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1. Full Text Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial
by Soria, Jean-Charles, Prof and Felip, Enriqueta, MD and Cobo, Manuel, MD and Lu, Shun, MD and Syrigos, Konstantinos, Prof and Lee, Ki Hyeong, MD and Göker, Erdem, MD and Georgoulias, Vassilis, Prof and Li, Wei, MD and Isla, Dolores, MD and Guclu, Salih Z, MD and Morabito, Alessandro, MD and Min, Young J, MD and Ardizzoni, Andrea, MD and Gadgeel, Shirish M, Prof and Wang, Bushi, PhD and Chand, Vikram K, MD and Goss, Glenwood D, Prof and LUX-Lung 8 Investigators
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 8, pp. 897 - 907
Summary Background There is a major unmet need for effective treatments in patients with squamous cell carcinoma of the lung. LUX-Lung 8 compared afatinib (an... 
Hematology, Oncology and Palliative Medicine | PLUS GEMCITABINE | SURVIVAL | GROWTH-FACTOR RECEPTOR | CANCER NSCLC | CISPLATIN | ONCOLOGY | ADENOCARCINOMA | PROTEIN EXPRESSION | EGFR MUTATIONS | HISTOLOGY | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Receptor, Epidermal Growth Factor - metabolism | Carcinoma, Squamous Cell - mortality | Time Factors | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Carcinoma, Squamous Cell - enzymology | Lung Neoplasms - enzymology | Kaplan-Meier Estimate | Treatment Outcome | Tumor Burden | Disease Progression | Disease-Free Survival | Carcinoma, Squamous Cell - drug therapy | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Intention to Treat Analysis | Quinazolines - adverse effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Neoplasm Staging | Medical colleges | Squamous cell carcinoma | Care and treatment | Product development | College teachers | Erlotinib | Index Medicus
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2. Full Text Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer
by Chen, Yi-Wei and Chen, Yu-Chih and Chen, Dow-Tien and Hsu, Han-Shui and Tseng, Ling-Ming and Huang, Pin-I and Lu, Kai-Hsi and Tai, Lung-Kuo and Yung, Ming-Chi and Chang, Shih-Ching and Ku, Hung-Hai and Chiou, Shih-Hwa and Lo, Wen-Liang
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2009, Volume 385, Issue 3, pp. 307 - 313
Aldehyde dehydrogenase 1 (ALDH1) has been considered to be a marker for cancer stem cells. However, the role of ALDH1 in head and neck squamous cell carcinoma... 
Cancer stem cell | Head and neck squamous cancer | Aldehyde dehydrogenase 1 | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | BIOPHYSICS | CARCINOMA | EXPRESSION | SNAIL | OCT-4 | Mesenchymal Stromal Cells - enzymology | Carcinoma, Squamous Cell - enzymology | Oligonucleotide Array Sequence Analysis | Isoenzymes - genetics | Humans | Middle Aged | Aldehyde Dehydrogenase - biosynthesis | Aldehyde Dehydrogenase - genetics | Male | Transcription Factors - genetics | Gene Knockdown Techniques | Retinal Dehydrogenase | Transcription Factors - metabolism | Biomarkers, Tumor - metabolism | Female | Aged | Head and Neck Neoplasms - enzymology | Tumor Cells, Cultured | Isoenzymes - biosynthesis | Neoplastic Stem Cells - enzymology | Snail Family Transcription Factors | Medical colleges | Squamous cell carcinoma | Aldehydes | Stem cells | Index Medicus
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3. Full Text RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors
by Patrick A. Oberholzer and Damien Kee and Piotr Dziunycz and Antje Sucker and Nyam Kamsukom and Robert Jones and Christine Roden and Clinton J. Chalk and Kristin Ardlie and Emanuele Palescandolo and Adriano Piris and Laura E. MacConaill and Caroline Robert and Günther F.L. Hofbauer and Grant A. McArthur and Dirk Schadendorf and Levi A. Garraway
Journal of Clinical Oncology, ISSN 0732-183X, 01/2012, Volume 30, Issue 3, pp. 316 - 321
Purpose RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas... 
