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cardenolides (137) 137
index medicus (117) 117
plant sciences (83) 83
biosynthesis (53) 53
biochemistry & molecular biology (48) 48
animals (44) 44
digoxin (42) 42
humans (41) 41
pharmacology & pharmacy (37) 37
cardenolide biosynthesis (36) 36
digitalis lanata (34) 34
cardiac glycosides (33) 33
cardenolides - metabolism (28) 28
cardenolide (27) 27
plants (27) 27
scrophulariaceae (25) 25
digitalis (24) 24
cardiac-glycosides (22) 22
male (21) 21
enzyme (19) 19
physiological aspects (19) 19
sodium-potassium-exchanging atpase - antagonists & inhibitors (19) 19
leaves (18) 18
chemistry, medicinal (17) 17
ecology (17) 17
gene expression (17) 17
progesterone (17) 17
shoot cultures (16) 16
digitalis purpurea (15) 15
digitoxin (15) 15
life sciences (15) 15
phylogeny (15) 15
rats (15) 15
research (15) 15
saponins (15) 15
analysis (14) 14
expression (14) 14
ouabain (14) 14
plantaginaceae (14) 14
progesterone 5-beta-reductase (14) 14
cardenolides - pharmacology (13) 13
purpurea (13) 13
sodium-potassium-exchanging atpase - metabolism (13) 13
cells, cultured (12) 12
digitalis-lanata (12) 12
enzymes (12) 12
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female (12) 12
glycosides (12) 12
herbivores (12) 12
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progesterone 5β-reductase (12) 12
purification (12) 12
digitalis - enzymology (11) 11
endogenous ouabain (11) 11
hypertension (11) 11
kinetics (11) 11
molecular-cloning (11) 11
peripheral vascular disease (11) 11
plant defense (11) 11
pyrrolizidine alkaloids (11) 11
sodium-pump (11) 11
steroids (11) 11
cell line, tumor (10) 10
progesterone 5 beta-reductase (10) 10
saponins - metabolism (10) 10
secondary metabolism (10) 10
apoptosis (9) 9
bovine adrenocortical-cells (9) 9
cell-cultures (9) 9
chemical ecology (9) 9
digitalis - metabolism (9) 9
foxglove (9) 9
growth (9) 9
heterologous expression (9) 9
metabolites (9) 9
secondary metabolites (9) 9
alkaloids (8) 8
amino acid sequence (8) 8
biotechnology & applied microbiology (8) 8
calcium - metabolism (8) 8
cancer (8) 8
cardenolides - chemistry (8) 8
cell biology (8) 8
chromatography, high pressure liquid (8) 8
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agriculture (7) 7
apoptosis - drug effects (7) 7
asclepiadaceae (7) 7
atpase (7) 7
biotechnology (7) 7
blood proteins - biosynthesis (7) 7
chemistry, organic (7) 7
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The New Phytologist, ISSN 0028-646X, 2/2010, Volume 185, Issue 3, pp. 687 - 700
The stereospecific 5β-reduction of progesterone is a required step for cardiac glycoside biosynthesis in foxglove plants. Recently, we have isolated the gene... 
Enzymes | Leaves | Complementary DNA | RNA | Metabolites | Genes | Cardenolides | Biosynthesis | Biochemistry | Plants | heterologous protein induction | plant defense | short‐chain dehydrogenase/reductase (SDR) family | cardenolide biosynthesis | teroid 5β‐reductase | wounding and abiotic stress | Short-chain dehydrogenase/reductase (SDR) family | Cardenolide biosynthesis | Heterologous protein induction | Plant defense | Wounding and abiotic stress | Steroid 5β-reductase | SHOOT CULTURES | SECONDARY METABOLISM | short-chain dehydrogenase/reductase (SDR) family | TISSUE-CULTURES | PROGESTERONE 5-BETA-REDUCTASE | PLANT SCIENCES | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | PURPUREA | DIGITALIS-LANATA EHRH | ENZYME | steroid 5 beta-reductase | OBSCURA | EXPRESSION | Digitalis - genetics | Amino Acid Sequence | Oxidoreductases - metabolism | Oxidoreductases - genetics | Cardenolides - metabolism | RNA, Messenger - genetics | DNA, Complementary - genetics | Digitalis - immunology | Models, Molecular | Molecular Sequence Data | Gene Expression Profiling | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Oxidoreductases - chemistry | Sequence Analysis, DNA | Metabolic Networks and Pathways | Genes, Plant - genetics | Digitalis - enzymology | Cloning, Molecular | Gene Expression Regulation, Plant | Kinetics | Index Medicus
Journal Article
Journal Article
Tetrahedron, ISSN 0040-4020, 07/2016, Volume 72, Issue 30, pp. 4556 - 4563
Cardenolides are composed of a steroid nucleus and a five-membered unsaturated lactone (butenolide) ring at C-17β. It is assumed that the butenolide ring is... 
Cardenolide biosynthesis | Lactonization | 21-O-Malonyl hemiester | Butenolide ring formation | Intramolecular hydrogen bond | ACID | VON UNGESATTIGTEN LACTONEN | BIOSYNTHESIS | UNSATURATED LACTONES | CHEMISTRY, ORGANIC | STEROID-REIHE | DIGITALIS-PURPUREA | Decarboxylation | Formations | Derivatives | Carbon | Nuclei | Hydroxyl groups | Carbonyls | Rings (mathematics)
Journal Article