and Cheng, Caixia and Zhang, Ling and Jia, Zhiwu and Li, Yaoping and Yang, Bin and Xu, Enwei and Wang, Juan and Yang, Jie and Bi, Yanghui and Chang, Lu and Wang, Yi and Zhang, Yingchun and Song, Bin and Li, Guodong and Shi, Ruyi and Liu, Jing and Zhang, Mingsheng and Cheng, Xiaolong and Cui, Yongping
Cancer letters, ISSN 0304-3835, 07/2017, Volume 397, pp. 83 - 93
MAPK pathway | FAT1 | EMT | Tumor suppressor | ESCC | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation | Cadherins - metabolism | Vimentin - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Epithelial-Mesenchymal Transition - drug effects | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Esophageal Neoplasms - pathology | Snail Family Transcription Factors - genetics | Transfection | RNA Interference | Time Factors | Vimentin - genetics | Female | Cadherins - genetics | Esophageal Squamous Cell Carcinoma | Carcinoma, Squamous Cell - enzymology | Snail Family Transcription Factors - metabolism | Neoplasm Invasiveness | Tumor Burden | Esophageal Neoplasms - enzymology | Animals | MAP Kinase Signaling System - drug effects | Esophageal Neoplasms - genetics | Mice, Nude | Cell Line, Tumor | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Mutation | Cell Movement | Prevention | Squamous cell carcinoma | Gene mutations | Stem cells | Physiological aspects | Muscle proteins | Esophageal cancer | Analysis | Index Medicus
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6. Full Text Squamous Cell Carcinoma “Transformation” Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas
by Jukna, Agita and Montanari, Gloria and Mengoli, Maria Cecilia and Cavazza, Alberto and Covi, Marisa and Barbieri, Fausto and Bertolini, Federica and Rossi, Giulio
Journal of thoracic oncology, ISSN 1556-0864, 04/2016, Volume 11, Issue 4, pp. e49 - e51
Adenocarcinoma | Squamous cell carcinoma | T790M | Lung | EGFR | Respiratory System | Oncology | Life Sciences & Biomedicine | Science & Technology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Carcinoma, Squamous Cell - enzymology | Lung Neoplasms - enzymology | Adenocarcinoma of Lung | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Adenocarcinoma - enzymology | ErbB Receptors - genetics | Antineoplastic Agents - therapeutic use | Adenocarcinoma - drug therapy | Drug Resistance, Neoplasm - genetics | Carcinoma, Squamous Cell - drug therapy | Female | Adenocarcinoma - genetics | Aged | Protein Kinase Inhibitors - pharmacology | Mutation
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7. Full Text mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis
by Iglesias-Bartolome, Ramiro and Patel, Vyomesh and Cotrim, Ana and Leelahavanichkul, Kantima and Molinolo, Alfredo A and Mitchell, James B and Gutkind, J. Silvio
Cell stem cell, ISSN 1934-5909, 09/2012, Volume 11, Issue 3, pp. 401 - 414
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell differentiation, maturation, development, hematopoiesis | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects | Index Medicus
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8. Full Text EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma
by Behrens, Carmen and Solis, Luisa M and Lin, Heather and Yuan, Ping and Tang, Ximing and Kadara, Humam and Riquelme, Erick and Galindo, Hector and Moran, Cesar A and Kalhor, Neda and Swisher, Stephen G and Simon, George R and Stewart, David J and Lee, J. Jack and Wistuba, Ignacio I
Clinical cancer research, ISSN 1078-0432, 12/2013, Volume 19, Issue 23, pp. 6556 - 6565
Life Sciences & Biomedicine | Oncology | Science & Technology | Pharmacology. Drug treatments | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Tumors | Pneumology | Multivariate Analysis | Prognosis | Lung Neoplasms - mortality | Humans | Carcinoma, Squamous Cell - surgery | Lung Neoplasms - pathology | Male | Lung - enzymology | DNA-Binding Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Carcinoma, Squamous Cell - mortality | Biomarkers, Tumor - metabolism | Female | Carcinoma, Squamous Cell - enzymology | Carcinoma, Non-Small-Cell Lung - surgery | Lung Neoplasms - enzymology | Adenocarcinoma - enzymology | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Disease Progression | Enhancer of Zeste Homolog 2 Protein | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - surgery | ROC Curve | Aged | Biomarkers, Tumor - genetics | Transcription Factors | Carcinoma, Non-Small-Cell Lung - enzymology | Polycomb Repressive Complex 2 - metabolism | Adenocarcinoma - mortality | Adenocarcinoma - surgery | Index Medicus | EGFR mutations | NSCLC | lung adenocarcinoma | KRAS mutations | brain metastasis | bronchial preneoplasia | lung squamous cell carcinoma | EZH2
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9. Full Text Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: Molecular bases for EGFR-targeted therapy
by Uribe, Pablo and Gonzalez, Sergio
Pathology, research and practice, ISSN 0344-0338, 2011, Volume 207, Issue 6, pp. 337 - 342
HNSCC | EGFR | Cutaneous squamous cell carcinoma | Life Sciences & Biomedicine | Pathology | Science & Technology | Skin Neoplasms - drug therapy | Carcinoma, Squamous Cell - genetics | Humans | ErbB Receptors - genetics | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Squamous Cell Carcinoma of Head and Neck | Skin Neoplasms - enzymology | Carcinoma - enzymology | Neoplasms, Squamous Cell - drug therapy | Head and Neck Neoplasms - enzymology | Precision Medicine | Carcinoma - drug therapy | Neoplasms, Squamous Cell - enzymology | Carcinoma, Squamous Cell - enzymology | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Head and Neck Neoplasms - drug therapy | Treatment Outcome | Animals | Carcinoma, Squamous Cell - drug therapy | Neoplasms, Squamous Cell - genetics | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Skin Neoplasms - genetics | Carcinoma - genetics | Head and Neck Neoplasms - genetics | Mutation | Index Medicus
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10. Full Text LUBAC determines chemotherapy resistance in squamous cell lung cancer
by Ruiz, E. Josue and Ruiz, E Josue and Diefenbacher, Markus E and Diefenbacher, Markus E and Nelson, Jessica K and Sancho, Rocio and Sancho, Rocio and Pucci, Fabio and Chakraborty, Atanu and Chakraborty, Atanu and Moreno, Paula and Annibaldi, Alessandro and Liccardi, Gianmaria and Encheva, Vesela and Mitter, Richard and Mitter, Richard and Rosenfeldt, Mathias and Snijders, Ambrosius P and Meier, Pascal and Calzado, Marco A and Calzado, Marco A and Behrens, Axel and Behrens, Axel
The Journal of experimental medicine, ISSN 0022-1007, 02/2019, Volume 216, Issue 2, pp. 450 - 465
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Carcinoma, Squamous Cell - enzymology | Lung Neoplasms - enzymology | Adenocarcinoma of Lung - pathology | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Multienzyme Complexes - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Multienzyme Complexes - genetics | Cisplatin - pharmacology | Adenocarcinoma of Lung - enzymology | Ubiquitination | Adenocarcinoma of Lung - genetics | Animals | Carcinoma, Squamous Cell - drug therapy | Adenocarcinoma of Lung - drug therapy | Mice | Proto-Oncogene Proteins p21(ras) - metabolism | Index Medicus | 307
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