GENE-MUTATIONS | MELANOMA | ONCOLOGY | PATHWAY | BRAF | KERATOACANTHOMA | SORAFENIB | NONMELANOMA SKIN CANCERS | CARCINOMA | PROGRESSION | ACTINIC KERATOSIS | Niacinamide - analogs & derivatives | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Carcinoma, Squamous Cell - chemically induced | Gene Expression Regulation, Neoplastic | Male | Benzenesulfonates - therapeutic use | Phenylurea Compounds | Protein Kinase Inhibitors - adverse effects | Benzenesulfonates - adverse effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Pyridines - adverse effects | Skin Neoplasms - enzymology | Mass Spectrometry | Aged, 80 and over | Adult | Female | Pyridines - therapeutic use | Skin Neoplasms - pathology | Carcinoma, Squamous Cell - enzymology | Genotype | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Vemurafenib | Indoles - adverse effects | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Skin Neoplasms - genetics | Sorafenib | Sulfonamides - adverse effects | Indoles - therapeutic use | Aged | Mutation | Index Medicus | Nmel | Mela5 | Mela7 | Original Reports | Epid1 | To8 | To11
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4. Full Text Comprehensive histologic analysis of ALK-rearranged lung carcinomas
by Yoshida, Akihiko and Tsuta, Koji and Nakamura, Harumi and Kohno, Takashi and Takahashi, Fumiaki and Asamura, Hisao and Sekine, Ikuo and Fukayama, Masashi and Shibata, Tatsuhiro and Furuta, Koh and Tsuda, Hitoshi
American Journal of Surgical Pathology, ISSN 0147-5185, 08/2011, Volume 35, Issue 8, pp. 1226 - 1234
A subset (1% to 5%) of non-small-cell lung carcinomas harbors the EML4-ALK fusion gene. Data from previous studies on the histomorphology of ALK-rearranged... 
EML4-ALK | lung | adenocarcinoma | histomorphology | SURGERY | GEFITINIB | EML4-ALK FUSION | EGFR MUTATIONS | PATHOLOGY | CANCER | SUBSET | TUMORS | RECLASSIFICATION | GENE-EXPRESSION | Immunohistochemistry | Multivariate Analysis | Pleural Neoplasms - genetics | Adenocarcinoma - pathology | Lymph Nodes - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Carcinoma, Squamous Cell - surgery | Lung Neoplasms - pathology | Male | Pneumonectomy | Carcinoma, Non-Small-Cell Lung - secondary | In Situ Hybridization | Adult | Female | Adenocarcinoma - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Pleural Neoplasms - secondary | Carcinoma, Squamous Cell - enzymology | Carcinoma, Non-Small-Cell Lung - surgery | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Neoplasm Invasiveness | Adenocarcinoma - enzymology | Lymphatic Metastasis | Reverse Transcriptase Polymerase Chain Reaction | Receptor Protein-Tyrosine Kinases - genetics | Gene Rearrangement | Lung Neoplasms - surgery | Pleural Neoplasms - enzymology | Aged | Carcinoma, Non-Small-Cell Lung - enzymology | Neoplasm Staging | Adenocarcinoma - surgery | Index Medicus
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5. Full Text EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma
by Behrens, Carmen and Solis, Luisa M and Lin, Heather and Yuan, Ping and Tang, Ximing and Kadara, Humam and Riquelme, Erick and Galindo, Hector and Moran, Cesar A and Kalhor, Neda and Swisher, Stephen G and Simon, George R and Stewart, David J and Lee, J. Jack and Wistuba, Ignacio I
Clinical Cancer Research, ISSN 1078-0432, 12/2013, Volume 19, Issue 23, pp. 6556 - 6565
Purpose: Enhancer of zeste homolog 2 (EZH2) promotes carcinogenesis by epigenetically silencing tumor suppressor genes. We studied EZH2 expression by... 
