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1. Full Text Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
by Duhen, Thomas and Duhen, Rebekka and Montler, Ryan and Moses, Jake and Moudgil, Tarsem and De Miranda, Noel F and Goodall, Cheri P and Blair, Tiffany C and Fox, Bernard A and McDermott, Jason E and Chang, Shu-Ching and Grunkemeier, Gary and Leidner, Rom and Bell, Richard Bryan and Weinberg, Andrew D and Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2724 - 13
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Adenocarcinoma of Lung - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Squamous Cell Carcinoma of Head and Neck - pathology | Ovarian Neoplasms - pathology | Transcriptome | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | Squamous Cell Carcinoma of Head and Neck - mortality | Ovarian Neoplasms - mortality | Antigens, CD - genetics | Squamous Cell Carcinoma of Head and Neck - immunology | Ovarian Neoplasms - genetics | Adenocarcinoma of Lung - mortality | Adenocarcinoma of Lung - genetics | Carcinoma, Squamous Cell - mortality | Melanoma - genetics | Integrin alpha Chains - immunology | Female | Adenocarcinoma of Lung - immunology | Apyrase - immunology | Immunophenotyping | Melanoma - pathology | Carcinoma, Squamous Cell - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8 Antigens - immunology | Squamous Cell Carcinoma of Head and Neck - genetics | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | Apyrase - genetics | CD8 Antigens - genetics | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Integrin alpha Chains - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Melanoma - mortality | Ovarian Neoplasms - immunology | Head | Phenotypes | Tumor cells | CD8 antigen | T cell receptors | Lymphocytes T | Patients | Metastases | T-cell receptor | CD103 antigen | Major histocompatibility complex | Lymphocytes | Immunotherapy | Head and neck cancer | Solid tumors | Cancer | Tumors | Index Medicus | BASIC BIOLOGICAL SCIENCES
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2. Full Text Immunosuppressive activity of CD14+ HLA‐DR− cells in squamous cell carcinoma of the head and neck
by Chikamatsu, Kazuaki and Sakakura, Koichi and Toyoda, Minoru and Takahashi, Katsumasa and Yamamoto, Takanori and Masuyama, Keisuke
Cancer science, ISSN 1347-9032, 06/2012, Volume 103, Issue 6, pp. 976 - 983
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation | Humans | Middle Aged | Male | Lipopolysaccharide Receptors - analysis | Squamous Cell Carcinoma of Head and Neck | Myeloid Cells - immunology | Aged, 80 and over | Adult | Female | B7-2 Antigen - immunology | HLA-DR Antigens - metabolism | Antibodies, Monoclonal - immunology | Transforming Growth Factor beta - immunology | Cells, Cultured | B7-2 Antigen - analysis | Lipopolysaccharide Receptors - immunology | B7-H1 Antigen - immunology | Carcinoma, Squamous Cell - immunology | Interleukin-7 Receptor alpha Subunit - analysis | Head and Neck Neoplasms - immunology | Interleukin-2 Receptor alpha Subunit - analysis | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Aged | B7-H1 Antigen - analysis | HLA-DR Antigens - immunology | Interferon-gamma - biosynthesis | Index Medicus | Original
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3. Full Text Cd44+ cells in head and neck squamous cell carcinoma suppress t-cell-mediated immunity by selective constitutive and inducible expression of PD-L1
by Lee, Yunqin and Shin, June Ho and Longmire, Michelle and Wang, Hua and Kohrt, Holbrook E and Chang, Howard Y and Sunwoo, John B
Clinical cancer research, ISSN 1078-0432, 07/2016, Volume 22, Issue 14, pp. 3571 - 3581
Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Squamous Cell - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Carcinoma, Squamous Cell - immunology | Head and Neck Neoplasms - metabolism | B7-H1 Antigen - metabolism | Head and Neck Neoplasms - immunology | STAT1 Transcription Factor - metabolism | Squamous Cell Carcinoma of Head and Neck | Animals | Epithelial-Mesenchymal Transition - immunology | Hyaluronan Receptors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | STAT3 Transcription Factor - metabolism | Index Medicus | SCCHN | Immune evasion | cancer stem cells | immune suppression | oral cancer | tumor heterogeneity