CANCER-CELLS | DNA METHYLATION | GENE | REPRESSION | ONCOLOGY | ADENOCARCINOMA | ZESTE HOMOLOG 2 | PROSTATE-CANCER | ENHANCER | HISTONE METHYLTRANSFERASE EZH2 | THYROID TRANSCRIPTION FACTOR-1 | Multivariate Analysis | Prognosis | Lung Neoplasms - mortality | Humans | Carcinoma, Squamous Cell - surgery | Lung Neoplasms - pathology | Male | Lung - enzymology | DNA-Binding Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Carcinoma, Squamous Cell - mortality | Biomarkers, Tumor - metabolism | Female | Carcinoma, Squamous Cell - enzymology | Carcinoma, Non-Small-Cell Lung - surgery | Lung Neoplasms - enzymology | Adenocarcinoma - enzymology | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Disease Progression | Enhancer of Zeste Homolog 2 Protein | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - surgery | ROC Curve | Aged | Biomarkers, Tumor - genetics | Transcription Factors | Carcinoma, Non-Small-Cell Lung - enzymology | Polycomb Repressive Complex 2 - metabolism | Adenocarcinoma - mortality | Adenocarcinoma - surgery | Index Medicus | EGFR mutations | NSCLC | lung adenocarcinoma | KRAS mutations | brain metastasis | bronchial preneoplasia | lung squamous cell carcinoma | EZH2
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6. Full Text mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis
by Iglesias-Bartolome, Ramiro and Patel, Vyomesh and Cotrim, Ana and Leelahavanichkul, Kantima and Molinolo, Alfredo A and Mitchell, James B and Gutkind, J. Silvio
Cell Stem Cell, ISSN 1934-5909, 09/2012, Volume 11, Issue 3, pp. 401 - 414
The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-renewing stem cells, which makes them vulnerable to physical and... 
MAMMALIAN TARGET | CANCER PATIENTS | RAPAMYCIN | HEAD | AGING PHENOTYPES | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RESPONSE | TUMOR | NECK | SKIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects | Index Medicus
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7. Full Text STAT3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients
by Vasquez-Dunddel, David and Pan, Fan and Zeng, Qi and Gorbounov, Mikhail and Albesiano, Emilia and Fu, Juan and Blosser, Richard L and Tam, Ada J and Bruno, Tullia and Zhang, Hao and Pardoll, Drew and Kim, Young
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1580 - 1589
Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC).... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEAD | THERAPY | GROWTH | EXPANSION | TUMOR | IMMUNOSUPPRESSIVE ACTIVITY | DIFFERENTIATION | ACCUMULATION | IDENTIFICATION | CARCINOMA | Myeloid Cells - enzymology | RNA, Small Interfering - genetics | T-Lymphocytes - physiology | Phosphorylation | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Arginase - metabolism | Gene Expression Regulation, Neoplastic | Gene Knockdown Techniques | Lipopolysaccharide Receptors - metabolism | STAT3 Transcription Factor - physiology | Superoxides - metabolism | Head and Neck Neoplasms - enzymology | HLA-DR Antigens - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promoter Regions, Genetic | Carcinoma, Squamous Cell - enzymology | Cells, Cultured | Arginase - genetics | Head and Neck Neoplasms - pathology | Protein Binding | Head and Neck Neoplasms - genetics | T-Lymphocytes - immunology | Protein Processing, Post-Translational | Myeloid Cells - pathology | Enzyme Repression | Cellular control mechanisms | Physiological aspects | Arginase | Genetic aspects | Research | Suppressor cells | Cancer | Index Medicus | Abridged Index Medicus
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8. Full Text APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development
by Henderson, Stephen and Chakravarthy, Ankur and Su, Xiaoping and Boshoff, Chris and Fenton, Tim Robert
Cell Reports, ISSN 2211-1247, 06/2014, Volume 7, Issue 6, pp. 1833 - 1841
APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected... 
BREAST-CANCER | HEAD | MUTAGENESIS | PHOSPHATIDYLINOSITOL 3-KINASE | DNA | SQUAMOUS-CELL CARCINOMA | CYTIDINE DEAMINASE | EXPRESSION | HUMAN CANCER | NECK-CANCER | CELL BIOLOGY | Protein Structure, Tertiary | Carcinoma, Squamous Cell - enzymology | Head and Neck Neoplasms - virology | Minor Histocompatibility Antigens | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Squamous Cell Carcinoma of Head and Neck | Class I Phosphatidylinositol 3-Kinases | Deamination | Cytosine - metabolism | Cytidine Deaminase - metabolism | Cell Transformation, Viral - genetics | Head and Neck Neoplasms - genetics | Head and Neck Neoplasms - enzymology | Mutation | Papillomaviridae - physiology | Index Medicus
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9. Full Text The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas
by Xiao, Zuoxiang and Jiang, Qun and Willette-Brown, Jami and Xi, Sichuan and Zhu, Feng and Burkett, Sandra and Back, Timothy and Song, Na-Young and Datla, Mahesh and Sun, Zhonghe and Goldszmid, Romina and Lin, Fanching and Cohoon, Travis and Pike, Kristen and Wu, Xiaolin and Schrump, David S and Wong, Kwok-Kin and Young, Howard A and Trinchieri, Giorgio and Wiltrout, Robert H and Hu, Yinling
Cancer Cell, ISSN 1535-6108, 04/2013, Volume 23, Issue 4, pp. 527 - 540
Here, we report that kinase-dead IKKα knockin mice develop spontaneous lung squamous cell carcinomas (SCCs) associated with IKKα downregulation and marked... 
TRANSFORMATION | SUPPRESSOR | KAPPA-B-KINASE | STEM-CELLS | ONCOLOGY | NITRIC-OXIDE SYNTHASE | MICE | SKIN | DIFFERENTIATION | P63 | CANCER | CELL BIOLOGY | Lung Neoplasms - genetics | Carcinoma, Squamous Cell - enzymology | Lung Neoplasms - enzymology | Phosphoproteins - biosynthesis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Cell Growth Processes - physiology | Lung Neoplasms - pathology | Mice, Transgenic | Transcription Factors - biosynthesis | I-kappa B Kinase - genetics | Cell Transformation, Neoplastic - metabolism | I-kappa B Kinase - physiology | Animals | I-kappa B Kinase - metabolism | Cell Transformation, Neoplastic - genetics | Cell Line, Tumor | Mice | Trans-Activators - biosynthesis | Cell Transformation, Neoplastic - pathology | Cell Differentiation - physiology | Disease Models, Animal
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10. Full Text High-frequency targetable EGFR mutations in sinonasal squamous cell carcinomas arising from inverted sinonasal papilloma
by Udager, Aaron M and Rolland, Delphine C.M and McHugh, Jonathan B and Betz, Bryan L and Murga-Zamalloa, Carlos and Carey, Thomas E and Marentette, Lawrence J and Hermsen, Mario A and DuRoss, Kathleen E and Lim, Megan S and Elenitoba-Johnson, Kojo S.J and Brown, Noah A
Cancer Research, ISSN 0008-5472, 07/2015, Volume 75, Issue 13, pp. 2600 - 2606
Inverted sinonasal papilloma (ISP) is a locally aggressive neoplasm associated with sinonasal squamous cell carcinoma (SNSCC) in 10% to 25% of cases. To date,... 
GROWTH-FACTOR RECEPTOR | INHIBITOR HKI-272 | HEAD | GEFITINIB | ONCOLOGY | SCHNEIDERIAN PAPILLOMAS | ERBB2 | NECK | PREVALENCE | LUNG-CANCER MODELS | LINES | Paranasal Sinus Neoplasms - genetics | Amino Acid Sequence | Carcinoma, Squamous Cell - enzymology | ErbB Receptors - metabolism | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Molecular Sequence Data | Sequence Analysis, DNA | Squamous Cell Carcinoma of Head and Neck | Papilloma, Inverted - genetics | Cell Line, Tumor | Female | Head and Neck Neoplasms - genetics | Aged | Head and Neck Neoplasms - enzymology | Mutation | Paranasal Sinus Neoplasms - enzymology | Papilloma, Inverted - enzymology | Index Medicus | sinonasal | Schneiderian | inverted papilloma | EGFR | squamous cell carcinoma
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11. Full Text Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma
by Califano, Joseph A and Khan, Zubair and Noonan, Kimberly A and Rudraraju, Lakshmi and Zhang, Zhe and Wang, Hao and Goodman, Steven and Gourin, Christine G and Ha, Patrick K and Fakhry, Carole and Saunders, John and Levine, Marshall and Tang, Mei and Neuner, Geoffrey and Richmon, Jeremy D and Blanco, Ray and Agrawal, Nishant and Koch, Wayne M and Marur, Shanthi and Weed, Donald T and Serafini, Paolo and Borrello, Ivan
Clinical Cancer Research, ISSN 1078-0432, 01/2015, Volume 21, Issue 1, pp. 30 - 38
Purpose: To determine if phosphodiesterase 5 (PDE5) inhibitors can augment immune function in patients with head and neck cancer through inhibition of... 