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4. Full Text A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency
by Punt, Simone and nkers, Emilie and Welters, M and Goedemans, Renske and Koljenović, Senada and Bloemena, Elisabeth and Snijders, Peter and Gorter, Arko and Burg, Sjoerd and Baatenburg de Jong, Robert Jan and Jordanova, Ekaterina S
Cancer Immunology, Immunotherapy: other biological response modifications, ISSN 0340-7004, 04/2016, Volume 65, Issue 4, pp. 393 - 403
Head and neck cancer | Th17 cell | Tumor microenvironment | T cell | IL-17 | Treg | Oncology | Immunology | Life Sciences & Biomedicine | Science & Technology | Forkhead Transcription Factors - immunology | Oropharyngeal Neoplasms - immunology | T-Lymphocytes, Regulatory - metabolism | Humans | Middle Aged | Interleukin-17 - immunology | Male | T-Lymphocytes, Regulatory - immunology | Papillomaviridae - immunology | T-Lymphocytes - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Aged, 80 and over | Papillomavirus Infections - immunology | Adult | Female | Papillomavirus Infections - virology | Granulocytes - metabolism | Papillomavirus Infections - complications | Kaplan-Meier Estimate | CD3 Complex - metabolism | Carcinoma, Squamous Cell - immunology | Oropharyngeal Neoplasms - complications | Tumor Microenvironment - immunology | Interleukin-17 - metabolism | Microscopy, Confocal | Carcinoma, Squamous Cell - complications | CD3 Complex - immunology | Lymphocyte Count | Th17 Cells - immunology | T-Lymphocytes - immunology | Aged | Granulocytes - immunology | Index Medicus | Original
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5. Full Text Ox40+ regulatory T cells in cutaneous squamous cell carcinoma suppress effector T-cell responses and associate with metastatic potential
by Lai, Chester and August, Suzannah and Albibas, Amel and Behar, Ramnik and Cho, Shin-Young and Polak, Marta E and Theaker, Jeffrey and Macleod, Amanda S and French, Ruth R and Glennie, Martin J and Al-Shamkhani, Aymen and Healy, Eugene
Clinical cancer research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16, pp. 4236 - 4248
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Skin Neoplasms - pathology | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Receptors, OX40 - agonists | Skin Neoplasms - immunology | Immunomodulation | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Immunophenotyping | Carcinoma, Squamous Cell - immunology | Skin Neoplasms - metabolism | T-Lymphocytes, Regulatory - immunology | Lymphocyte Activation - immunology | Neoplasm Metastasis | Phenotype | Receptors, OX40 - metabolism | T-Lymphocyte Subsets - metabolism | Biomarkers | Lymphocyte Count | Immunologic Memory | Lymphocytes, Tumor-Infiltrating - metabolism | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
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6. Full Text Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
by Hendry, Shona and Salgado, Roberto and Gevaert, Thomas and Russell, Prudence A and John, Tom and Thapa, Bibhusal and Christie, Michael and van de Vijver, Koen and Estrada, M. V and Gonzalez-Ericsson, Paula I and Sanders, Melinda and Solomon, Benjamin and Solinas, Cinzia and Van den Eynden, Gert G. G. M and Allory, Yves and Preusser, Matthias and Hainfellner, Johannes and Pruneri, Giancarlo and Vingiani, Andrea and Demaria, Sandra and Symmans, Fraser and Nuciforo, Paolo and Comerma, Laura and Thompson, E. A and Lakhani, Sunil and Kim, Seong-Rim and Schnitt, Stuart and Colpaert, Cecile and Sotiriou, Christos and Scherer, Stefan J and Ignatiadis, Michail and Badve, Sunil and Pierce, Robert H and Viale, Giuseppe and Sirtaine, Nicolas and Penault-Llorca, Frederique and Sugie, Tomohagu and Fineberg, Susan and Paik, Soonmyung and Srinivasan, Ashok and Richardson, Andrea and Wang, Yihong and Chmielik, Ewa and Brock, Jane and Johnson, Douglas B and Balko, Justin and Wienert, Stephan and Bossuyt, Veerle and Michiels, Stefan and Ternes, Nils and Burchardi, Nicole and Luen, Stephen J and Savas, Peter and Klauschen, Frederick and Watson, Peter H and Nelson, Brad H and Criscitiello, Carmen and O'Toole, Sandra and Larsimont, Denis and de Wind, Roland and Curigliano, Giuseppe and Andre, Fabrice and Lacroix-Triki, Magali and van de Vijver, Mark and Rojo, Federico and Floris, Giuseppe and Bedri, Shahinaz and Sparano, Joseph and Rimm, David and Nielsen, Torsten and Kos, Zuzana and Hewitt, Stephen and Singh, Baljit and Farshid, Gelareh and Loibl, Sibylle and Allison, Kimberly H and Tung, Nadine and Adams, Sylvia and Willard-Gallo, Karen and Horlings, Hugo M and Gandhi, Leena and Moreira, Andre and Hirsch, Fred and Dieci, Maria V and Urbanowicz, Maria and Brcic, Iva and Korski, Konstanty and Gaire, Fabien and Koeppen, Hartmut and Lo, Amy and Giltnane, Jennifer and Rebelatto, Marlon C and Steele, Keith E and Zha, Jiping and Emancipator, Kenneth and Juco, Jonathan W and Denkert, Carsten and Reis-Filho, Jorge and Loi, Sherene and Fox, Stephen B
Advances in anatomic pathology, ISSN 1072-4109, 11/2017, Volume 24, Issue 6, pp. 311 - 335
Life Sciences & Biomedicine | Pathology | Science & Technology | Immunohistochemistry | Mesothelioma - immunology | Predictive Value of Tests | Mesothelioma - pathology | Carcinoma, Squamous Cell - pathology | Humans | Brain Neoplasms - pathology | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Pathology - standards | Gastrointestinal Neoplasms - pathology | Endometrial Neoplasms - immunology | Squamous Cell Carcinoma of Head and Neck | Brain Neoplasms - immunology | Female | Carcinoma, Non-Small-Cell Lung - pathology | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Biomarkers, Tumor - analysis | Urogenital Neoplasms - pathology | Melanoma - pathology | Carcinoma, Squamous Cell - immunology | Head and Neck Neoplasms - pathology | Urogenital Neoplasms - immunology | Carcinoma, Non-Small-Cell Lung - immunology | Gastrointestinal Neoplasms - immunology | Head and Neck Neoplasms - immunology | Lung Neoplasms - immunology | Phenotype | Lymphocytes, Tumor-Infiltrating - pathology | Biopsy | Melanoma - immunology | Endometrial Neoplasms - pathology | Pathology - methods | Lymphocytes, Tumor-Infiltrating - immunology | Ovarian Neoplasms - immunology | Biomarkers | Lymphocytes | Immunotherapy | tumor-infiltrating | Cancer
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7. Full Text PD-1 expression in head and neck squamous cell carcinomas derives primarily from functionally anergic CD4 + TILs in the presence of PD-L1 + TAMs
by Mattox, Austin K and Lee, Jina and Westra, William H and Pierce, Robert H and Ghossein, Ronald and Faquin, William C and Diefenbach, Thomas J and Morris, Luc G and Lin, Derrick T and Wirth, Lori J and Lefranc-Torres, Armida and Ishida, Eiichi and Chakravarty, Patrick D and Johnson, Lauren and Zeng, Yang C and Chen, Huabiao and Poznansky, Mark C and Iyengar, Neil M and Pai, Sara I
Cancer research (Chicago, Ill.), ISSN 0008-5472, 11/2017, Volume 77, Issue 22, pp. 6365 - 6374
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | CD4-Positive T-Lymphocytes - metabolism | Kaplan-Meier Estimate | Mouth Neoplasms - metabolism | Carcinoma, Squamous Cell - immunology | Mouth Neoplasms - immunology | CD4-Positive T-Lymphocytes - immunology | Tumor Microenvironment - immunology | Macrophages - metabolism | B7-H1 Antigen - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Clonal Anergy - immunology | Mouth Neoplasms - pathology | Lymphocytes, Tumor-Infiltrating - metabolism | CD8-Positive T-Lymphocytes - immunology | Macrophages - immunology | Microscopy, Fluorescence | Lymphocytes, Tumor-Infiltrating - immunology | Therapy | Regulators | Tongue | Squamous cell carcinoma | Anergy | Tumor-infiltrating lymphocytes | PD-1 protein | CD8 antigen | Helper cells | Blocking antibodies | Hepatocellular carcinoma | CD4 antigen | Oral cavity | Immune checkpoint | Lymphocytes | Cell death | Immunotherapy | PD-L1 protein | Foxp3 protein | Head and neck cancer | Head & neck cancer | Head and neck carcinoma | Apoptosis | Index Medicus | CD4 | CD8+ T cells | macrophages | oral tongue squamous cell carcinoma | head and neck cancer | PD-L1 | B7-H1 | PD-1 | immune checkpoint blockade
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