SURVIVAL | CANCER-PATIENTS | DELAYED-HYPERSENSITIVITY | ONCOLOGY | PULMONARY ARTERIAL-HYPERTENSION | PROTEIN EXPRESSION | REGULATORY T-CELLS | NITRIC-OXIDE | SUPPRESSOR-CELLS | MYELOID CELLS | ANTIGEN | Carcinoma, Squamous Cell - enzymology | Humans | Middle Aged | Head and Neck Neoplasms - drug therapy | Phosphodiesterase 5 Inhibitors - administration & dosage | Male | Carbolines - administration & dosage | Carcinoma, Squamous Cell - immunology | Tadalafil | Head and Neck Neoplasms - immunology | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - drug therapy | Immunity, Cellular - drug effects | T-Lymphocytes - drug effects | Aged, 80 and over | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Adult | Female | T-Lymphocytes - immunology | Aged | Cyclic Nucleotide Phosphodiesterases, Type 5 - immunology | Head and Neck Neoplasms - enzymology | Index Medicus
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12. Full Text AXL mediates resistance to cetuximab therapy
by Brand, Toni M and Iida, Mari and Stein, Andrew P and Corrigan, Kelsey L and Braverman, Cara M and Luthar, Neha and Toulany, Mahmoud and Gill, Parkash S and Salgia, Ravi and Kimple, Randall J and Wheeler, Deric L
Cancer Research, ISSN 0008-5472, 08/2014, Volume 74, Issue 18, pp. 5152 - 5164
The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired resistance to this agent is a common clinical outcome. In this study,... 
CELL LUNG-CANCER | PHASE-III TRIAL | BREAST-CANCER | RECEPTOR TYROSINE KINASES | PLUS CETUXIMAB | ONCOLOGY | COLORECTAL-CANCER | ACQUIRED-RESISTANCE | EGFR BLOCKADE | TUMOR-GROWTH | MOLECULAR-MECHANISMS | RNA, Small Interfering - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Proto-Oncogene Proteins - biosynthesis | Squamous Cell Carcinoma of Head and Neck | Transfection | Antibodies, Monoclonal, Humanized - pharmacology | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Cetuximab | Carcinoma, Non-Small-Cell Lung - pathology | Proto-Oncogene Proteins - metabolism | Carcinoma, Squamous Cell - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Cell Growth Processes - drug effects | Head and Neck Neoplasms - drug therapy | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Receptor Protein-Tyrosine Kinases - genetics | Mice, Nude | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | RNA, Small Interfering - administration & dosage | Index Medicus | Resistance | AXL | EGFR
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13. Full Text Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma
by Kurashige, J and Watanabe, M and Iwatsuki, M and Kinoshita, K and Saito, S and Hiyoshi, Y and Kamohara, H and Baba, Y and Mimori, K and Baba, H
British Journal of Cancer, ISSN 0007-0920, 01/2012, Volume 106, Issue 1, pp. 182 - 188
BACKGROUND: F-box and WD repeat domain-containing 7 (FBXW7) is a cell cycle regulatory gene whose protein product ubiquitinates positive cell cycle regulators... 
ubiquitin ligase | FBXW7 | microRNA | SURVIVAL | APOPTOSIS | PROFILES | CYCLIN-E | PROGNOSIS | ADENOCARCINOMA | PROLIFERATION | ONCOLOGY | GASTRIC-CANCER | DEGRADATION | EXPRESSION | Immunohistochemistry | F-Box-WD Repeat-Containing Protein 7 | Carcinoma, Squamous Cell - enzymology | Prognosis | F-Box Proteins - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Male | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Esophageal Neoplasms - pathology | Esophageal Neoplasms - enzymology | Base Sequence | Cell Line, Tumor | Female | Aged | MicroRNAs - physiology | Real-Time Polymerase Chain Reaction | Index Medicus | Molecular Diagnostics
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